EKS-ORC-00364
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00364
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11364.64.2E-109482738257
StatusUnreviewed
Ensembl ProteinENSOCUP00000013271
UniProt AccessionG1T9G5;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000015434ENSOCUP00000013271ENSOCUT00000015446
OrganismOryctolagus cuniculus
Functional Description
Protein Length1175
Protein Sequence
(FASTA)
MCTGNYTFVP YMVTPHNKVY CCDSSLMKGL TELMQPNLEL LLGPICLPLV DRFIRLLKVA 60
QASSSQYFRE SILSDIRKAR NLYTGKELAA ELARIRQRVD NIEVLTADIV INLLLSYRDI 120
QDYDSIVQLV ETLEKLPTFD LASHHHVKFH YAFALNRINF KDDNFFNIEI LEPVVREEGK 180
NNLDYCELSR VHKVQRLTSI YNDTSKFCNG HSMFKKAFES EPTLQSGINY AVLLLAAGHQ 240
FESSFELRKV GVKISSLLGK KGNLENLQSY WEVGFFLGAS VLANDHMRVI QASEKLFKLK 300
TPACYLKTNV PQVYVETILI YKHFVKLTTE QPVAKQELVD FWMDFLVEAT KTDVTVVRFP 360
VLILEPTKIY QPSYLSINNE VEEKTISIWH VLPDDKKGIH EWNFSAASVR GVSISKFEER 420
CCFLYVLHNS DDFQIYFCTE LHCKKFFEMV NTITEEKGRG AEEGDCEGDS LEYDYEYDEN 480
GDRVVLGKGT YGIVYAGRDL SNQVRIAIKE IPERDSRYSQ PLHEEIALHK HLKHKNIVQY 540
LGSFSENGFI KIFMEQVPGG SLSALLRSKW GPLKDNEQTI GFYTKQILEG LKYLHDNQIV 600
HRDIKGDNVL INTYSGVLKI SDFGTSKRLA GINPCTETFT GTLQYMAPEI IDKGPRGYGK 660
AADIWSVGCT IIEMATGKPP FYELGEPQAA MFKVGMFKVH PEIPESMSAE AKAFILKCFE 720
PDPDKRACAN DLLVDEFLKV SSKKKKTQPK LSALSAGSNE YLRSISLPVP VLVEDTSSSS 780
EYGSVSPDTE LKADPFSFKT RAKSCGEKDV KGIRTLFLGI PDENFEDHSA PPSPEEKDSG 840
FFLLRKDSER RATLHRILTE DQDKIVRNLM ESLAQGAEEP KLKWEHITTL IASLREFVRS 900
TDRKIIATTL SKLKLELDFD SHGISQVQVV LFGFQDAVNK VLRNHNIKPH WMFALDSIIR 960
KAVQTAITIL VPELRPHFSL ASESDTADPE DLDVEDDHEE QPSNQTVRRP QAATEDAVAT 1020
SGVSTLSSTV SHDSQSAHRS LTLQLGRMKI ETNSRLLEEL VQKEKELQAL LLRAIEEKDQ 1080
EIKHLKLKSQ PIDIPGLPAC HLNSPGTDTK DSELTDWLRE NGADEDTISR FLAEEYTLVD 1140
VLYSVTREDL KCLRLRGGML CSLWKAIIDF REKHT 1175
Nucleotide Sequence
(FASTA)
ATGTGCACTG GGAACTACAC CTTTGTCCCT TACATGGTGA CACCACACAA CAAGGTCTAC 60
TGCTGTGACA GCAGCCTCAT GAAGGGCTTG ACTGAGCTCA TGCAACCCAA CTTGGAGCTG 120
CTTCTCGGAC CCATCTGCTT ACCTCTTGTG GATCGTTTCA TTCGACTTTT GAAGGTGGCA 180
CAGGCAAGTT CCAGCCAATA TTTCCGTGAA TCTATACTCA GCGATATCAG GAAAGCTCGA 240
AATTTATACA CTGGTAAAGA ATTGGCAGCT GAATTGGCAA GAATTCGGCA ACGAGTAGAT 300
AATATTGAAG TCTTGACAGC AGATATTGTG ATCAACCTGT TACTTTCCTA CAGAGATATC 360
CAGGATTATG ATTCTATTGT GCAGCTGGTG GAAACTTTAG AAAAATTGCC AACCTTTGAT 420
TTGGCCTCTC ATCACCATGT GAAGTTTCAT TATGCATTTG CACTGAACAG AATAAATTTT 480
AAAGATGATA ATTTTTTTAA CATTGAAATA TTGGAGCCTG TGGTAAGAGA GGAAGGCAAA 540
AACAATTTAG ACTATTGTGA GCTTTCAAGA GTACATAAAG TTCAGAGGCT GACATCTATA 600
TACAATGACA CTTCAAAATT CTGTAATGGA CATTCTATGT TCAAAAAGGC ATTTGAGTCT 660
GAGCCAACAC TGCAGTCGGG AATTAATTAT GCTGTCCTCC TCCTGGCAGC CGGTCACCAG 720
TTTGAATCTT CCTTTGAGCT TCGGAAAGTT GGGGTGAAGA TAAGTAGCCT TCTCGGTAAA 780
AAAGGAAACT TGGAAAATCT CCAGAGCTAC TGGGAAGTTG GGTTTTTTCT AGGGGCCAGT 840
GTCCTGGCCA ACGACCACAT GCGAGTCATT CAAGCATCAG AAAAGCTTTT TAAACTGAAG 900
ACACCAGCAT GCTATTTAAA AACAAATGTA CCTCAAGTCT ATGTAGAGAC AATTTTGATA 960
TATAAGCATT TTGTGAAACT GACCACAGAG CAGCCTGTGG CCAAGCAAGA GCTCGTGGAC 1020
TTTTGGATGG ATTTCTTGGT GGAGGCCACA AAAACAGATG TTACTGTTGT TAGGTTTCCA 1080
GTATTAATAT TAGAACCAAC CAAAATCTAC CAGCCTTCTT ATTTGTCTAT CAACAATGAA 1140
GTCGAAGAAA AAACAATATC TATCTGGCAT GTACTTCCTG ATGACAAGAA AGGCATTCAC 1200
GAGTGGAACT TCAGTGCTGC TTCTGTCAGG GGAGTGAGTA TTTCTAAATT TGAAGAACGA 1260
TGCTGCTTTC TGTATGTGCT TCACAATTCT GATGATTTCC AAATCTATTT CTGTACAGAG 1320
CTTCACTGTA AAAAGTTTTT TGAAATGGTG AACACCATCA CTGAGGAGAA GGGGAGAGGT 1380
GCAGAGGAAG GGGACTGTGA AGGTGACTCT CTGGAGTATG ACTACGAATA TGATGAAAAT 1440
GGAGACAGAG TTGTTTTGGG CAAAGGCACC TATGGAATCG TCTATGCAGG TCGAGACCTG 1500
AGCAACCAAG TCAGAATTGC TATTAAGGAA ATCCCAGAGA GAGATAGCAG ATACTCTCAG 1560
CCCCTACATG AAGAAATAGC ATTGCATAAG CACCTGAAGC ACAAAAATAT TGTCCAGTAT 1620
CTGGGCTCTT TCAGTGAAAA CGGTTTTATT AAAATCTTCA TGGAGCAGGT CCCAGGAGGA 1680
AGTCTTTCTG CTCTTCTTCG TTCCAAATGG GGCCCCTTAA AAGACAATGA GCAAACAATT 1740
GGCTTTTATA CAAAGCAAAT ACTAGAAGGA TTAAAATACC TCCATGACAA TCAAATAGTA 1800
CATCGGGATA TAAAGGGTGA CAACGTGTTG ATTAACACCT ATAGTGGGGT GCTCAAGATC 1860
TCTGACTTCG GAACATCAAA GAGGCTTGCT GGCATTAACC CGTGCACTGA AACTTTCACT 1920
GGTACCCTTC AGTACATGGC ACCAGAAATC ATAGACAAGG GACCTCGTGG CTACGGGAAG 1980
GCTGCAGACA TCTGGTCTGT GGGCTGCACG ATCATCGAGA TGGCCACCGG AAAGCCCCCG 2040
TTTTATGAGC TGGGAGAACC ACAGGCAGCT ATGTTCAAGG TGGGAATGTT TAAAGTCCAC 2100
CCCGAGATCC CGGAGTCCAT GTCTGCAGAG GCGAAGGCGT TCATCCTGAA ATGTTTTGAA 2160
CCAGACCCTG ACAAGAGAGC TTGTGCTAAT GACTTGCTTG TTGATGAGTT CTTAAAAGTT 2220
TCAAGCAAAA AGAAAAAGAC ACAACCTAAG CTTTCAGCTC TTTCAGCTGG ATCAAATGAG 2280
TATCTCAGGA GCATCTCCTT GCCAGTGCCC GTCCTGGTGG AGGACACGAG CAGCAGCAGC 2340
GAGTACGGCT CTGTTTCCCC CGACACTGAG CTAAAGGCGG ACCCCTTCTC CTTCAAAACC 2400
AGAGCCAAAT CCTGCGGCGA GAAAGATGTC AAAGGAATAC GGACCCTCTT CCTGGGCATT 2460
CCAGATGAGA ACTTCGAGGA CCACAGCGCG CCCCCTTCCC CCGAGGAGAA GGACTCTGGG 2520
TTCTTCCTGC TGCGGAAGGA CAGCGAGCGC CGCGCCACGC TGCACAGGAT CCTGACTGAA 2580
GACCAAGACA AAATTGTGAG AAACCTGATG GAATCTCTAG CTCAGGGGGC TGAAGAACCT 2640
AAACTAAAAT GGGAGCACAT CACAACTCTC ATTGCAAGCC TCAGAGAATT TGTGAGATCC 2700
ACTGACCGAA AAATTATAGC CACTACACTG TCTAAGCTGA AATTAGAGCT GGACTTCGAC 2760
AGCCATGGTA TCAGCCAAGT CCAGGTGGTG CTCTTTGGCT TCCAGGATGC TGTCAATAAA 2820
GTTCTTCGGA ATCATAATAT CAAGCCACAC TGGATGTTCG CCTTGGACAG TATCATCCGA 2880
AAGGCAGTAC AGACAGCTAT TACCATTCTT GTTCCAGAAC TAAGGCCACA TTTTAGCCTT 2940
GCATCTGAAA GTGACACTGC TGACCCAGAG GACTTGGATG TAGAAGATGA CCACGAGGAA 3000
CAGCCATCAA ATCAAACTGT CCGAAGACCA CAGGCTGCCA CTGAAGATGC TGTGGCTACC 3060
TCAGGGGTGA GCACGCTCAG CTCTACTGTG TCCCACGATT CCCAGAGCGC TCACCGATCA 3120
CTCACCTTGC AGCTTGGAAG GATGAAAATA GAAACAAATA GCAGATTACT GGAAGAATTG 3180
GTTCAGAAAG AGAAAGAATT GCAAGCACTC CTTCTTCGAG CCATTGAAGA AAAAGACCAG 3240
GAAATTAAGC ACCTGAAGCT TAAGTCCCAA CCAATAGATA TTCCTGGGTT GCCTGCCTGT 3300
CATCTAAATT CTCCTGGCAC AGATACTAAA GATTCTGAAC TTACTGACTG GCTGAGAGAA 3360
AACGGAGCTG ATGAAGACAC TATAAGTCGG TTTTTGGCTG AGGAGTATAC ACTAGTGGAT 3420
GTTCTCTACT CTGTTACACG CGAAGATTTA AAATGCCTGA GACTAAGGGG AGGGATGCTG 3480
TGCTCACTAT GGAAGGCCAT CATCGACTTC CGAGAAAAAC ACACTTGA 3528
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 482   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  536
         5789**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 537   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  596
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k
Q: 597   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  653
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWs+gc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+
Q: 654   GPRGYGKAADIWSVGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  713
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         f+ kc+e dp+kr++a++LL +efl
Q: 714   FILKCFEPDPDKRACANDLLVDEFL  738
         **********************996
Domain Sequence
(FASTA)
DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180
ADIWSVGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240
DPDKRACAND LLVDEFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00361
EKS-ANC-00378
EKS-BOT-00387
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-EQC-00380
EKS-FEC-00376
EKS-GAG-00327
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-ICT-00372
EKS-LAC-00401
EKS-LOA-00395
EKS-MAM-00386
EKS-MEG-00320
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-NOL-00355
EKS-ORN-00500
EKS-ORA-00336
EKS-ORL-00460
EKS-OTG-00390
EKS-PES-00346
EKS-POA-00379
EKS-RAN-00402
EKS-SAH-00359
EKS-SUS-00345
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-XET-00502
EKS-XIM-00493
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013