EKS-ORC-00401

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00401

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	533.2	1.5E-160	163	420	258

Status

Unreviewed

Ensembl Protein

ENSOCUP00000009956

UniProt Accession

G1T1J7;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK3

Gene Synonyms/Alias

SGK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000011573	ENSOCUP00000009956	ENSOCUT00000011578

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

497

Protein Sequence
(FASTA)

MQRVYTMDYK ESCPSVSIPS SDEHREKKKR FTVYKVLVSV GRSEWFVFRR YAEFDKLYNT 60

LKKQFPAMAL KIPAKRIFGD NFDPDFIKQR RAGLNEFIQN LVRHPELYNH PDVRAFLLMD 120

SPKHQSDPSE DEDERNTQKV LHSTSPNINL GPSGNPHAKP TDFDFLKVIG KGSFGKVLLA 180

KRKLDGKFYA VKVLQKKIVL NRKEQKHIMA ERNVLLKNVK HPFLVGLHYS FQTTEKLYFV 240

LDFINGGELF FHLQRERSFP EHRARFYAAE IASALGYLHS IKIVYRDLKP ENILLDSVGH 300

VVLTDFGLCK EGIAISDTTT TFCGTPEYLA PEVIRKQPYD NTVDWWCLGA VLYEMLYGLP 360

PFYCRDVAEM YDNILHKPLS LRPGVSLTAW SILEELLEKN RQNRLGAKED FLEIQNHPFF 420

ESLSWTDLVQ KKIPPPFNPN VAGPDDIRNF DTAFTEETVP YSVCVSSDYS IVNASVLEAD 480

DAFVGFSYAP PSEDLFL 497

Nucleotide Sequence
(FASTA)

ATGCAAAGAG TGTATACCAT GGACTACAAG GAAAGCTGCC CGAGTGTAAG CATTCCCAGC 60

TCTGATGAAC ACAGAGAGAA AAAGAAGAGG TTTACTGTTT ATAAAGTGCT GGTCTCAGTG 120

GGCAGGAGTG AGTGGTTTGT CTTCAGGAGA TACGCAGAGT TTGATAAACT TTACAACACT 180

TTAAAGAAAC AGTTTCCTGC TATGGCCCTG AAAATTCCTG CCAAGAGAAT ATTTGGGGAT 240

AATTTTGATC CAGATTTTAT TAAACAAAGA AGAGCAGGAC TGAATGAATT CATTCAGAAC 300

TTAGTCAGGC ATCCAGAGCT TTACAACCAT CCAGATGTCA GAGCATTCCT TCTAATGGAC 360

AGTCCGAAGC ATCAGTCAGA TCCATCTGAA GATGAGGATG AAAGAAATAC TCAGAAGGTA 420

CTACACTCTA CCTCACCGAA CATCAACCTG GGACCGTCTG GAAATCCTCA TGCTAAGCCG 480

ACTGACTTTG ATTTTTTAAA AGTTATTGGG AAAGGCAGCT TTGGCAAGGT TCTTCTTGCA 540

AAACGAAAAC TGGATGGAAA ATTTTATGCT GTCAAGGTAT TACAGAAAAA AATAGTTCTC 600

AACAGAAAAG AGCAAAAGCA TATTATGGCT GAACGTAATG TGCTCTTGAA AAATGTGAAG 660

CATCCATTTT TGGTTGGATT ACATTATTCC TTCCAAACAA CTGAAAAGCT TTATTTTGTT 720

CTGGATTTTA TTAATGGAGG GGAGCTGTTT TTTCACTTAC AAAGAGAACG GTCCTTTCCG 780

GAACACAGGG CAAGGTTTTA TGCTGCTGAA ATTGCCAGTG CATTGGGTTA TTTGCACTCC 840

ATCAAAATAG TGTACAGGGA CTTGAAACCA GAAAATATTC TTTTGGATTC AGTAGGACAT 900

GTTGTCTTAA CAGATTTTGG GCTTTGTAAA GAAGGAATTG CTATTTCTGA TACCACCACA 960

ACATTCTGTG GGACACCAGA GTATCTCGCA CCCGAAGTAA TCAGGAAACA GCCATATGAC 1020

AACACTGTAG ATTGGTGGTG CCTGGGCGCT GTCCTTTATG AAATGTTGTA TGGATTGCCT 1080

CCTTTTTATT GCCGAGATGT TGCTGAAATG TATGATAATA TTCTTCACAA GCCCCTAAGT 1140

TTGAGGCCAG GGGTGAGCCT CACAGCTTGG TCCATTCTGG AAGAACTCCT AGAAAAAAAC 1200

AGGCAAAATC GACTTGGTGC CAAAGAAGAC TTTCTTGAAA TTCAGAACCA TCCTTTTTTT 1260

GAATCACTCA GCTGGACTGA CCTGGTACAA AAGAAGATTC CACCACCATT CAATCCTAAT 1320

GTGGCTGGAC CCGATGATAT CAGGAACTTC GACACAGCAT TTACAGAAGA AACAGTTCCG 1380

TATTCCGTGT GTGTGTCTTC TGACTATTCT ATAGTGAACG CCAGTGTCTT GGAGGCAGAT 1440

GATGCATTCG TTGGTTTCTC TTACGCACCT CCTTCAGAAG ACCTGTTTTT GTGA 1494

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         fdflkvigkgsfgkvllakrk d+kfyavkvlqkk++l++ke+khimaernvllknvkhp

Q: 163   FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHP  222

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglhysfqt+eklyfvld++nggelffhlqrersf+e+rarfyaaeiasalgylhs++

Q: 223   FLVGLHYSFQTTEKLYFVLDFINGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK  282

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds ghvvltdfglcke+i+++dtt+tfcgtpeylapev+rk+pyd+t

Q: 283   IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT  342

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfy+rdvaemydnil+kpl+l+pg+s++a+++leellek+r+

Q: 343   VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKNRQ  402

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         +rlgakedflei+nh+ff

Q: 403   NRLGAKEDFLEIQNHPFF  420

         *****************9

Domain Sequence
(FASTA)

FDFLKVIGKG SFGKVLLAKR KLDGKFYAVK VLQKKIVLNR KEQKHIMAER NVLLKNVKHP 60

FLVGLHYSFQ TTEKLYFVLD FINGGELFFH LQRERSFPEH RARFYAAEIA SALGYLHSIK 120

IVYRDLKPEN ILLDSVGHVV LTDFGLCKEG IAISDTTTTF CGTPEYLAPE VIRKQPYDNT 180

VDWWCLGAVL YEMLYGLPPF YCRDVAEMYD NILHKPLSLR PGVSLTAWSI LEELLEKNRQ 240

NRLGAKEDFL EIQNHPFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016023	; C:cytoplasmic membrane-bounded vesicle
GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR001683	; Phox.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF00787	; PX; 1.

SMARTs

SM00312	; PX; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50195	; PX; 1.

Prints

Created Date

20-Feb-2013