EKS-ORC-00262

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00262

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.0	9.2E-136	234	521	288

Status

Unreviewed

Ensembl Protein

ENSOCUP00000012928

UniProt Accession

G1T8L9;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000015048	ENSOCUP00000012928	ENSOCUT00000015045

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

532

Protein Sequence
(FASTA)

MGWLEELRGQ LPISSVILLS VHARANFLDN MLLRSSGKLN VGTKKEDGES TAPTPRPKIL 60

RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR 120

RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHKALLI SVTVCSLLLV LIILFCYFRY 180

KRQETRPRYS IGLEQDETYI PPGESLRDLI EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI 240

GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300

SWTQLYLITD YHENGSLYDY LKSTTLDTKS MLKLAYSSVS GLCHLHTEIF STQGKPAIAH 360

RDLKSKNILV KKNGTCCIAD LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN 420

HFQSYIMADM YSFGLILWEI ARRCVSGGIV EEYQLPYHDL VPSDPSYEDM REIVCIKKLR 480

PSFPNRWSSD ECLRQMGKLM TECWAHNPAS RLTALRVKKT LAKMSESQDI KL 532

Nucleotide Sequence
(FASTA)

ATGGGTTGGC TGGAGGAACT CCGCGGGCAG CTTCCCATTT CCTCCGTCAT TCTTCTGTCT 60

GTGCACGCGA GGGCAAACTT CCTTGATAAC ATGCTTTTGC GAAGTTCAGG AAAATTAAAT 120

GTGGGCACCA AGAAAGAGGA TGGCGAAAGT ACAGCCCCCA CCCCTCGTCC GAAGATCCTG 180

CGTTGTAAAT GCCATCACCA TTGTCCGGAG GACTCGGTCA ACAATATTTG CAGCACAGAC 240

GGATATTGTT TCACAATGAT TGAAGAAGAT GACTCTGGGA TGCCGGTCGT CACTTCCGGA 300

TGTCTTGGCC TAGAAGGCTC AGATTTTCAG TGTCGGGATA CCCCCATTCC TCATCAAAGA 360

AGATCCATTG AATGCTGCAC AGAAAGGAAT GAATGTAATA AGGATCTACA CCCCACACTG 420

CCTCCATTGA AAAACAGAGA TTTTGTTGAT GGACCCATCC ACCACAAGGC CCTACTCATA 480

TCGGTGACGG TCTGTAGTTT GCTCTTGGTC CTTATCATTC TCTTCTGTTA CTTCAGGTAT 540

AAGAGGCAAG AAACCAGACC TCGGTACAGC ATCGGGTTGG AACAGGATGA AACTTACATT 600

CCTCCAGGAG AGTCCCTGAG AGACCTAATC GAGCAGTCTC AAAGCTCGGG AAGTGGATCA 660

GGCCTCCCTC TGCTGGTCCA AAGGACGATA GCTAAGCAGA TTCAGATGGT GAAGCAGATT 720

GGAAAAGGTC GCTATGGGGA AGTTTGGATG GGCAAGTGGC GTGGCGAAAA GGTGGCCGTG 780

AAAGTGTTCT TCACCACGGA GGAAGCCAGC TGGTTCAGAG AGACCGAAAT CTACCAGACA 840

GTGTTGATGA GGCACGAAAA CATTTTGGGG TTTATTGCTG CAGACATCAA GGGAACAGGG 900

TCCTGGACCC AGTTGTACCT AATCACAGAC TACCATGAAA ATGGTTCCCT TTATGATTAC 960

TTGAAGTCCA CCACTCTAGA CACAAAGTCG ATGCTGAAGC TAGCCTACTC TTCTGTCAGT 1020

GGCTTATGCC ACTTACACAC CGAAATCTTC AGTACGCAAG GCAAACCAGC AATTGCCCAC 1080

CGAGATCTGA AAAGTAAGAA CATCCTGGTG AAGAAAAATG GAACTTGCTG TATAGCTGAC 1140

CTGGGCCTGG CTGTTAAATT TATTAGTGAT ACCAATGAAG TTGACATACC ACCCAACACT 1200

CGAGTTGGCA CAAAGCGCTA TATGCCTCCC GAAGTGTTGG ATGAAAGCTT GAACAGAAAT 1260

CACTTTCAGT CTTACATCAT GGCTGACATG TACAGTTTTG GACTCATCCT TTGGGAGATT 1320

GCTAGGAGAT GTGTATCGGG AGGTATTGTG GAAGAGTACC AGCTTCCCTA TCATGACCTA 1380

GTGCCCAGTG ACCCCTCCTA TGAGGACATG AGAGAGATTG TATGCATCAA GAAGTTACGT 1440

CCCTCATTCC CCAACCGGTG GAGTAGTGAT GAGTGTCTAA GGCAGATGGG GAAGCTCATG 1500

ACGGAATGCT GGGCTCACAA TCCTGCATCC AGGCTGACGG CTCTGCGCGT TAAGAAAACC 1560

CTTGCCAAGA TGTCGGAGTC CCAGGACATT AAACTC 1596

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 234   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  353

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 354   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  411

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWE+a+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 412   VLDESLNRNHFQSYIMADMYSFGLILWEIARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  470

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 471   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  521

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEIARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0001502	; P:cartilage condensation
GO:0009953	; P:dorsal/ventral pattern formation
GO:0006954	; P:inflammatory response
GO:0035108	; P:limb morphogenesis
GO:0001550	; P:ovarian cumulus expansion
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0060041	; P:retina development in camera-type eye
GO:0031290	; P:retinal ganglion cell axon guidance
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013