EKS-ORC-00248
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00248
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK412.76.7E-12439291253
StatusUnreviewed
Ensembl ProteinENSOCUP00000024465
UniProt AccessionG1U4Y9;
Protein Name
Protein Synonyms/Alias
Gene NamePLK3
Gene Synonyms/Alias PLK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000012460ENSOCUP00000010725ENSOCUT00000012458
ENSOCUG00000012460ENSOCUP00000024465ENSOCUT00000021775
OrganismOryctolagus cuniculus
Functional Description
Protein Length624
Protein Sequence
(FASTA)
AGPGPPQSAS PRPEPEMLAG RPAPDPGRLI TDPGSGRTYF KGRLLGKGGF ARCYEATDTE 60
TGSAYAVKVI PQSRVAKPHQ REKILNEIEL HRDLQHRHIV RFSHHFEDAD NIYIFRELCS 120
RKSLAHIWKA RHTLLEPEVR YYLRQILSGL KYLHQRGILH RDLKLGNFFI TENMELKVGD 180
FGLAARLEPP EQRKKTICGT PNYVAPEVLL RQGHGPEADV WSLGCVMYTL LCGSPPFETA 240
DLKETYRCIK QVHYTLPASL SLPARQLLAA ILRASPRDRP SIDQILRHDF FTKGYTPDRL 300
PVSSCVTVPD LTPPNPARSL FAKVTKSLFG RKKNKNKNHP EERDEVSCLV SGLVRTSIGH 360
QDARPEAPAA SGPPPVSLVE TAGEDSSPRG TPASSGDGFE EGLTVATVVE SALCALRNCV 420
AFMPPAEQNP APLAQPEPLV WVSKWVDYSN KFGFGYQLSS RRVAVLFNDG THMALSANRK 480
TVHYNPTSTK HFSFSVGAVP RALQPQLGVL RYFTSYMEQH LMKGGDLPSV EEVEVPAPPL 540
LLQWVKTDQA LLMLFSDGTV QVNFYGDHTK LILSGWEPLL VTFVARNRSA CTYLASHLRQ 600
LGCSPDLRQR LRYALRLLRD RSPA 624
Nucleotide Sequence
(FASTA)
GCCGGACCCG GGCCGCCTCA GAGTGCCTCG CCCAGACCCG AGCCCGAGAT GCTGGCCGGG 60
CGGCCGGCGC CGGACCCCGG GCGCCTCATC ACCGACCCGG GCAGCGGCCG CACCTACTTC 120
AAAGGCCGCT TGTTGGGCAA GGGGGGCTTC GCCCGCTGCT ACGAGGCCAC GGACACAGAG 180
ACCGGCAGCG CCTACGCGGT CAAAGTCATC CCGCAGAGTC GTGTCGCCAA GCCGCATCAG 240
CGCGAGAAGA TCTTGAACGA GATTGAACTG CACCGAGACC TGCAGCACCG CCATATCGTG 300
CGCTTCTCGC ACCACTTTGA GGATGCAGAC AACATATACA TTTTTCGGGA GCTTTGCAGT 360
CGAAAGTCCC TGGCCCACAT CTGGAAGGCC CGACACACCC TGTTGGAGCC GGAGGTTCGC 420
TACTACCTGC GGCAGATTCT TTCCGGCCTC AAGTACTTGC ACCAGCGAGG CATCTTGCAC 480
CGGGACCTCA AGCTGGGAAA TTTCTTCATC ACCGAGAACA TGGAACTCAA GGTGGGGGAT 540
TTTGGGCTGG CAGCTCGGTT GGAACCGCCA GAGCAGAGGA AGAAGACCAT CTGTGGCACC 600
CCCAACTATG TGGCTCCAGA AGTACTGCTG AGACAGGGTC ATGGCCCTGA GGCAGATGTG 660
TGGTCACTGG GCTGTGTCAT GTACACTCTG CTGTGTGGGA GCCCCCCCTT TGAGACGGCT 720
GACCTGAAGG AGACGTACCG CTGCATCAAG CAGGTTCACT ACACGCTGCC CGCCAGCCTC 780
TCACTGCCTG CCCGGCAGCT CCTGGCCGCC ATCCTGCGGG CCTCGCCCCG AGACCGCCCC 840
TCTATCGACC AGATCCTGCG CCATGACTTC TTTACCAAGG GCTACACCCC CGACCGGCTC 900
CCCGTCAGCA GTTGCGTGAC AGTCCCAGAC CTGACACCCC CCAATCCGGC TAGGAGTCTG 960
TTTGCCAAAG TCACCAAGAG CCTCTTTGGC AGGAAGAAGA ATAAGAACAA GAACCATCCT 1020
GAGGAGCGGG ATGAAGTCTC CTGTTTGGTG AGCGGCCTTG TGCGCACATC CATTGGCCAC 1080
CAGGATGCCA GGCCCGAGGC TCCAGCAGCT TCTGGCCCAC CTCCCGTCAG CCTGGTAGAG 1140
ACAGCGGGTG AAGACAGCTC CCCCCGTGGG ACGCCGGCGA GCAGCGGAGA TGGGTTTGAA 1200
GAAGGTCTGA CCGTGGCCAC GGTGGTGGAG TCAGCCCTCT GTGCCCTGAG AAACTGTGTG 1260
GCTTTCATGC CCCCAGCGGA ACAGAACCCG GCCCCTCTGG CCCAGCCGGA GCCTCTTGTG 1320
TGGGTCAGCA AGTGGGTTGA CTACTCCAAC AAGTTTGGCT TTGGGTATCA GCTGTCCAGC 1380
CGCCGCGTAG CTGTGCTCTT CAACGATGGC ACTCACATGG CCTTGTCAGC CAACAGAAAG 1440
ACTGTGCACT ACAACCCCAC GAGCACAAAG CACTTCTCCT TCTCCGTGGG TGCCGTGCCC 1500
CGGGCCCTGC AGCCGCAGCT GGGCGTCCTG CGGTACTTCA CCTCGTACAT GGAGCAGCAC 1560
CTCATGAAGG GTGGAGATCT GCCCAGCGTG GAAGAGGTGG AGGTGCCTGC CCCGCCCTTG 1620
CTGTTGCAGT GGGTCAAGAC GGATCAGGCC CTGCTCATGC TGTTTAGTGA TGGCACTGTC 1680
CAGGTGAACT TCTACGGGGA CCACACCAAG CTGATCCTCA GTGGCTGGGA GCCTCTGCTT 1740
GTAACCTTTG TGGCCCGGAA TCGCAGTGCT TGTACTTACC TCGCTTCCCA CCTGCGGCAG 1800
CTGGGCTGCT CGCCCGACCT GCGGCAGCGA CTCCGCTACG CTCTGCGGCT GCTCAGGGAC 1860
CGCAGCCCAG CC 1872
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y +g+llGkGgfa+cye++d+et++++avkv+p+s++ak++qrek+ +eie+hr+l+h++
Q: 39    YFKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH  98
         789*********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         iv+++++fed++n+y++ elcsr+sla+++k+r++l epevryylrqi+sglkylh++ i
Q: 99    IVRFSHHFEDADNIYIFRELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI  158
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         lhrdlklgn+f++e++e+k+gdfGla+rle++e+rkkt+cGtPny+aPevl ++gh+ e+
Q: 159   LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEA  218
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         d+WslGc++ytll+G+PPfet++lkety++ik+ +y+lP+sls +a++l+a++l+++P++
Q: 219   DVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRD  278
         ************************************************************
S: 241   rpsleevlkdefl  253
         rps++++l+++f+
Q: 279   RPSIDQILRHDFF  291
         ************8
Domain Sequence
(FASTA)
YFKGRLLGKG GFARCYEATD TETGSAYAVK VIPQSRVAKP HQREKILNEI ELHRDLQHRH 60
IVRFSHHFED ADNIYIFREL CSRKSLAHIW KARHTLLEPE VRYYLRQILS GLKYLHQRGI 120
LHRDLKLGNF FITENMELKV GDFGLAARLE PPEQRKKTIC GTPNYVAPEV LLRQGHGPEA 180
DVWSLGCVMY TLLCGSPPFE TADLKETYRC IKQVHYTLPA SLSLPARQLL AAILRASPRD 240
RPSIDQILRH DFF 253
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00245
EKS-ANC-00251
EKS-BOT-00262
EKS-CAJ-00268
EKS-CAF-00269
EKS-CAP-00297
EKS-CII-00157
EKS-DAR-00597
EKS-EQC-00253
EKS-FEC-00248
EKS-GAG-00219
EKS-GAA-00323
EKS-GOG-00260
EKS-HOS-00269
EKS-ICT-00247
EKS-LAC-00274
EKS-LOA-00272
EKS-MAM-00264
EKS-MAE-00013
EKS-MEG-00206
EKS-MOD-00261
EKS-MUM-00293
EKS-MUP-00259
EKS-ORN-00339
EKS-ORL-00316
EKS-OTG-00268
EKS-PAT-00249
EKS-PTV-00033
EKS-RAN-00277
EKS-SAH-00246
EKS-SUS-00227
EKS-TAG-00277
EKS-TEN-00330
EKS-XET-00337
EKS-XIM-00331
Gene Ontology
GO:0005813; C:centrosome
GO:0005795; C:Golgi stack
GO:0005730; C:nucleolus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0090166; P:Golgi disassembly
GO:0043066; P:negative regulation of apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:2000777; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO:0006974; P:response to DNA damage stimulus
GO:0006970; P:response to osmotic stress
GO:0009314; P:response to radiation
GO:0000302; P:response to reactive oxygen species
GO:0000084; P:S phase of mitotic cell cycle
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR020658; Ser/Thr_kinase_Plk3.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013