EKS-ORC-00435

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00435

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	451.6	1.2E-135	24	308	285

Status

Unreviewed

Ensembl Protein

ENSOCUP00000012726

UniProt Accession

G1TYT9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK13

Gene Synonyms/Alias

MAPK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000014799	ENSOCUP00000022256	ENSOCUT00000021244
ENSOCUG00000014799	ENSOCUP00000026060	ENSOCUT00000033095
ENSOCUG00000014799	ENSOCUP00000012726	ENSOCUT00000014798

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ 60

SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ 120

KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 180

GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG 240

TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 300

QALAHDYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES 360

Nucleotide Sequence
(FASTA)

ATGTCTCAGG AGAGGCCCAC GTTCTATCGG CAGGAGCTGA ACAAGACAAT CTGGGAGGTG 60

CCCGAGCGTT ACCAGAATCT GTCCCCGGTG GGCTCTGGCG CCTATGGCTC CGTGTGTGCT 120

GCTTTTGACA CAAAAACTGG GTTGCGCGTT GCTGTGAAGA AGCTGTCCAG GCCTTTTCAG 180

TCCATCATTC ATGCCAAAAG GACCTACAGG GAGCTGCGGC TACTCAAACA TATGAAACAT 240

GAAAATGTGA TTGGTCTATT GGACGTCTTT ACACCTGCAA GGTCTCTGGA GGAGTTCAAT 300

GACGTGTATC TGGTGACGCA TCTCATGGGG GCAGATCTGA ACAACATTGT GAAATGCCAA 360

AAGCTTACAG ATGACCACGT TCAGTTCCTT ATCTACCAAA TCCTCCGAGG CCTAAAGTAT 420

ATACATTCAG CGGACATAAT TCACAGGGAC CTAAAGCCTA GTAACCTAGC TGTGAACGAA 480

GACTGTGAGC TGAAGATCCT GGATTTTGGG TTGGCGCGAC ACACTGATGA TGAAATGACG 540

GGCTACGTGG CCACCAGGTG GTATCGGGCT CCTGAGATCA TGCTGAACTG GATGCATTAC 600

AACCAGACAG TTGATATTTG GTCGGTCGGA TGCATAATGG CGGAGCTGTT GACTGGAAGA 660

ACACTGTTTC CTGGTACAGA CCATATTGAT CAGTTGAAGC TCATTTTAAG ACTCGTTGGA 720

ACCCCAGGGG CTGAGCTTTT GAAGAAAATC TCCTCAGAGT CTGCAAGAAA CTATATTCAG 780

TCTTTGACCC AGATGCCGAA GATGAACTTT GCAAATGTAT TTATTGGTGC CAACCCCTTG 840

GCCGTTGACC TGCTGGAGAA GATGCTTGTT TTGGACTCAG ATAAGAGAAT CACAGCAGCC 900

CAAGCCCTCG CGCACGACTA CTTTGCCCAG TACCACGATC CGGACGACGA GCCGGTGGCC 960

GACCCTTACG ATCAGTCTTT TGAAAGCAGG GACCTGCTCA TAGACGAGTG GAAAAGCCTG 1020

ACCTATGATG AAGTCATCAG CTTCGTGCCG CCACCCCTCG ACCAAGAAGA GATGGAGTCC 1080

TGA 1083

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+p+g+Gayg v++a+d++t+ rva+kklsrpfq+ ++akrt+REl+llk++kheN+

Q: 24    YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV  83

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp+++lee++dvYlvt+lm++dL++++k qkl+d+h+++l+yqilrglky+Hs

Q: 84    IGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS  143

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsNl+vnedcelkildFGlar++d+e    +t+yvatrwYraPei+l++++

Q: 144   ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMH  199

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI+aElltg++lfpg+d+idql++il+++gtp +e lkki+se+arnyi

Q: 200   YNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI  259

         ************************************************************

S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +sl++++k++f+++f  a++ a+dLlek+Lvld+dkRi++++aL+h+Y+

Q: 260   QSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHDYF  308

         ************************************************6

Domain Sequence
(FASTA)

YQNLSPVGSG AYGSVCAAFD TKTGLRVAVK KLSRPFQSII HAKRTYRELR LLKHMKHENV 60

IGLLDVFTPA RSLEEFNDVY LVTHLMGADL NNIVKCQKLT DDHVQFLIYQ ILRGLKYIHS 120

ADIIHRDLKP SNLAVNEDCE LKILDFGLAR HTDDEMTGYV ATRWYRAPEI MLNWMHYNQT 180

VDIWSVGCIM AELLTGRTLF PGTDHIDQLK LILRLVGTPG AELLKKISSE SARNYIQSLT 240

QMPKMNFANV FIGANPLAVD LLEKMLVLDS DKRITAAQAL AHDYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032755	; P:positive regulation of interleukin-6 production
GO:0006970	; P:response to osmotic stress

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013