EKS-ORC-00440
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00440
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK408.02.2E-12211300290
StatusUnreviewed
Ensembl ProteinENSOCUP00000011800
UniProt AccessionG1T5Z7;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK3
Gene Synonyms/Alias MAPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000013716ENSOCUP00000011800ENSOCUT00000013714
OrganismOryctolagus cuniculus
Functional Description
Protein Length349
Protein Sequence
(FASTA)
KGQKFPRPPP YKILRCVGEG VSGPLSSAYD HVRKTRVAIK KISPFEHQTY CQRTLREIQI 60
LLRFSHENVI GIRDILRAPT LEAMRDVYYI VQDLMETDLY KLLKSQQLSN DHICYFLYQI 120
LRGLKYIHSA NVLHRDLKPS NLLINTTCDL KICDFGLARI ADPEHDHTGF LTEYVATRWY 180
RAPEIMLNSK GYTKSIDIWS VGCILAEMLS NRPIFPGKHY LDQLNHILGI LGSPSQEDLN 240
CIINMKARNY LQSLPAKTKV AWAKLFPKSD SKALDLLDRM LTFNPNKRIT VEEALAHLYL 300
EQYYDPTDEP VAEEPFTFDM ELDDLPKERL KELIFQETAR FQPGAPEGP 349
Nucleotide Sequence
(FASTA)
AAGGGGCAGA AATTCCCCCG GCCCCCGCCA TACAAAATAC TCAGATGCGT CGGCGAAGGT 60
GTCTCTGGGC CTCTCAGCTC AGCCTATGAC CACGTGCGCA AGACCCGCGT GGCCATCAAG 120
AAGATCAGTC CCTTCGAACA CCAGACCTAC TGCCAGCGCA CGCTGAGGGA GATCCAGATC 180
CTGCTACGCT TCTCCCATGA GAACGTCATC GGCATCCGGG ACATTCTTCG GGCTCCCACC 240
CTGGAAGCCA TGAGGGATGT GTACTACATC GTGCAGGACC TCATGGAGAC AGACCTGTAC 300
AAGTTGCTCA AAAGCCAGCA ACTAAGCAAC GACCACATCT GCTACTTCCT CTACCAGATC 360
CTGCGGGGTC TCAAGTACAT CCACTCGGCC AACGTGCTCC ACCGGGACCT GAAGCCCTCC 420
AACCTGCTCA TCAACACCAC CTGCGACCTT AAGATCTGTG ATTTCGGCCT GGCCCGCATT 480
GCAGACCCTG AACATGACCA CACCGGCTTC CTGACGGAGT ACGTGGCCAC GCGCTGGTAC 540
CGGGCCCCAG AGATCATGCT CAACTCCAAG GGCTATACTA AGTCCATCGA CATCTGGTCT 600
GTGGGCTGCA TCCTGGCCGA GATGCTCTCC AACCGGCCCA TCTTCCCTGG CAAGCACTAC 660
CTGGACCAGC TCAACCACAT TCTAGGCATC CTGGGCTCGC CGTCCCAGGA GGACCTGAAC 720
TGCATCATCA ACATGAAGGC CCGGAACTAC CTGCAGTCCC TGCCTGCCAA GACCAAGGTG 780
GCCTGGGCCA AGCTGTTTCC CAAGTCAGAC TCCAAAGCCC TGGACCTGCT GGATCGGATG 840
TTGACCTTCA ACCCCAACAA GCGCATCACT GTGGAGGAGG CCCTGGCTCA CCTCTACCTG 900
GAACAGTACT ATGACCCGAC GGACGAGCCG GTGGCCGAGG AGCCCTTCAC CTTCGACATG 960
GAGTTGGATG ATCTACCCAA GGAGCGGCTG AAGGAGCTCA TCTTCCAGGA GACGGCCCGC 1020
TTCCAGCCGG GGGCTCCGGA GGGGCCCTAG 1050
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y+ l+ +geG  g   sa+d+ +++rvaikk+s pf+++t ++rtlRE+++l +++heN+
Q: 11    YKILRCVGEGVSGPLSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFSHENV  69
         778899**************************9.**************************
S: 61    iklldvftpeeeleelkdvY.lvtelmetdLkkviksqklsdehiklllyqilrglkylH  119
         i + d++++ + le+++dvY +v++lmetdL+k++ksq+ls++hi ++lyqilrglky+H
Q: 70    IGIRDILRAPT-LEAMRDVYyIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIH  128
         *********99.9****995489*************************************
S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeills  177
         sanv+HrDlKPsNll+n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l+
Q: 129   SANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLN  188
         ************************************99999*******************
S: 178   lkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseear  237
         +k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +ar
Q: 189   SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKAR  248
         ************************************************************
S: 238   nyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         ny++slp k+k  +++lfpk++++aldLl+++L+++p+kRi+veeaL+h Yl
Q: 249   NYLQSLPAKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHLYL  300
         *************************************************997
Domain Sequence
(FASTA)
YKILRCVGEG VSGPLSSAYD HVRKTRVAIK KISPFEHQTY CQRTLREIQI LLRFSHENVI 60
GIRDILRAPT LEAMRDVYYI VQDLMETDLY KLLKSQQLSN DHICYFLYQI LRGLKYIHSA 120
NVLHRDLKPS NLLINTTCDL KICDFGLARI ADPEHDHTGF LTEYVATRWY RAPEIMLNSK 180
GYTKSIDIWS VGCILAEMLS NRPIFPGKHY LDQLNHILGI LGSPSQEDLN CIINMKARNY 240
LQSLPAKTKV AWAKLFPKSD SKALDLLDRM LTFNPNKRIT VEEALAHLYL 290
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00436
EKS-ANC-00449
EKS-BOT-00462
EKS-CAJ-00472
EKS-CAF-00465
EKS-CAP-00493
EKS-CII-00260
EKS-CIS-00220
EKS-DAR-00867
EKS-DAN-00034
EKS-DIO-00097
EKS-DRM-00222
EKS-ECT-00064
EKS-EQC-00449
EKS-ERE-00049
EKS-FEC-00445
EKS-GOG-00456
EKS-ICT-00441
EKS-LAC-00477
EKS-LOA-00471
EKS-MAM-00463
EKS-MAE-00072
EKS-MOD-00453
EKS-MUM-00493
EKS-MUP-00452
EKS-MYL-00457
EKS-ORA-00408
EKS-ORL-00529
EKS-POA-00449
EKS-PTV-00167
EKS-RAN-00475
EKS-SAH-00430
EKS-TAS-00069
EKS-TUT-00168
EKS-SCP-00101
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0031143; C:pseudopodium
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0051216; P:cartilage development
GO:0071260; P:cellular response to mechanical stimulus
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0000165; P:MAPK cascade
GO:2000657; P:negative regulation of apolipoprotein binding
GO:0009887; P:organ morphogenesis
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
GO:0006974; P:response to DNA damage stimulus
GO:0043330; P:response to exogenous dsRNA
GO:0019233; P:sensory perception of pain
GO:0006351; P:transcription, DNA-dependent
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008349; MAPK_ERK1/2.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01770; ERK1ERK2MAPK.
Created Date20-Feb-2013