EKS-ORC-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph478.44.4E-144635892258
StatusUnreviewed
Ensembl ProteinENSOCUP00000012994
UniProt AccessionG1T8S1;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000015119ENSOCUP00000012994ENSOCUT00000015118
OrganismOryctolagus cuniculus
Functional Description
Protein Length1005
Protein Sequence
(FASTA)
LAPTRGRLPP SLWPATTTSA AATCTLLRWT EMNLLDTSTI HGDWGWLTYP AHGWDSINEV 60
DEAFQPIHTY QVCNVMSPNQ NNWLRTSWVP RDGARRVYAE IKFTLRDCNS MPGVLGTCKE 120
TFNLYYLESD RDLGSSTQES QFLKIDTIAA DESFTGADLG VRRLKLNTEV RGVGPLSKRG 180
FYLAFQDIGA CLAILSLRIY YKKCPAMVRN LAAFSEAVTG ADSSSLVEVR GQCVRHSEER 240
DTPKMYCSAE GEWLVPIGKC VCSAGYEERR DACVACELGF YKSAPGDQLC ARCPPHSHSA 300
APAAQACRCD LSYYRAALDP PSAACTRPPS APVNLISSVN GTSVTLEWAP PLDPGGRSDI 360
TYNAVCRRCP WALSHCEACG SGPRFVPQQT SLVQASLLVA NLLAHMNYSF WIEAVNGVSD 420
LSPEPRRAAV VNITTNQAAP SQVVVIRQER TGQTSVSLLW QEPEQPNGII LEYEIKYYEK 480
DKEMQSYSTL KAVTTSATVS GLKPGTRYVF QVRARTSAGC GRFSQAMEVE TGKPRPRYDT 540
RTIVWICLTL ITGLVVLLVL LICKKRHCGY SKAFQDSDEE KMHYQSGQAP PPVFLPLHHP 600
PGKFPEPQIC AEPHNYEEPG RAGRGFTREI EASRIHIEKI IGSGESGEVC YGWLRVPGQR 660
DVPVAIKALK AGYTERQRRD FLSEASIMGQ FDHPNIIRLE GVVTRGRLAM IVTEYMENGS 720
LDAFLRTHDG QFTIMQLVGM LRGVGAGMRY LSDLGYVHRD LAARNVLVGG DLVCKVSDFG 780
LSRVLEDDPE AAYTTTGGKI PIRWTAPEAI AFRTFSSASD VWSFGVVMWE VLAYGERPYW 840
NMTNRDVISS VEEGYRLPAP MGCPRALHQL MLDCWHKDRA QRPRFSHIVS VLDALIRSPE 900
SLRATATTSR CPPPAFARSC FDLRAGGGGG GGLTVGDWLD SIRMGRYRDH FAAGGYSSLG 960
MVLRMNAQDV RALGITLMGH QKKILGSIQT MRAQLSSTQG PRRHL 1005
Nucleotide Sequence
(FASTA)
CTTGCACCCA CCCGGGGCCG GTTACCACCA TCGTTGTGGC CCGCCACCAC CACCTCTGCC 60
GCTGCCACTT GTACCCTGCT GAGATGGACA GAAATGAACT TGCTGGACAC GTCGACCATC 120
CACGGGGACT GGGGCTGGCT CACGTATCCG GCTCACGGGT GGGACTCCAT CAACGAGGTG 180
GATGAGGCCT TCCAGCCCAT TCACACGTAC CAGGTGTGCA ACGTCATGAG CCCCAACCAG 240
AACAACTGGC TGCGCACAAG CTGGGTGCCC CGCGACGGCG CACGGCGCGT CTACGCCGAG 300
ATCAAGTTCA CCCTGCGCGA CTGCAACAGC ATGCCCGGCG TGCTGGGCAC CTGCAAGGAG 360
ACCTTCAACC TCTACTACCT GGAGTCGGAC CGCGACCTGG GCTCCAGCAC CCAGGAGAGC 420
CAGTTCCTCA AGATCGACAC CATCGCGGCC GACGAGAGCT TCACCGGCGC CGACCTGGGC 480
GTGCGGCGGC TCAAGCTCAA CACCGAGGTG CGCGGCGTGG GCCCCCTCAG CAAGCGCGGC 540
TTCTACCTGG CCTTCCAGGA CATCGGCGCC TGCCTCGCCA TCCTCTCTCT CCGCATCTAC 600
TACAAGAAGT GCCCCGCCAT GGTGCGCAAC CTGGCCGCCT TCTCGGAGGC GGTGACCGGG 660
GCCGACTCCT CCTCGCTGGT GGAGGTCCGG GGCCAGTGTG TGCGGCACTC GGAGGAGCGG 720
GACACGCCCA AGATGTACTG CAGCGCCGAG GGCGAGTGGC TGGTGCCCAT TGGCAAGTGC 780
GTGTGCAGTG CCGGCTACGA GGAGCGGCGG GATGCCTGTG TGGCCTGCGA GCTGGGCTTC 840
TACAAGTCGG CCCCTGGGGA CCAGCTGTGT GCCCGCTGCC CTCCCCACAG CCACTCTGCA 900
GCCCCGGCTG CCCAGGCCTG CCGCTGTGAC CTCAGCTACT ACCGTGCAGC CCTGGACCCG 960
CCGTCTGCAG CCTGCACCCG GCCGCCCTCA GCACCCGTGA ACCTGATCTC CAGTGTGAAT 1020
GGGACGTCCG TGACCCTGGA GTGGGCCCCT CCCCTGGACC CCGGCGGCCG CAGCGACATC 1080
ACCTACAACG CCGTGTGCCG CCGCTGCCCC TGGGCACTGA GCCACTGCGA GGCGTGCGGG 1140
AGCGGCCCCC GCTTCGTGCC CCAGCAGACG AGCCTGGTGC AGGCCAGCCT GCTGGTGGCC 1200
AACCTGCTGG CCCACATGAA CTACTCCTTC TGGATCGAGG CCGTCAATGG CGTGTCCGAC 1260
CTGAGCCCCG AGCCCCGCCG GGCCGCCGTG GTCAACATCA CCACGAACCA GGCAGCCCCG 1320
TCCCAGGTGG TGGTGATCCG GCAGGAGCGC ACAGGGCAGA CTAGCGTGTC GCTGCTGTGG 1380
CAGGAGCCGG AGCAGCCCAA TGGCATCATC CTGGAGTACG AGATCAAGTA CTATGAGAAG 1440
GACAAGGAGA TGCAGAGCTA CTCCACGCTC AAGGCTGTCA CCACCAGTGC CACCGTGTCA 1500
GGCCTCAAGC CGGGCACGCG CTACGTGTTC CAGGTCCGAG CCCGCACCTC GGCAGGCTGC 1560
GGCCGCTTCA GCCAGGCCAT GGAGGTGGAG ACGGGGAAAC CCCGGCCCCG CTACGACACC 1620
CGCACCATCG TCTGGATCTG CCTGACGCTC ATCACTGGCC TGGTCGTGCT CTTGGTCCTG 1680
CTCATCTGCA AGAAGAGGCA CTGCGGCTAC AGCAAGGCCT TCCAGGACTC GGACGAGGAG 1740
AAGATGCATT ACCAGAGCGG GCAGGCGCCC CCACCTGTCT TCCTGCCCCT GCACCACCCC 1800
CCAGGGAAGT TTCCAGAGCC CCAGATCTGC GCAGAACCCC ACAACTACGA GGAGCCGGGC 1860
CGGGCGGGCC GTGGTTTCAC CCGCGAGATT GAGGCCTCCC GGATCCACAT CGAGAAAATC 1920
ATCGGCTCCG GAGAGTCCGG GGAAGTCTGC TACGGGTGGC TACGGGTGCC GGGGCAGCGG 1980
GACGTGCCCG TGGCCATCAA GGCCCTCAAA GCCGGCTACA CGGAGAGGCA GAGGCGGGAC 2040
TTCCTGAGCG AGGCGTCCAT CATGGGCCAG TTCGACCACC CCAACATCAT CCGCCTTGAG 2100
GGTGTCGTCA CACGGGGCCG TCTGGCGATG ATCGTGACCG AGTACATGGA GAATGGCTCT 2160
CTGGACGCCT TCCTGAGGAC CCACGACGGG CAGTTCACCA TCATGCAGCT GGTGGGCATG 2220
CTCCGGGGCG TGGGCGCCGG CATGCGCTAC CTCTCGGACC TGGGCTACGT GCACCGCGAC 2280
CTGGCCGCCC GCAACGTGCT GGTGGGCGGC GACCTGGTCT GCAAAGTGTC TGACTTCGGG 2340
CTCTCGCGCG TGCTGGAGGA CGACCCAGAG GCTGCCTACA CCACCACGGG AGGCAAGATC 2400
CCCATCCGCT GGACAGCCCC TGAGGCCATC GCCTTCCGGA CCTTCTCCTC GGCCAGCGAC 2460
GTGTGGAGCT TCGGGGTGGT CATGTGGGAG GTGCTGGCCT ACGGGGAGCG GCCCTACTGG 2520
AACATGACCA ACCGGGACGT CATCAGCTCG GTGGAGGAGG GGTACCGGCT GCCGGCGCCC 2580
ATGGGTTGCC CCCGCGCCCT GCACCAGCTC ATGCTGGACT GTTGGCACAA GGACCGGGCC 2640
CAGCGGCCCC GCTTCTCCCA CATCGTCAGC GTCCTCGATG CGCTGATCCG GAGTCCCGAG 2700
AGTCTGCGGG CCACGGCCAC TACCAGCAGG TGCCCGCCCC CTGCCTTTGC CCGCAGCTGC 2760
TTTGACCTGC GAGCAGGTGG GGGTGGGGGC GGGGGCCTCA CGGTGGGGGA CTGGCTGGAC 2820
TCCATCCGCA TGGGCCGCTA CCGAGACCAC TTCGCCGCTG GCGGATACTC CTCCCTGGGC 2880
ATGGTGCTGC GGATGAACGC GCAGGACGTG CGTGCCCTGG GCATCACCCT CATGGGCCAC 2940
CAGAAGAAGA TCCTAGGCAG CATCCAGACC ATGAGAGCGC AGCTGAGCAG CACCCAGGGC 3000
CCGCGCCGGC ACCTC 3015
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iek+iG+Ge Gevc G l++pg+r+++vaik+lkag+te+qrrdflseasi+Gqfdhp
Q: 635   IHIEKIIGSGESGEVCYGWLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHP  694
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+++  mivteymeng+ld+flr++dgqft++qlvgmlrG+++gm+ylsd+
Q: 695   NIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDL  754
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarn+lv  +lvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaia+r+
Q: 755   GYVHRDLAARNVLVGGDLVCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAFRT  814
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         f+sasdvws+G+v+wevl+yGerpyw+m+n+dvi+++eegyrlp+pm+cp+al+qlmldc
Q: 815   FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPRALHQLMLDC  874
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         w+kdra+rp+f++ivs+l
Q: 875   WHKDRAQRPRFSHIVSVL  892
         ***************985
Domain Sequence
(FASTA)
IHIEKIIGSG ESGEVCYGWL RVPGQRDVPV AIKALKAGYT ERQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT RGRLAMIVTE YMENGSLDAF LRTHDGQFTI MQLVGMLRGV GAGMRYLSDL 120
GYVHRDLAAR NVLVGGDLVC KVSDFGLSRV LEDDPEAAYT TTGGKIPIRW TAPEAIAFRT 180
FSSASDVWSF GVVMWEVLAY GERPYWNMTN RDVISSVEEG YRLPAPMGCP RALHQLMLDC 240
WHKDRAQRPR FSHIVSVL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00010
EKS-ANC-00008
EKS-BOT-00009
EKS-CAJ-00010
EKS-CAF-00011
EKS-CAP-00008
EKS-DAR-00014
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-GOG-00010
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-MYL-00012
EKS-NOL-00010
EKS-OCP-00001
EKS-ORN-00013
EKS-ORL-00016
EKS-OTG-00011
EKS-PAT-00013
EKS-PES-00012
EKS-POA-00007
EKS-RAN-00010
EKS-SAH-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0043005; C:neuron projection
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0007411; P:axon guidance
GO:0016322; P:neuron remodeling
GO:0043410; P:positive regulation of MAPK cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777; P:protein autophosphorylation
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0006929; P:substrate-dependent cell migration
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013