EKS-ORC-00460

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00460

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSKL	300.9	1.8E-89	844	1054	211

Status

Unreviewed

Ensembl Protein

ENSOCUP00000011998

UniProt Accession

G1T6G2;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KC1

Gene Synonyms/Alias

RPS6KC1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000013953	ENSOCUP00000011998	ENSOCUT00000013957

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1064

Protein Sequence
(FASTA)

MTSPWERSAD LARFYTVTEP QRHPRGYTVY KVTARVVSRR NPEDVQEIIV WKRYSDFKKL 60

HKELWQIHKN LFRHSELFPP FAKGIVFGRF EETVIEERRQ CAEDLLQFSA NIPALYNSKQ 120

LEDFFKGGII NDGSELIGPA EAYPDSLVDS FPECSTEGFS SDSDLVSLTV DVDSLAELDD 180

GMASNQNSPI RTSGLNLSSD SSALGAVASD SEQNKTEEER ESRSRFPGSL KPRLGKRDYL 240

EKAGELIKLA LKKEEEDDYE AASDFYRRGV DLLLEGVQGE SSPTRREAVK RRTAEYLMRA 300

ESISSLHRKP QLDDLSQPPG LLSSRPPWNL RSPAEELKAF RVLGVIDKVL LVMDTRTEQT 360

FILKGLRKSS EYSRNRKTII PRCVPNMVCL HKYIISEESV FLVLQHVEGG KLWSYISKFL 420

NRSPEESFEI KGVKKSTLTQ VHLQQPTASP QDSSSFESRG SDGGSMLKAL PLKTSLTPSS 480

QDDSNQEDDG QDSSPKWPDS GSSSEEECTT SYLTLCNEYG QEKIEPGSLS EEPFLKTEGS 540

GVDTKAMKSF PAHLGAGSDG TGPQLVTQEL KFFPGDEDPE AVRSPGASES LSRSKNSPME 600

FFRIDSKDST SELLGLDLGE KLYSLKSEPL KPFFALPEGD SSSRSFDGSE SKVELKAQDS 660

ISRGSDDSVP VISFKDVAFD DISGTDEGRP DLLVNLPGEL EATKEAAAMG PTKFAQATMG 720

IIENKLLEAP DVLCLRLSPE QCLAHEAQDT EKLSEPCRPQ PHSVTEKHYA QEDLGRLFVA 780

AADQSSSGEP SLLHSTDPKL QGLGITASIK EEHLVHISNS LSGANEYNVN TDTLKPEEVL 840

LFSDQTDDLA KEEATALFQR DSEIKGESGL VLDGDKEIHQ IFEDLDKKLA LNSRFYIPEG 900

CIQRWAAEMV VALDALHREG IVCRDLNPNN ILLNDRGHIQ LTYFSRWSEV EDSCDSDAIE 960

RMYCAPGLEV GAITEETEAC DWWSLGAVLF ELLTGKTLVE CHPAGINTHT TLNMPECVSE 1020

EARSLIQQLL QFNPLERLGA GVAGVEDIKS HPFFTPVDWA ELMR 1064

Nucleotide Sequence
(FASTA)

ATGACCTCTC CCTGGGAGCG GAGTGCCGAC TTGGCTCGTT TCTATACTGT CACCGAGCCC 60

CAGCGACACC CGAGGGGCTA CACTGTGTAT AAGGTCACCG CCCGGGTTGT TTCACGAAGA 120

AATCCAGAGG ATGTCCAGGA GATAATTGTA TGGAAGAGAT ACAGTGATTT TAAGAAACTG 180

CATAAAGAGC TGTGGCAAAT TCATAAAAAC CTATTTCGAC ATTCAGAGTT GTTTCCTCCT 240

TTTGCAAAAG GAATAGTGTT TGGACGATTT GAGGAAACTG TTATTGAAGA GAGAAGACAG 300

TGCGCTGAAG ACCTGCTCCA GTTTTCTGCC AATATTCCTG CTCTTTACAA CAGTAAACAA 360

CTTGAAGATT TCTTCAAGGG TGGAATAATT AATGATGGTT CTGAATTAAT TGGTCCTGCT 420

GAAGCTTACC CTGATTCCCT CGTTGATTCC TTTCCTGAGT GTAGCACAGA AGGCTTCTCC 480

AGTGACAGCG ATCTGGTATC TCTTACTGTT GATGTGGATT CTCTTGCCGA GTTAGATGAT 540

GGAATGGCTT CCAATCAAAA TTCTCCCATT AGAACTTCTG GTCTCAATCT TTCTTCGGAT 600

TCTTCAGCAC TAGGGGCTGT TGCCTCTGAC AGCGAACAGA ATAAAACAGA AGAAGAAAGG 660

GAAAGTCGTA GCCGCTTTCC TGGCAGTTTA AAACCCAGGC TTGGCAAGAG AGATTATTTG 720

GAGAAAGCAG GAGAATTAAT AAAGCTGGCT TTGAAAAAGG AAGAAGAAGA CGACTATGAA 780

GCTGCTTCTG ATTTTTATCG GAGAGGAGTT GACTTGCTCC TAGAAGGCGT TCAAGGAGAG 840

TCGAGCCCTA CGCGCCGGGA AGCTGTGAAG AGGAGAACAG CAGAGTATCT CATGCGGGCT 900

GAAAGTATCT CCAGTCTTCA TAGGAAGCCT CAACTTGATG ATCTGTCTCA GCCTCCAGGA 960

TTACTAAGTT CAAGGCCCCC TTGGAACCTA AGGAGCCCTG CCGAGGAGCT GAAGGCCTTC 1020

AGAGTCCTTG GGGTGATTGA CAAGGTTTTA CTTGTAATGG ACACAAGGAC TGAACAGACC 1080

TTCATTTTAA AAGGTCTAAG GAAAAGCAGC GAGTACAGCA GGAACAGAAA GACCATCATC 1140

CCCCGCTGTG TGCCCAACAT GGTGTGTCTG CACAAGTACA TCATCTCGGA GGAGTCGGTG 1200

TTTCTGGTGC TACAGCACGT GGAAGGTGGC AAACTTTGGT CATATATCAG TAAATTTCTA 1260

AACAGAAGCC CTGAAGAGAG CTTTGAAATC AAGGGAGTGA AAAAATCTAC ACTCACTCAA 1320

GTTCACCTGC AACAGCCAAC TGCTAGTCCT CAGGACAGCA GCAGCTTTGA ATCCAGAGGC 1380

AGTGACGGTG GAAGTATGCT TAAAGCTCTT CCTTTGAAGA CTAGTCTCAC TCCAAGTTCT 1440

CAGGACGACA GCAACCAGGA AGATGATGGC CAAGATAGCT CTCCAAAATG GCCAGATTCT 1500

GGCTCAAGTT CAGAAGAAGA ATGCACCACT AGTTATTTAA CATTATGCAA TGAATATGGG 1560

CAAGAGAAGA TTGAACCAGG GTCTTTGAGT GAGGAGCCTT TCCTGAAGAC TGAAGGAAGT 1620

GGTGTTGATA CCAAAGCCAT GAAGAGCTTC CCAGCCCACC TTGGTGCCGG CAGTGACGGC 1680

ACAGGCCCAC AGCTGGTGAC TCAGGAGCTG AAGTTCTTCC CTGGAGATGA AGACCCAGAA 1740

GCAGTCCGTT CTCCAGGGGC ATCAGAGTCC CTCAGCAGAT CGAAAAATAG CCCCATGGAA 1800

TTCTTCAGGA TAGACAGCAA GGACAGCACA AGTGAACTCC TGGGACTTGA TTTGGGAGAA 1860

AAATTGTATA GTCTGAAATC AGAACCTTTG AAACCATTCT TTGCACTTCC AGAGGGAGAC 1920

AGCTCTTCCA GGAGTTTTGA TGGCAGTGAG AGCAAGGTCG AGTTGAAAGC TCAGGACAGC 1980

ATTAGCAGGG GCTCCGATGA CTCAGTGCCT GTTATTTCGT TTAAAGATGT TGCTTTTGAT 2040

GATATCAGTG GTACTGATGA AGGAAGGCCT GATCTTCTCG TCAATCTACC TGGTGAACTG 2100

GAGGCAACAA AAGAAGCTGC AGCCATGGGA CCTACTAAGT TTGCCCAGGC TACCATGGGC 2160

ATAATAGAAA ACAAACTCTT GGAAGCCCCC GATGTTTTAT GCCTGAGACT GAGTCCTGAA 2220

CAATGCCTAG CACATGAAGC ACAAGACACG GAGAAGTTGA GTGAGCCCTG TAGGCCCCAA 2280

CCCCACAGTG TAACAGAGAA GCACTATGCA CAGGAGGACC TGGGGAGGTT GTTTGTAGCA 2340

GCTGCTGATC AGAGTAGTTC AGGAGAGCCG TCCTTGTTAC ACAGCACAGA TCCTAAGTTG 2400

CAAGGACTTG GAATAACTGC AAGCATCAAA GAAGAGCACT TAGTCCATAT TTCTAATTCA 2460

CTCTCAGGTG CTAATGAATA TAATGTAAAC ACAGACACTT TAAAACCAGA AGAAGTGTTA 2520

CTGTTTTCAG ATCAGACTGA TGATTTGGCT AAAGAAGAAG CGACTGCTTT ATTCCAGAGA 2580

GACTCTGAGA TTAAGGGAGA AAGTGGGTTA GTGCTGGATG GAGACAAGGA AATACATCAG 2640

ATTTTTGAGG ACCTTGATAA AAAATTAGCA CTAAACTCCA GGTTTTATAT CCCAGAGGGC 2700

TGCATTCAAA GATGGGCAGC TGAAATGGTG GTAGCCCTTG ATGCTTTACA TAGAGAGGGA 2760

ATTGTGTGCC GCGATTTGAA CCCAAACAAC ATCTTATTGA ATGATAGAGG ACACATTCAG 2820

CTAACGTATT TTAGCAGGTG GAGTGAGGTG GAAGATTCCT GTGACAGCGA TGCCATAGAG 2880

AGAATGTACT GTGCGCCAGG TTTAGAGGTT GGAGCCATCA CGGAAGAAAC AGAAGCCTGT 2940

GACTGGTGGA GTCTGGGTGC TGTCCTCTTT GAACTTCTCA CTGGCAAGAC TCTGGTAGAG 3000

TGCCATCCAG CAGGAATAAA CACTCACACT ACCCTGAACA TGCCAGAATG TGTCTCTGAA 3060

GAGGCTCGCT CACTCATTCA ACAGCTCTTG CAGTTCAACC CACTGGAGCG CCTTGGTGCT 3120

GGAGTTGCTG GTGTTGAAGA CATCAAATCG CATCCATTTT TCACCCCTGT GGATTGGGCA 3180

GAACTGATGA GATGA 3195

Domain Profile

S: 132   esllllvgeeptsrsqreaeeesearvklefssdkskaprGnrirregqnsspssskeik  191

         +++++l++ee+t+++qr++e ++e+  +l+++                        kei+

Q: 844   DQTDDLAKEEATALFQRDSEIKGESGLVLDGD------------------------KEIH  879

         67777888888888888888888888888888........................8899

S: 192   lvsedadkslealsrgldkalqsvdkalslrravwslpEelikqWaaelvvaleaLHeeg  251

         +++ed+dk+l++ sr                   +++pE++i++Waae+vval+aLH+eg

Q: 880   QIFEDLDKKLALNSR-------------------FYIPEGCIQRWAAEMVVALDALHREG  920

         999999999999999...................**************************

S: 252   vlirDlnadniLldskGhllltYfgrwsevekscrreavdnlysAP..Evgaiselteas  309

         +++rDln++niLl+++Gh++ltYf+rwseve+sc+++a++++y+AP  Evgai+e+tea+

Q: 921   IVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPglEVGAITEETEAC  980

         **********************************************999***********

S: 310   DwWslGalLyelLtGkalaeahPsgiqahtelqlPevvSeeAkdLleeLLqfePalRlGa  369

         DwWslGa+L+elLtGk+l+e+hP+gi++ht+l++Pe+vSeeA++L+++LLqf+P +RlGa

Q: 981   DWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGA  1040

         ************************************************************

S: 370   GeagvdelkaHPFF  383

         G+agv+++k+HPFF

Q: 1041  GVAGVEDIKSHPFF  1054

         *************9

Domain Sequence
(FASTA)

DQTDDLAKEE ATALFQRDSE IKGESGLVLD GDKEIHQIFE DLDKKLALNS RFYIPEGCIQ 60

RWAAEMVVAL DALHREGIVC RDLNPNNILL NDRGHIQLTY FSRWSEVEDS CDSDAIERMY 120

CAPGLEVGAI TEETEACDWW SLGAVLFELL TGKTLVECHP AGINTHTTLN MPECVSEEAR 180

SLIQQLLQFN PLERLGAGVA GVEDIKSHPF F 211

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005769	; C:early endosome
GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004672	; F:protein kinase activity
GO:0007154	; P:cell communication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR007330	; MIT.
IPR001683	; Phox.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF04212	; MIT; 1.
PF00069	; Pkinase; 1.
PF00787	; PX; 1.

SMARTs

SM00745	; MIT; 1.
SM00312	; PX; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50195	; PX; 1.

Prints

Created Date

20-Feb-2013