EKS-ORC-00148
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00148
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb494.19.4E-149419676258
StatusUnreviewed
Ensembl ProteinENSOCUP00000024356
UniProt AccessionG1T071;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA1
Gene Synonyms/Alias RPS6KA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000010887ENSOCUP00000024356ENSOCUT00000024783
ENSOCUG00000010887ENSOCUP00000009371ENSOCUT00000010892
OrganismOryctolagus cuniculus
Functional Description
Protein Length736
Protein Sequence
(FASTA)
SCPSLREPLA LGGALQNLSP VQNGQASGEE AGLEPAKDEG VLKEISITHH VKAGSEKADP 60
SHFELLKVLG QGSFGKVFLV RKVTRPDSGH LYAMKVLKKA TLKVRDRVRT KMERDILADV 120
NHPFVVKLHY AFQTEGKLYL ILDFLRGGDL FTRLSKEVMF TEEDVKFYLA ELALGLDHLH 180
SLGIIYRDLK PENILLDEEG HIKLTDFGLS KEAIDHEKKA YSFCGTVEYM APEVVNRQGH 240
THSADWWSYG VLMFEMLTGS LPFQGKDRKD TMNLILKAKL GMPQFLSTEA QSLLRALFKR 300
NPANRLGSGP DGAEEIKRHV FYSTIDWNKL YRREIKPPFK PAVAQPDDTF YFDTEFTSRT 360
PKDSPGIPPS AGAHQLFRGF SFVATGLMED DSKSRATQAP LHSVVQQLHG KNLVFSDGYV 420
VKETIGVGSY SVCKRCVHKA TNTEYAVKVI DKSKRDPSEE IEILLRYGQH PNIITLKDVY 480
DDGKHVYLVT ELMRGGELLD KILRQKFFSE REASCVLHTI SKTVEYLHSQ GVVHRDLKPS 540
NILYVDESGN PECLRICDFG FAKQLRAENG LLMTPCYTAN FVAPEVLKRQ GYDEGCDIWS 600
LGILLYTMLA GYTPFANGPS DTPEEILSRI GSGKFTLSGG NWNTVSEAAK DLVSKMLHVD 660
PHRRLTAKQV LQHPWITQKD KLPQSQLSHQ DLQLVKGAMA ATYSALNSSK PTPQLKPIES 720
SILAQRRVRK LPSTTL 736
Nucleotide Sequence
(FASTA)
TCCTGCCCCT CCCTCCGGGA GCCCCTGGCT CTTGGGGGTG CCCTGCAGAA TCTCTCTCCT 60
GTGCAGAATG GCCAGGCCTC GGGGGAAGAA GCCGGACTTG AGCCAGCCAA GGATGAGGGC 120
GTCCTCAAGG AGATCTCCAT CACGCACCAC GTCAAGGCTG GCTCCGAGAA GGCCGACCCG 180
TCCCACTTCG AGCTCCTCAA GGTTTTGGGA CAGGGATCCT TTGGCAAAGT CTTCCTGGTG 240
CGCAAGGTCA CCCGGCCTGA CAGTGGGCAC CTGTATGCCA TGAAGGTGCT GAAGAAGGCG 300
ACATTGAAAG TGCGCGACCG CGTCCGGACC AAGATGGAGA GGGACATCCT GGCCGACGTG 360
AACCACCCCT TTGTGGTGAA GCTGCACTAT GCCTTCCAGA CAGAGGGCAA GCTCTATCTC 420
ATTCTGGACT TCCTGCGCGG TGGGGACCTC TTCACACGGC TCTCAAAAGA GGTCATGTTC 480
ACAGAGGAGG ACGTGAAGTT TTACCTGGCC GAGCTGGCGT TGGGTCTGGA CCACCTGCAT 540
AGCCTGGGCA TCATTTACAG AGACCTCAAG CCTGAGAACA TTCTTCTGGA CGAGGAGGGC 600
CACATCAAGC TCACTGACTT TGGCCTGAGC AAGGAGGCCA TCGACCACGA GAAGAAGGCC 660
TACTCCTTCT GCGGGACAGT GGAGTACATG GCCCCCGAGG TCGTCAACCG CCAGGGCCAC 720
ACCCACAGCG CCGACTGGTG GTCCTACGGG GTGTTGATGT TCGAGATGCT GACAGGCTCC 780
CTGCCCTTCC AGGGGAAGGA CCGGAAGGAC ACCATGAACC TGATTCTCAA GGCGAAGCTC 840
GGCATGCCCC AGTTTCTGAG CACTGAAGCC CAGAGCCTCC TGCGAGCCCT GTTCAAACGG 900
AATCCTGCCA ACCGGCTGGG CTCTGGCCCC GATGGGGCAG AGGAAATCAA GCGGCACGTC 960
TTCTATTCCA CCATCGACTG GAACAAGCTG TATCGCCGTG AAATCAAGCC GCCCTTCAAA 1020
CCGGCCGTGG CCCAGCCCGA TGACACCTTC TACTTTGACA CAGAATTCAC ATCCCGCACT 1080
CCCAAGGATT CCCCAGGCAT CCCCCCTAGC GCCGGTGCTC ATCAGCTGTT CCGTGGCTTC 1140
AGCTTCGTGG CCACCGGCCT GATGGAGGAC GACAGCAAGT CCCGGGCCAC GCAGGCACCA 1200
CTGCACTCCG TGGTACAGCA ACTCCATGGG AAGAACCTTG TTTTCAGCGA TGGCTACGTG 1260
GTGAAGGAGA CAATCGGTGT GGGCTCCTAC TCCGTGTGCA AGCGCTGTGT CCACAAGGCC 1320
ACCAACACGG AGTACGCTGT CAAGGTCATT GACAAGAGTA AGCGGGACCC CTCAGAAGAG 1380
ATTGAGATTC TTCTGCGGTA CGGGCAGCAC CCCAACATCA TCACGCTGAA AGACGTGTAT 1440
GACGACGGCA AACACGTGTA CCTGGTGACG GAGCTGATGC GGGGCGGGGA GCTGCTGGAC 1500
AAGATCCTGC GGCAGAAGTT CTTCTCGGAG CGGGAGGCCA GCTGTGTCCT GCACACCATC 1560
AGCAAGACCG TGGAGTACCT GCACTCGCAG GGGGTGGTGC ACAGGGACCT CAAGCCCAGC 1620
AACATCCTAT ACGTGGACGA GTCGGGGAAC CCCGAGTGCC TGCGCATCTG TGACTTCGGC 1680
TTTGCCAAGC AGCTGCGGGC TGAGAACGGG CTCCTCATGA CCCCTTGCTA CACAGCCAAC 1740
TTCGTGGCAC CCGAGGTGCT GAAGCGCCAG GGCTATGATG AAGGCTGTGA CATCTGGAGC 1800
CTGGGCATCC TGCTGTACAC CATGCTGGCA GGATACACGC CGTTCGCCAA CGGGCCCAGC 1860
GACACTCCGG AGGAGATCCT GAGCCGCATC GGCAGTGGGA AGTTCACCCT CAGCGGGGGC 1920
AACTGGAACA CAGTGTCCGA GGCCGCCAAG GACCTGGTGT CCAAGATGCT GCACGTGGAC 1980
CCCCACCGGC GCCTCACAGC CAAGCAGGTG CTGCAGCACC CGTGGATCAC GCAGAAGGAC 2040
AAGCTCCCCC AGAGCCAGCT GTCCCACCAG GATCTGCAGC TCGTGAAGGG AGCCATGGCA 2100
GCCACATACT CCGCGCTCAA CAGCTCCAAG CCCACCCCGC AGCTGAAGCC CATAGAGTCG 2160
TCCATCCTGG CCCAGCGGCG GGTGAGGAAG CTGCCGTCCA CCACCCTGTG A 2211
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         y+vke++GvGsysvckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd
Q: 419   YVVKETIGVGSYSVCKRCVHKATNTEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  478
         689*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelld+i+++kffsereas +l+t++k+veylh+qGvvhrdlk
Q: 479   VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASCVLHTISKTVEYLHSQGVVHRDLK  538
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nilyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+
Q: 539   PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  598
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaGy+pfangp+dt+eeil +i++Gkf+lsG++w++vse+akdlvsk+l+
Q: 599   WSLGILLYTMLAGYTPFANGPSDTPEEILSRIGSGKFTLSGGNWNTVSEAAKDLVSKMLH  658
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl+++q+l+h+w+
Q: 659   VDPHRRLTAKQVLQHPWI  676
         *****************8
Domain Sequence
(FASTA)
YVVKETIGVG SYSVCKRCVH KATNTEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKHVYL VTELMRGGEL LDKILRQKFF SEREASCVLH TISKTVEYLH SQGVVHRDLK 120
PSNILYVDES GNPECLRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180
WSLGILLYTM LAGYTPFANG PSDTPEEILS RIGSGKFTLS GGNWNTVSEA AKDLVSKMLH 240
VDPHRRLTAK QVLQHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00153
EKS-BOT-00160
EKS-CAE-00123
EKS-CAJ-00166
EKS-CAF-00167
EKS-CAP-00160
EKS-CHH-00022
EKS-DAR-00450
EKS-EQC-00159
EKS-ERE-00040
EKS-FEC-00151
EKS-GAG-00138
EKS-GAA-00191
EKS-GOG-00161
EKS-HOS-00166
EKS-LAC-00172
EKS-LOA-00161
EKS-MAM-00159
EKS-MAE-00059
EKS-MEG-00129
EKS-MIM-00076
EKS-MOD-00160
EKS-MUM-00165
EKS-MUP-00163
EKS-MYL-00171
EKS-NOL-00154
EKS-OCP-00101
EKS-ORN-00201
EKS-ORL-00188
EKS-OTG-00166
EKS-PAT-00151
EKS-PES-00143
EKS-POA-00157
EKS-PRC-00043
EKS-PTV-00145
EKS-RAN-00158
EKS-SAH-00155
EKS-SOA-00029
EKS-SUS-00142
EKS-TAG-00190
EKS-TAR-00208
EKS-TEN-00200
EKS-XET-00151
EKS-XIM-00195
EKS-SCP-00067
Gene Ontology
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0043066; P:negative regulation of apoptotic process
GO:2000491; P:positive regulation of hepatic stellate cell activation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013