EKS-ORC-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	240.4	3.0E-71	584	813	230

Status

Unreviewed

Ensembl Protein

ENSOCUP00000012740

UniProt Accession

G1T864;

Protein Name

Protein Synonyms/Alias

Gene Name

TYK2

Gene Synonyms/Alias

TYK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000014816	ENSOCUP00000012740	ENSOCUT00000014818

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1166

Protein Sequence
(FASTA)

AVRTMFLCQR RAGSRGSLPG AAAAQPLAAG GGLRVLLHEP WVTFGEVSLT AEEVCVHIAH 60

RIGITPPCFN LFALFDVQAQ VWLPPNHVLE VSRDETLTLY FRMRFYFRNW HGMNPQEPAV 120

YRCGPPGTEA PSERPEQGVQ LLDPASFEYL FEQGKHEFVN DVASLWELSS EEETHHFKNE 180

SLGMAFLHLC HLALCRGVPL EEVARKTSFK DCIPRSFRQQ IHQHNALTRL RLRNVFRRFL 240

RAFQPGRLSQ QAVMVKYLAT LERLAPRFGS ERTPVCCLRL LAQADGEPCY IRDHRPAPAD 300

PGPEAAPGPP THEVLVTGTG GIQWRPVLAE VRAGRLFLLG LDPAAAGASP GGRGPQALAA 360

PRPCPSPPPW SDGPRSMDWP HLLPQPSVGA CSRTGICQPL WTLCICGSGT SASVWVSFFI 420

IGTKDSSLGS CEDKRFSVAH RSGQRAIHGR ISEPFVQAKL RPADGLYLVQ WSTSHFHRLI 480

LTVAQRDPGP GLQTLRLRKF PIELRDGAFV LEGWARSFTS VRELRAALQG CSLRAGDDCF 540

LLRRCCLPQP GEISNLIVTR GPRASSRPPN LSQLSFHRVR QDDLRQLSHL GQGTRTNVYE 600

GLLQVGGPEE AQVDGGEPLA PSGGQELRVV LKVLDASHHD VALAFYETAS LMSQVSHVHL 660

AFVHGVCVRG SENIMVTEYV EHGPLDVWLR RERGRVPMAW KVAAAQQLAS ALSYLEDKNL 720

AHGNVCGRNI LLARLGLAEG ATPFIKLSDP GVGLAVLSRE ERVERIPWTA PECLPAGNSS 780

LIPAADKWGF GATLLEICFD GETPLQSHSP SEVRPRGLML HRGPWPCKGM AYLNCASMQI 840

KVFVSTKVNA TCFSYYIEKL LIFLGAVHVK VPRAKSKELK SGYVRSARGG TGRRGRSKGP 900

LSARRRCLPG PGWVRAAPAL QCGSSGGSGW GGGPAPLLPP LSASRPSAGE KSVQLVMEYV 960

PLGSLRDYLP RHSVGLAQLL LFAQQICEGM AYLHGQHYIH RDLAARNVLL DHDRLVKIGD 1020

FGLAKAVPEG REYYCVREDG DSPVFWYAPE CLKDSKFYYA SDVWSFGVTL YELLTHCDAS 1080

QSPPSKFLEL IGLTQGQMAV LRLTELLDRG ERLPRPDRCP GEIYLLMKNC WEAEASFRPS 1140

FQNLVPVLKA LHEQYRGQAP SVFSVC 1166

Nucleotide Sequence
(FASTA)

GCTGTGAGGA CCATGTTTCT GTGCCAGAGA AGAGCCGGCT CCAGGGGCAG CCTGCCGGGC 60

GCGGCTGCCG CTCAGCCCCT GGCTGCGGGG GGAGGCCTGC GGGTGCTCCT GCACGAGCCC 120

TGGGTCACGT TTGGGGAGGT TTCGCTGACT GCTGAGGAGG TCTGTGTCCA CATCGCACAC 180

AGGATCGGCA TCACTCCACC CTGCTTCAAC CTCTTTGCCC TCTTCGATGT CCAGGCCCAA 240

GTCTGGCTGC CCCCAAACCA TGTCCTGGAG GTGTCCAGGG ACGAGACCCT GACCCTGTAT 300

TTCCGCATGA GGTTTTACTT CCGGAACTGG CACGGCATGA ATCCCCAGGA GCCGGCTGTG 360

TACCGCTGCG GGCCCCCAGG GACCGAGGCT CCCTCAGAAC GGCCAGAACA GGGAGTCCAA 420

CTCCTGGACC CGGCCTCGTT TGAGTACCTT TTTGAGCAGG GCAAACACGA GTTTGTGAAT 480

GACGTGGCCT CGCTGTGGGA GCTGTCCAGT GAGGAGGAGA CCCACCACTT TAAGAACGAG 540

AGCCTGGGCA TGGCCTTCCT GCACCTCTGC CACCTGGCTC TGTGCCGCGG CGTCCCGCTG 600

GAGGAGGTGG CCAGGAAGAC CAGCTTCAAG GACTGCATCC CGCGCTCCTT CCGCCAGCAG 660

ATCCACCAGC ACAACGCGCT GACCCGGCTG CGCTTGCGCA ACGTCTTCCG CAGGTTCCTG 720

CGCGCCTTCC AGCCCGGCCG CCTCTCGCAG CAGGCGGTCA TGGTGAAGTA CCTGGCCACG 780

CTGGAGCGCC TGGCGCCCCG CTTCGGCTCG GAGCGCACGC CCGTGTGCTG CCTGCGGCTG 840

CTGGCCCAGG CCGACGGGGA GCCCTGCTAC ATCCGGGACC ACAGGCCGGC CCCCGCAGAC 900

CCCGGCCCCG AGGCCGCGCC GGGACCCCCC ACCCACGAGG TGCTGGTGAC AGGCACCGGT 960

GGCATCCAGT GGCGGCCGGT CCTGGCCGAG GTGAGGGCGG GGCGCCTTTT CCTCCTTGGC 1020

CTGGACCCTG CTGCAGCAGG TGCCTCCCCA GGGGGGAGGG GCCCGCAGGC CTTGGCTGCG 1080

CCACGCCCCT GCCCATCTCC CCCTCCTTGG TCTGATGGCC CGCGGAGCAT GGATTGGCCG 1140

CACCTGCTGC CCCAGCCGAG TGTGGGCGCC TGCAGCAGGA CCGGAATCTG TCAGCCGTTG 1200

TGGACGCTTT GCATCTGTGG GTCTGGGACG TCGGCCTCTG TGTGGGTCTC GTTTTTCATT 1260

ATTGGAACAA AGGATTCAAG TCTGGGTTCT TGTGAAGACA AGAGGTTTAG TGTGGCCCAC 1320

CGTTCTGGTC AAAGAGCAAT CCATGGCAGG ATTTCGGAGC CATTCGTGCA GGCCAAGCTG 1380

CGGCCCGCGG ACGGCCTCTA CCTCGTCCAG TGGAGCACCA GCCACTTCCA CCGCCTCATC 1440

CTCACCGTGG CCCAGCGCGA CCCGGGCCCC GGCCTGCAGA CCCTGCGTCT GCGCAAGTTT 1500

CCCATCGAGC TCCGGGACGG GGCCTTCGTG CTGGAGGGCT GGGCTCGCTC CTTCACCAGT 1560

GTGCGCGAGC TGCGGGCCGC CCTGCAGGGC TGCTCGCTGC GGGCGGGGGA CGACTGCTTC 1620

CTGCTGCGCC GCTGCTGCCT GCCGCAGCCT GGAGAAATCT CGAACCTCAT TGTGACGCGG 1680

GGGCCCCGGG CCAGCTCCAG GCCGCCCAAC CTCAGCCAGC TCAGTTTCCA CCGAGTCCGG 1740

CAGGACGACC TCCGGCAGCT GTCGCACTTG GGCCAGGGCA CAAGGACCAA TGTGTATGAG 1800

GGCCTGCTGC AAGTGGGGGG CCCTGAGGAG GCTCAGGTAG ACGGTGGGGA GCCCCTGGCC 1860

CCCAGTGGGG GCCAGGAGCT TCGAGTGGTG CTTAAGGTAC TGGACGCCAG TCACCACGAC 1920

GTCGCCCTGG CCTTCTACGA GACCGCCAGC CTCATGAGCC AGGTGTCCCA CGTGCACCTG 1980

GCTTTTGTGC ACGGCGTGTG TGTGCGCGGC TCGGAGAACA TCATGGTGAC CGAGTACGTG 2040

GAGCACGGGC CCCTGGATGT GTGGCTGCGG CGGGAGAGGG GCCGGGTGCC CATGGCCTGG 2100

AAGGTGGCGG CAGCCCAGCA GCTGGCCAGC GCCCTCAGCT ATCTGGAGGA CAAGAACCTG 2160

GCCCATGGTA ACGTGTGCGG CCGGAACATC CTGCTGGCCC GGCTGGGGCT GGCCGAGGGC 2220

GCCACTCCCT TCATCAAACT CAGCGACCCC GGCGTGGGCC TGGCCGTCCT GTCCAGGGAA 2280

GAGCGGGTGG AGCGGATCCC CTGGACGGCC CCCGAGTGCC TGCCCGCCGG GAACAGCAGC 2340

CTGATACCTG CGGCCGACAA GTGGGGCTTC GGCGCCACAC TGCTGGAGAT CTGCTTTGAC 2400

GGCGAAACCC CGCTGCAAAG CCACAGCCCC TCCGAGGTTC GTCCAAGGGG GCTCATGCTT 2460

CATCGGGGCC CCTGGCCATG CAAGGGTATG GCATACTTGA ACTGTGCCAG CATGCAAATC 2520

AAGGTATTCG TAAGTACAAA AGTAAACGCC ACCTGTTTTA GTTATTACAT AGAAAAGTTG 2580

TTAATATTTT TAGGGGCGGT ACATGTTAAA GTGCCCAGAG CAAAATCCAA GGAGTTAAAG 2640

AGTGGCTATG TTAGGAGCGC GAGGGGCGGG ACTGGGAGGC GGGGCCGGAG CAAGGGGCCT 2700

TTAAGCGCCA GGAGGCGCTG TCTGCCGGGA CCAGGATGGG TGAGAGCCGC CCCAGCTCTC 2760

CAGTGTGGGT CATCGGGGGG CTCGGGGTGG GGGGGAGGCC CTGCCCCGCT TCTGCCCCCA 2820

CTCAGTGCAT CCCGCCCCTC TGCAGGTGAG AAGTCGGTGC AGCTCGTCAT GGAGTACGTG 2880

CCCCTGGGCA GCCTTCGGGA CTACCTGCCC CGGCACAGCG TCGGGCTGGC CCAGCTGCTG 2940

CTCTTCGCCC AGCAGATCTG CGAGGGCATG GCCTACCTGC ACGGGCAGCA CTACATCCAC 3000

CGGGACCTGG CTGCACGCAA CGTGCTCCTG GACCACGACA GGCTGGTCAA GATCGGCGAC 3060

TTTGGCCTTG CCAAGGCCGT GCCCGAGGGC CGCGAGTACT ACTGCGTGCG GGAGGATGGG 3120

GACAGCCCCG TGTTCTGGTA CGCCCCCGAG TGCCTCAAGG ACTCCAAGTT TTACTACGCG 3180

TCCGACGTCT GGTCCTTCGG CGTCACGCTC TATGAACTGC TGACGCACTG TGACGCCAGC 3240

CAGAGCCCCC CCTCGAAATT CCTTGAGCTC ATCGGCCTCA CCCAGGGCCA GATGGCGGTG 3300

CTGAGGCTGA CGGAGCTGCT GGACCGCGGG GAGAGGCTGC CGCGGCCGGA CAGGTGCCCC 3360

GGCGAGATCT ACCTTCTCAT GAAGAACTGC TGGGAGGCGG AGGCCTCGTT CCGCCCCAGC 3420

TTCCAGAACC TCGTCCCCGT CCTCAAGGCC CTGCACGAGC AGTACCGGGG CCAGGCGCCC 3480

TCGGTGTTCA GCGTGTGCTG A 3501

Domain Profile

S: 1     lkqiesLgkgtftkvfevre.............daegdsteee..valkvLkesgedisr  45

         l+q+++Lg+gt+t+v+e+ +             ++  +s+++e  v+lkvL+ s++d++

Q: 584   LRQLSHLGQGTRTNVYEGLLqvggpeeaqvdggEPLAPSGGQElrVVLKVLDASHHDVAL  643

         56899***************9999998888655478888887778***************

S: 46    dfkreaeilsqlshehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslld  105

         +f+++a+++sq+sh h+++++gvcv+++en++V+eyve+G+Ld++Lr+++ ++++++++

Q: 644   AFYETASLMSQVSHVHLAFVHGVCVRGSENIMVTEYVEHGPLDVWLRRERGRVPMAWKVA  703

         ************************************************************

S: 106   vakqlakameYLedkklvhrdvaarnvLveresn.egtppfvklsdpglakavnqdeYyl  164

          a+qla+a++YLedk+l h++v++rn+L++r +  eg +pf+klsdpg+  av      l

Q: 704   AAQQLASALSYLEDKNLAHGNVCGRNILLARLGLaEGATPFIKLSDPGVGLAV------L  757

         **********************************999****************......*

S: 165   vreerdsripwlapeclseakn.lstasdvWsFgvtlyelltcskgesplrseslerkle  223

         +reer +ripw+apecl + ++ l+ a+d+W+Fg+tl+e+  c +ge+pl+s+s++   e

Q: 758   SREERVERIPWTAPECLPAGNSsLIPAADKWGFGATLLEI--CFDGETPLQSHSPS---E  812

         ******************99999*****************..***********999...3

S: 224   l  224

Q: 813   V  813

Domain Sequence
(FASTA)

LRQLSHLGQG TRTNVYEGLL QVGGPEEAQV DGGEPLAPSG GQELRVVLKV LDASHHDVAL 60

AFYETASLMS QVSHVHLAFV HGVCVRGSEN IMVTEYVEHG PLDVWLRRER GRVPMAWKVA 120

AAQQLASALS YLEDKNLAHG NVCGRNILLA RLGLAEGATP FIKLSDPGVG LAVLSREERV 180

ERIPWTAPEC LPAGNSSLIP AADKWGFGAT LLEICFDGET PLQSHSPSEV 230

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045	; Tyr_kinase_non-rcpt_TYK2_N.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.

Prosites

PS50057	; FERM_3; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.
PR01827	; YKINASETYK2.

Created Date

20-Feb-2013