EKS-ORC-00269

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00269

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	480.1	2.0E-144	571	832	262

Status

Unreviewed

Ensembl Protein

ENSOCUP00000010405

UniProt Accession

G1T2L4;

Protein Name

Protein Synonyms/Alias

Gene Name

ERN1

Gene Synonyms/Alias

ERN1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000012090	ENSOCUP00000015447	ENSOCUT00000030989
ENSOCUG00000012090	ENSOCUP00000010405	ENSOCUT00000012094

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

977

Protein Sequence
(FASTA)

MPARRLLLFL ALLLPSSGLQ IFGSSSTVTL PETLLFVSTL DGSLHAVSKR TGSIKWTLKE 60

DPVLQVPTHV EEPAFLPDPN DGSLYTLGGK NNEGLTKLPF TIPELVQASP CRSSDGILYM 120

GKKQDIWYVI DLLTGEKQQT LSSAFADSLC PSTSLLYLGR TEYTITMYDT KTRELRWNAT 180

YFDYAASLPE DDMDYKMSHF VSNGDGLVVT VDSESGDVLW IQNYGSPVVA FYVWQREGLR 240

KVMHINVAVE TLRYLTFMSG EVGRITKWKY PFPKETEAKS KLTPTLYVGK YSTSLYASPS 300

MVHEGVAVVP RGSTLPLLEG PQTDGVTIGD KGECVITPST DLKFDPGLKG KNKLNYLRNY 360

WLLIGHHETP LSASTKMLER FPNNLPKHRE NVIPADSEKK SFEEVINMVD QTSENTPTTV 420

SPDVEEKLAR APAKAEAPVD SMLKDMATII LSTFLLIGWV AFIITYPLNM HQQQQLQHQQ 480

FQKELEKIQL LQQQQLPFPP PGDVTQDADL LDACSPYSES SGTSSPSTSP RASNHSLHSS 540

GSASRAGASL SLEPDVEDEE ASMVMVGKIS FCPKDVLGHG AEGTIVYRGM FDNRNVAVKR 600

ILPECFSFAD REVQLLRESD EHPNVIRYFC TERDRQFQYI AIELCAATLQ EYVEQKDFFH 660

LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK PHNILLSMPN AHGKIKAMIS DFGLCKKLAV 720

GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ 780

RQANILLGAY SLDCFHPEKH EDVVARELIE KMIAMDPQKR PSAKHVLKHP FFWSLEKQLQ 840

FFQDVSDRIE KESLDGPIVR QLERGGRAVV KMDWRENITV PLQTDLRKFR TYKGGSIRDL 900

LRAMRNKKHH YRELPPEVRE TLGSLPDDFV RYFTSRFPHL LSHTYRAMEL CSQERLFQPY 960

YSHEPPELRP PVTPDAL 977

Nucleotide Sequence
(FASTA)

ATGCCGGCCC GGCGGTTGCT GCTGTTCCTG GCGCTGCTGC TGCCCAGCTC TGGGTTGCAG 60

ATATTTGGAA GTTCCAGCAC AGTGACACTT CCTGAAACCT TGTTGTTTGT ATCGACCCTG 120

GATGGAAGTT TGCATGCTGT CAGCAAGAGG ACAGGCTCAA TCAAGTGGAC TTTAAAGGAA 180

GATCCAGTCC TGCAGGTCCC AACACATGTG GAAGAGCCTG CATTCCTCCC AGATCCTAAT 240

GATGGCAGCC TGTATACACT TGGAGGCAAG AATAATGAAG GCCTGACAAA ACTTCCCTTT 300

ACAATCCCGG AGTTGGTACA GGCATCCCCG TGCCGAAGTT CCGACGGCAT CCTTTACATG 360

GGTAAAAAGC AGGACATCTG GTACGTCATC GATCTCCTGA CCGGGGAAAA GCAGCAGACT 420

TTGTCATCGG CCTTTGCAGA CAGTCTCTGT CCATCAACTT CACTTCTGTA TCTTGGGCGA 480

ACAGAATATA CCATCACCAT GTATGACACC AAAACCAGAG AGCTTCGGTG GAACGCCACC 540

TACTTTGACT ACGCAGCCTC ACTTCCTGAA GATGACATGG ACTACAAGAT GTCCCACTTT 600

GTGTCCAATG GCGATGGGCT CGTGGTGACC GTCGACAGTG AATCTGGAGA CGTCCTGTGG 660

ATCCAAAACT ATGGCTCCCC TGTGGTGGCC TTCTATGTGT GGCAGCGGGA GGGTCTGCGG 720

AAGGTGATGC ACATCAACGT GGCCGTGGAG ACCCTGCGCT ACCTGACCTT CATGTCTGGG 780

GAGGTGGGGC GCATCACCAA GTGGAAGTAC CCGTTCCCCA AGGAGACGGA GGCCAAGAGC 840

AAGCTGACGC CCACTCTGTA TGTTGGGAAA TACTCAACCA GCCTCTACGC CTCCCCGTCA 900

ATGGTACATG AAGGGGTTGC TGTCGTGCCC CGAGGCAGCA CTCTTCCTTT GCTGGAAGGC 960

CCCCAGACCG ATGGTGTCAC CATAGGGGAC AAAGGGGAGT GTGTGATCAC GCCCAGCACG 1020

GACCTCAAGT TTGACCCCGG ACTCAAAGGG AAAAACAAAC TTAACTACTT GAGGAATTAC 1080

TGGCTTCTGA TAGGACACCA TGAAACCCCA CTGTCTGCCT CTACCAAGAT GCTGGAGAGA 1140

TTCCCCAACA ATCTGCCCAA ACATCGGGAA AATGTGATTC CTGCTGATTC TGAGAAAAAG 1200

AGCTTTGAGG AAGTTATCAA CATGGTTGAC CAGACTTCAG AGAACACACC GACCACCGTG 1260

TCTCCGGACG TGGAAGAGAA ACTGGCTCGT GCCCCTGCCA AGGCCGAGGC CCCTGTGGAC 1320

TCCATGCTCA AGGACATGGC CACCATCATC CTGAGCACGT TTCTACTGAT CGGCTGGGTG 1380

GCCTTCATCA TCACATACCC CCTGAACATG CATCAGCAGC AGCAGCTCCA GCACCAGCAG 1440

TTCCAGAAGG AGCTGGAGAA GATCCAGCTC CTGCAGCAGC AGCAGCTGCC CTTCCCCCCA 1500

CCCGGAGACG TGACGCAGGA CGCTGACCTC CTGGATGCCT GCAGCCCATA CTCAGAGAGC 1560

TCGGGCACCA GCAGCCCCAG CACGTCCCCC AGGGCCTCCA ACCACTCACT GCACTCCAGC 1620

GGCTCTGCCT CCAGGGCTGG GGCCAGCCTC TCCCTGGAGC CGGATGTTGA GGATGAGGAA 1680

GCCAGCATGG TGATGGTTGG GAAGATTTCA TTCTGTCCTA AAGACGTCCT GGGCCATGGA 1740

GCTGAGGGCA CAATTGTGTA CCGGGGCATG TTTGACAACC GCAACGTGGC CGTGAAGAGG 1800

ATCCTCCCTG AGTGTTTCAG CTTCGCCGAC CGTGAGGTGC AGCTGCTGCG AGAATCAGAC 1860

GAGCATCCGA ACGTGATCCG CTACTTCTGC ACGGAGAGGG ACCGGCAGTT CCAGTACATT 1920

GCCATCGAGC TGTGCGCGGC CACCCTGCAG GAGTATGTGG AGCAGAAGGA CTTTTTCCAC 1980

CTTGGCCTGG AGCCCATCAC CTTGCTGCAG CAGACCACCT CGGGCCTGGC GCACCTCCAC 2040

TCGCTCAACA TTGTTCACAG AGACCTGAAA CCCCACAACA TTCTCCTCTC CATGCCCAAT 2100

GCACATGGCA AGATTAAGGC TATGATCTCT GACTTCGGCC TCTGTAAGAA GCTGGCAGTG 2160

GGCAGGCACA GCTTCAGCCG CCGTTCTGGG GTGCCCGGCA CAGAGGGCTG GATCGCCCCG 2220

GAGATGCTGA GTGAAGACTG CAAGGAGAAC CCTACCTACA CAGTGGACAT CTTCTCTGCG 2280

GGCTGCGTCT TTTACTACGT CATCTCTGAG GGCAGTCACC CGTTTGGCAA GTCCCTGCAG 2340

CGGCAGGCCA ACATCCTCCT GGGTGCCTAC AGCCTTGACT GCTTCCACCC AGAGAAGCAC 2400

GAGGATGTCG TTGCCCGGGA GCTGATAGAG AAGATGATCG CCATGGACCC TCAGAAGCGC 2460

CCCTCGGCGA AGCACGTGCT CAAACACCCG TTCTTCTGGA GCCTGGAGAA GCAGCTCCAG 2520

TTCTTTCAGG ATGTGAGTGA CCGGATAGAA AAGGAGTCCC TGGACGGCCC GATAGTGAGG 2580

CAGCTGGAGC GAGGCGGGAG AGCTGTGGTG AAGATGGACT GGCGGGAGAA CATCACCGTC 2640

CCCCTGCAGA CAGATCTGCG TAAATTCAGA ACCTATAAAG GTGGCTCCAT CAGAGACCTC 2700

CTCCGAGCCA TGAGAAACAA GAAGCACCAC TACCGGGAGC TCCCGCCGGA GGTGCGCGAG 2760

ACGCTGGGCT CCCTCCCCGA CGACTTCGTG CGCTACTTCA CGTCCCGCTT CCCCCACCTC 2820

CTCTCACACA CTTACCGGGC CATGGAGCTC TGCAGCCAGG AGAGACTCTT CCAGCCCTAC 2880

TACTCCCATG AGCCCCCGGA GCTCCGGCCC CCAGTGACTC CGGACGCCCT C 2931

Domain Profile

S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60

         f+pkdvlG+GaeGt+v+rG+f++r+vavkr+l+e++++a+rev+llresdehpnviryfc

Q: 571   FCPKDVLGHGAEGTIVYRGMFDNRNVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC  630

         79**********************************************************

S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         te+drqf+yia+elcaa+lq+yve+kd+  + +lepi+ll+q++sGlahlhsl+ivhrdl

Q: 631   TERDRQFQYIAIELCAATLQEYVEQKDFF-HLGLEPITLLQQTTSGLAHLHSLNIVHRDL  689

         ****************************9.******************************

S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180

         kp+nil+s+p+a+gk++++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e++ke

Q: 690   KPHNILLSMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE  749

         ************************************************************

S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240

         ++t++vdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g++sld++++ek+e+v+a++li

Q: 750   NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAYSLDCFHPEKHEDVVARELI  809

         ************************************************************

S: 241   skmidkdplkrpsakkvlkhplf  263

         +kmi++dp+krpsak+vlkhp+f

Q: 810   EKMIAMDPQKRPSAKHVLKHPFF  832

         **********************9

Domain Sequence
(FASTA)

FCPKDVLGHG AEGTIVYRGM FDNRNVAVKR ILPECFSFAD REVQLLRESD EHPNVIRYFC 60

TERDRQFQYI AIELCAATLQ EYVEQKDFFH LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK 120

PHNILLSMPN AHGKIKAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN 180

PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ RQANILLGAY SLDCFHPEKH EDVVARELIE 240

KMIAMDPQKR PSAKHVLKHP FF 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030176	; C:integral to endoplasmic reticulum membrane
GO:0005637	; C:nuclear inner membrane
GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006987	; P:activation of signaling protein activity involved in unfolded protein response
GO:0007050	; P:cell cycle arrest
GO:0006917	; P:induction of apoptosis
GO:0006397	; P:mRNA processing
GO:1900103	; P:positive regulation of endoplasmic reticulum unfolded protein response
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 5.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013