EKS-ORC-00007
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00007
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph509.11.9E-153618877260
StatusUnreviewed
Ensembl ProteinENSOCUP00000020714
UniProt AccessionG1T3S2;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB3
Gene Synonyms/Alias EPHB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000012637ENSOCUP00000020714ENSOCUT00000025780
ENSOCUG00000012637ENSOCUP00000010881ENSOCUT00000012640
OrganismOryctolagus cuniculus
Functional Description
Protein Length983
Protein Sequence
(FASTA)
ERREPGLLGI KAPLALCVEI SRACSVAPPE TLMDTKWVTS ELAWTSHPES GWEEVSGYDE 60
AMNPIRTYQV CNVQESSQNN WLRTGFIWRR DVQRVYVELK FTVRDCNSIP NIPGSCKETF 120
NLFYYEADGD VASASSPFWM ENPYVKVDTI APDESFSRLD SGRVNTKVRS FGPLSKAGFY 180
LAFQDQGACM SLISVRAFYK KCASTTAGFA LFPETLTGAE PTSLVIAPGT CISNAVEVSV 240
PLKLYCNGDG EWMVPVGACT CATGHEPAAK ESQCRPCPPG SYKAKQGEGP CLPCPPNSRT 300
TSPAASICTC HNNFYRADSD SADSACTTVP SAPRGVISNV NETSLILEWS EPRDLGGRDD 360
LLYNVICKKC RGSPGSGGPS SCSRCDDNVE FVPRQLGLTE RRVHISHLLA HTRYTFEVQA 420
VNGVSGKSPL PPRYAAVNIT TNQAAPSEVP TLHLHSSSGS SLTLSWAPPE RPNGVILDYE 480
MKYFEKSEGI ASTVTSQKNS VQLDGLRPDA RYVVQVRART VAGYGQYSRP AEFETTSERG 540
SGAQQLQEQL PLIVGSATAG ASLPPAPRKQ RHGPDSEYTE KLQQYITPGM KVYIDPFTYE 600
DPNEAVREFA KEIDVSCVKI EEVIGAGEFG EVCRGRLKQP GRREVFVAIK TLKVGYTERQ 660
RRDFLSEASI MGQFDHPNII RLEGVVTKSR PVMILTEFME NCALDSFLRL NDGQFTVIQL 720
VGMLRGIAAG MKYLSEMNYV HRDLAARNIL VNSNLVCKVS DFGLSRFLED DPSDPTYTSS 780
LGGKIPIRWT APEAIAYRKF TSASDVWSYG IVMWEVMSYG ERPYWDMSNQ DVINAVEQDY 840
RLPPPMDCPT ALHQLMLDCW VRDRNLRPKF SQIVNTLDKL IRNAASLKVI ANAQSGMSQP 900
LLDRTVPDYT TFTTVGDWLD AIKMGRYKES FVSAGFASFD LVAQMTAEDL LRIGVTLAGH 960
QKKILSSIQD MRLQMSQTLP VQV 983
Nucleotide Sequence
(FASTA)
GAGCGCAGGG AGCCCGGGCT GCTCGGGATA AAGGCCCCGC TGGCCCTTTG TGTGGAGATT 60
AGCAGAGCCT GTAGTGTGGC TCCTCCAGAG ACCCTCATGG ACACCAAGTG GGTGACATCT 120
GAGTTGGCGT GGACATCTCA TCCAGAAAGT GGGTGGGAGG AGGTGAGCGG CTACGACGAG 180
GCCATGAACC CCATCCGCAC CTACCAGGTG TGCAATGTGC AGGAATCGAG CCAGAACAAC 240
TGGCTGCGTA CCGGGTTCAT CTGGCGGCGG GACGTGCAGC GAGTCTACGT GGAGCTCAAG 300
TTCACCGTGC GCGACTGCAA CAGCATCCCC AACATCCCCG GCTCCTGCAA GGAAACCTTC 360
AACCTCTTCT ACTACGAGGC CGATGGCGAC GTGGCCTCCG CCTCGTCCCC CTTCTGGATG 420
GAGAACCCCT ACGTGAAAGT GGACACCATC GCGCCCGATG AGAGCTTCTC CCGGCTCGAC 480
AGTGGCCGTG TCAACACCAA GGTGCGCAGC TTCGGGCCGC TTTCCAAAGC CGGCTTCTAC 540
CTGGCCTTCC AAGACCAGGG CGCCTGCATG TCGCTCATCT CCGTGCGTGC CTTCTACAAA 600
AAGTGCGCCT CCACCACTGC GGGCTTCGCA CTCTTCCCAG AGACCCTGAC GGGCGCTGAG 660
CCCACCTCGC TGGTCATTGC ACCTGGCACC TGCATCTCCA ACGCTGTGGA GGTGTCGGTG 720
CCGCTGAAGC TCTACTGCAA TGGAGACGGG GAGTGGATGG TGCCCGTGGG GGCCTGCACC 780
TGTGCCACCG GCCATGAGCC AGCTGCCAAG GAGTCACAGT GCCGCCCCTG TCCCCCAGGG 840
AGCTACAAGG CGAAGCAGGG AGAGGGGCCC TGCCTGCCCT GCCCTCCCAA CAGCCGTACC 900
ACCTCGCCAG CCGCCAGCAT CTGCACCTGC CACAATAACT TCTACCGCGC AGACTCCGAC 960
TCTGCCGACA GTGCCTGCAC CACCGTGCCG TCTGCACCCC GGGGTGTCAT CTCCAATGTA 1020
AATGAGACCT CGCTGATCCT GGAGTGGAGC GAGCCCCGGG ACCTGGGCGG GCGGGACGAC 1080
CTCTTGTACA ATGTCATCTG CAAGAAGTGC CGCGGGAGCC CCGGCTCTGG GGGTCCCTCC 1140
AGCTGCTCCC GCTGCGACGA CAACGTGGAG TTTGTGCCTC GGCAGCTGGG CCTGACCGAA 1200
CGCCGGGTGC ACATCAGCCA TCTGTTGGCC CACACGCGCT ACACCTTTGA GGTGCAGGCG 1260
GTCAACGGTG TCTCGGGCAA GAGCCCTCTG CCTCCCCGCT ACGCAGCTGT GAATATCACC 1320
ACCAACCAGG CCGCCCCGTC CGAGGTGCCC ACCCTGCACC TGCACAGCAG CTCCGGCAGC 1380
AGTCTGACCC TGTCCTGGGC GCCCCCGGAA CGGCCCAACG GAGTCATCCT GGACTATGAG 1440
ATGAAGTACT TCGAGAAGAG CGAGGGCATC GCCTCCACTG TGACCAGCCA GAAGAACTCC 1500
GTGCAGCTGG ACGGGCTGCG GCCGGACGCC CGCTATGTGG TCCAAGTCCG AGCCCGCACC 1560
GTGGCTGGCT ACGGGCAGTA CAGCCGCCCG GCCGAGTTTG AGACCACCAG CGAGAGAGGC 1620
TCCGGTGCCC AGCAGCTCCA GGAGCAGCTT CCCCTCATCG TCGGCTCGGC CACCGCTGGG 1680
GCCTCCCTTC CCCCTGCCCC CAGGAAGCAG CGGCACGGTC CGGACTCGGA GTACACGGAG 1740
AAGCTGCAGC AATATATCAC TCCCGGAATG AAGGTTTACA TCGACCCTTT TACCTACGAG 1800
GACCCTAACG AGGCCGTGCG TGAGTTTGCC AAGGAGATTG ACGTGTCCTG TGTCAAGATC 1860
GAGGAGGTGA TCGGAGCTGG GGAGTTCGGG GAAGTGTGCC GGGGCCGGCT GAAGCAGCCC 1920
GGCCGCCGCG AAGTGTTCGT GGCCATCAAG ACGCTGAAGG TGGGCTACAC GGAGAGGCAG 1980
CGGCGGGACT TCCTGAGCGA GGCCTCCATC ATGGGCCAGT TTGACCACCC CAACATCATC 2040
CGGCTGGAGG GCGTGGTCAC CAAAAGCCGG CCAGTGATGA TCCTCACCGA GTTCATGGAG 2100
AATTGCGCCC TGGACTCCTT CCTCCGGCTC AACGATGGGC AGTTCACAGT CATCCAGCTG 2160
GTGGGCATGC TGCGGGGCAT CGCAGCCGGC ATGAAGTACT TGTCCGAGAT GAACTACGTG 2220
CACCGGGACC TGGCCGCCCG GAACATCCTG GTTAACAGCA ACCTGGTGTG CAAGGTCTCC 2280
GACTTCGGCC TCTCCCGCTT CCTGGAGGAC GACCCCTCTG ACCCTACCTA CACCAGCTCC 2340
CTGGGCGGGA AGATCCCCAT CCGCTGGACT GCCCCAGAGG CCATAGCCTA TCGGAAGTTC 2400
ACGTCTGCTA GTGACGTCTG GAGCTACGGC ATCGTCATGT GGGAAGTCAT GAGCTATGGA 2460
GAGCGACCCT ACTGGGACAT GAGCAACCAG GATGTCATCA ATGCCGTAGA GCAAGATTAC 2520
CGGCTGCCAC CGCCCATGGA CTGCCCCACA GCACTGCACC AGCTCATGCT GGACTGCTGG 2580
GTGCGAGACC GGAACCTCAG GCCCAAATTC TCCCAGATTG TCAACACCCT AGACAAGCTT 2640
ATCCGCAATG CTGCCAGCCT CAAGGTCATC GCCAATGCCC AGTCGGGCAT GTCCCAGCCC 2700
CTCCTGGACC GCACAGTCCC AGATTACACA ACCTTCACGA CAGTTGGTGA TTGGTTGGAC 2760
GCCATCAAGA TGGGACGGTA CAAGGAAAGC TTCGTCAGTG CGGGCTTTGC ATCCTTCGAC 2820
CTGGTGGCCC AGATGACCGC AGAGGACCTG CTCCGCATCG GTGTCACCTT GGCCGGCCAC 2880
CAGAAGAAGA TCCTCAGTAG TATCCAGGAC ATGCGGCTGC AGATGAGCCA GACCCTGCCT 2940
GTGCAGGTCT GA 2952
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevc+Grlk+pg+re+ vaiktlk g+te+qrrdflseasi+Gqfdhp
Q: 618   VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHP  677
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+men+aldsflr +dgqftviqlvgmlrGia+gmkyls+m
Q: 678   NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM  737
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt+s ggkipirwtapeaiay
Q: 738   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPsDPTYTSSlGGKIPIRWTAPEAIAY  797
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdmsnqdvi+a+e++yrlpppmdcp+al+qlml
Q: 798   RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML  857
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcw +dr+ rpkf+qiv++l
Q: 858   DCWVRDRNLRPKFSQIVNTL  877
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVCRGRL KQPGRREVFV AIKTLKVGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMILTE FMENCALDSF LRLNDGQFTV IQLVGMLRGI AAGMKYLSEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDPSDPTY TSSLGGKIPI RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVINAVE QDYRLPPPMD CPTALHQLML 240
DCWVRDRNLR PKFSQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00007
EKS-ANC-00006
EKS-BOT-00005
EKS-CAJ-00014
EKS-CAF-00007
EKS-CAP-00005
EKS-DAR-00007
EKS-DIO-00001
EKS-EQC-00007
EKS-FEC-00005
EKS-GAG-00007
EKS-GAA-00005
EKS-GOG-00006
EKS-HOS-00008
EKS-ICT-00006
EKS-LAC-00005
EKS-MAM-00006
EKS-MEG-00006
EKS-MUM-00007
EKS-MUP-00007
EKS-MYL-00008
EKS-NOL-00007
EKS-ORN-00006
EKS-ORA-00005
EKS-ORL-00004
EKS-OTG-00006
EKS-PAT-00007
EKS-PES-00005
EKS-RAN-00007
EKS-SAH-00006
EKS-SUS-00005
EKS-TAG-00006
EKS-TAR-00004
EKS-TUT-00006
EKS-XET-00006
EKS-XIM-00005
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005003; F:ephrin receptor activity
GO:0001525; P:angiogenesis
GO:0007413; P:axonal fasciculation
GO:0016477; P:cell migration
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0022038; P:corpus callosum development
GO:0060997; P:dendritic spine morphogenesis
GO:0048546; P:digestive tract morphogenesis
GO:0060021; P:palate development
GO:0051965; P:positive regulation of synapse assembly
GO:0046777; P:protein autophosphorylation
GO:0050770; P:regulation of axonogenesis
GO:0043088; P:regulation of Cdc42 GTPase activity
GO:0022407; P:regulation of cell-cell adhesion
GO:0032314; P:regulation of Rac GTPase activity
GO:0031290; P:retinal ganglion cell axon guidance
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0048538; P:thymus development
GO:0001655; P:urogenital system development
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013