EKS-ORC-00352
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00352
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK347.55.2E-104118375258
StatusUnreviewed
Ensembl ProteinENSOCUP00000011428
UniProt AccessionG1T535;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K11
Gene Synonyms/Alias MAP3K11;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000013282ENSOCUP00000021611ENSOCUT00000023303
ENSOCUG00000013282ENSOCUP00000011428ENSOCUT00000013280
OrganismOryctolagus cuniculus
Functional Description
Protein Length838
Protein Sequence
(FASTA)
MEPLKNLFLK SPLGSWNGGG GGGGGGSGGR PEGSPRAAAY ANPVWTALFD YEPSGQDELA 60
LRKGDRVEVL SRDAAISGDE GWWAGQVGGQ VGIFPSNYVS RGGGPPPCEV ASFQELRLEE 120
VIGIGGFGKV YRGSWRGELV AVKAARQDPD EDISVTAESV RQEARLFAML AHPNIIALKA 180
VCLEEPNLCL VMEYAAGGPL SRALAGRRVP PHVLVNWAVQ IARGMHYLHC EALVPVIHRD 240
LKSNNILLLQ PIEGDDMEHK TLKITDFGLA REWHKTTQMS AAGTYAWMAP EVIKASTFSK 300
GSDVWSFGVL LWELLTGEVP YRGIDCLAVA YGVAVNKLTL PIPSTCPEPF AQLMADCWAQ 360
DPHRRPDFAS ILQQLEALEA QVLREMPRDS FHSMQEGWKR EIQGLFDELR AKEKELLSRE 420
EELTRAAREQ RSQAEQLRRR EHLLAQWELE VFERELTLLL QQVDRERPHV RRRRGTFKRS 480
KLRARDGGER ISMPLDFKHR ITVQASPGLD RRKNVFEVGA GDSPTFPRFR AIQLEPAEPG 540
QAWGRQSPRR LEDSSSGERR GCRAWGPSPP KPGEAQDGRR RSRVEEATWN LDSEDSSPLG 600
SPSTPPALNG NPPRPSPEPE EPRRPSPGER GSSSGTPKLI QRALLRGTAL LASLGLGRDL 660
QPPAGRERGE LPPASPVPVP PPSPAEPPPS SLIRFSAKTP TPAPLLLDLA VPAGQPSAKS 720
PRREETRGGT VSPPPGTSRS APGTPGTPRS PPLGLISRPR PSPLRSRIDP WSFVSAGPRP 780
SPLPSPQPAP RRAPWTLFPD SDPFWDSPPA NPFQGRPQDC RAQTKDVGAQ APWAPEAG 838
Nucleotide Sequence
(FASTA)
ATGGAGCCCT TGAAGAACCT CTTCCTGAAG AGCCCTCTGG GGTCCTGGAA CGGCGGGGGC 60
GGCGGCGGCG GCGGCGGCAG CGGGGGCCGG CCGGAGGGGT CGCCCAGGGC AGCGGCGTAT 120
GCCAACCCCG TGTGGACAGC CCTGTTCGAC TACGAGCCCA GCGGGCAGGA TGAGCTGGCA 180
CTGCGGAAGG GCGACCGTGT GGAGGTGCTG TCTCGGGACG CGGCCATCTC CGGAGATGAG 240
GGCTGGTGGG CGGGCCAGGT GGGTGGCCAG GTGGGCATCT TTCCATCCAA CTACGTGTCA 300
AGGGGTGGCG GGCCGCCTCC CTGCGAGGTG GCCAGCTTCC AGGAGCTGCG GCTGGAGGAG 360
GTGATCGGCA TCGGCGGCTT CGGCAAGGTG TACCGGGGCA GCTGGCGGGG CGAGCTGGTG 420
GCCGTGAAGG CGGCCCGCCA GGACCCGGAC GAGGACATCA GCGTGACGGC GGAGAGCGTC 480
CGTCAGGAGG CCCGGCTCTT TGCCATGCTG GCGCACCCCA ACATCATCGC CCTCAAGGCC 540
GTGTGCCTGG AGGAGCCCAA CCTGTGCCTG GTGATGGAGT ACGCGGCCGG GGGGCCCCTC 600
AGCCGCGCCC TGGCCGGCCG CCGCGTGCCC CCGCATGTGC TGGTCAACTG GGCCGTGCAG 660
ATCGCCCGCG GGATGCACTA CCTGCACTGC GAAGCCCTGG TGCCCGTCAT CCACCGCGAC 720
CTCAAATCCA ACAACATCCT GCTGCTGCAG CCCATTGAGG GTGACGACAT GGAACACAAG 780
ACGCTGAAGA TCACCGACTT TGGCCTGGCC CGAGAGTGGC ACAAGACCAC GCAGATGAGC 840
GCTGCCGGCA CGTACGCCTG GATGGCGCCC GAGGTCATCA AGGCCTCCAC CTTCTCCAAG 900
GGCAGCGACG TCTGGAGCTT TGGGGTGCTG CTGTGGGAAC TACTGACCGG GGAAGTGCCC 960
TACCGCGGGA TCGACTGCCT TGCCGTGGCC TATGGCGTGG CCGTTAACAA GCTCACACTG 1020
CCCATCCCAT CCACCTGCCC GGAGCCCTTT GCACAGCTTA TGGCCGACTG CTGGGCGCAG 1080
GACCCCCACC GCAGGCCCGA CTTCGCCTCC ATCCTGCAGC AGCTGGAGGC ACTGGAGGCA 1140
CAGGTCCTGC GGGAAATGCC GCGGGACTCG TTCCATTCCA TGCAGGAAGG CTGGAAACGC 1200
GAGATCCAGG GCCTGTTCGA CGAGCTGCGG GCCAAGGAGA AGGAGCTGCT GAGCCGCGAG 1260
GAGGAGCTGA CGCGCGCGGC GCGCGAGCAG CGGTCGCAGG CGGAGCAGCT GCGGCGGCGC 1320
GAGCACCTGC TGGCCCAGTG GGAGCTGGAG GTGTTCGAGC GCGAGCTGAC GCTGCTGCTG 1380
CAGCAAGTGG ACCGCGAGCG GCCGCACGTG CGCCGCCGCC GCGGCACCTT CAAGCGGAGC 1440
AAGCTGCGGG CGCGCGACGG GGGCGAGCGC ATCAGCATGC CACTCGACTT TAAGCACCGC 1500
ATCACCGTGC AGGCCTCGCC CGGCCTTGAC CGGAGGAAAA ACGTCTTCGA AGTCGGAGCT 1560
GGGGACTCGC CCACCTTCCC CCGGTTCCGG GCCATCCAGT TGGAGCCTGC AGAGCCGGGC 1620
CAGGCGTGGG GCCGCCAGTC CCCCAGGCGT CTAGAAGACT CGAGCAGCGG CGAGCGGCGA 1680
GGGTGCCGGG CCTGGGGTCC CAGTCCCCCC AAGCCCGGAG AGGCCCAGGA CGGGAGGAGG 1740
AGGTCCCGCG TGGAGGAAGC CACCTGGAAT CTGGATTCAG AGGACTCGTC GCCCTTGGGG 1800
TCTCCTTCCA CACCGCCGGC GCTCAACGGT AACCCTCCGC GGCCGAGCCC AGAGCCGGAG 1860
GAGCCCCGGC GGCCCAGCCC CGGCGAGCGC GGGAGCAGCT CCGGGACGCC CAAGCTGATC 1920
CAGCGCGCAC TCCTGCGCGG CACCGCCCTG CTCGCCTCGC TGGGCCTCGG CCGCGACCTG 1980
CAGCCACCAG CGGGCCGCGA GCGCGGGGAG CTGCCGCCAG CGTCCCCCGT GCCGGTACCC 2040
CCACCGAGCC CAGCTGAGCC ACCTCCTTCC TCACTCATCC GCTTCTCAGC CAAGACGCCC 2100
ACCCCGGCGC CCCTGCTGCT GGACCTGGCT GTCCCCGCGG GCCAGCCCTC GGCCAAGAGC 2160
CCCCGCCGCG AGGAGACACG CGGAGGCACC GTCTCACCTC CGCCTGGGAC GTCACGCTCC 2220
GCTCCGGGCA CCCCGGGCAC ACCGCGCTCC CCACCCCTGG GCCTCATCAG CCGACCTCGG 2280
CCCTCACCCC TCCGCAGCCG CATCGACCCG TGGAGCTTCG TGTCAGCGGG GCCCCGGCCA 2340
TCACCCCTGC CCTCGCCACA GCCTGCGCCC CGACGGGCAC CCTGGACCTT GTTCCCGGAC 2400
TCGGACCCTT TCTGGGACTC CCCGCCTGCC AACCCCTTCC AGGGGAGGCC TCAGGACTGC 2460
AGGGCGCAGA CCAAAGACGT GGGTGCCCAG GCTCCATGGG CGCCGGAGGC GGGG 2514
Domain Profile
S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60
         lee+ig g fgkvy+++wr++ vavK++r++  e  + ++e++++ea+l+++l+hpnii+
Q: 118   LEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEdiSVTAESVRQEARLFAMLAHPNIIA  177
         789****************************99988999*********************
S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120
         l++vcleepnl+lvmey++gg Ls++l++   r+++++vlv+wa+qiArGm+YLh ea +
Q: 178   LKAVCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWAVQIARGMHYLHCEALV  234
         *****************************...9***************************
S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173
         ++ihrdLks+n+Ll       ++e+ktlki+dFG are++k+t+msaagt+awmaPEv+k
Q: 235   PVIHRDLKSNNILLlqpiegdDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIK  294
         *********************9**************************************
S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233
         ++++s+ sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++Lm
Q: 295   ASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLM  354
         ************************************************************
S: 234   kecwnedpekRpsfseivksl  254
          +cw++dp++Rp+f++i+++l
Q: 355   ADCWAQDPHRRPDFASILQQL  375
         *****************9986
Domain Sequence
(FASTA)
LEEVIGIGGF GKVYRGSWRG ELVAVKAARQ DPDEDISVTA ESVRQEARLF AMLAHPNIIA 60
LKAVCLEEPN LCLVMEYAAG GPLSRALAGR RVPPHVLVNW AVQIARGMHY LHCEALVPVI 120
HRDLKSNNIL LLQPIEGDDM EHKTLKITDF GLAREWHKTT QMSAAGTYAW MAPEVIKAST 180
FSKGSDVWSF GVLLWELLTG EVPYRGIDCL AVAYGVAVNK LTLPIPSTCP EPFAQLMADC 240
WAQDPHRRPD FASILQQL 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00376
EKS-CAJ-00383
EKS-CAF-00376
EKS-CAP-00409
EKS-DIO-00059
EKS-EQC-00374
EKS-FEC-00364
EKS-GAA-00460
EKS-GOG-00367
EKS-HOS-00383
EKS-ICT-00356
EKS-LAC-00397
EKS-LOA-00385
EKS-MAM-00375
EKS-MOD-00366
EKS-MUM-00408
EKS-MUP-00370
EKS-MYL-00374
EKS-NOL-00344
EKS-ORN-00483
EKS-ORL-00446
EKS-OTG-00378
EKS-PAT-00356
EKS-PES-00335
EKS-POA-00366
EKS-PTV-00099
EKS-RAN-00391
EKS-SAH-00352
EKS-TAR-00479
EKS-TEN-00477
EKS-XIM-00473
Gene Ontology
GO:0005813; C:centrosome
GO:0005874; C:microtubule
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0007257; P:activation of JUN kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0008283; P:cell proliferation
GO:0000080; P:G1 phase of mitotic cell cycle
GO:0007017; P:microtubule-based process
GO:0046330; P:positive regulation of JNK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR011511; SH3_2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF07653; SH3_2; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013