EKS-ORC-00351
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00351
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src423.43.2E-127231480250
StatusUnreviewed
Ensembl ProteinENSOCUP00000011386
UniProt AccessionG1T504;
Protein Name
Protein Synonyms/Alias
Gene NameBLK
Gene Synonyms/Alias BLK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000013226ENSOCUP00000011386ENSOCUT00000013225
ENSOCUG00000013226ENSOCUP00000011394ENSOCUT00000013236
OrganismOryctolagus cuniculus
Functional Description
Protein Length495
Protein Sequence
(FASTA)
SKKQVKEKGK SHWSPATVSA QSKAPPPLPP LVSDAVGGSV AISSLFLPEG HFVVALYDYA 60
AVNDQDLHMV RGEKLQILQE TGDWWLARSL VTGKEGYVPS NFVAGVESLE VEKWFFKSIS 120
RKEAERQLLA PVNKAGSFLI RESETSQGAF SLSVKDASPQ GEVVKHYKIR SLDEGGYYIS 180
PRATFPSLQA LVEHYSEKGD GLCQRLTLPC VGVAPQSPWA QDEWEIPRQS LKLVRKLGSG 240
QFGEVWMGYY KNNVKVAIKT LKEGTMSPEA FLGEANLMKT LQHERLVRLY AVVTREPIYI 300
VTEYMARGCL LDFLKTDEGS KLSLPRLIDM SAQIAEGMAY IEHMNSIHRD LRAANILVSE 360
ALSCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIQFG VFTIKADVWS FGILLMEIVT 420
YGRVPYPGMS NPEVIRSLER GYRMPRPDSC PPELYRDVIA ECWRDRPEER PTFEFLQSVL 480
EDFYTATERQ YELQP 495
Nucleotide Sequence
(FASTA)
AGCAAAAAGC AAGTCAAAGA GAAGGGCAAG AGCCACTGGA GCCCCGCGAC GGTCAGCGCT 60
CAGAGCAAAG CACCCCCACC ACTACCGCCC CTGGTGAGTG ACGCGGTGGG AGGCAGCGTG 120
GCCATCTCTT CCCTGTTCCT TCCAGAGGGA CATTTTGTGG TGGCCCTGTA CGACTATGCA 180
GCCGTGAATG ACCAGGACCT GCACATGGTG AGGGGCGAGA AGCTACAGAT CTTGCAGGAA 240
ACTGGAGACT GGTGGTTGGC CAGGTCGCTC GTCACGGGGA AAGAAGGCTA CGTGCCCAGC 300
AACTTTGTGG CCGGAGTCGA GTCCCTGGAG GTGGAAAAGT GGTTCTTTAA GTCAATCAGC 360
AGGAAAGAGG CCGAGAGGCA GCTTCTAGCT CCAGTCAACA AGGCCGGCTC CTTCCTCATA 420
AGAGAGAGCG AAACCAGTCA AGGCGCTTTC TCTCTGTCGG TGAAGGACGC CAGCCCCCAG 480
GGGGAGGTGG TCAAACACTA TAAGATCCGC TCCCTGGATG AAGGGGGCTA CTACATCTCC 540
CCCCGGGCCA CCTTCCCCTC CCTCCAGGCC CTGGTGGAGC ACTATTCTGA GAAGGGGGAC 600
GGTCTATGCC AGAGGCTGAC CCTGCCCTGT GTGGGCGTGG CTCCTCAGAG CCCCTGGGCC 660
CAGGACGAGT GGGAGATCCC CCGGCAGTCT CTGAAGCTGG TCAGGAAGCT GGGCTCAGGG 720
CAGTTTGGCG AAGTCTGGAT GGGTTACTAC AAGAACAACG TGAAGGTGGC CATCAAGACC 780
TTGAAGGAGG GAACCATGTC TCCAGAAGCC TTCCTGGGCG AGGCCAACCT GATGAAGACC 840
CTGCAGCACG AGCGGCTGGT GCGCCTCTAC GCCGTGGTCA CCAGGGAGCC CATCTACATC 900
GTCACGGAGT ACATGGCCAG AGGCTGCTTG CTGGATTTCC TGAAGACGGA TGAAGGCAGC 960
AAATTGTCCC TCCCACGGCT GATCGACATG TCAGCCCAGA TTGCCGAAGG CATGGCGTAC 1020
ATAGAGCACA TGAACTCCAT CCACCGCGAC CTGAGGGCGG CCAACATCCT CGTGTCCGAG 1080
GCGCTGAGCT GTAAAATCGC TGACTTTGGC CTGGCCCGCA TCATCGACAG CGAGTACACC 1140
GCCCAGGAGG GAGCCAAGTT CCCCATCAAG TGGACTGCGC CCGAAGCCAT CCAGTTCGGG 1200
GTGTTCACCA TCAAAGCAGA CGTGTGGTCA TTTGGGATCC TCTTGATGGA AATTGTCACG 1260
TATGGGCGGG TGCCATATCC AGGGATGAGC AACCCCGAGG TCATCCGCAG CCTGGAGCGC 1320
GGCTACCGCA TGCCGCGCCC GGACTCCTGC CCGCCCGAGC TGTACCGCGA CGTCATCGCC 1380
GAGTGCTGGC GGGACCGGCC GGAGGAGCGG CCCACCTTCG AGTTCCTGCA GTCGGTGCTG 1440
GAGGACTTCT ACACGGCCAC CGAGCGGCAG TACGAGCTGC AGCCC 1485
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv+klG+GqfGevw+g++k++vkva+ktlkegt+speafl ea+++k+l+he+lv+ly
Q: 231   LKLVRKLGSGQFGEVWMGYYKNNVKVAIKTLKEGTMSPEAFLGEANLMKTLQHERLVRLY  290
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyivte+ma+G+lldflk++eg+kl+lp+l+d++aq+aeGmay+e++n ihr
Q: 291   AVVTR-EPIYIVTEYMARGCLLDFLKTDEGSKLSLPRLIDMSAQIAEGMAYIEHMNSIHR  349
         *****.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+e l +k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv
Q: 350   DLRAANILVSEALSCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIQFGVFTIKADV  408
         **************************.899******************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239
         WsfGill+eivt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+ +pe
Q: 409   WSFGILLMEIVTYGRVPYPGMSNPEVIRSLERGYRMPRPDSCPPELYRdVIAECWRDRPE  468
         ***********************************************99***********
S: 240   erPtfetlqevl  251
         erPtfe+lq+vl
Q: 469   ERPTFEFLQSVL  480
         ********9986
Domain Sequence
(FASTA)
LKLVRKLGSG QFGEVWMGYY KNNVKVAIKT LKEGTMSPEA FLGEANLMKT LQHERLVRLY 60
AVVTREPIYI VTEYMARGCL LDFLKTDEGS KLSLPRLIDM SAQIAEGMAY IEHMNSIHRD 120
LRAANILVSE ALSCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIQFG VFTIKADVWS 180
FGILLMEIVT YGRVPYPGMS NPEVIRSLER GYRMPRPDSC PPELYRDVIA ECWRDRPEER 240
PTFEFLQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00345
EKS-ANC-00360
EKS-BOT-00372
EKS-CAJ-00377
EKS-CAF-00372
EKS-CAP-00405
EKS-DAR-00751
EKS-EQC-00363
EKS-FEC-00359
EKS-GAG-00314
EKS-GOG-00363
EKS-HOS-00379
EKS-ICT-00353
EKS-LAC-00386
EKS-LOA-00381
EKS-MAM-00373
EKS-MEG-00304
EKS-MOD-00360
EKS-MUM-00404
EKS-MUP-00366
EKS-NOL-00339
EKS-ORN-00479
EKS-ORL-00443
EKS-OTG-00375
EKS-PAT-00352
EKS-PES-00329
EKS-POA-00361
EKS-PTV-00095
EKS-RAN-00386
EKS-SAH-00342
EKS-SUS-00325
EKS-TAG-00443
EKS-TAR-00476
EKS-TUT-00099
EKS-XIM-00469
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0032024; P:positive regulation of insulin secretion
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013