EKS-ORC-00015
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00015
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR532.51.9E-1609981265268
StatusUnreviewed
Ensembl ProteinENSOCUP00000012731
UniProt AccessionG1T855;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameIGF1R
Gene Synonyms/Alias IGF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000014795ENSOCUP00000012731ENSOCUT00000014804
ENSOCUG00000014795ENSOCUP00000017914ENSOCUT00000027441
OrganismOryctolagus cuniculus
Functional Description
Protein Length1367
Protein Sequence
(FASTA)
MKSGSGGGSR TSAWGLLFLS AALSVWPTSG EICGPGIDIR NDFQQLKRLE NCTVIEGFLH 60
ILLISKAEDY RNYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 120
EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKSPKECGD 180
MCPGTLEEKP LCEKTAINNE YNYRCWTTNR CQKMCPSACG KRACTENNEC CHPECLGSCH 240
APDDDTACVA CRHYYFSGVC VPACPPNTYR FEGWRCVDRD FCANIPNADG GDSEGFVIHD 300
GECMQECPSG FIRNGSQSMF CIPCEGPCPK VCEEDKKTKT IDSVNSAQML QGCTIFKGNL 360
LINIRRGNNI ASELENFMGL IEVVTGYVKI SHSHALVSLS FLKNLRQILG EEQLEGNYSF 420
YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEDVTGTKG RQSKGDINTR 480
NNGERASCES DILHFTSTNT WKNRIILTWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG 540
QDACGSNSWN MVDVDLPPNK DLEPGILLQG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE 600
ILYIRTNASV PSIPLDILSA SNSSSQLIVK WSPPSLPNGN LSYYIVRWQR QPQDGYLYRH 660
NYCSKDKIPI RKYADGTIDV EEVTENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK 720
VFENFLHNSI FVPRPERKRR DVAQVANTTL SGRGRNGTAV DMYNSTDLEE LETEYPFFET 780
RVDKEITVIS NLRPFTSYRI DIHSCNHEAE KLGCSASNFV FARTKPAEGA DDIPGPVTWE 840
ARPENSIFLK WPEPENPNGL ILMYEIKYGS QIEDQRECVS RQQYRKYGGA KLNRLNPGNY 900
TARIQATSLS GNGSWTEPVF FYVPAKATYE SFMHLIIALP VAILLIVGGL LIVLYVFHRK 960
RSNSRLGNGV LYASVNPEYF SAADVYVPDE WEVAREKITM SRELGQGSFG MVYEGVAKGV 1020
VKDEPETRVA IKTVNEAASM RERIEFLNEA SVMKEFNCHH VVRLLGVVSQ GQPTLVIMEL 1080
MTRGDLKSYL RSLRPEVEQQ NRAPAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN 1140
CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT THSDVWSFGV 1200
VLWEIATLAE QPYQGFSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ YNPKMRPSFL 1260
EIIGSVRDEM EPGFREVSFY YSEENKPPEA EELDLEPENM ESVPLDPSAN AAAAVAALQP 1320
DRHKAENGPS AGAMVLRASF DERRPYAHMN GGRTDERALP LPQSSTC 1367
Nucleotide Sequence
(FASTA)
ATGAAGTCTG GCTCCGGAGG AGGGTCCCGG ACCTCGGCGT GGGGGCTCCT GTTTCTCTCC 60
GCCGCGCTCT CGGTCTGGCC GACGAGTGGA GAAATCTGCG GGCCGGGCAT CGACATCCGC 120
AATGACTTCC AGCAGCTGAA GCGCCTGGAG AACTGCACGG TGATCGAGGG CTTCCTCCAC 180
ATCCTGCTCA TCTCCAAGGC CGAGGACTAC CGCAACTACC GCTTCCCCAA GCTCACCGTC 240
ATCACCGAGT ACCTGCTGCT GTTCCGCGTG GCCGGCCTGG AGAGCCTCGG GGACCTGTTC 300
CCCAACCTCA CGGTCATCCG CGGCTGGAAG CTCTTCTACA ACTATGCCCT GGTCATTTTC 360
GAGATGACTA ACCTCAAAGA CATAGGGCTC TATAACCTGA GGAACATCAC CCGGGGGGCC 420
ATCAGGATCG AGAAGAACGC CGACCTCTGC TACCTCTCCA CGGTGGACTG GTCTCTCATC 480
CTGGACGCCG TGTCCAACAA CTACATTGTG GGGAACAAGT CCCCAAAGGA GTGCGGGGAC 540
ATGTGTCCAG GGACCTTGGA GGAGAAGCCG TTGTGCGAGA AGACCGCCAT CAACAACGAG 600
TACAACTACC GCTGCTGGAC CACCAACCGC TGCCAGAAAA TGTGCCCCAG CGCGTGCGGG 660
AAGCGGGCAT GCACCGAGAA CAACGAATGC TGCCACCCCG AGTGCCTGGG CAGCTGCCAC 720
GCGCCTGACG ACGACACGGC CTGCGTCGCC TGCCGCCACT ACTATTTCTC CGGCGTCTGC 780
GTGCCCGCCT GCCCGCCCAA CACCTACCGA TTCGAGGGCT GGCGCTGCGT GGACCGCGAC 840
TTCTGCGCCA ACATCCCTAA CGCCGATGGC GGCGACTCCG AGGGCTTTGT CATCCACGAC 900
GGCGAGTGCA TGCAGGAGTG CCCGTCGGGC TTCATCCGCA ACGGCAGCCA GAGCATGTTC 960
TGCATTCCCT GTGAAGGTCC GTGCCCCAAG GTCTGTGAGG AAGACAAGAA AACAAAGACC 1020
ATTGATTCTG TTAATTCTGC TCAAATGCTC CAAGGCTGCA CCATCTTCAA GGGGAATCTG 1080
CTCATTAACA TCCGACGAGG CAATAACATT GCCTCGGAGC TGGAGAACTT CATGGGGCTC 1140
ATCGAGGTGG TGACGGGCTA CGTGAAGATC AGCCACTCGC ACGCCTTGGT CTCCTTGTCC 1200
TTCCTGAAGA ACCTCCGCCA GATCCTAGGG GAGGAGCAGC TGGAAGGGAA CTACTCCTTC 1260
TACGTCCTGG ACAACCAGAA CTTGCAGCAG CTCTGGGACT GGGACCACCG CAACCTGACC 1320
ATCAAAGCTG GGAAGATGTA CTTCGCCTTC AACCCCAAAC TGTGCGTGTC GGAAATTTAC 1380
CGCATGGAGG ACGTGACGGG GACGAAAGGA CGCCAGAGCA AGGGCGACAT AAACACCAGG 1440
AACAACGGGG AGAGAGCCTC CTGTGAGAGC GACATCCTGC ATTTCACCTC CACCAACACG 1500
TGGAAGAACC GCATCATCCT AACCTGGCAC CGCTACCGCC CCCCTGACTA CAGGGATCTC 1560
ATCAGCTTCA CCGTCTACTA CAAGGAGGCA CCCTTTAAAA ATGTGACGGA GTATGATGGG 1620
CAGGACGCCT GCGGCTCCAA CAGCTGGAAC ATGGTGGACG TGGACCTCCC TCCCAACAAG 1680
GACCTAGAGC CTGGTATTCT ACTGCAAGGG CTGAAGCCCT GGACTCAGTA CGCCGTCTAC 1740
GTCAAGGCCG TGACCCTCAC CATGGTGGAG AATGACCACA TCCGAGGGGC CAAGAGTGAA 1800
ATCTTGTACA TTCGCACCAA CGCCTCAGTT CCTTCCATCC CCTTGGACAT CCTCTCGGCA 1860
TCCAACTCCT CGTCTCAGCT GATCGTGAAG TGGAGCCCCC CGTCCCTGCC CAACGGGAAC 1920
CTGAGCTACT ACATCGTGAG GTGGCAGCGG CAGCCCCAGG ACGGCTACCT GTACCGGCAC 1980
AACTACTGCT CCAAAGACAA AATTCCCATC AGGAAGTATG CGGACGGCAC CATCGACGTG 2040
GAGGAGGTGA CGGAGAACCC CAAGACGGAG GTCTGTGGCG GAGAGAAGGG GCCTTGCTGC 2100
GCGTGCCCCA AGACCGAAGC CGAGAAGCAG GCTGAGAAGG AGGAGGCGGA GTACCGCAAG 2160
GTGTTCGAGA ACTTCCTGCA CAACTCCATC TTCGTGCCCA GACCCGAGAG GAAGCGGAGA 2220
GATGTCGCCC AGGTGGCCAA CACCACGCTG TCCGGCCGAG GCAGGAACGG CACGGCGGTG 2280
GACATGTACA ACAGCACGGA CCTGGAGGAG CTGGAGACAG AATACCCTTT CTTTGAGACC 2340
AGAGTGGACA AGGAGATAAC GGTCATATCT AACCTGCGGC CGTTTACTTC CTACCGCATC 2400
GATATCCACA GCTGCAACCA CGAGGCGGAG AAGCTGGGGT GCAGTGCCTC CAACTTTGTC 2460
TTTGCGAGAA CCAAGCCTGC AGAAGGAGCG GATGACATTC CGGGCCCTGT GACCTGGGAA 2520
GCAAGGCCTG AAAACTCCAT CTTTCTGAAG TGGCCGGAAC CTGAGAACCC CAACGGATTG 2580
ATCCTAATGT ATGAGATAAA ATACGGGTCT CAGATCGAGG ACCAGAGGGA ATGTGTGTCC 2640
AGACAGCAGT ACCGAAAGTA TGGAGGAGCC AAGCTCAACC GGCTAAACCC GGGGAACTAT 2700
ACAGCCCGGA TTCAGGCTAC GTCGCTCTCC GGGAACGGGT CGTGGACGGA GCCTGTGTTC 2760
TTCTATGTCC CAGCCAAAGC CACCTACGAG AGCTTCATGC ACCTGATCAT CGCGCTGCCG 2820
GTCGCCATCC TGCTCATCGT GGGAGGGCTG CTGATCGTGC TGTACGTCTT CCACAGGAAG 2880
AGAAGTAACA GCAGACTGGG GAACGGAGTG CTGTACGCCT CTGTGAACCC GGAGTACTTC 2940
AGTGCAGCCG ACGTATACGT CCCTGACGAG TGGGAGGTGG CGCGGGAGAA GATCACCATG 3000
AGCCGCGAGC TTGGCCAGGG CTCCTTCGGG ATGGTCTACG AAGGCGTCGC CAAGGGCGTG 3060
GTAAAGGATG AGCCGGAAAC CAGGGTGGCC ATCAAGACGG TGAACGAGGC CGCCAGCATG 3120
CGGGAGAGGA TCGAGTTTCT CAACGAGGCG TCTGTGATGA AGGAGTTCAA TTGTCACCAC 3180
GTGGTGCGGT TGCTGGGGGT GGTGTCCCAG GGCCAGCCCA CCCTGGTCAT CATGGAGCTG 3240
ATGACGCGAG GGGACCTCAA GAGCTATCTC AGGTCCCTGC GACCGGAAGT GGAGCAACAG 3300
AATCGGGCCC CAGCCCCTCC GAGTCTGAGT AAGATGATCC AAATGGCCGG GGAGATTGCA 3360
GATGGCATGG CATACCTCAA CGCCAACAAG TTCGTGCACA GAGACCTTGC TGCCCGGAAC 3420
TGCATGGTGG CCGAGGATTT CACAGTCAAG ATCGGAGATT TCGGAATGAC GCGGGACATC 3480
TACGAGACGG ACTACTACCG GAAAGGGGGG AAAGGCTTGC TGCCCGTGCG CTGGATGTCC 3540
CCCGAGTCCC TCAAAGATGG AGTCTTCACC ACCCACTCTG ACGTCTGGTC CTTCGGAGTC 3600
GTCCTCTGGG AGATCGCCAC GCTGGCAGAG CAGCCGTACC AGGGATTCTC CAACGAGCAG 3660
GTCCTGCGCT TCGTCATGGA GGGCGGCCTT CTGGACAAGC CGGACAACTG CCCCGACATG 3720
CTGTTTGAGC TGATGCGCAT GTGTTGGCAA TACAACCCCA AGATGCGGCC TTCCTTCCTG 3780
GAGATCATCG GCAGTGTCAG AGACGAGATG GAGCCCGGCT TCCGCGAGGT CTCCTTCTAC 3840
TACAGCGAGG AGAACAAGCC GCCCGAGGCC GAGGAGCTCG ACCTGGAGCC CGAGAACATG 3900
GAGAGCGTGC CCCTGGACCC CTCCGCGAAC GCCGCTGCCG CCGTCGCCGC CCTGCAGCCC 3960
GACAGGCACA AGGCCGAGAA CGGCCCGAGT GCAGGGGCGA TGGTCCTGCG AGCCAGCTTT 4020
GACGAGAGGC GACCCTACGC GCACATGAAT GGGGGCCGCA CAGACGAGCG GGCCCTGCCG 4080
CTGCCGCAGT CTTCGACCTG C 4101
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+++relGqGsfGmvyeGvak+vvk+e etrvaiktvneaas+reriefl+easvmkef+
Q: 998   ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFN  1057
         799*********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeee.neaalappaldkliqmaa  119
         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrpe+e ++ a app+l+k+iqma+
Q: 1058  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEqQNRAPAPPSLSKMIQMAG  1117
         ***************************************995666777************
S: 120   eiadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvr  179
         eiadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvr
Q: 1118  EIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR  1177
         ************************************************************
S: 180   wmspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpenc  239
         wmspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqG+sneqvl+fv++gg+l+kp+nc
Q: 1178  WMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGFSNEQVLRFVMEGGLLDKPDNC  1237
         ************************************************************
S: 240   pelltelmrlcwqynpklrpsfleivel  267
         p++l+elmr+cwqynpk+rpsflei+ +
Q: 1238  PDMLFELMRMCWQYNPKMRPSFLEIIGS  1265
         *************************976
Domain Sequence
(FASTA)
ITMSRELGQG SFGMVYEGVA KGVVKDEPET RVAIKTVNEA ASMRERIEFL NEASVMKEFN 60
CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPEV EQQNRAPAPP SLSKMIQMAG 120
EIADGMAYLN ANKFVHRDLA ARNCMVAEDF TVKIGDFGMT RDIYETDYYR KGGKGLLPVR 180
WMSPESLKDG VFTTHSDVWS FGVVLWEIAT LAEQPYQGFS NEQVLRFVME GGLLDKPDNC 240
PDMLFELMRM CWQYNPKMRP SFLEIIGS 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00013
EKS-BOT-00014
EKS-CAJ-00017
EKS-CAF-00016
EKS-CAP-00015
EKS-CII-00007
EKS-DAR-00020
EKS-DRM-00003
EKS-EQC-00017
EKS-FEC-00015
EKS-GAG-00015
EKS-GAA-00023
EKS-HOS-00017
EKS-LOA-00014
EKS-MAM-00016
EKS-MEG-00016
EKS-MOD-00014
EKS-MUM-00014
EKS-MUP-00017
EKS-MYL-00017
EKS-ORN-00027
EKS-ORA-00015
EKS-ORL-00022
EKS-OTG-00015
EKS-PAT-00016
EKS-PES-00016
EKS-PEM-00008
EKS-POA-00015
EKS-RAN-00016
EKS-SAH-00013
EKS-SUS-00013
EKS-TAG-00014
EKS-TAR-00025
EKS-TEN-00028
EKS-TUT-00007
EKS-XET-00015
EKS-XIM-00025
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0043559; F:insulin binding
GO:0005010; F:insulin-like growth factor-activated receptor activity
GO:0007420; P:brain development
GO:0031017; P:exocrine pancreas development
GO:0006955; P:immune response
GO:0051389; P:inactivation of MAPKK activity
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0030238; P:male sex determination
GO:0030879; P:mammary gland development
GO:0043066; P:negative regulation of apoptotic process
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0045740; P:positive regulation of DNA replication
GO:0043410; P:positive regulation of MAPK cascade
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0060740; P:prostate gland epithelium morphogenesis
GO:0046777; P:protein autophosphorylation
GO:0051262; P:protein tetramerization
GO:0046328; P:regulation of JNK cascade
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013