EKS-ORC-00115

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00115

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	481.3	7.9E-145	1079	1339	261

Status

Reviewed

Ensembl Protein

ENSOCUP00000011247

UniProt Accession

Q09YN5;

Protein Name

Hepatocyte growth factor receptor

Protein Synonyms/Alias

HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met;

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000013060	ENSOCUP00000023323	ENSOCUT00000023489
ENSOCUG00000013060	ENSOCUP00000011247	ENSOCUT00000013064

Organism

Oryctolagus cuniculus

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity).

Protein Length

1382

Protein Sequence
(FASTA)

MKAPAVLAPG ILVLLFTLVP RSHGECKEAL VKSEMNVNMK YQLPNFTAET PIQNVLLHQH 60

HVYLGAINHI YVLNDKDLQK VAEYTTGPVL EHPDCLPCQD CSSKANSSGA VWKDNINLAL 120

LVDKYYDDQL ISCGSVNRGT CQRHVLPPDN PADIQSGVYC MFSPQADEEP GQCPDCVVSP 180

LGAKVLLSKK QRFIYFFVGN TINSSYLPDH SLHSISVRRL KETQDGFKFL TDQSYIDVLP 240

EFRDSYPIKY VHAFESNHFI YFLTVQKETL DAQTFHTRII RFCSKDSGLH SYMEMPLECI 300

LTEKRRKRAT REEVFNILQA AYVSKPGAHL ARQIGATPND DILYGVFAQS KPDSAEPMNR 360

SAVCAFPIKY INEFFNKIVN KNNVKCLQHF YGPNHEHCFN RTLLRNSSDC EARSDEYRTE 420

LTTALQRVDL FMGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQVVISR TILNVPHVNF 480

RLDSHPVSPE VVVEHPLNQN GYTLVVTGNK ITKIPLNGLG CGHFQSCSQC LSAPPFVQCG 540

WCHDKCVPSE ECPSGTWTQE ICLPAIYKVF PASAPLEGGT TLTICGWDFG FRKNNKFDLK 600

KTKVLLGNES CALNLSESTT NTLKCTVGAT THEHFNMSIT VSNSRGRTQY STFSYVAPVI 660

TSISPSYGPK AGGTLLTLTG KYLDSGNSRH ISIGGKTCTL KSMSNSILEC YTPAQTISTE 720

FPVKLEIDLA SRETSSFSYR EDPIVDEFYP TKSFISGGST ITGVGKNLDS VSVPRMVISV 780

HEAGSNFTVA CQHRSNSEII CCTTPSLQQL NLHLPLKTKA FFMLDGILSK HFDLTYVHNP 840

VFKPFEKPVM ISMGNENVLE IKGNDIDPEA VKGEVLKVGN KSCENIHSDS EAVLCTVPND 900

LLKLNSELNI EWKQAVSSTV LGKVIVQPDQ NFMGLIVGGV SISIILLLLL GLFLWLKKKK 960

RIKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG 1020

SCRQVQYPLT DLSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH 1080

FSEVIGRGHF GCVYHGTLLD NDGKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV 1140

LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK 1200

FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK 1260

FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DALYEVMLKC 1320

WHPKAEMRPS FSELVSRIST IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNVDGTV 1380

DT 1382

Nucleotide Sequence
(FASTA)

ATGAAGGCGC CCGCTGTGCT TGCACCTGGC ATCCTTGTGC TCCTGTTTAC CTTGGTGCCG 60

AGGAGCCATG GGGAGTGTAA AGAGGCACTG GTGAAGTCCG AGATGAATGT GAACATGAAG 120

TATCAGCTTC CCAACTTCAC CGCTGAAACG CCCATCCAGA ACGTCCTTCT GCACCAGCAT 180

CACGTCTACC TCGGTGCCAT CAACCACATC TACGTTTTAA ATGACAAAGA CCTTCAGAAG 240

GTTGCTGAAT ACACGACCGG GCCCGTGCTG GAACACCCGG ACTGTTTGCC GTGTCAGGAC 300

TGCAGCAGCA AAGCCAATTC CTCAGGTGCT GTTTGGAAAG ATAACATCAA CCTGGCTCTG 360

CTTGTTGACA AGTACTATGA TGACCAACTC ATTAGCTGTG GCAGCGTCAA CAGAGGGACC 420

TGCCAGCGAC ACGTCCTCCC ACCTGATAAT CCTGCTGACA TACAGTCGGG GGTTTACTGT 480

ATGTTCTCCC CACAGGCAGA TGAAGAGCCT GGCCAGTGTC CTGACTGCGT GGTGAGCCCC 540

CTGGGAGCCA AAGTTCTCCT ATCCAAAAAG CAGCGCTTCA TCTACTTCTT TGTGGGCAAT 600

ACCATAAATT CTTCTTACCT TCCAGATCAC TCATTGCATT CGATATCAGT GAGAAGGCTG 660

AAGGAAACAC AGGATGGTTT TAAGTTTCTG ACGGATCAGT CCTATATTGA TGTCCTACCC 720

GAGTTCCGAG ATTCCTACCC CATTAAGTAT GTCCACGCTT TTGAAAGCAA CCATTTTATT 780

TACTTCCTGA CGGTCCAAAA GGAAACTCTA GATGCTCAGA CTTTCCACAC AAGAATCATC 840

AGGTTCTGTT CCAAGGACTC CGGCTTGCAT TCCTACATGG AAATGCCTCT GGAGTGTATT 900

CTCACGGAGA AGAGGAGGAA GAGAGCCACC AGGGAGGAAG TGTTTAATAT CCTTCAGGCT 960

GCATATGTCA GTAAGCCTGG GGCCCATCTT GCTAGGCAGA TTGGAGCCAC CCCGAATGAT 1020

GACATTCTCT ATGGGGTGTT CGCCCAGAGC AAACCAGATT CCGCTGAACC CATGAATCGA 1080

TCTGCCGTCT GTGCATTCCC TATCAAATAT ATCAATGAAT TCTTCAACAA GATCGTCAAC 1140

AAAAACAACG TGAAATGTCT CCAGCATTTT TATGGACCCA ATCATGAGCA CTGCTTCAAT 1200

AGGACACTTT TGAGGAATTC GTCAGACTGT GAGGCACGCA GCGATGAATA CCGTACAGAG 1260

CTGACCACCG CGCTGCAGCG TGTGGACTTA TTCATGGGCC AGTTCAACCA AGTCCTCTTA 1320

ACATCCATCT CCACCTTCAT TAAAGGCGAC CTCACCATTG CTAACCTCGG GACCTCAGAG 1380

GGCCGTTTCA TGCAGGTTGT GATTTCTCGA ACGATACTGA ACGTCCCTCA TGTGAATTTT 1440

CGCCTGGATT CCCACCCTGT GTCTCCAGAA GTAGTTGTGG AGCACCCATT AAACCAGAAT 1500

GGCTACACAC TGGTGGTCAC AGGAAACAAG ATTACCAAAA TCCCATTGAA TGGGTTGGGC 1560

TGTGGACATT TCCAGTCCTG CAGTCAGTGT CTCTCCGCCC CTCCCTTTGT GCAATGTGGC 1620

TGGTGCCATG ACAAGTGTGT GCCGTCAGAG GAATGCCCCA GCGGGACGTG GACTCAAGAG 1680

ATCTGTCTGC CTGCAATCTA CAAGGTTTTC CCAGCCAGTG CACCCCTTGA GGGAGGGACC 1740

ACACTGACCA TCTGTGGCTG GGACTTTGGG TTCAGGAAGA ATAATAAATT TGATTTAAAG 1800

AAAACCAAAG TCCTCCTTGG AAATGAAAGC TGTGCCTTGA ACTTAAGTGA GAGCACGACA 1860

AATACGTTGA AATGCACAGT TGGTGCTACA ACGCATGAGC ATTTCAATAT GTCCATAACT 1920

GTTTCAAACA GTCGAGGGAG AACACAGTAT AGTACATTTT CTTATGTGGC TCCTGTAATA 1980

ACAAGTATTT CTCCAAGTTA TGGCCCCAAG GCTGGTGGCA CTTTACTCAC TTTAACTGGA 2040

AAATACCTGG ACAGTGGAAA TTCCAGACAC ATTTCAATTG GTGGAAAAAC ATGTACTTTA 2100

AAAAGCATGT CAAACAGTAT TCTTGAGTGT TATACTCCAG CCCAAACCAT TTCAACTGAA 2160

TTTCCTGTTA AATTGGAAAT CGACTTAGCC AGCCGAGAAA CCAGCAGCTT CAGTTACCGG 2220

GAAGACCCCA TTGTGGATGA ATTTTATCCA ACCAAATCTT TTATTAGTGG TGGAAGCACC 2280

ATAACAGGTG TTGGAAAAAA CCTGGATTCA GTTAGTGTCC CAAGGATGGT AATAAGTGTG 2340

CACGAAGCAG GAAGTAACTT CACAGTGGCA TGTCAGCATC GGTCCAACTC AGAGATCATC 2400

TGCTGCACCA CTCCTTCACT GCAACAGCTG AATCTGCACC TCCCCCTGAA AACCAAAGCC 2460

TTTTTCATGT TGGATGGGAT CCTTTCCAAA CACTTTGATC TCACTTATGT ACATAATCCT 2520

GTGTTTAAGC CTTTTGAAAA GCCAGTGATG ATCTCAATGG GCAATGAAAA TGTACTGGAA 2580

ATTAAGGGAA ATGATATTGA CCCTGAAGCA GTTAAAGGTG AAGTGTTGAA AGTTGGAAAT 2640

AAGAGCTGTG AGAACATACA CTCAGATTCT GAAGCCGTCT TATGCACGGT CCCCAATGAC 2700

CTGCTGAAAT TGAACAGTGA ACTAAATATA GAGTGGAAGC AAGCAGTTTC TTCAACTGTC 2760

CTTGGAAAAG TAATAGTTCA ACCAGATCAG AATTTTATGG GATTGATTGT TGGTGGTGTC 2820

TCCATATCAA TAATACTTTT ATTATTACTT GGACTGTTTT TGTGGCTAAA AAAGAAAAAG 2880

CGCATTAAAG ATCTGGGCAG TGAATTAGTT CGCTATGATG CAAGAGTTCA CACTCCTCAT 2940

TTGGATAGGC TTGTAAGTGC CCGAAGTGTG AGCCCAACTA CAGAAATGGT TTCAAATGAA 3000

TCTGTAGACT ACAGAGCTAC TTTTCCAGAA GACCAGTTTC CTAACTCATC TCAGAATGGA 3060

TCATGCAGAC AAGTGCAGTA TCCTCTGACG GACCTGTCTC CCATCCTAAC TAGTGGAGAC 3120

TCTGATATAT CCAGTCCATT ACTGCAAAAT ACTGTCCACA TTGACCTCAG TGCTTTAAAT 3180

CCAGAGCTGG TCCAAGCAGT CCAGCACGTA GTGATTGGGC CAAGTAGCCT GATTGTGCAT 3240

TTCAGTGAAG TCATAGGAAG AGGGCATTTT GGTTGTGTAT ATCATGGGAC TTTGTTGGAC 3300

AATGATGGCA AGAAAATTCA CTGTGCTGTG AAATCTTTGA ATAGAATCAC TGACATAGGA 3360

GAAGTTTCCC AGTTCCTGAC TGAGGGGATC ATCATGAAAG ACTTCAGTCA TCCCAATGTC 3420

CTGTCACTCT TGGGAATCTG CCTTCGAAGT GAAGGGTCTC CACTGGTGGT CCTACCGTAC 3480

ATGAAACATG GAGATCTCAG AAATTTCATT CGAAATGAGA CACATAACCC GACTGTAAAA 3540

GATCTTATTG GCTTTGGTCT TCAAGTAGCA AAAGGCATGA AATACCTTGC AAGCAAAAAG 3600

TTTGTCCACA GAGACTTGGC TGCAAGAAAC TGTATGTTGG ATGAAAAATT CACTGTCAAA 3660

GTTGCTGATT TTGGTCTTGC CCGAGATATG TATGATAAAG AATACTATAG TGTACACAAC 3720

AAAACAGGTG CAAAACTGCC AGTGAAGTGG ATGGCTTTAG AAAGTCTGCA AACTCAGAAG 3780

TTTACAACCA AATCTGATGT GTGGTCCTTC GGCGTGCTCC TGTGGGAGCT GATGACAAGA 3840

GGAGCCCCAC CTTACCCTGA TGTGAACACC TTTGACATAA CCGTGTACCT GCTGCAAGGC 3900

AGGAGACTCC TGCAACCCGA ATACTGCCCA GATGCCTTGT ACGAAGTGAT GCTAAAGTGC 3960

TGGCACCCGA AAGCCGAAAT GCGCCCGTCC TTCTCAGAAC TGGTCTCCAG GATATCCACG 4020

ATCTTCTCTA CTTTCATTGG GGAGCACTAT GTCCACGTGA ATGCGACTTA CGTGAACGTG 4080

AAATGTGTGG CTCCCTATCC TTCTCTGCTG TCATCGCAGG ATAACGTGGA TGGCACAGTG 4140

GACACGTGA 4149

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d+++kki++avksl+ritdi++v++fl+eg++mk+++hp

Q: 1079  VHFSEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP  1138

         7999********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1139  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1198

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1199  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1258

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd+ly+vm

Q: 1259  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDALYEVM  1317

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k+++rp+fs+lvs+is

Q: 1318  LKCWHPKAEMRPSFSELVSRIS  1339

         ********************98

Domain Sequence
(FASTA)

VHFSEVIGRG HFGCVYHGTL LDNDGKKIHC AVKSLNRITD IGEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITVYLL QGRRLLQPEY CPDALYEVML 240

KCWHPKAEMR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0030534	; P:adult behavior
GO:0007420	; P:brain development
GO:0048754	; P:branching morphogenesis of a tube
GO:0042593	; P:glucose homeostasis
GO:0001889	; P:liver development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0014902	; P:myotube differentiation
GO:0001890	; P:placenta development
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013