EKS-ORC-00214

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00214

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.5	2.7E-116	60	311	252

Status

Unreviewed

Ensembl Protein

ENSOCUP00000011319

UniProt Accession

G1TG57;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK1

Gene Synonyms/Alias

MARK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000013143	ENSOCUP00000011319	ENSOCUT00000013148
ENSOCUG00000013143	ENSOCUP00000015905	ENSOCUT00000023689

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

795

Protein Sequence
(FASTA)

MSARTPLPTV NERDTENHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 60

RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 120

KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKCIVH 180

RDLKAENLLL DADMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 240

WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 300

SLEQIMKDRW MNVGHEEEEL KPYAEPEPDF NDTKRIDVMV TMGFARDEIN DALINQKYDE 360

VMATYILLGR KPPEFEGGES LSSGNLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR 420

RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDVARK LGSTTVGSKS EMTASPLVGP 480

ERKKSSTIPS SNVYSGGSMA RRNTYVCERT TDRYTALQNG KDSSLTEMSV SSMSSAGSAV 540

ASAVPSTRPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGT TQRVPAASPS AHSISAATPD 600

RTRFPRGSSS RSTFHGEQLR ERRSAAYNGP PASPSHETGA FSHARRGTST GIISKITSKF 660

VRRDPSEGEA SGRTDTSRST SGEPKERDKE EGKDSKPRSL RFTWSMKTTS SMDPNDMMRE 720

IRKVLDANNC DYEQKERFLL FCVHGDARQD SLVQWEMEVC KLPRLSLNGV RFKRISGTSI 780

AFKNIASKIA NELKL 795

Nucleotide Sequence
(FASTA)

ATGTCGGCCC GGACGCCATT GCCGACGGTG AACGAGCGGG ACACGGAGAA TCATACTTCT 60

GTGGATGGAT ACACTGAACC ACACATCCAG CCTACCAAAT CAAGTAGCAG ACAGAACATC 120

CCTCGTTGTA GAAACTCCAT TACGTCAGCA ACAGATGAAC AGCCTCACAT TGGAAATTAT 180

CGTTTACAAA AAACAATAGG GAAGGGAAAT TTTGCCAAAG TGAAATTGGC AAGACATGTT 240

CTAACTGGTA GAGAGGTTGC TGTGAAAATA ATAGACAAAA CTCAGCTAAA TCCTACCAGT 300

CTACAAAAGT TGTTTCGGGA AGTACGAATA ATGAAGATAT TGAATCATCC TAATATAGTA 360

AAATTGTTTG AAGTTATTGA AACAGAGAAG ACCCTCTATT TAGTCATGGA ATACGCGAGT 420

GGGGGTGAAG TATTTGATTA CTTAGTTGCC CATGGAAGAA TGAAAGAGAA AGAGGCCCGT 480

GCAAAATTTA GGCAGATTGT ATCTGCTGTA CAGTATTGTC ATCAGAAGTG CATTGTTCAC 540

CGTGATCTTA AGGCTGAAAA TCTTCTTCTT GATGCTGACA TGAATATTAA AATTGCTGAC 600

TTTGGTTTTA GTAATGAATT TACAGTTGGG AACAAATTGG ACACATTTTG TGGAAGCCCC 660

CCCTACGCTG CTCCAGAGTT ATTCCAAGGG AAGAAGTATG ATGGGCCTGA AGTGGATGTA 720

TGGAGTCTTG GCGTCATTCT CTATACATTA GTGAGTGGCT CTCTGCCTTT TGATGGCCAG 780

AACCTAAAGG AGCTGCGGGA GCGAGTCTTA CGAGGGAAGT ACCGTATTCC CTTCTATATG 840

TCCACAGACT GTGAAAATCT CCTGAAGAAA TTATTAGTGC TGAATCCAAT AAAGAGAGGC 900

AGCTTGGAAC AAATAATGAA AGATCGATGG ATGAATGTTG GTCACGAAGA AGAAGAACTA 960

AAGCCATATG CTGAGCCTGA ACCAGATTTC AATGACACAA AAAGAATAGA TGTTATGGTC 1020

ACCATGGGTT TTGCACGTGA TGAAATAAAT GACGCCTTAA TAAATCAGAA ATATGATGAA 1080

GTTATGGCTA CTTATATTCT TCTAGGTAGA AAACCACCTG AATTTGAAGG CGGTGAGTCG 1140

TTATCCAGTG GGAATTTGTG TCAGAGGTCC CGGCCCAGCA GTGACTTAAA CAACAGCACT 1200

CTCCAGTCCC CCGCTCACCT GAAGGTCCAG CGGAGCATCT CGGCAAACCA GAAGCAGCGT 1260

CGTTTTAGTG ACCACGCTGG TCCATCCATT CCTCCTGCTG TGTCCTATAC CAAAAGACCT 1320

CAGGCCAACA GCGTGGAGAG TGAACAGAAA GAGGAGTGGG ACAAAGACGT GGCTCGTAAA 1380

CTTGGCAGCA CAACGGTAGG ATCAAAAAGC GAGATGACGG CAAGCCCTCT TGTGGGACCA 1440

GAGCGGAAAA AATCTTCAAC TATTCCAAGT AGCAATGTGT ATTCTGGAGG TAGCATGGCA 1500

AGAAGGAACA CCTATGTCTG TGAAAGGACC ACAGATCGAT ACACAGCATT GCAGAATGGA 1560

AAAGACAGCA GCCTCACGGA GATGTCTGTG AGCAGCATGT CTTCAGCGGG CTCTGCTGTG 1620

GCTTCCGCCG TTCCCTCAAC ACGACCCCGC CACCAGAAAT CCATGTCCAC TTCTGGCCAT 1680

CCTATTAAAG TCACACTGCC AACCATTAAA GATGGTTCTG AAGCTTACCG GCCTGGTACT 1740

ACCCAGAGAG TGCCTGCTGC TTCCCCATCT GCTCACAGCA TCAGTGCCGC CACCCCAGAC 1800

CGGACCCGTT TTCCCCGAGG GAGCTCCAGC AGAAGTACTT TCCATGGCGA ACAGCTCCGA 1860

GAGCGGCGCA GCGCTGCTTA TAATGGGCCA CCTGCCTCCC CATCCCATGA AACAGGTGCA 1920

TTCTCACATG CCAGAAGGGG GACATCAACT GGTATAATCA GCAAAATCAC GTCCAAATTT 1980

GTTCGCAGGG ATCCAAGTGA AGGCGAAGCC AGTGGCAGAA CCGACACCTC AAGAAGTACG 2040

TCAGGGGAAC CAAAAGAAAG AGACAAGGAA GAGGGTAAAG ATTCCAAGCC GCGTTCTTTG 2100

CGGTTCACAT GGAGTATGAA GACCACTAGC TCCATGGACC CTAATGACAT GATGAGAGAA 2160

ATCCGGAAAG TATTAGATGC AAATAACTGT GATTATGAAC AGAAAGAGAG GTTTTTGCTT 2220

TTCTGTGTCC ATGGAGATGC TAGACAAGAC AGCCTTGTGC AGTGGGAGAT GGAAGTCTGC 2280

AAGTTGCCAC GGCTGTCACT TAATGGGGTC CGCTTCAAGC GAATATCTGG AACATCTATT 2340

GCCTTTAAGA ACATTGCGTC CAAAATAGCA AATGAGCTTA AGCTG 2385

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l+kt+G+g+f+kVkla+h +t+++vavKii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 60    YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  119

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 120   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  179

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 180   HRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  239

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+klLv +p kR

Q: 240   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKR  299

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i+k++w+

Q: 300   GSLEQIMKDRWM  311

         ***********8

Domain Sequence
(FASTA)

YRLQKTIGKG NFAKVKLARH VLTGREVAVK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KLLVLNPIKR 240

GSLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0070300	; F:phosphatidic acid binding
GO:0005546	; F:phosphatidylinositol-4,5-bisphosphate binding
GO:0001786	; F:phosphatidylserine binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013