EKS-ORC-00075

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00075

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	450.8	2.2E-135	26	310	285

Status

Unreviewed

Ensembl Protein

ENSOCUP00000024150

UniProt Accession

G1T8E2;

Protein Name

Protein Synonyms/Alias

Gene Name

GSK3B

Gene Synonyms/Alias

GSK3B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000014932	ENSOCUP00000024150	ENSOCUT00000025856
ENSOCUG00000014932	ENSOCUP00000012837	ENSOCUT00000014932

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

390

Protein Sequence
(FASTA)

DKDGSKVTTV VATPGQGPDR PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD 60

KRFKNRELQI MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK 120

QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG 180

EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL LLGQPIFPGD SGVDQLVEII 240

KVLGTPTREQ IREMNPNYTE FKFPQIKAHP WTKVFRPRTP PEAIALCSRL LEYTPTARLT 300

PLEACAHSFF DELRDPNVKL PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAAST 360

PTNATAASVE NSLYRITEYN SCSKSISTSC 390

Nucleotide Sequence
(FASTA)

GACAAGGATG GCAGCAAGGT AACTACAGTG GTGGCAACTC CTGGGCAGGG TCCAGACAGG 60

CCACAAGAAG TCAGTTATAC AGACACTAAA GTGATTGGAA ATGGGTCATT TGGTGTAGTA 120

TATCAAGCAA AACTTTGTGA TTCAGGAGAA TTGGTTGCCA TCAAGAAAGT ATTACAGGAC 180

AAGAGATTTA AGAACCGAGA GCTCCAGATT ATGAGAAAGC TAGATCATTG TAACATAGTC 240

CGTTTGCGTT ATTTCTTCTA CTCGAGTGGT GAGAAGAAAG ATGAGGTCTA TCTTAATCTG 300

GTGCTGGACT ATGTTCCGGA AACAGTATAC AGAGTTGCCA GACACTATAG TCGAGCCAAA 360

CAGACACTCC CTGTCATCTA TGTCAAGTTG TATATGTATC AGCTGTTTCG AAGTTTAGCC 420

TATATCCATT CCTTTGGAAT CTGCCATCGG GATATTAAAC CACAGAACCT CTTGTTGGAT 480

CCTGATACAG CTGTTTTAAA ACTCTGTGAC TTTGGAAGTG CAAAGCAGCT GGTCCGAGGA 540

GAACCCAATG TTTCGTATAT CTGTTCTCGG TACTATAGGG CACCAGAGTT GATCTTTGGA 600

GCCACTGATT ATACCTCCAG TATAGATGTA TGGTCTGCAG GCTGTGTATT GGCTGAGCTG 660

TTGCTAGGAC AGCCAATATT TCCAGGAGAC AGTGGTGTGG ATCAGTTGGT GGAAATAATC 720

AAGGTCCTGG GAACACCAAC AAGGGAGCAA ATTAGAGAAA TGAACCCAAA TTACACAGAA 780

TTCAAATTTC CTCAAATTAA GGCACATCCT TGGACTAAGG TCTTCCGACC CCGAACTCCA 840

CCAGAGGCAA TTGCACTGTG TAGCCGTCTG CTGGAGTACA CACCAACTGC CCGACTGACA 900

CCACTGGAAG CTTGTGCACA TTCATTTTTT GATGAATTAC GGGACCCAAA TGTCAAACTA 960

CCAAATGGGC GAGACACACC TGCACTCTTC AACTTCACCA CTCAAGAACT GTCAAGTAAT 1020

CCACCTTTGG CTACCATCCT TATTCCTCCT CATGCTAGGA TTCAAGCAGC TGCTTCAACC 1080

CCTACAAATG CCACAGCAGC CTCAGTAGAA AACAGTCTTT ACAGAATTAC TGAATATAAT 1140

TCATGTTCCA AGTCCATCAG CACAAGCTGC 1170

Domain Profile

S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60

         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+y

Q: 26    YTDTKVIGNGSFGVVYQAKLCDSGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY  84

         5789**********************.*********************************

S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120

         ff++s ekkd+vylnlvl+y+Pet+++v+r+++++k++l+v++vkly+yQlfr+lay+hs

Q: 85    FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS  144

         ************************************************************

S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180

         ++i+HrDiKPqNll+d++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++y

Q: 145   FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY  204

         ************************************************************

S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240

         t++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf+

Q: 205   TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP  264

         ************************************************************

S: 241   kikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         +ik+++++kv++ ++++ea++l++++l+y+p++Rl++le++ah+ff

Q: 265   QIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF  310

         *********************************************9

Domain Sequence
(FASTA)

YTDTKVIGNG SFGVVYQAKL CDSGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF 60

FYSSGEKKDE VYLNLVLDYV PETVYRVARH YSRAKQTLPV IYVKLYMYQL FRSLAYIHSF 120

GICHRDIKPQ NLLLDPDTAV LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT 180

SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ 240

IKAHPWTKVF RPRTPPEAIA LCSRLLEYTP TARLTPLEAC AHSFF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030877	; C:beta-catenin destruction complex
GO:0005813	; C:centrosome
GO:0005829	; C:cytosol
GO:0043198	; C:dendritic shaft
GO:0030426	; C:growth cone
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0050321	; F:tau-protein kinase activity
GO:0007409	; P:axonogenesis
GO:0044337	; P:canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process
GO:0016477	; P:cell migration
GO:0001837	; P:epithelial to mesenchymal transition
GO:0006983	; P:ER overload response
GO:0045444	; P:fat cell differentiation
GO:0005977	; P:glycogen metabolic process
GO:0021766	; P:hippocampus development
GO:0044027	; P:hypermethylation of CpG island
GO:0035556	; P:intracellular signal transduction
GO:0007520	; P:myoblast fusion
GO:0043066	; P:negative regulation of apoptotic process
GO:0051534	; P:negative regulation of NFAT protein import into nucleus
GO:0032091	; P:negative regulation of protein binding
GO:0031333	; P:negative regulation of protein complex assembly
GO:0009887	; P:organ morphogenesis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0001954	; P:positive regulation of cell-matrix adhesion
GO:0033138	; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800	; P:positive regulation of peptidyl-threonine phosphorylation
GO:0032092	; P:positive regulation of protein binding
GO:0031334	; P:positive regulation of protein complex assembly
GO:0046827	; P:positive regulation of protein export from nucleus
GO:0032855	; P:positive regulation of Rac GTPase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006611	; P:protein export from nucleus
GO:0035372	; P:protein localization to microtubule
GO:0000320	; P:re-entry into mitotic cell cycle
GO:0006349	; P:regulation of gene expression by genetic imprinting
GO:0032886	; P:regulation of microtubule-based process
GO:0071109	; P:superior temporal gyrus development

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013