EKS-ORC-00357

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00357

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	317.8	6.3E-95	17	259	243

Status

Unreviewed

Ensembl Protein

ENSOCUP00000012936

UniProt Accession

G1T8M6;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100351826

Gene Synonyms/Alias

LOC100351826;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000015053	ENSOCUP00000012936	ENSOCUT00000015054

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

800

Protein Sequence
(FASTA)

MSSLGTSFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 60

SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNKSE EMDMDHIMTW ATDVAKGMHY 120

LHMEAPVKVI HRDLKSRNVV IAADGVLKIC DFGASRFHNH TTHMSLVGTF PWMAPEVIQS 180

LPVSETCDTY SYGVVLWEML TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH 240

QCWEADAKKR PSFKQIIAIL ESMRNDTSLP DQCNSFLHNK AEWRCEIEAT LERLKKLERD 300

LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LPSFEIGAWT EDDVYFWVQQ LVTKGDSCVE 360

MSVYASLFKE NNITGKRLLL LEEEDLKDMG IVSKGHIIHL KSAIEKLTHD YLNLFHFPPL 420

IKDSGGGPEE NEEKIVNLEL VFGFHLKPGT GPQDCKWKMY MEMDGDEIAI TYIKDVTFNT 480

NLPDAEILKM TKPPFVMEKW IVGIAANQTV ECSVTYESDV RTPKSTKHVH RIQWSKAKPQ 540

DEVKAVQLAI QTVLPNAEGT PGSRSDSSAD CQWLDTLRLR QIASNTSLQR SQSNPILGSS 600

FFPYFDDQVS YAAAVRRTQA PIKYQQITPI NQSRSSSPTQ YGLTKNFSSL HLNSRDSGFS 660

SLNTDSASER GRYSDRSRNK YERGSVSLNS SPRGRYGGKS QHSTPSRERY SGKCYRVSHP 720

ALGTHQSPEF RRSPNDRRQP RTIPGMPLHT ETDARAGDEE SKGSEGGWTK VEYRKKPLRP 780

SPTKAGKERV RGNLRGRRTF 800

Nucleotide Sequence
(FASTA)

ATGTCGTCTC TCGGCACCTC CTTTGTGCAG ATCAAATTCG ATGACTTGCA GTTTTTTGAA 60

AACTGCGGCG GAGGAAGTTT TGGGAGTGTC TACCGAGCCA AATGGATCTC CCAGGACAAG 120

GAGGTGGCGG TGAAGAAGCT GCTGAAGATC GAGAAGGAGG CAGAAATCCT CAGTGTCCTC 180

AGCCACAGAA ACATCATCCA GTTTTACGGA GTAATTCTCG AGCCTCCCAA CTATGGCATC 240

GTCACAGAAT ATGCTTCTCT GGGGTCTCTC TATGATTACA TCAACAGCAA CAAAAGTGAA 300

GAGATGGACA TGGATCACAT CATGACCTGG GCCACTGATG TAGCCAAAGG AATGCACTAT 360

TTACACATGG AGGCACCGGT CAAGGTGATT CACAGAGACC TCAAGTCAAG AAACGTTGTG 420

ATAGCCGCTG ATGGAGTACT AAAGATCTGT GATTTCGGTG CCTCCCGGTT CCATAACCAT 480

ACAACACACA TGTCCTTGGT TGGAACTTTC CCCTGGATGG CTCCAGAAGT TATCCAGAGT 540

CTCCCCGTGT CGGAAACTTG TGACACATAT TCTTATGGTG TGGTTCTCTG GGAGATGCTA 600

ACAAGGGAGG TCCCCTTTAA AGGTTTGGAA GGATTACAAG TAGCTTGGCT TGTAGTGGAA 660

AAAAACGAGA GATTAACCAT TCCCAGCAGT TGCCCCAGAA GTTTTGCTGA ACTGTTACAC 720

CAGTGTTGGG AAGCTGATGC CAAGAAACGG CCGTCGTTCA AGCAGATCAT TGCCATCCTG 780

GAGTCCATGC GCAATGACAC GAGCCTTCCT GACCAGTGCA ACTCGTTCCT GCACAACAAG 840

GCAGAGTGGA GGTGCGAAAT TGAGGCCACC CTGGAGAGGC TAAAGAAACT CGAGCGCGAC 900

CTCAGCTTTA AGGAGCAGGA ACTTAAAGAA CGAGAGAGAC GTTTGAAGAT GTGGGAGCAG 960

AAGCTGACGG AGCAGTCCAA CACCCCGCTG CTGCCTTCCT TTGAGATTGG CGCGTGGACC 1020

GAAGACGACG TGTATTTTTG GGTTCAGCAG CTCGTCACAA AAGGCGACTC CTGTGTAGAG 1080

ATGAGTGTGT ACGCCAGCTT GTTCAAGGAG AACAACATCA CGGGGAAGCG GCTGCTCCTT 1140

CTGGAGGAAG AAGACTTGAA AGACATGGGC ATTGTCTCCA AGGGGCATAT CATCCATCTG 1200

AAGTCAGCCA TTGAGAAATT GACCCATGAT TACCTGAACC TGTTTCACTT CCCACCGCTC 1260

ATTAAGGACT CGGGAGGTGG GCCTGAAGAG AATGAGGAAA AAATCGTGAA CCTGGAACTG 1320

GTTTTTGGTT TTCACTTGAA ACCAGGAACT GGCCCACAGG ATTGTAAGTG GAAAATGTAT 1380

ATGGAGATGG ATGGGGATGA AATTGCAATA ACCTACATAA AAGATGTGAC ATTCAACACT 1440

AACCTACCTG ATGCAGAGAT TTTAAAGATG ACAAAGCCTC CATTTGTAAT GGAGAAGTGG 1500

ATTGTGGGAA TAGCAGCGAA TCAGACTGTG GAGTGCAGCG TCACCTATGA GAGTGACGTG 1560

AGAACTCCAA AAAGCACGAA GCATGTGCAC CGGATCCAGT GGAGCAAGGC AAAGCCTCAG 1620

GACGAGGTGA AAGCAGTCCA GCTGGCCATT CAGACTGTGC TCCCCAACGC CGAGGGCACC 1680

CCGGGCAGCA GGTCGGACTC CAGTGCCGAC TGCCAGTGGC TGGACACCCT GAGGTTGCGG 1740

CAGATTGCAT CCAACACTTC CTTACAGCGC TCCCAGAGCA ACCCCATCCT GGGCTCATCC 1800

TTCTTCCCCT ACTTCGATGA CCAGGTCTCC TATGCTGCTG CTGTGAGGAG GACCCAGGCG 1860

CCCATCAAGT ACCAGCAGAT CACACCCATA AACCAGTCCC GAAGCTCCTC TCCCACACAG 1920

TACGGACTGA CCAAGAACTT CTCCTCTCTA CATCTCAACT CCAGAGACAG CGGCTTTTCC 1980

AGTCTTAACA CGGACAGCGC TTCCGAAAGG GGTCGGTACT CAGATAGGAG CAGGAACAAA 2040

TACGAGCGTG GCAGCGTCTC ACTCAACTCT TCTCCCAGAG GAAGATACGG TGGGAAGAGT 2100

CAGCATTCCA CCCCTTCCAG AGAAAGGTAT TCTGGAAAGT GCTACAGGGT TTCTCATCCC 2160

GCACTCGGCA CTCACCAGTC ACCTGAGTTC AGAAGGAGCC CAAATGACCG TCGCCAGCCC 2220

AGGACCATAC CAGGGATGCC GCTGCACACG GAGACGGACG CACGAGCCGG GGATGAGGAG 2280

AGCAAAGGGA GCGAAGGCGG GTGGACCAAG GTGGAGTATC GCAAGAAGCC CCTACGGCCC 2340

TCTCCCACCA AGGCTGGGAA GGAAAGGGTG CGAGGAAACC TGCGTGGGAG GAGGACCTTT 2400

Domain Profile

S: 2     eleeligsgafgkvykakwrkke..vavKklreeaeekekleklereakllsklshpnii  59

         ++ e +g g+fg+vy+akw +++  vavKkl +          +e+ea++ls lsh+nii

Q: 17    QFFENCGGGSFGSVYRAKWISQDkeVAVKKLLK----------IEKEAEILSVLSHRNII  66

         67799**************665444****9987..........899**************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119

         +++Gv+le+pn+++v+ey++ gsL++++++++++e+d++++++wa+++A+Gm+YLh eap

Q: 67    QFYGVILEPPNYGIVTEYASLGSLYDYINSNKSEEMDMDHIMTWATDVAKGMHYLHMEAP  126

         ************************************************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         +k+ihrdLks+nv++ +++ +lkicdFG +r+++++t+ms  gt+ wmaPEv+++ +vse

Q: 127   VKVIHRDLKSRNVVI-AADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSE  185

         ***************.********************************************

S: 180   ksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwne  239

         ++D +SygvvLWe+ltrevP+k+l+ l++a+ v++k++rl+ipsscp+++++L+++cw++

Q: 186   TCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEA  245

         ************************************************************

S: 240   dpekRpsfseivks  253

         d++kRpsf++i+ +

Q: 246   DAKKRPSFKQIIAI  259

         ***********986

Domain Sequence
(FASTA)

QFFENCGGGS FGSVYRAKWI SQDKEVAVKK LLKIEKEAEI LSVLSHRNII QFYGVILEPP 60

NYGIVTEYAS LGSLYDYINS NKSEEMDMDH IMTWATDVAK GMHYLHMEAP VKVIHRDLKS 120

RNVVIAADGV LKICDFGASR FHNHTTHMSL VGTFPWMAPE VIQSLPVSET CDTYSYGVVL 180

WEMLTREVPF KGLEGLQVAW LVVEKNERLT IPSSCPRSFA ELLHQCWEAD AKKRPSFKQI 240

IAI 243

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007257	; P:activation of JUN kinase activity
GO:0007050	; P:cell cycle arrest
GO:0007010	; P:cytoskeleton organization
GO:0000077	; P:DNA damage checkpoint
GO:0043065	; P:positive regulation of apoptotic process
GO:0009314	; P:response to radiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00454

; SAM; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013