EKS-ORC-00152
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00152
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKG509.41.9E-153123381259
StatusUnreviewed
Ensembl ProteinENSOCUP00000009871
UniProt AccessionG1T1D4;
Protein Name
Protein Synonyms/Alias cGMP-dependent protein kinase 1;
Gene NamePRKG1
Gene Synonyms/Alias PRKG1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000011473ENSOCUP00000009871ENSOCUT00000011479
OrganismOryctolagus cuniculus
Functional Description
Protein Length433
Protein Sequence
(FASTA)
QTHYENGEYI IRQGARGDTF FIISKGKVNV TREDSPSEDP IFLRTLGKGD WFGEKALQGE 60
DVRTANVIAA EAVTCLVIDR DSFKHLIGGL DDVSNKAYED AEAKAKYEAE AAFFANLKLS 120
DFNIIDTLGV GGFGRVELVQ LKSEESKTFA MKILKKRHIV DTRQQEHIRS EKQIMQGAHS 180
DFIVRLYRTF KDSKYLYMLM EACLGGELWT ILRDRGSFED STTRFYTACV VEAFAYLHSK 240
GIIYRDLKPE NLILDHRGYA KLVDFGFAKK IGFGKKTWTF CGTPEYVAPE IILNKGHDIS 300
ADYWSLGILM YELLTGSPPF SGPDPMKTYN IILRGIDMIE FPKKIAKNAA NLIKKLCRDT 360
PSERLGNLKN GVKDIQKHKW FEGFNWEGLR KGTLTPPIIP SVASPTDTSN FDSFPEDNDE 420
PPPDDNSGWD IDF 433
Nucleotide Sequence
(FASTA)
CAGACCCACT ATGAAAATGG GGAATATATT ATCAGACAAG GTGCAAGAGG AGACACCTTC 60
TTTATCATCA GCAAAGGAAA GGTAAATGTC ACTCGCGAAG ACTCACCAAG TGAAGACCCT 120
ATCTTTCTCA GAACTTTAGG AAAAGGAGAC TGGTTTGGAG AGAAAGCCTT GCAGGGGGAA 180
GATGTGAGAA CAGCGAATGT AATTGCTGCA GAAGCCGTAA CCTGCCTTGT GATTGACAGA 240
GACTCTTTCA AGCATCTGAT TGGAGGGCTG GATGACGTTT CTAACAAAGC CTATGAGGAT 300
GCAGAAGCTA AAGCAAAATA TGAAGCCGAA GCTGCCTTCT TCGCCAACCT GAAGCTGTCT 360
GATTTCAACA TCATCGACAC CCTTGGAGTT GGAGGTTTCG GGCGAGTGGA GCTGGTCCAG 420
TTGAAGAGTG AAGAATCCAA AACATTTGCA ATGAAGATTC TCAAGAAGCG CCACATAGTG 480
GACACGAGAC AGCAGGAACA CATTCGCTCG GAGAAGCAAA TCATGCAGGG CGCGCATTCC 540
GACTTCATCG TGAGACTCTA CAGAACATTT AAGGACAGCA AATATTTGTA TATGTTGATG 600
GAAGCTTGCC TAGGAGGAGA GCTCTGGACC ATTCTCAGGG ATAGAGGTTC ATTTGAAGAT 660
TCTACAACCA GATTTTACAC AGCATGTGTG GTAGAAGCTT TTGCCTATCT GCATTCCAAA 720
GGAATCATTT ATCGGGACCT CAAGCCAGAA AATCTCATCC TAGATCACCG AGGTTATGCT 780
AAATTGGTTG ATTTTGGCTT TGCAAAGAAA ATAGGATTTG GAAAGAAAAC ATGGACTTTC 840
TGTGGGACTC CAGAGTATGT GGCTCCAGAG ATCATCCTGA ATAAAGGCCA TGACATTTCA 900
GCCGACTACT GGTCACTGGG AATCCTAATG TATGAACTTC TGACTGGCAG CCCACCTTTC 960
TCAGGCCCAG ATCCTATGAA AACCTATAAC ATCATATTGA GAGGCATCGA CATGATAGAA 1020
TTTCCAAAGA AGATTGCCAA AAATGCTGCT AATTTAATTA AAAAACTATG CAGGGACACC 1080
CCTTCAGAAA GACTAGGAAA TTTGAAAAAC GGAGTGAAAG ACATTCAAAA GCACAAATGG 1140
TTTGAAGGCT TTAACTGGGA AGGTTTAAGA AAAGGCACCT TGACACCTCC TATAATACCA 1200
AGTGTTGCAT CACCCACAGA CACTAGCAAC TTTGACAGCT TCCCTGAGGA CAATGATGAA 1260
CCACCACCTG ACGACAACTC AGGCTGGGAC ATAGACTTCT AA 1302
Domain Profile
S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61
         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf
Q: 123   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  182
         79**********************************************************
S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121
         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i
Q: 183   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  242
         ************************************************************
S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181
         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d
Q: 243   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  302
         ************************************************************
S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241
         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrd+p+
Q: 303   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDTPS  362
         ************************************************************
S: 242   erlgylkggikdikkhkwf  260
         erlg+lk+g+kdi+khkwf
Q: 363   ERLGNLKNGVKDIQKHKWF  381
         ******************9
Domain Sequence
(FASTA)
NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60
IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120
IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180
YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDTPS 240
ERLGNLKNGV KDIQKHKWF 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00157
EKS-ANC-00161
EKS-BOT-00165
EKS-CAJ-00169
EKS-CAF-00172
EKS-CAP-00164
EKS-CHH-00026
EKS-CII-00108
EKS-DAR-00454
EKS-EQC-00164
EKS-GAG-00141
EKS-GAA-00195
EKS-HOS-00171
EKS-ICT-00160
EKS-LAC-00175
EKS-LOA-00164
EKS-MAM-00163
EKS-MOD-00164
EKS-MUM-00170
EKS-MUP-00169
EKS-MYL-00175
EKS-NOL-00158
EKS-ORN-00205
EKS-ORA-00146
EKS-ORL-00191
EKS-OTG-00171
EKS-PAT-00156
EKS-PES-00146
EKS-SAH-00160
EKS-SUS-00144
EKS-TAG-00194
EKS-TAR-00212
EKS-TEN-00205
EKS-TUT-00151
EKS-VIP-00078
EKS-XIM-00200
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005246; F:calcium channel regulator activity
GO:0030553; F:cGMP binding
GO:0004692; F:cGMP-dependent protein kinase activity
GO:0016358; P:dendrite development
GO:0030900; P:forebrain development
GO:0090331; P:negative regulation of platelet aggregation
GO:0001764; P:neuron migration
GO:0043087; P:regulation of GTPase activity
GO:0007165; P:signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR002374; cGMP_dep_kinase.
IPR018490; cNMP-bd-like.
IPR018488; cNMP-bd_CS.
IPR000595; cNMP-bd_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014710; RmlC-like_jellyroll.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00027; cNMP_binding; 1.
PF00069; Pkinase; 1.
SMARTs
SM00100; cNMP; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00888; CNMP_BINDING_1; 1.
PS00889; CNMP_BINDING_2; 1.
PS50042; CNMP_BINDING_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00104; CGMPKINASE.
Created Date20-Feb-2013