EKS-ORC-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.7	1.0E-185	457	735	279

Status

Unreviewed

Ensembl Protein

ENSOCUP00000010919

UniProt Accession

G1T3V4;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000012680	ENSOCUP00000010919	ENSOCUT00000012685

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

767

Protein Sequence
(FASTA)

MSVQSSSGSL EGPPSWSQLS TSPTPGSAAA ARSLLNHTPP SGRPREGSAM DELHSLDPRR 60

QELLEARFTG VASGSTGSTG SCSVGAKAST NNESSNHSFG SLGSLSDKES ETPEKKQSES 120

SRGRKRKAEN QNESSQGKSI GGRGHKISDY FEYQGGNGSS PVRGVPPAIR SPQNSHSHST 180

PSSSVRPNSP SPTALAFGDH PVVQPKQLSF KITQTDLTML KLAALESNKN QDLEKKEGRI 240

DDLLRANCDL RRQIDEQQKL LEKYKERLNK CISMSKKLLI EKSTQEKLSS REKSMQDRLR 300

LGHFTTVRHG ASFTEQWTDG FAFQNLVKQQ EWVNQQREDI ERQRKLLAKR KPPTANNSQA 360

PSTNSEPKQR KNKAVNGAEN DPFVRPNLPQ LLTLAEYHEQ EEIFKLRLGH LKKEEAEIQA 420

ELERLERVRN LHIRELKRIN NEDNSQFKDH PTLNERYLLL HLLGRGGFSE VYKAFDLYEQ 480

RYAAVKIHQL NKSWRDEKKE NYHKHACREY RIHKELDHPR IVKLYDYFSL DTDTFCTVLE 540

YCEGNDLDFY LKQHKLMSEK EARSIVMQIV NALRYLNEIK PPIIHYDLKP GNILLVDGTA 600

CGEIKITDFG LSKIMDDDSY GVDGMDLTSQ GAGTYWYLPP ECFVVGKEPP KISNKVDVWS 660

VGVIFFQCLY GRKPFGHNQS QQDILQENTI LKATEVQFPV KPVVSSEAKA FIRRCLAYRK 720

EDRFDVHQLA NDPYLLPHMR RSNSSGNLHM AGLTASPTPP SSSIITY 767

Nucleotide Sequence
(FASTA)

ATGAGTGTCC AAAGTAGCAG TGGAAGTTTG GAGGGGCCGC CATCTTGGTC CCAGCTCTCC 60

ACGTCTCCAA CCCCGGGCTC GGCGGCGGCG GCCAGGTCCC TGCTGAATCA CACGCCGCCA 120

TCCGGGAGGC CCAGGGAAGG TAGTGCAATG GATGAGCTTC ATAGCCTGGA TCCAAGAAGG 180

CAAGAGTTAT TGGAAGCTAG GTTTACTGGA GTTGCAAGTG GGAGCACTGG GAGCACTGGC 240

AGTTGCAGTG TTGGAGCTAA AGCCTCAACA AATAATGAAA GCTCTAATCA CAGTTTTGGA 300

AGCTTGGGAT CTTTAAGTGA CAAAGAATCA GAGACACCAG AGAAGAAACA GTCGGAATCA 360

TCTAGGGGAA GAAAGAGAAA AGCAGAAAAC CAGAATGAAA GTAGTCAGGG AAAAAGTATT 420

GGGGGACGTG GCCATAAAAT TAGTGACTAT TTTGAATACC AAGGTGGGAA TGGCTCAAGT 480

CCAGTAAGAG GCGTACCTCC TGCAATCCGT TCTCCTCAAA ATTCACATTC ACATTCCACG 540

CCTTCCTCAT CTGTTCGACC GAATAGCCCT TCTCCTACAG CATTAGCTTT TGGGGACCAC 600

CCTGTTGTAC AACCAAAGCA GTTATCCTTT AAAATTACTC AGACTGATCT CACAATGCTG 660

AAATTAGCAG CATTAGAAAG TAATAAAAAC CAGGACCTGG AAAAGAAGGA AGGTCGTATA 720

GATGATTTGC TCAGGGCTAA CTGTGATCTC AGACGGCAAA TAGATGAACA ACAAAAATTA 780

CTTGAAAAAT ACAAAGAACG ATTAAATAAG TGTATATCAA TGAGCAAGAA ACTTCTTATT 840

GAAAAGAGTA CACAAGAAAA ACTGTCAAGC AGAGAGAAGA GTATGCAAGA TAGATTACGC 900

CTTGGACACT TTACCACAGT TAGACATGGC GCCTCATTTA CTGAACAATG GACAGATGGT 960

TTTGCATTTC AGAATCTTGT GAAGCAACAA GAGTGGGTGA ATCAGCAAAG GGAAGATATT 1020

GAAAGGCAAA GGAAACTTCT AGCCAAACGC AAACCTCCCA CAGCTAATAA TTCTCAGGCA 1080

CCCTCTACCA ATTCTGAACC AAAACAAAGG AAAAACAAAG CAGTCAATGG AGCAGAAAAT 1140

GATCCCTTTG TTAGACCAAA TTTACCACAA CTGTTGACTT TGGCAGAATA TCATGAACAG 1200

GAAGAAATTT TCAAACTTAG ACTAGGACAT CTCAAAAAGG AAGAGGCAGA AATCCAGGCA 1260

GAACTTGAAC GTTTGGAAAG AGTCAGAAAT CTTCACATAC GAGAGCTCAA AAGAATAAAC 1320

AATGAAGATA ATTCACAGTT CAAAGATCAC CCAACATTAA ACGAGAGATA TTTATTACTT 1380

CATTTACTTG GTAGAGGTGG CTTCAGTGAA GTATACAAGG CTTTTGACCT TTATGAACAA 1440

AGATATGCTG CTGTGAAGAT CCATCAGCTT AATAAAAGCT GGAGAGATGA GAAAAAAGAA 1500

AACTACCACA AACATGCCTG CAGAGAGTAT AGAATACACA AAGAACTGGA TCACCCCAGA 1560

ATAGTTAAAC TCTATGATTA TTTCTCCTTG GATACAGACA CATTTTGTAC AGTGTTAGAA 1620

TACTGTGAAG GCAATGACTT GGATTTCTAT CTGAAGCAAC ACAAATTAAT GTCTGAGAAG 1680

GAAGCTAGAT CTATTGTAAT GCAGATTGTG AATGCACTAA GATATCTCAA TGAGATCAAA 1740

CCCCCTATTA TACATTATGA TCTTAAGCCA GGAAACATCC TTCTGGTGGA TGGGACAGCA 1800

TGTGGAGAAA TCAAAATCAC TGATTTTGGG CTGTCCAAGA TTATGGATGA CGACAGCTAT 1860

GGTGTAGATG GAATGGATCT CACTTCCCAA GGGGCAGGCA CTTACTGGTA TTTACCTCCC 1920

GAGTGCTTTG TAGTTGGAAA AGAGCCACCA AAGATTTCCA ACAAGGTTGA TGTGTGGTCG 1980

GTCGGAGTCA TCTTCTTTCA GTGTCTTTAC GGAAGGAAGC CATTTGGTCA CAATCAATCT 2040

CAACAAGACA TTCTTCAAGA AAATACAATA TTAAAAGCCA CAGAAGTTCA ATTCCCTGTA 2100

AAACCAGTTG TAAGCAGTGA AGCCAAGGCC TTTATAAGAC GGTGTTTGGC ATACCGAAAA 2160

GAAGATCGAT TCGATGTGCA CCAACTGGCA AATGACCCAT ATCTTCTCCC ACACATGAGA 2220

AGATCAAATT CTTCAGGAAA CTTACACATG GCTGGGCTGA CAGCATCCCC GACGCCCCCT 2280

TCTTCCAGCA TAATTACTTA CTGA 2304

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 457   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  516

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 517   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  576

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 577   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  635

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 636   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  695

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvsseakafirrclayrkedr+dv+qla+d+yl

Q: 696   VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL  735

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSS EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013