EKS-ORC-00442

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00442

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	405.7	1.1E-121	55	347	293

Status

Unreviewed

Ensembl Protein

ENSOCUP00000022728

UniProt Accession

G1T8U7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK7

Gene Synonyms/Alias

MAPK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000015154	ENSOCUP00000013022	ENSOCUT00000015150
ENSOCUG00000015154	ENSOCUP00000022728	ENSOCUT00000029915

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

725

Protein Sequence
(FASTA)

MAEPLKEEDG EDGSGEPPGS VKAEPVHTAA SVAAKNLALL KARSFDVTFD VGDEYEIIET 60

IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL RELKILKHFK HDNIIAIKDI 120

LRPTVPYGEF KSVYVVLDLM ESDLHQIIHS SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH 180

RDLKPSNLLV NENCELKIGD FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT 240

QAIDLWSVGC IFGEMLARRQ LFPGKNYVHQ LQLIMTVLGT PSPAVVQAVG AERVRAYIQS 300

LPPRQPVPWE TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY HDPDDEPDCA 360

PPFDFAFDRE ALTRERIKEA IVAEIEDFHA RREGIRQQIR FQPSLQPVAS EPGCPDVEMP 420

SPWAPSGDCA MESPPPVPPP CPGPAPDTID LTLQPPPAAS EPAPPKREGA ISDNTKAALK 480

AALLKSLRSR LRDGPSVPLE APEPRKPVTA LGGPSTDPLA GLVLSDNDRS LLERWTRMAR 540

ACPPPGPGPH PAGPPVPAPV PAALQTATSS SLVAPQSLVT PAGLPGPSAP GVLPYFPAAP 600

PPPDPRAAPP PSTSESPDVN LVTQQLSKSQ VEDPLPPVFS GTPKGSGAGY GVGFDLEEFL 660

NQSFDMGVAD GPQDGQADSA SLSASLLADW LEGHGINPAD IESLQREIQM DSPMLLADLA 720

DLQEP 725

Nucleotide Sequence
(FASTA)

ATGGCCGAGC CCCTTAAAGA GGAAGATGGC GAGGATGGCT CTGGGGAGCC CCCCGGGTCG 60

GTGAAGGCTG AACCCGTCCA CACCGCAGCC TCGGTCGCCG CCAAGAACCT GGCCCTGCTC 120

AAGGCCCGTT CCTTCGATGT GACCTTCGAC GTGGGCGACG AGTACGAGAT CATCGAGACG 180

ATCGGCAATG GGGCCTACGG GGTGGTGTCA TCCGCCCGCC GCCGCCTCAC CGGCCAGCAG 240

GTAGCCATCA AGAAGATCCC TAATGCTTTC GACGTGGTGA CCAATGCCAA ACGGACCCTC 300

AGGGAGCTGA AGATCCTCAA ACACTTCAAA CACGACAACA TCATTGCCAT CAAGGATATC 360

CTGAGGCCCA CGGTGCCCTA TGGCGAGTTC AAATCCGTCT ACGTGGTCCT AGACCTGATG 420

GAGAGCGACC TGCACCAGAT CATCCACTCT TCGCAGCCGC TCACGCTGGA GCACGTGCGC 480

TACTTCCTCT ACCAGCTGCT GCGGGGCCTC AAGTACATGC ACTCGGCCCA GGTCATCCAC 540

CGTGACCTCA AGCCCTCCAA CCTGCTGGTG AACGAGAACT GCGAGCTCAA GATCGGGGAC 600

TTTGGTATGG CCCGTGGCCT GTGCACGTCT CCCGCCGAGC ACCAGTACTT CATGACCGAG 660

TACGTGGCCA CCCGCTGGTA CCGGGCCCCC GAGCTCATGC TCTCCCTGCA CGAGTACACC 720

CAGGCTATCG ACCTCTGGTC CGTGGGCTGC ATCTTTGGCG AGATGCTGGC CCGGCGCCAG 780

CTCTTCCCAG GCAAAAACTA TGTGCATCAG CTACAGCTGA TCATGACGGT GCTGGGCACC 840

CCGTCGCCGG CCGTGGTTCA GGCTGTGGGG GCCGAGAGGG TGCGGGCCTA TATCCAGAGC 900

CTGCCGCCGC GCCAGCCTGT GCCCTGGGAG ACCGTGTACC CGGGTGCTGA CCGTCAGGCC 960

CTCTCCCTGC TGGGCCGCAT GCTGCGTTTC GAGCCCAGTG CCCGCATCTC AGCCGCCGCC 1020

GCCCTGCGCC ATCCCTTCCT GGCCAAGTAC CATGACCCTG ATGATGAGCC TGACTGTGCC 1080

CCGCCCTTTG ACTTTGCCTT TGACCGTGAG GCCCTCACCC GGGAGCGCAT TAAGGAGGCC 1140

ATTGTGGCTG AGATCGAGGA CTTCCATGCC CGGCGAGAGG GCATCCGCCA GCAGATCCGT 1200

TTCCAGCCTT CCCTGCAGCC TGTGGCCAGC GAGCCTGGCT GCCCAGACGT TGAGATGCCC 1260

AGTCCCTGGG CACCCAGCGG GGACTGTGCC ATGGAGTCGC CCCCACCCGT CCCACCGCCG 1320

TGCCCTGGCC CTGCACCTGA CACCATTGAT CTGACCCTGC AGCCACCCCC AGCAGCCAGC 1380

GAACCCGCCC CACCGAAGAG AGAGGGCGCC ATCTCAGACA ACACCAAGGC CGCTCTCAAA 1440

GCCGCCCTGC TCAAGTCCCT GCGGAGCCGC CTCCGAGATG GGCCCAGCGT CCCCCTGGAA 1500

GCTCCTGAGC CTCGAAAGCC GGTGACAGCC CTCGGGGGCC CCTCGACTGA CCCTCTGGCC 1560

GGGCTGGTGC TCAGTGACAA TGACCGCAGT CTGCTGGAGC GCTGGACTCG CATGGCCCGG 1620

GCCTGCCCAC CCCCTGGCCC TGGTCCCCAC CCTGCTGGCC CTCCTGTGCC TGCCCCTGTC 1680

CCAGCTGCAC TCCAGACTGC CACCTCCAGC AGCCTCGTGG CTCCCCAGTC ACTTGTGACA 1740

CCCGCTGGGT TGCCAGGCCC CAGTGCCCCG GGAGTGCTGC CTTACTTCCC AGCCGCCCCT 1800

CCTCCTCCAG ACCCCCGGGC TGCCCCTCCC CCTTCTACAT CAGAGTCGCC CGACGTCAAC 1860

CTAGTGACCC AGCAGCTGTC CAAGTCGCAG GTGGAGGACC CTCTGCCCCC CGTGTTCTCA 1920

GGCACTCCAA AGGGCAGCGG GGCCGGCTAC GGTGTTGGCT TTGACCTGGA GGAATTCCTA 1980

AACCAGTCTT TTGACATGGG TGTGGCTGAC GGGCCCCAGG ACGGCCAGGC AGACTCGGCC 2040

TCCCTGTCGG CCTCCTTGCT CGCGGACTGG CTGGAGGGCC ACGGCATAAA CCCTGCCGAC 2100

ATCGAGTCCC TGCAGCGGGA GATCCAGATG GACTCCCCGA TGCTGCTGGC TGACTTGGCT 2160

GACCTCCAGG AGCCCTGA 2178

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         ye ++++g+Gaygvv sa ++ t+++vaikk+ ++f+  t+akrtlRElk+lk++kh+Ni

Q: 55    YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI  114

         77899*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i + d+++p+  + e+k+vY+v +lme+dL+++i+s+  l+ eh++++lyq+lrglky+H

Q: 115   IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSqPLTLEHVRYFLYQLLRGLKYMH  174

         ***********************************9889*********************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk...lteyvatrwYraPeill  176

         sa+viHrDlKPsNllvne+celki dFG+ar   ++  ++   +teyvatrwYraPe++l

Q: 175   SAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHqyfMTEYVATRWYRAPELML  234

         *******************************955444333489*****************

S: 177   slkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseea  236

         sl+eyt+a+D+WsvGCI++E+l++++lfpgk++++ql++i++vlgtps  +++++  e++

Q: 235   SLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMTVLGTPSPAVVQAVGAERV  294

         ************************************************************

S: 237   rnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         r+yi+slp+++  ++e+++p a+++al Ll ++L ++p+ Ris++ aL+hp+l

Q: 295   RAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL  347

         ***************************************************97

Domain Sequence
(FASTA)

YEIIETIGNG AYGVVSSARR RLTGQQVAIK KIPNAFDVVT NAKRTLRELK ILKHFKHDNI 60

IAIKDILRPT VPYGEFKSVY VVLDLMESDL HQIIHSSQPL TLEHVRYFLY QLLRGLKYMH 120

SAQVIHRDLK PSNLLVNENC ELKIGDFGMA RGLCTSPAEH QYFMTEYVAT RWYRAPELML 180

SLHEYTQAID LWSVGCIFGE MLARRQLFPG KNYVHQLQLI MTVLGTPSPA VVQAVGAERV 240

RAYIQSLPPR QPVPWETVYP GADRQALSLL GRMLRFEPSA RISAAAALRH PFL 293

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0006915	; P:apoptotic process
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0000165	; P:MAPK cascade
GO:0043066	; P:negative regulation of apoptotic process
GO:0034115	; P:negative regulation of heterotypic cell-cell adhesion
GO:0051534	; P:negative regulation of NFAT protein import into nucleus
GO:0060761	; P:negative regulation of response to cytokine stimulus
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0051247	; P:positive regulation of protein metabolic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0045765	; P:regulation of angiogenesis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013