EKS-ORC-00157
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00157
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC471.21.1E-141407667261
StatusUnreviewed
Ensembl ProteinENSOCUP00000011861
UniProt AccessionG1T644;
Protein Name
Protein Synonyms/Alias Protein kinase C epsilon type;
Gene NamePRKCE
Gene Synonyms/Alias PRKCE;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000013785ENSOCUP00000011861ENSOCUT00000013787
OrganismOryctolagus cuniculus
Functional Description
Protein Length736
Protein Sequence
(FASTA)
MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT 60
NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE 120
PEGKVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP 180
TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKC AGLKKQETPD EVGSQRFSVN 240
MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA 300
KVLADLGVTP DKITNSGQRR KKLIAGAESP QPTSGSSPSE EDRSKSAPTS PCDQELKELE 360
NNIRKALSFD NRGEEHRAAS STDGQLGSPE NGEVRQGQAK RLGLDEFNFI KVLGKGSFGK 420
VMLAELKGKD EVYAVKVLKK DVILQDDDVD CTMTEKRILA LARKHPYLTQ LYCCFQTKDR 480
LFFVMEYVNG GDLMFQIQRS RKFDEPRSRF YAAEVTSALM FLHQHGVIYR DLKLDNILLD 540
AEGHCKLADF GMCKEGILNG VTTTTFCGTP DYIAPEILQE LEYGPSVDWW ALGVLMYEMM 600
AGQPPFEADN EDDLFESILH DDVLYPVWLS KEAVSILKAF MTKNPHKRLG CVAAQNGEDA 660
IKQHPFFKEI DWVLLEQKKI KPPFKPRIKT KRDVNNFDQD FTREEPVLTL VDEAIVKQIN 720
QEEFKGFSYF GEDLMP 736
Nucleotide Sequence
(FASTA)
ATGGTAGTGT TCAATGGCCT GCTGAAGATC AAAATCTGCG AGGCCGTGAG CTTGAAGCCC 60
ACAGCCTGGT CGCTGCGCCA TGCGGTGGGA CCCCGGCCGC AGACTTTCCT GCTCGACCCC 120
TACATCGCCC TCAACGTGGA CGACTCGCGC ATCGGCCAGA CAGCCACCAA ACAGAAGACC 180
AACAGCCCGG CCTGGCACGA CGAATTCGTC ACTGATGTGT GCAATGGGCG CAAGATCGAG 240
CTGGCCGTCT TTCACGATGC CCCCATCGGC TACGACGACT TCGTGGCCAA CTGCACCATC 300
CAGTTCGAGG AGCTGCTGCA GAACGGGAGC CGCCACTTCG AGGACTGGAT TGACCTGGAG 360
CCAGAAGGAA AAGTGTATGT GATCATCGAT CTTTCAGGAT CGTCGGGTGA AGCACCTAAA 420
GACAATGAAG AGCGCGTGTT CCGGGAGCGC ATGCGGCCGA GGAAGCGGCA GGGGGCGGTC 480
AGGCGCAGGG TCCACCAGGT CAACGGCCAC AAGTTCATGG CCACCTACCT TCGGCAGCCC 540
ACCTACTGCT CCCACTGCAG AGACTTCATC TGGGGTGTCA TAGGAAAGCA GGGATACCAG 600
TGTCAAGTTT GCACCTGTGT CGTCCACAAG CGGTGCCATG AGCTCATCAT CACGAAGTGT 660
GCTGGGTTAA AGAAACAAGA AACCCCCGAT GAGGTGGGCT CGCAGCGGTT CAGCGTCAAC 720
ATGCCCCACA AGTTCGGCAT CCACAACTAC AAGGTCCCCA CCTTCTGTGA CCACTGCGGG 780
TCCTTGCTCT GGGGCCTCTT GCGGCAGGGC TTGCAGTGTA AAGTCTGCAA AATGAATGTT 840
CACCGTCGAT GTGAGACCAA CGTGGCTCCC AACTGCGGAG TAGATGCCAG AGGAATCGCC 900
AAAGTGCTGG CCGACCTGGG GGTCACTCCG GACAAAATCA CCAACAGTGG CCAGAGGAGG 960
AAAAAGCTCA TCGCTGGTGC CGAGTCCCCA CAGCCCACGT CTGGAAGCTC ACCGTCCGAG 1020
GAAGATCGGT CCAAGTCAGC ACCCACCTCC CCCTGTGACC AGGAATTAAA AGAACTTGAA 1080
AACAACATCC GGAAGGCCTT GTCATTTGAC AACCGAGGGG AGGAACACCG GGCAGCATCA 1140
TCCACCGACG GCCAGCTGGG GAGCCCCGAG AACGGTGAAG TGCGGCAAGG CCAGGCCAAG 1200
CGCTTGGGTC TGGATGAGTT CAACTTCATC AAGGTTTTGG GCAAAGGCAG CTTTGGCAAG 1260
GTCATGCTGG CCGAGCTCAA GGGCAAAGAT GAAGTGTATG CCGTGAAGGT CTTAAAGAAG 1320
GACGTCATCC TCCAGGACGA CGACGTGGAC TGCACCATGA CGGAGAAGAG GATCTTGGCT 1380
CTGGCGCGGA AGCACCCGTA CCTAACCCAA CTCTACTGCT GCTTTCAGAC CAAGGACCGG 1440
CTGTTCTTCG TCATGGAATA CGTCAACGGT GGGGACCTCA TGTTCCAGAT CCAGCGCTCC 1500
CGAAAATTCG ACGAGCCTCG TTCCCGGTTC TACGCTGCAG AGGTGACGTC AGCCCTCATG 1560
TTCCTGCACC AACATGGCGT CATCTACAGG GATTTGAAAC TGGACAACAT CCTTCTGGAT 1620
GCTGAAGGGC ACTGCAAGCT GGCCGACTTC GGGATGTGCA AGGAAGGGAT TCTCAATGGC 1680
GTGACCACCA CCACCTTCTG TGGCACCCCT GACTACATAG CTCCGGAGAT CCTGCAGGAG 1740
CTGGAATATG GCCCATCGGT GGATTGGTGG GCCCTAGGGG TGTTAATGTA CGAGATGATG 1800
GCTGGGCAGC CCCCGTTTGA GGCGGACAAT GAGGACGACC TGTTTGAGTC CATCCTGCAC 1860
GACGATGTGT TGTACCCCGT CTGGCTCAGC AAGGAGGCCG TCAGCATCCT GAAAGCTTTC 1920
ATGACCAAGA ACCCCCACAA GCGCCTGGGC TGTGTGGCGG CCCAGAACGG CGAGGACGCC 1980
ATCAAACAGC ACCCCTTCTT CAAGGAGATC GACTGGGTGC TGCTGGAGCA GAAAAAAATC 2040
AAACCACCAT TTAAGCCGCG AATTAAAACC AAAAGAGACG TCAACAACTT TGACCAAGAC 2100
TTCACGCGGG AAGAGCCGGT CCTCACGCTG GTGGACGAAG CCATCGTGAA GCAGATCAAC 2160
CAGGAAGAAT TCAAAGGCTT CTCCTACTTC GGGGAAGACC TGATGCCCTG A 2211
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+++kvlGkGsfgkv+laelk++de+ya+kvlkkdv+lqdddv++t++ekr+lala+k+p
Q: 407   FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP  466
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g
Q: 467   YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHG  526
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         +iyrdlkldn+lldaeGh+kladfG+cke+il+g tt+tfcGtPdyiaPeil+e eyg s
Q: 527   VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPS  586
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+ilk+++tk+p+
Q: 587   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPH  646
         ************************************************************
S: 241   krlGv..keegeedikehaff  259
         krlG+  +++ge++ik+h+ff
Q: 647   KRLGCvaAQNGEDAIKQHPFF  667
         *****6449***********9
Domain Sequence
(FASTA)
FNFIKVLGKG SFGKVMLAEL KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP 60
YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG 120
VIYRDLKLDN ILLDAEGHCK LADFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS 180
VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPH 240
KRLGCVAAQN GEDAIKQHPF F 261
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00162
EKS-ANC-00164
EKS-BOT-00170
EKS-CAE-00130
EKS-CAJ-00174
EKS-CAF-00177
EKS-CAP-00170
EKS-DAR-00463
EKS-DRM-00083
EKS-FEC-00160
EKS-GAG-00146
EKS-GAA-00205
EKS-GOG-00168
EKS-HOS-00176
EKS-ICT-00165
EKS-LAC-00185
EKS-LOA-00169
EKS-MAM-00168
EKS-MEG-00135
EKS-MIM-00077
EKS-MUM-00175
EKS-MUP-00174
EKS-MYL-00179
EKS-NOL-00163
EKS-ORN-00215
EKS-ORL-00201
EKS-OTG-00176
EKS-PAT-00161
EKS-PES-00150
EKS-POA-00166
EKS-RAN-00165
EKS-SUS-00146
EKS-TAG-00198
EKS-TAR-00222
EKS-TAS-00059
EKS-TEN-00214
EKS-XET-00158
EKS-XIM-00208
EKS-SCP-00080
Gene Ontology
GO:0005829; C:cytosol
GO:0005783; C:endoplasmic reticulum
GO:0005794; C:Golgi apparatus
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004699; F:calcium-independent protein kinase C activity
GO:0008047; F:enzyme activator activity
GO:0035276; F:ethanol binding
GO:0046872; F:metal ion binding
GO:0030546; F:receptor activator activity
GO:0071361; P:cellular response to ethanol
GO:0071456; P:cellular response to hypoxia
GO:0035556; P:intracellular signal transduction
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0035641; P:locomotory exploration behavior
GO:0002281; P:macrophage activation involved in immune response
GO:0030838; P:positive regulation of actin filament polymerization
GO:0071777; P:positive regulation of cell cycle cytokinesis
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:2001031; P:positive regulation of cellular glucuronidation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0010763; P:positive regulation of fibroblast migration
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032024; P:positive regulation of insulin secretion
GO:0050996; P:positive regulation of lipid catabolic process
GO:0043410; P:positive regulation of MAPK cascade
GO:0070257; P:positive regulation of mucus secretion
GO:0032230; P:positive regulation of synaptic transmission, GABAergic
GO:0090303; P:positive regulation of wound healing
GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0051209; P:release of sequestered calcium ion into cytosol
GO:0043278; P:response to morphine
GO:0035669; P:TRAM-dependent toll-like receptor 4 signaling pathway
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013