EKS-ORC-00209

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00209

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	413.5	3.9E-124	23	304	282

Status

Unreviewed

Ensembl Protein

ENSOCUP00000009826

UniProt Accession

G1T199;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK5

Gene Synonyms/Alias

MAPKAPK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000011427	ENSOCUP00000009826	ENSOCUT00000011424

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

473

Protein Sequence
(FASTA)

MSEESDMEKA IKETSILEEY NINWTQKLGA GISGPVRVCV KKSTQERLAL KILLDRPKAR 60

NEVRLHMMCA THPNIVQIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF 120

TEKQASQVTK QIALALQHCH SLNVAHRDLK PENLLFKDNS LDAPVKLCDF GFAKIDQGDL 180

MTPQFTPYYV APQVLEAQRR HQKEKSGIIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP 240

FYSKHHSRTI PKDMRRKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD 300

HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL 360

RKRKLLGTKP KDGVYIHDQE NGAEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ 420

EAWKYNRECK LLRDSLQSFS WNGRGFTDKV DRLKLAEIVK QVIEEQTTSH ESQ 473

Nucleotide Sequence
(FASTA)

ATGTCGGAGG AGAGCGACAT GGAGAAAGCC ATCAAGGAAA CCTCCATTTT AGAAGAATAC 60

AATATCAATT GGACTCAGAA GCTGGGAGCT GGAATTAGTG GTCCAGTTAG AGTCTGTGTG 120

AAGAAATCTA CCCAAGAACG GCTTGCACTG AAAATTCTTC TTGATCGTCC AAAAGCTAGA 180

AATGAGGTAC GTCTGCACAT GATGTGTGCC ACACACCCCA ATATAGTTCA GATTATTGAA 240

GTGTTTGCTA ACAGTGTACA GTTTCCTCAT GAGTCCAGTC CCAGGGCTCG ACTCTTAATT 300

GTAATGGAGA TGATGGAAGG GGGCGAGCTA TTTCACAGAA TCAGCCAGCA CCGGCACTTT 360

ACAGAGAAGC AAGCCAGCCA AGTAACAAAG CAGATAGCTT TGGCCCTACA GCACTGTCAC 420

TCGTTAAACG TCGCACACAG AGACCTCAAG CCTGAAAATC TTCTTTTCAA GGATAATTCT 480

TTGGATGCCC CAGTGAAGTT ATGTGACTTT GGATTTGCTA AAATTGACCA AGGTGACTTG 540

ATGACACCCC AGTTCACCCC TTATTATGTA GCACCTCAGG TACTGGAGGC ACAGAGAAGG 600

CATCAGAAGG AGAAGTCTGG CATCATACCT ACCTCGCCAA CGCCCTATAC TTACAACAAG 660

AGCTGTGACT TGTGGTCCCT AGGGGTGATT ATCTACGTGA TGCTGTGCGG ATATCCCCCT 720

TTTTACTCCA AACACCACAG CCGGACGATC CCAAAGGATA TGCGGAGAAA GATCATGACA 780

GGCAGTTTTG AGTTTCCAGA GGAAGAGTGG AGCCAGATCT CGGAGATGGC CAAAGACGTT 840

GTGAGGAAGC TCCTGAAAGT CAAGCCAGAG GAAAGACTCA CCATCGAGGG AGTTTTGGAC 900

CACCCTTGGC TCAACTCCAC CGAAGCCCTG GATAATGTGC TACCGTCTGC TCAACTGATG 960

ATGGATAAGG CGGTGGTGGC GGGAATCCAG CAGGCTCACG CGGAGCAGTT GGCCAACATG 1020

AGAATTCAGG ACCTGAAAGT CAGCCTCAAA CCCCTGCACT CGGTGAACAA CCCCATTCTG 1080

AGGAAGAGGA AGCTACTTGG CACCAAGCCA AAGGATGGTG TTTATATCCA CGACCAAGAG 1140

AATGGCGCTG AAGATTCAAA TGTTGCCTTG GAGAAGCTCC GAGATGTGAT TGCCCAGTGT 1200

ATTCTCCCAC AGGCTGGTAA AGGAGAGAAT GAAGACGAGA AGTTGAATGA AGTAATGCAG 1260

GAAGCTTGGA AGTATAACCG GGAATGCAAA CTCCTAAGAG ACAGTCTGCA AAGCTTCAGC 1320

TGGAATGGTC GTGGATTCAC AGATAAAGTA GATCGACTAA AACTGGCAGA AATTGTGAAA 1380

CAAGTGATAG AAGAGCAAAC CACGTCCCAT GAATCCCAA 1419

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidvf  61

         +++++lG+Gisg v+ cvkk+t+e+ alkil dr+k+r+ev+lh+++++h+niv++i+vf

Q: 23    NWTQKLGAGISGPVRVCVKKSTQERLALKILLDRPKARNEVRLHMMCATHPNIVQIIEVF  82

         689*********************************************************

S: 62    ensfe......dekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         +ns++      +++rll+v+e++eGGel++ri+++++ftek+as+v+k+ia al+++hs

Q: 83    ANSVQfphessPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALQHCHSL  142

         ****99999999************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaeke  175

         n+ahrDlkpenlL+++++ +apvklcDfg+ak   ++ +l+tp++t++yvaP+vlea+++

Q: 143   NVAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQFTPYYVAPQVLEAQRR  200

         ********************************..89***********************9

S: 176   e.............allydksCDlWslGvilyillcGypPfyskk.graiskklkeriqe  221

         +             +++y+ksCDlWslGvi+y++lcGypPfysk+ +r+i+k+++++i++

Q: 201   HqkeksgiiptsptPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHhSRTIPKDMRRKIMT  260

         99*****************************************9979*************

S: 222   gkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         g++efPeeeWs++se+akd++rklLk++p+erltie vl+hpw+

Q: 261   GSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL  304

         *******************************************6

Domain Sequence
(FASTA)

NWTQKLGAGI SGPVRVCVKK STQERLALKI LLDRPKARNE VRLHMMCATH PNIVQIIEVF 60

ANSVQFPHES SPRARLLIVM EMMEGGELFH RISQHRHFTE KQASQVTKQI ALALQHCHSL 120

NVAHRDLKPE NLLFKDNSLD APVKLCDFGF AKIDQGDLMT PQFTPYYVAP QVLEAQRRHQ 180

KEKSGIIPTS PTPYTYNKSC DLWSLGVIIY VMLCGYPPFY SKHHSRTIPK DMRRKIMTGS 240

FEFPEEEWSQ ISEMAKDVVR KLLKVKPEER LTIEGVLDHP WL 282

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0046777	; P:protein autophosphorylation
GO:0007265	; P:Ras protein signal transduction
GO:0006417	; P:regulation of translation
GO:0090400	; P:stress-induced premature senescence

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013