EKS-ORC-00227

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00227

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	286.9	1.4E-85	9	265	257

Status

Unreviewed

Ensembl Protein

ENSOCUP00000012642

UniProt Accession

G1T7Y1;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK1

Gene Synonyms/Alias

CHEK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000014703	ENSOCUP00000012642	ENSOCUT00000014704

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

476

Protein Sequence
(FASTA)

MAVPFVEDWD LVQTLGEGAY GEVQLAVNRI TEEAVAVKIV DMKRAIDCPE NIKKEICINK 60

MLNHENVVKF YGHRREGNIQ YLFLEYCSGG ELFDRIEPDI GMPEQDAQRF FHQLMAGVVY 120

LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRHNNR ERLLNKMCGT LPYVAPELLK 180

RKDFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA 240

LLHKILVENP SVRITIPDIK KDRWYNKPLK KGAKRPRATS GGVSESPGGF SKHIQSNLDF 300

SLVNSTSSEE NVKYSSSQPE PRTGLSLWDT SPSYIDKLVQ GISFSQPTCP DHMLLNSQLL 360

GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETCEKL GYQWKKSCMN QVTVSTTDRR 420

NNKLIFKVNL VEMDEKILVD FRLSKGDGLE FKRHFLKIKG KLSDVVSSQK VWLPAT 476

Nucleotide Sequence
(FASTA)

ATGGCAGTGC CCTTTGTGGA AGATTGGGAC TTGGTGCAAA CCCTGGGAGA AGGTGCCTAT 60

GGAGAAGTTC AACTTGCTGT GAATAGAATA ACTGAAGAGG CAGTTGCAGT GAAGATTGTG 120

GACATGAAGC GTGCCATAGA CTGCCCGGAA AATATTAAGA AAGAGATTTG TATCAATAAA 180

ATGTTAAATC ATGAAAATGT AGTAAAATTC TATGGTCACA GGAGAGAAGG CAATATCCAG 240

TATCTATTTT TGGAGTACTG CAGTGGAGGA GAGCTTTTTG ACAGAATAGA GCCAGACATA 300

GGCATGCCTG AACAGGATGC TCAGAGGTTC TTCCACCAAC TCATGGCAGG AGTGGTTTAT 360

CTGCATGGTA TTGGGATAAC ACATAGGGAT ATTAAGCCAG AAAATCTCCT GTTGGATGAA 420

AGGGATAACC TCAAAATCTC CGACTTTGGC TTGGCCACAG TGTTTCGGCA TAATAATCGT 480

GAGCGTTTAT TGAACAAGAT GTGTGGTACA TTACCTTATG TTGCTCCAGA GCTTCTGAAG 540

AGAAAAGATT TTCATGCAGA ACCAGTTGAT GTTTGGTCCT GTGGAATAGT ACTTACTGCA 600

ATGCTGGCTG GAGAATTACC ATGGGACCAG CCCAGTGACA GTTGTCAGGA ATATTCTGAT 660

TGGAAAGAAA AAAAAACATA CCTCAATCCT TGGAAAAAAA TCGATTCTGC CCCTTTAGCT 720

CTGCTGCATA AAATCCTAGT TGAGAATCCA TCAGTAAGGA TTACCATTCC AGACATAAAA 780

AAAGATAGAT GGTACAACAA GCCACTCAAG AAAGGGGCGA AGAGACCCCG AGCCACTTCA 840

GGTGGTGTAT CAGAGTCTCC TGGTGGATTT TCTAAGCATA TTCAATCCAA TTTGGACTTC 900

TCTCTGGTAA ACAGTACTTC GAGTGAAGAA AATGTGAAAT ATTCCAGTTC TCAACCAGAG 960

CCACGGACAG GACTCTCCTT ATGGGACACC AGTCCTTCAT ACATTGATAA ACTGGTACAA 1020

GGGATCAGTT TTTCCCAGCC CACCTGTCCT GATCATATGC TTTTGAATAG TCAATTACTT 1080

GGCACCCCAG GATCCTCACA GAATCCCTGG CAACGCTTGG TCAAAAGAAT GACGAGATTC 1140

TTTACTAAAC TGGATGCAGA CAAATCTTAT CAGTGCTTGA AGGAGACCTG TGAGAAGTTG 1200

GGCTATCAGT GGAAGAAGAG TTGTATGAAT CAGGTTACTG TATCGACTAC TGACAGGAGA 1260

AACAATAAAC TGATTTTCAA AGTGAATTTG GTAGAAATGG ATGAGAAGAT ATTGGTTGAC 1320

TTCCGACTTT CTAAGGGTGA TGGATTGGAG TTCAAGAGAC ACTTCCTGAA GATTAAAGGG 1380

AAGCTGAGTG ATGTTGTGAG CAGCCAGAAA GTTTGGCTTC CTGCCACATG A 1431

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         ++l++tlGeg++g+V+la+++ t+e+vavKi++ k++  +  e+ik+Ei i k+l+h+n+

Q: 9     WDLVQTLGEGAYGEVQLAVNRITEEAVAVKIVDMKRAI-DCPENIKKEICINKMLNHENV  67

         7899******************************7764.5579*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +k++   ++ +  yl+ley+sggeLfd+ie +  ++e++a+++f+ql+++v Ylh  gi+

Q: 68    VKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEQDAQRFFHQLMAGVVYLHGIGIT  127

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg...klletfcGsppYaaPellkgkkYegp  177

         HrD+KpeNllld+++n+ki+DFGla++f+++   +ll+++cG++pY+aPellk+k+++++

Q: 128   HRDIKPENLLLDERDNLKISDFGLATVFRHNnreRLLNKMCGTLPYVAPELLKRKDFHAE  187

         **************************9988877799************************

S: 178   kvDvWslGvvLyalvtgklPfdee..nlkellekilkgkleipkk.lskelesLlrklLv  234

         +vDvWs+G+vL a+++g+lP+d++  +++e++++ +k+++  p k +++    Ll+k+Lv

Q: 188   PVDVWSCGIVLTAMLAGELPWDQPsdSCQEYSDWKEKKTYLNPWKkIDSAPLALLHKILV  247

         ***********************97679999999999999888778**************

S: 235   vdpekRatieeilkhewl  252

         ++p+ R+ti +i+k++w+

Q: 248   ENPSVRITIPDIKKDRWY  265

         *****************5

Domain Sequence
(FASTA)

WDLVQTLGEG AYGEVQLAVN RITEEAVAVK IVDMKRAIDC PENIKKEICI NKMLNHENVV 60

KFYGHRREGN IQYLFLEYCS GGELFDRIEP DIGMPEQDAQ RFFHQLMAGV VYLHGIGITH 120

RDIKPENLLL DERDNLKISD FGLATVFRHN NRERLLNKMC GTLPYVAPEL LKRKDFHAEP 180

VDVWSCGIVL TAMLAGELPW DQPSDSCQEY SDWKEKKTYL NPWKKIDSAP LALLHKILVE 240

NPSVRITIPD IKKDRWY 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000785	; C:chromatin
GO:0000781	; C:chromosome, telomeric region
GO:0000794	; C:condensed nuclear chromosome
GO:0005657	; C:replication fork
GO:0005524	; F:ATP binding
GO:0035402	; F:histone kinase activity (H3-T11 specific)
GO:0071260	; P:cellular response to mechanical stimulus
GO:0048096	; P:chromatin-mediated maintenance of transcription
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0045839	; P:negative regulation of mitosis
GO:0010569	; P:regulation of double-strand break repair via homologous recombination
GO:2000615	; P:regulation of histone H3-K9 acetylation
GO:0046602	; P:regulation of mitotic centrosome separation
GO:0010767	; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013