EKS-ORC-00018

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00018

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/PHK	519.5	2.1E-156	20	290	271

Status

Reviewed

Ensembl Protein

ENSOCUP00000011717

UniProt Accession

P00518;

Protein Name

Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform

Protein Synonyms/Alias

Phosphorylase kinase subunit gamma-1;

Gene Name

PHKG1

Gene Synonyms/Alias

PHKG1; PHKG;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000013618	ENSOCUP00000011717	ENSOCUT00000013615

Organism

Oryctolagus cuniculus

Functional Description

Phosphorylase b kinase catalyzes the phosphorylation ofserine in certain substrates, including troponin I.

Protein Length

389

Protein Sequence
(FASTA)

MTRDAALPGS HSTHGFYENY EPKEILGSPR GVSSVVRRCI HKPTCKEYAV KIIDVTGGGS 60

FSAEEVQELR EATLKEVDIL RKVSGHPNII QLKDTYETNT FFFLVFDLMK KGELFDYLTE 120

KVTLSEKETR KIMRALLEVI CALHKLNIVH RDLKPENILL DDDMNIKLTD FGFSCQLDPG 180

EKLREVCGTP SYLAPEIIEC SMNDNHPGYG KEVDMWSTGV IMYTLLAGSP PFWHRKQMLM 240

LRMIMSGNYQ FGSPEWDDYS DTVKDLVSRF LVVQPQKRYT AEEALAHPFF QQYVVEEVRH 300

FSPRGKFKVI CLTVLASVRI YYQYRRVKPV TREIVIRDPY ALRPLRRLID AYAFRIYGHW 360

VKKGQQQNRA ALFENTPKAV LFSLAEDDY 389

Nucleotide Sequence
(FASTA)

ATGACCCGCG ACGCGGCACT GCCTGGCTCT CACTCCACAC ATGGCTTCTA CGAGAATTAT 60

GAGCCCAAGG AGATCCTGGG CAGCCCCAGA GGAGTTAGCA GTGTGGTCAG GCGCTGCATC 120

CACAAGCCCA CGTGCAAGGA GTATGCCGTG AAGATCATTG ATGTCACTGG TGGAGGCAGC 180

TTCAGCGCTG AGGAGGTGCA GGAGCTGCGA GAAGCCACGC TGAAGGAGGT GGACATCCTA 240

CGCAAGGTCT CGGGGCACCC CAACATCATA CAGCTGAAGG ACACTTATGA GACCAACACT 300

TTCTTCTTCT TGGTGTTTGA CCTGATGAAG AAAGGGGAGC TCTTTGACTA CCTCACTGAG 360

AAGGTCACCT TGAGTGAGAA GGAAACCCGA AAAATCATGA GGGCCCTGCT GGAGGTGATC 420

TGCGCTTTGC ACAAACTCAA CATTGTGCAT CGGGACCTGA AGCCCGAGAA CATCCTCTTG 480

GATGATGACA TGAACATCAA GCTCACAGAC TTCGGCTTTT CCTGCCAGCT GGACCCCGGA 540

GAGAAGCTGC GAGAGGTCTG TGGGACCCCC AGTTACTTGG CTCCTGAGAT CATCGAGTGC 600

TCCATGAATG ACAACCACCC AGGCTATGGG AAGGAGGTGG ACATGTGGAG CACAGGGGTC 660

ATCATGTACA CCCTGCTGGC CGGCTCCCCG CCCTTCTGGC ACCGGAAGCA GATGCTGATG 720

CTGAGGATGA TCATGAGTGG CAACTACCAG TTTGGCTCAC CGGAATGGGA TGATTACTCC 780

GACACGGTCA AGGACTTGGT TTCTCGCTTC TTGGTGGTCC AGCCCCAGAA GCGCTACACG 840

GCTGAAGAGG CCCTGGCACA CCCCTTCTTC CAGCAGTACG TGGTGGAGGA AGTGCGCCAC 900

TTCAGCCCCC GGGGGAAGTT CAAGGTGATC TGCCTAACCG TGCTGGCTTC GGTGCGCATC 960

TACTACCAGT ACCGCCGGGT GAAGCCCGTC ACCAGGGAGA TCGTCATCCG GGACCCCTAC 1020

GCCCTCCGAC CTCTGCGCCG CCTCATCGAC GCCTACGCTT TCCGAATCTA CGGCCACTGG 1080

GTGAAGAAGG GGCAGCAGCA GAACCGGGCT GCCCTCTTTG AGAACACCCC CAAGGCTGTG 1140

CTCTTCTCGC TGGCTGAGGA TGACTACTGA 1170

Domain Profile

S: 1     yepkeilG..rGvssvvrrciekatgqefavkiidvs.aeklseeevkelreatlkevei  57

         yepkeilG  rGvssvvrrci+k+t++e+avkiidv+ ++++s eev+elreatlkev+i

Q: 20    YEPKEILGspRGVSSVVRRCIHKPTCKEYAVKIIDVTgGGSFSAEEVQELREATLKEVDI  79

         9******9999**************************899********************

S: 58    lrqvsGhpsiiklkdvyesssflflvfdlmkkGelfdyltekvtlseketrkimrallea  117

         lr+vsGhp+ii+lkd+ye+++f+flvfdlmkkGelfdyltekvtlseketrkimralle+

Q: 80    LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV  139

         ************************************************************

S: 118   veylhaknivhrdlkpenillddneniklsdfGfstqleeGeklrelcGtpgylapeilk  177

         ++ lh+ nivhrdlkpenilldd++nikl+dfGfs+ql++Geklre+cGtp+ylapei++

Q: 140   ICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIE  199

         ************************************************************

S: 178   csmdeeapGyskevdlwalGvilytllaGsppfwhrkqllmlrlimeGkyqftspewddi  237

         csm++++pGy+kevd+w++Gvi+ytllaGsppfwhrkq+lmlr+im+G+yqf+spewdd+

Q: 200   CSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDY  259

         ************************************************************

S: 238   seevkdliskllvvdpekrltaeealahpff  268

         s++vkdl+s++lvv+p+kr+taeealahpff

Q: 260   SDTVKDLVSRFLVVQPQKRYTAEEALAHPFF  290

         ******************************8

Domain Sequence
(FASTA)

YEPKEILGSP RGVSSVVRRC IHKPTCKEYA VKIIDVTGGG SFSAEEVQEL REATLKEVDI 60

LRKVSGHPNI IQLKDTYETN TFFFLVFDLM KKGELFDYLT EKVTLSEKET RKIMRALLEV 120

ICALHKLNIV HRDLKPENIL LDDDMNIKLT DFGFSCQLDP GEKLREVCGT PSYLAPEIIE 180

CSMNDNHPGY GKEVDMWSTG VIMYTLLAGS PPFWHRKQML MLRMIMSGNY QFGSPEWDDY 240

SDTVKDLVSR FLVVQPQKRY TAEEALAHPF F 271

Keyword

3D-structure; ATP-binding; Calmodulin-binding; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Glycogen metabolism; Kinase; Muscle protein; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005964	; C:phosphorylase kinase complex
GO:0005524	; F:ATP binding
GO:0004689	; F:phosphorylase kinase activity
GO:0005978	; P:glycogen biosynthetic process

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR002291	; Phosph_kin_gamma.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01049

; PHOSPHBKNASE.

Created Date

20-Feb-2013