EKS-ORC-00273

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00273

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	374.4	3.0E-112	134	400	267

Status

Unreviewed

Ensembl Protein

ENSOCUP00000012047

UniProt Accession

G1T6K1;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000014003	ENSOCUP00000012047	ENSOCUT00000014014

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

432

Protein Sequence
(FASTA)

SPIQETSPAQ ALPTDVSSAS LHRRSQPAAG GALVREAQWG LEACKLTDAA CAPVEGPPDA 60

IAGLQAEEMQ MYPLGTASAP NFTIENPWDD HLILRLLSGL SKPVNSYPNV FEWQCKLPAI 120

KPKTEFQLGS LMVYVNHLLG EGAFAQVYET THGDVDDTKN KQKFTLKVQK PANPWEFYIG 180

TQLMERLSPI SRHMFIKFYS AHLFQNGSIL VGDLYSYGTL LNAINLYKNT PEKVMPQALV 240

ISFAIRMLYM IEQVHDCEII HGDIKPDNFI LGNRFLEQDS DEDDLSADLA LIDLGQSIDM 300

KLFPKGTAFT GKCETSGFQC IEMLSNKPWN YQIDYFGVAA TVYCMLFGTY MKVKNEGGVW 360

KPEGLFRRLP HLEVWEEFFH LMLNIPDCHH LPSLALLRQK LRTLFQQHYA SKVRTQRNRL 420

IVLLLEYKRS RK 432

Nucleotide Sequence
(FASTA)

AGTCCAATTC AAGAGACAAG CCCAGCACAA GCACTCCCCA CCGACGTCTC TTCAGCATCC 60

TTACACCGTC GGAGCCAGCC TGCAGCAGGC GGTGCACTTG TCCGCGAGGC CCAGTGGGGC 120

CTGGAGGCGT GTAAGCTCAC AGACGCAGCC TGTGCCCCTG TGGAGGGCCC CCCAGATGCC 180

ATCGCTGGGC TCCAAGCAGA AGAGATGCAG ATGTATCCTC TTGGGACTGC CAGTGCTCCA 240

AACTTCACTA TCGAGAACCC ATGGGATGAT CATTTGATTC TCAGACTTCT ATCTGGACTT 300

TCAAAACCAG TGAATTCCTA TCCAAATGTT TTTGAATGGC AATGCAAACT TCCAGCCATC 360

AAGCCCAAGA CCGAATTTCA GTTGGGTTCT TTGATGGTCT ATGTCAATCA CCTTCTTGGA 420

GAAGGGGCCT TTGCTCAAGT CTATGAAACT ACCCATGGAG ACGTGGATGA CACCAAAAAT 480

AAACAGAAAT TTACTTTAAA GGTGCAGAAG CCTGCCAACC CCTGGGAGTT CTACATTGGG 540

ACCCAGCTGA TGGAGAGACT CAGTCCAATC TCACGGCACA TGTTTATCAA GTTCTACTCT 600

GCCCACCTGT TCCAGAATGG GAGCATATTA GTAGGAGATC TCTACAGTTA TGGAACACTA 660

CTAAATGCCA TTAACCTCTA TAAAAATACC CCTGAAAAAG TGATGCCCCA AGCTCTCGTC 720

ATCTCTTTTG CCATCAGAAT GCTCTACATG ATTGAACAAG TCCATGACTG TGAAATCATT 780

CATGGAGACA TTAAGCCGGA TAACTTCATA CTGGGAAACA GGTTTTTGGA GCAGGACAGT 840

GACGAGGATG ATTTGTCTGC TGACTTGGCA CTGATTGACC TGGGTCAGAG TATAGATATG 900

AAACTGTTTC CCAAAGGAAC TGCGTTTACA GGAAAATGTG AGACGTCTGG TTTTCAGTGT 960

ATTGAGATGC TCAGTAACAA GCCATGGAAC TATCAGATCG ATTACTTTGG AGTTGCTGCC 1020

ACAGTGTACT GCATGCTCTT TGGCACTTAC ATGAAGGTGA AAAACGAAGG GGGCGTTTGG 1080

AAGCCTGAGG GCCTCTTTAG AAGGCTTCCT CACCTGGAGG TGTGGGAGGA ATTCTTCCAC 1140

CTGATGCTGA ATATACCAGA TTGCCACCAC CTGCCGTCTC TGGCGCTGCT GAGGCAGAAG 1200

CTGAGGACGC TGTTCCAGCA GCACTACGCG AGCAAGGTCA GGACGCAGCG CAACAGGCTG 1260

ATTGTGCTGC TCCTGGAGTA CAAGAGGTCG AGGAAA 1296

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++++geGa+a+vy+ +h    d+k+++++ lKv+kpan+WefYI +ql+eRl  +

Q: 134   YVNHLLGEGAFAQVYETTHgdvdDTKNKQKFTLKVQKPANPWEFYIGTQLMERLS-PISR  192

         79********************99******************************9.7789

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++i+++sa+lfq++s+lv +++sygtll++in++k++ +kvm+++lv+++++++l+++e

Q: 193   HMFIKFYSAHLFQNGSILVGDLYSYGTLLNAINLYKNTPEKVMPQALVISFAIRMLYMIE  252

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkad.kdkeekglkliDfgrsiDmkllpdgtkfkgk  176

         ++H++eIiHgD+kPdnf+lgnr+ ++   +d+ ++ l+liD+g+siDmkl+p+gt+f+gk

Q: 253   QVHDCEIIHGDIKPDNFILGNRFLEQDSdEDDLSADLALIDLGQSIDMKLFPKGTAFTGK  312

         ***********************9998736777778************************

S: 177   aktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkk  236

         ++t++f+cieml++k+w+Yq+D+fg+aa+++++lfg+y++v++egg wk++  ++rl++

Q: 313   CETSGFQCIEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGVWKPEGLFRRLPHL  372

         ************************************************************

S: 237   elwekiferlLNisdastlpsleelveek  265

         e+we++f+ +LNi+d+++lpsl  l++ k

Q: 373   EVWEEFFHLMLNIPDCHHLPSLALLRQ-K  400

         ***********************9994.4

Domain Sequence
(FASTA)

YVNHLLGEGA FAQVYETTHG DVDDTKNKQK FTLKVQKPAN PWEFYIGTQL MERLSPISRH 60

MFIKFYSAHL FQNGSILVGD LYSYGTLLNA INLYKNTPEK VMPQALVISF AIRMLYMIEQ 120

VHDCEIIHGD IKPDNFILGN RFLEQDSDED DLSADLALID LGQSIDMKLF PKGTAFTGKC 180

ETSGFQCIEM LSNKPWNYQI DYFGVAATVY CMLFGTYMKV KNEGGVWKPE GLFRRLPHLE 240

VWEEFFHLML NIPDCHHLPS LALLRQK 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013