EPS-ORC-00126

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00126

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	540.3	1.5E-162	106	440	335

Status

Unreviewed

Ensembl Protein

ENSOCUP00000009296

UniProt Accession

G1T005;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF1

Gene Synonyms/Alias

PPEF1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000010801	ENSOCUP00000009296	ENSOCUT00000010805

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

627

Protein Sequence
(FASTA)

LRATLIIQNW YRGYRARLKA RQHYALAIFQ SIEYADEQSQ MQLSNFFSFM LENYTRVHEE 60

DPKLASRLFE SNVQDIKDRQ DYVGLVEVPD SYEGPRLQFP LSFPDIDLLI EAFKKQQILH 120

AHYVLEVLFE TKKILMQKSN FTHINTSPSK EITICGDLHG KLDDLFMIFY KNGLPSEKNS 180

YIFNGDFVDR GKNSVEILMI LFVSFLVYPN NLHLNRGNHE DFMMNLRYGF TREVLHKYKI 240

HGKKILQMLE EVYTWLPIGT IIDNEILVIH GGISDSTDLC LLHRVQRNKM KSVLMPPMSI 300

IGDNASNLKK NKLGVTINMP DKTEQNDSFS EQLSKHEWEQ VTDILWSDPR GRKGCYPNTS 360

RGGGCYFGPD VTSKVLSKYQ LKLLIRSHEC KPEGYEICHD GKVITVFSAS NYYEEGSNRG 420

AYIRLSFGTS LRFFQYQVTK ATYSKPLHQR VNTIESSAIK ILKERIIGRK TDLIRAFQLQ 480

DHSRSGKIST TQWAFSMENV LGLNLPWRSL SSHLVNTDKN GDIDYMSSFQ DIHIEKPVKE 540

AQSTVIETLY RYRSDLQIIF NIIDSDHSGL ISMEEFRAMW NLFSSHYNVH IDDFQVNELA 600

NTMDLNKDGS IDFNEFLKAF YVVHKFD 627

Nucleotide Sequence
(FASTA)

CTGAGAGCCA CATTGATCAT CCAGAACTGG TACCGAGGTT ACAGAGCTCG CCTCAAGGCC 60

AGACAGCACT ATGCCCTCGC CATCTTCCAG TCCATTGAAT ATGCTGATGA GCAAAGCCAA 120

ATGCAGCTAT CCAACTTCTT TTCTTTCATG TTGGAAAACT ATACTCGTGT ACATGAGGAA 180

GATCCAAAGT TGGCGAGTCG ACTGTTTGAA AGCAATGTCC AGGATATCAA GGACAGACAG 240

GACTATGTGG GATTGGTAGA AGTCCCAGAC TCCTATGAGG GTCCTCGGCT GCAATTTCCT 300

CTCAGTTTTC CTGATATCGA TTTACTTATT GAGGCCTTCA AGAAACAACA GATACTTCAT 360

GCTCATTATG TCTTAGAGGT GCTGTTTGAA ACCAAGAAAA TCCTCATGCA GAAGTCGAAT 420

TTCACTCACA TAAATACTTC TCCCTCCAAA GAGATAACAA TCTGTGGTGA TTTGCATGGG 480

AAACTTGATG ACCTTTTTAT GATCTTCTAT AAGAATGGCC TCCCCTCAGA GAAAAACTCA 540

TACATCTTCA ACGGTGACTT TGTAGACCGA GGAAAAAATT CCGTAGAGAT CCTAATGATC 600

CTGTTTGTGA GTTTTCTTGT GTACCCCAAT AACCTGCACT TGAACAGAGG CAACCATGAA 660

GACTTTATGA TGAATCTGAG GTACGGCTTC ACAAGAGAAG TTTTGCATAA ATACAAGATA 720

CATGGGAAGA AAATCTTACA AATGTTGGAA GAAGTCTATA CCTGGCTTCC AATTGGTACG 780

ATCATTGACA ATGAGATCCT GGTCATACAT GGTGGGATAT CTGATTCCAC AGACTTGTGT 840

TTACTCCACC GTGTACAAAG AAACAAAATG AAATCTGTGC TGATGCCACC AATGTCAATA 900

ATTGGAGACA ATGCCTCCAA CTTGAAGAAA AATAAACTAG GTGTCACCAT TAATATGCCA 960

GATAAAACCG AACAAAATGA CTCTTTTTCT GAACAGCTAT CAAAGCACGA ATGGGAGCAG 1020

GTTACTGATA TTCTGTGGAG CGATCCCAGA GGCAGAAAAG GCTGCTATCC AAACACAAGT 1080

CGCGGTGGGG GCTGCTATTT TGGTCCAGAC GTGACGTCTA AGGTTCTCAG TAAATACCAG 1140

TTGAAGCTGC TCATCAGGTC TCATGAATGC AAACCCGAAG GGTATGAAAT CTGCCATGAC 1200

GGAAAGGTCA TCACTGTATT TTCTGCTTCT AACTATTATG AAGAAGGCAG CAACCGAGGC 1260

GCTTACATCA GACTGAGTTT TGGTACCAGC CTTCGATTTT TCCAGTACCA AGTAACTAAG 1320

GCAACATACT CGAAGCCTCT TCACCAAAGG GTGAATACTA TTGAAAGCAG TGCCATTAAG 1380

ATATTAAAAG AGAGGATAAT TGGACGAAAA ACTGACCTCA TCCGTGCCTT CCAGCTTCAA 1440

GACCATAGTC GATCAGGAAA AATTTCAACG ACCCAGTGGG CTTTTTCCAT GGAGAACGTT 1500

TTGGGGCTGA ACTTACCATG GAGATCCCTG AGTTCCCACC TAGTAAATAC AGACAAAAAT 1560

GGAGACATTG ACTATATGTC CAGCTTCCAG GATATCCACA TTGAAAAACC TGTGAAAGAG 1620

GCTCAGTCTA CTGTCATTGA AACTTTGTAC CGATATCGAT CTGACCTGCA AATCATATTT 1680

AATATCATTG ATTCTGATCA CTCAGGTCTG ATCTCCATGG AAGAATTCCG GGCCATGTGG 1740

AACCTTTTCA GTTCTCACTA CAACGTTCAT ATTGATGATT TCCAGGTTAA CGAGCTCGCC 1800

AACACAATGG ACTTAAACAA GGATGGGAGC ATTGACTTCA ATGAGTTTTT AAAGGCTTTC 1860

TATGTAGTGC ATAAGTTCGA T 1881

Domain Profile

S: 1     idlllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddl  60

         idll+e+fkk++ilha+yvlevlfe+kk+l q  n++h++t++ske+t++GdlhGklddl

Q: 106   IDLLIEAFKKQQILHAHYVLEVLFETKKILMQKSNFTHINTSPSKEITICGDLHGKLDDL  165

         8***********************************************************

S: 61    llvlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmn  120

         +++++knGlPse+n+y+fnGdfvdrGk+++e+l++l ++flv+Pn+++lnrGnhed++mn

Q: 166   FMIFYKNGLPSEKNSYIFNGDFVDRGKNSVEILMILFVSFLVYPNNLHLNRGNHEDFMMN  225

         ************************************************************

S: 121   aryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksv  180

         +ryGf++evl+kyk +gk+il++leevy+wlP+g+i+d+++lv+hGG+s+st+l ll++v

Q: 226   LRYGFTREVLHKYKIHGKKILQMLEEVYTWLPIGTIIDNEILVIHGGISDSTDLCLLHRV  285

         ************************************************************

S: 181   erkkrksvllpPeessrd................lgrldtdgepreslteteweqiidil  224

         +r+k+ksvl+pP+    d                  + +++ + +e+l ++eweq+ dil

Q: 286   QRNKMKSVLMPPMSIIGDnasnlkknklgvtinmPDKTEQNDSFSEQLSKHEWEQVTDIL  345

         ************976666888999***999998767778888889***************

S: 225   wsdPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvt  284

         wsdPr+++G++Pnt rG+G+yfGPdvt+++l ky+lkl+irsheckpegyei+hdgkv+t

Q: 346   WSDPRGRKGCYPNTSRGGGCYFGPDVTSKVLSKYQLKLLIRSHECKPEGYEICHDGKVIT  405

         ************************************************************

S: 285   ifsasnyyeegsnkgayiklnsqltprfvqyivak  319

         +fsasnyyeegsn+gayi+l+ ++  rf+qy+v+k

Q: 406   VFSASNYYEEGSNRGAYIRLSFGTSLRFFQYQVTK  440

         ********************************996

Domain Sequence
(FASTA)

IDLLIEAFKK QQILHAHYVL EVLFETKKIL MQKSNFTHIN TSPSKEITIC GDLHGKLDDL 60

FMIFYKNGLP SEKNSYIFNG DFVDRGKNSV EILMILFVSF LVYPNNLHLN RGNHEDFMMN 120

LRYGFTREVL HKYKIHGKKI LQMLEEVYTW LPIGTIIDNE ILVIHGGISD STDLCLLHRV 180

QRNKMKSVLM PPMSIIGDNA SNLKKNKLGV TINMPDKTEQ NDSFSEQLSK HEWEQVTDIL 240

WSDPRGRKGC YPNTSRGGGC YFGPDVTSKV LSKYQLKLLI RSHECKPEGY EICHDGKVIT 300

VFSASNYYEE GSNRGAYIRL SFGTSLRFFQ YQVTK 335

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 2.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013