EKS-ORC-00319
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00319
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK356.89.8E-107170578409
StatusUnreviewed
Ensembl ProteinENSOCUP00000010856
UniProt AccessionG1T3P8;
Protein Name
Protein Synonyms/Alias Eukaryotic translation initiation factor 2-alpha kinase 1;
Gene NameEIF2AK1
Gene Synonyms/Alias EIF2AK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000012606ENSOCUP00000010856ENSOCUT00000012611
ENSOCUG00000012606ENSOCUP00000018278ENSOCUT00000024244
OrganismOryctolagus cuniculus
Functional Description
Protein Length626
Protein Sequence
(FASTA)
MLGGSAGTRG GEAEGDGAGA VGAVAPPPAI DFPAEVSDPK YDESDVPAEL QVLKEPLQQP 60
AFPFAVANQL LLVSLLEHLS HVHEPNPLRS RQVFKLLCQT FIKMGLLSSF TCSDEFSSLR 120
LHHNRAITHL MRSARERVRQ DPCADNSHIQ KIRSREVALE AQTSRYLNEF EELSILGKGG 180
YGRVYKVRNK LDGQYYAIKK ILIKGATKTD CMKVLREVKV LAGLQHPNIV GYHTAWIEHV 240
HVHVQAELLA LFFRSDFHLC YFCVSRDQYG VKNDASSSSS IIFAEFSPEK EKSSDECAVE 300
SQNNKLVNYT TNLVVRDTGE FESSTERQEN GSIVERQLLF GHNSDVEEDF TSAEESSEED 360
LSALRHTEVQ YHLMLHIQMQ LCELSLWDWI AERNRRSREC VDESACPYVM VSVATKIFQE 420
LVEGVFYIHN MGIVHRDLKP RNIFLHGPDQ QVKIGDFGLA CADIIQKNAA RTSRNGERAP 480
THTSRVGTCL YASPEQLEGS EYDAKSDMYS VGVILLELFQ PFGTEMERAE VLTGVRAGRI 540
PDSLSKRCPA QAKYVQLLTR RNASQRPSAL QLLQSELFQN SAHVNLTLQM KIIEQEREIE 600
ELKKQLSLLS QARGVRSDRR DGELPA 626
Nucleotide Sequence
(FASTA)
ATGCTGGGGG GCAGCGCCGG GACCCGCGGG GGCGAAGCCG AGGGCGACGG GGCGGGGGCG 60
GTGGGGGCGG TGGCCCCGCC GCCCGCCATC GACTTCCCCG CTGAGGTGTC GGATCCCAAG 120
TATGACGAGT CGGATGTCCC GGCAGAGCTG CAGGTGCTGA AGGAGCCGCT GCAGCAGCCA 180
GCCTTCCCCT TCGCCGTCGC CAACCAGCTG CTGCTCGTCT CCCTGCTGGA GCACCTGAGT 240
CATGTGCACG AGCCAAACCC GCTTCGCTCC AGACAGGTGT TTAAACTGCT CTGTCAGACC 300
TTCATCAAAA TGGGGCTGCT GTCTTCCTTC ACCTGCAGCG ACGAGTTTAG CTCATTGAGG 360
CTGCATCACA ACAGAGCTAT TACGCATCTG ATGAGGTCCG CCAGAGAGAG AGTTCGGCAG 420
GATCCCTGTG CTGATAATTC TCATATCCAG AAAATCAGGT CGCGAGAAGT TGCCTTGGAA 480
GCACAGACCT CACGATACTT GAATGAGTTT GAAGAGCTCT CCATCCTGGG GAAAGGTGGC 540
TATGGCCGAG TGTACAAGGT CAGGAATAAA TTAGATGGCC AGTATTATGC AATTAAAAAA 600
ATTCTGATTA AAGGTGCAAC TAAAACAGAT TGCATGAAGG TATTACGAGA AGTGAAAGTG 660
CTGGCGGGCC TCCAGCACCC TAATATCGTA GGCTATCACA CCGCGTGGAT AGAGCATGTC 720
CACGTTCACG TTCAAGCTGA GTTACTCGCC CTGTTCTTTC GCAGTGACTT TCATCTTTGC 780
TATTTTTGTG TCTCCAGAGA TCAATATGGT GTTAAAAATG ATGCAAGCAG CAGCTCATCC 840
ATTATTTTCG CTGAGTTCTC CCCAGAAAAA GAAAAATCCT CTGACGAATG TGCCGTTGAG 900
AGTCAGAATA ACAAACTGGT GAACTACACC ACCAACTTAG TGGTGAGGGA CACCGGTGAG 960
TTTGAATCGT CCACGGAGCG CCAAGAGAAC GGCTCGATCG TGGAGCGTCA GCTACTGTTC 1020
GGGCATAACT CAGACGTAGA AGAGGATTTC ACGTCCGCGG AGGAATCTTC TGAGGAAGAC 1080
TTAAGCGCGT TGCGGCACAC AGAGGTGCAG TACCACCTGA TGCTGCATAT CCAGATGCAG 1140
CTGTGCGAGC TGTCCCTGTG GGACTGGATC GCCGAGAGGA ACAGGCGGAG CCGAGAGTGC 1200
GTGGACGAAT CTGCCTGTCC TTATGTTATG GTCAGTGTTG CAACAAAAAT TTTTCAAGAA 1260
CTGGTGGAAG GTGTGTTTTA CATACATAAC ATGGGCATCG TGCACAGAGA CCTGAAGCCT 1320
AGAAATATTT TTCTTCATGG TCCTGATCAA CAAGTGAAAA TAGGAGACTT TGGTCTGGCC 1380
TGCGCCGACA TCATCCAGAA GAATGCGGCC CGGACCAGCA GAAACGGGGA GAGAGCACCC 1440
ACACACACTT CCCGAGTGGG CACCTGTCTG TACGCCTCGC CCGAGCAGTT GGAAGGATCG 1500
GAGTATGATG CCAAGTCAGA CATGTACAGC GTCGGCGTGA TCCTGCTGGA GCTCTTCCAG 1560
CCCTTCGGGA CAGAGATGGA GCGGGCAGAG GTCCTGACGG GCGTGCGAGC TGGCCGCATA 1620
CCCGACTCCC TCAGTAAGAG GTGCCCGGCG CAGGCCAAGT ACGTCCAGCT GCTGACCAGG 1680
AGGAACGCGT CCCAGCGGCC GTCCGCCCTT CAGCTGCTGC AGAGTGAGCT CTTCCAGAAC 1740
TCCGCGCATG TTAACCTCAC CCTACAGATG AAGATAATAG AGCAGGAAAG AGAAATCGAG 1800
GAACTCAAGA AGCAGCTGAG CCTCCTCTCC CAGGCCCGAG GGGTGAGGAG TGACAGGCGA 1860
GACGGAGAGC TCCCTGCCTA G 1881
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59
         fee+ +lGkGg+g+V+k++nkld+++yaik+i ++ a+k+ ++kv+revk+La l+hpni
Q: 170   FEELSILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTdCMKVLREVKVLAGLQHPNI  229
         899*********************************************************
S: 60    vrYfaawleekeesl................................tdsseveaeaele  87
         v Y++aw+e+ +  +                                ++ss ++ae+++e
Q: 230   VGYHTAWIEHVHVHVqaellalffrsdfhlcyfcvsrdqygvkndasSSSSIIFAEFSPE  289
         ************999******************************95459999******9
S: 88    esesseesdtk.................................................  98
         +++ss+e  ++                                                 
Q: 290   KEKSSDECAVEsqnnklvnyttnlvvrdtgefessterqengsiverqllfghnsdveed  349
         999999988888899*********************************************
S: 99    ........................llyiqmelceketLkdwiderk......llesrsel  128
                                 +l+iqm+lce  +L+dwi er+      ++es++ +
Q: 350   ftsaeesseedlsalrhtevqyhlMLHIQMQLCE-LSLWDWIAERNrrsrecVDESACPY  408
         **********************************.********99989999899999999
S: 129   vm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLatalaealk  182
         vm     ++f++l+eg+ y+H++g++HrdLkp+niFl+  d+qvKigDFgLa+a++ +++
Q: 409   VMvsvatKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHgPDQQVKIGDFGLACADIIQKN  468
         99************************************99********************
S: 183   edvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfstemer  242
         +  ++++ +++++ht++vgt+ly+sPeqle+s+Y++k+D++s+G+il+eL++pf temer
Q: 469   AARTSRNGERAPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSVGVILLELFQPFGTEMER  528
         ************************************************************
S: 243   vetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292
         +e+lt +r g+ip+++++++p ++k++q l++r++++Rpsa +ll+sel+
Q: 529   AEVLTGVRAGRIPDSLSKRCPAQAKYVQLLTRRNASQRPSALQLLQSELF  578
         ***********************************************986
Domain Sequence
(FASTA)
FEELSILGKG GYGRVYKVRN KLDGQYYAIK KILIKGATKT DCMKVLREVK VLAGLQHPNI 60
VGYHTAWIEH VHVHVQAELL ALFFRSDFHL CYFCVSRDQY GVKNDASSSS SIIFAEFSPE 120
KEKSSDECAV ESQNNKLVNY TTNLVVRDTG EFESSTERQE NGSIVERQLL FGHNSDVEED 180
FTSAEESSEE DLSALRHTEV QYHLMLHIQM QLCELSLWDW IAERNRRSRE CVDESACPYV 240
MVSVATKIFQ ELVEGVFYIH NMGIVHRDLK PRNIFLHGPD QQVKIGDFGL ACADIIQKNA 300
ARTSRNGERA PTHTSRVGTC LYASPEQLEG SEYDAKSDMY SVGVILLELF QPFGTEMERA 360
EVLTGVRAGR IPDSLSKRCP AQAKYVQLLT RRNASQRPSA LQLLQSELF 409
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00318
EKS-ANC-00332
EKS-BOT-00340
EKS-CAJ-00349
EKS-CAF-00348
EKS-CAP-00374
EKS-CII-00191
EKS-CIS-00092
EKS-DAR-00704
EKS-EQC-00332
EKS-FEC-00331
EKS-GAG-00286
EKS-GAA-00423
EKS-GOG-00338
EKS-HOS-00347
EKS-ICT-00324
EKS-LAC-00356
EKS-LOA-00351
EKS-MAM-00345
EKS-MEG-00281
EKS-MOD-00336
EKS-MUM-00375
EKS-MUP-00334
EKS-MYL-00339
EKS-ORN-00444
EKS-ORA-00299
EKS-ORL-00411
EKS-OTG-00345
EKS-PAT-00323
EKS-PES-00300
EKS-PEM-00181
EKS-POA-00332
EKS-PTV-00080
EKS-RAN-00355
EKS-SAH-00319
EKS-SUS-00303
EKS-TAG-00416
EKS-TAR-00447
EKS-TEN-00443
EKS-XIM-00431
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0020037; F:heme binding
GO:0008285; P:negative regulation of cell proliferation
GO:0046986; P:negative regulation of hemoglobin biosynthetic process
GO:0046777; P:protein autophosphorylation
GO:0046501; P:protoporphyrinogen IX metabolic process
GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR015516; Haem-reg_EIF2A_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013