EKS-ORC-00464
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00464
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RIPK349.11.9E-10419285267
StatusUnreviewed
Ensembl ProteinENSOCUP00000010138
UniProt AccessionG1T201;
Protein Name
Protein Synonyms/Alias
Gene NameRIPK1
Gene Synonyms/Alias RIPK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000011791ENSOCUP00000010138ENSOCUT00000011792
OrganismOryctolagus cuniculus
Functional Description
Protein Length670
Protein Sequence
(FASTA)
QQADMSLDDI KMKSSDFLEK ADLDSGGFGE VSLCFHRLHG LVILKKVYTG PKRAEYNESL 60
LEEGRMMHRL KHSRVVELLG VVMEEGNYCL VMEYMEKGSL MHVLKAEISI PLSVKGRIIA 120
ETIEGMCYLH GEGVIHKDLK PENILVDNDF HIKIADLGVA SFKTWSKLTK EEHNEQRKVN 180
STRKKTGGTL CYMAPEHLND VNAKPTEKSD VYSFAIVLWA VLANKEPYEN AICEQQLILC 240
IKSGNRPDVD DVAEDCPGEL IRLMELCWEA DPRARPTFPD IEERFRPFYS SHYEEFVEED 300
VKSLKKRYPE QSAVVKRMQS LQLDCVPVPP SRSNSATEQP SSLHSSQGFM TGPVEVSFFS 360
ACPEISQEEN EPSLQSKLQE EANYHLYGSR MDKQTRQPPR QSVAYSREEE RRRRVSYDPF 420
AQQTPYENVQ KTGIKVHSYP GTTSHSNAAH QPTGLTSQPQ LPYWNNGVYS LHGFGTRPLE 480
PGTAGQAVWY GPSLSPMSSL YKTPVPETNL LGNTPTIPFS SLSPAEESMK CSIYNSSGIQ 540
LGACNYMEIG GISSPPLECL CTNLQEPASK YQAIFDDTTS LTDKHLSPVR DNLGKHWKNC 600
ARKLGLTESQ IDEIDHDYER DGLKEKVYQM LQKWLMREGT KGATVGKLAR ALHQCSRQDL 660
LTCLIQLSQK 670
Nucleotide Sequence
(FASTA)
CAGCAAGCAG ACATGTCTTT GGATGACATT AAAATGAAGT CCAGTGACTT CCTGGAGAAG 60
GCGGATCTGG ACAGCGGCGG CTTCGGGGAG GTGTCTCTGT GCTTCCACAG ACTCCACGGC 120
TTAGTGATCC TGAAGAAGGT GTACACAGGG CCCAAGCGTG CCGAGTACAA CGAGTCTCTG 180
CTCGAGGAGG GGAGGATGAT GCACAGGCTG AAGCACAGCC GGGTGGTGGA GCTCCTGGGC 240
GTCGTCATGG AAGAGGGGAA CTACTGCCTG GTGATGGAGT ACATGGAGAA GGGCAGCCTG 300
ATGCACGTGC TCAAAGCCGA GATCAGTATC CCGCTTTCTG TAAAAGGAAG GATCATTGCA 360
GAGACCATCG AAGGGATGTG CTACCTGCAC GGAGAAGGTG TGATTCACAA GGACCTGAAG 420
CCCGAGAACA TCCTCGTCGA CAACGACTTC CACATTAAGA TCGCCGACCT TGGCGTTGCT 480
TCCTTTAAGA CGTGGAGCAA ACTGACTAAA GAGGAACACA ACGAGCAGAG GAAAGTGAAT 540
AGCACCCGCA AGAAAACTGG CGGCACCCTG TGCTACATGG CCCCCGAGCA CCTGAATGAC 600
GTCAACGCGA AGCCCACGGA GAAGTCGGAC GTGTACAGCT TTGCCATCGT ACTCTGGGCA 660
GTCCTTGCCA ATAAGGAGCC GTACGAAAAT GCCATCTGTG AGCAGCAGCT GATTCTCTGC 720
ATAAAGTCCG GCAACCGGCC CGACGTGGAC GACGTCGCCG AGGACTGCCC CGGGGAGCTC 780
ATCCGCCTCA TGGAGCTCTG CTGGGAGGCG GACCCGAGAG CGCGGCCCAC GTTCCCTGAT 840
ATTGAAGAAA GATTTAGACC GTTTTATTCA AGTCATTACG AGGAATTCGT AGAAGAGGAT 900
GTGAAGAGCT TAAAGAAGCG GTATCCGGAG CAGAGTGCAG TCGTGAAGAG AATGCAGTCT 960
CTCCAGCTGG ACTGTGTGCC AGTGCCTCCG AGCAGGTCGA ATTCAGCCAC GGAACAGCCC 1020
AGCTCCCTGC ACAGTTCCCA GGGCTTCATG ACGGGTCCAG TGGAGGTGTC CTTTTTCTCT 1080
GCCTGCCCTG AGATCTCGCA AGAAGAGAAT GAGCCCAGCC TGCAGAGTAA GCTCCAGGAG 1140
GAAGCCAACT ACCATCTTTA CGGCAGCCGC ATGGACAAGC AGACGAGACA GCCGCCCAGG 1200
CAGAGTGTGG CCTACAGCAG AGAGGAGGAG AGGAGACGGA GGGTTTCCTA TGACCCTTTT 1260
GCTCAGCAGA CACCCTATGA AAATGTTCAG AAAACAGGAA TAAAAGTCCA CAGTTACCCT 1320
GGTACAACCA GTCATAGCAA TGCAGCACAC CAACCAACAG GACTAACCAG CCAACCCCAA 1380
CTGCCATATT GGAACAATGG AGTCTACAGT CTACATGGTT TTGGAACAAG GCCTTTGGAG 1440
CCGGGAACAG CAGGTCAAGC AGTTTGGTAT GGGCCAAGTC TAAGCCCAAT GTCAAGTCTG 1500
TATAAAACTC CAGTGCCTGA GACCAACCTA CTAGGAAACA CGCCCACCAT TCCATTCAGC 1560
TCCTTGTCGC CAGCAGAAGA GTCTATGAAA TGCAGCATAT ACAACAGCAG TGGCATTCAG 1620
CTTGGAGCCT GTAACTACAT GGAGATCGGC GGGATAAGCT CACCACCACT AGAATGCTTG 1680
TGCACAAACT TACAGGAGCC AGCTTCTAAG TACCAAGCCA TCTTTGATGA CACCACGAGT 1740
CTGACGGACA AACACCTGAG CCCCGTCAGG GACAACCTGG GAAAACACTG GAAAAACTGT 1800
GCCCGGAAGC TGGGCCTCAC CGAATCGCAG ATCGACGAGA TTGACCATGA CTATGAGCGA 1860
GACGGACTGA AAGAGAAGGT TTACCAGATG CTCCAGAAGT GGCTGATGCG GGAAGGCACC 1920
AAGGGGGCCA CCGTGGGGAA GCTGGCCCGT GCGCTGCACC AGTGTTCCAG ACAGGATCTC 1980
CTCACCTGTC TGATACAGCT CAGCCAGAAG TAG 2013
Domain Profile
S: 3     elelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsyvl  62
         e + ++sGgfg+v+ ++hr +++ +++k  v++++++++++++llee+++m++l++s+v+
Q: 19    EKADLDSGGFGEVSLCFHRLHGLVILKK--VYTGPKRAEYNESLLEEGRMMHRLKHSRVV  76
         55679***********************..******************************
S: 63    kllGvikeeeklglvmeymenGsLeklLkseielpwplkfRilkevvlgmnyLhslkPpl  122
         +llGv+ ee+++ lvmeyme+GsL+++Lk+ei++p+++k Ri+ e+++gm+yLh  +  +
Q: 77    ELLGVVMEEGNYCLVMEYMEKGSLMHVLKAEISIPLSVKGRIIAETIEGMCYLHGEG--V  134
         ********************************************************9..*
S: 123   lhkDLkpeniLlDnelhvkiaDfGlskfm.......eessqskevsssa..egGtlaYla  173
         +hkDLkpeniL+Dn++h+kiaD+G+++f        ee++++++v+s+   +gGtl Y+a
Q: 135   IHKDLKPENILVDNDFHIKIADLGVASFKtwskltkEEHNEQRKVNSTRkkTGGTLCYMA  194
         ****************************559999998888888888776669********
S: 174   PelleevnkkaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevse  233
         Pe+l++vn+k++eksDvYsfaiv+Wavla+kepye++++++q+i+++k+gnRP++++v+e
Q: 195   PEHLNDVNAKPTEKSDVYSFAIVLWAVLANKEPYENAICEQQLILCIKSGNRPDVDDVAE  254
         ************************************************************
S: 234   elPrevpqlieLmkrcWeadpeeRPsFleieekt  267
         ++P e   li+Lm+ cWeadp++RP+F +iee++
Q: 255   DCPGE---LIRLMELCWEADPRARPTFPDIEERF  285
         ***88...**********************9975
Domain Sequence
(FASTA)
EKADLDSGGF GEVSLCFHRL HGLVILKKVY TGPKRAEYNE SLLEEGRMMH RLKHSRVVEL 60
LGVVMEEGNY CLVMEYMEKG SLMHVLKAEI SIPLSVKGRI IAETIEGMCY LHGEGVIHKD 120
LKPENILVDN DFHIKIADLG VASFKTWSKL TKEEHNEQRK VNSTRKKTGG TLCYMAPEHL 180
NDVNAKPTEK SDVYSFAIVL WAVLANKEPY ENAICEQQLI LCIKSGNRPD VDDVAEDCPG 240
ELIRLMELCW EADPRARPTF PDIEERF 267
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00459
EKS-ANC-00481
EKS-BOT-00492
EKS-CAJ-00501
EKS-CAF-00491
EKS-CAP-00524
EKS-CII-00101
EKS-CIS-00243
EKS-DAR-00917
EKS-ECT-00077
EKS-EQC-00478
EKS-ERE-00060
EKS-FEC-00470
EKS-GAG-00410
EKS-GAA-00600
EKS-GOG-00482
EKS-HOS-00501
EKS-ICT-00469
EKS-LAC-00505
EKS-LOA-00498
EKS-MAM-00488
EKS-MEG-00401
EKS-MIM-00096
EKS-MOD-00485
EKS-MUM-00524
EKS-MUP-00482
EKS-MYL-00482
EKS-NOL-00447
EKS-ORN-00626
EKS-ORA-00429
EKS-ORL-00571
EKS-OTG-00500
EKS-PAT-00463
EKS-PES-00430
EKS-PEM-00271
EKS-POA-00478
EKS-PTV-00182
EKS-RAN-00507
EKS-SAH-00462
EKS-SOA-00063
EKS-SUS-00433
EKS-TAG-00559
EKS-TAR-00616
EKS-TAS-00074
EKS-TEN-00621
EKS-TUT-00197
EKS-XET-00646
EKS-XIM-00616
Gene Ontology
GO:0031264; C:death-inducing signaling complex
GO:0005739; C:mitochondrion
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006915; P:apoptotic process
GO:0006917; P:induction of apoptosis
GO:0060555; P:induction of necroptosis by extracellular signals
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032757; P:positive regulation of interleukin-8 production
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0042327; P:positive regulation of phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760; P:positive regulation of tumor necrosis factor production
GO:0046777; P:protein autophosphorylation
GO:0070926; P:regulation of ATP:ADP antiporter activity
GO:0034612; P:response to tumor necrosis factor
GO:0007165; P:signal transduction
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR025735; RHIM_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
PF12721; RHIM; 1.
SMARTs
SM00005; DEATH; 1.
Prosites
PS50017; DEATH_DOMAIN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013