EKS-ORC-00184

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00184

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	531.0	6.8E-160	365	638	274

Status

Unreviewed

Ensembl Protein

ENSOCUP00000018140

UniProt Accession

G1TA17;

Protein Name

Protein Synonyms/Alias

Gene Name

MAST4

Gene Synonyms/Alias

MAST4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000015705	ENSOCUP00000013497	ENSOCUT00000015712
ENSOCUG00000015705	ENSOCUP00000018140	ENSOCUT00000030311

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

706

Protein Sequence
(FASTA)

MDESSILRRR GLQKELSLPR RGSLCRTSNR KSLIGNGQSP ALPRPHSPLS AHAAGNSPQD 60

SPRNFSPSAS AHFSFARRTD GRRWSLASLP SSGYGTNTPS STVSSSCSSQ EKLHQLPYQP 120

TPDELHFLSK HFCTTESIAA ENRCRNTPMR PRSRSLSPGR SPACCDHEII MMNHVYKERF 180

PKATAQMEER LKEIITSYSP DNVLPLADGV LSFTHHQIIE LARDCLDKSH QGLITSRYFL 240

ELQHKLDKLL QEAHDRSESG ELAFIKQLVR KILIVIARPA RLLECLEFDP EEFYYLLEAA 300

EGHAKEGQGI KTDIPRYIIS QLGLNKDPLE GECPAWTNVS LAQAHFFKSS NASLKLRRKP 360

RESDFETIKL ISNGAYGAVY FVRHKESRQR FAMKKINKQN LILRNQIQQA FVERDILTFA 420

ENPFVVSMYC SFETRRHLCM VMEYVEGGDC ATLMKNMGPL PVDMARMYFA ETVLALEYLH 480

NYGIVHRDLK PDNLLVTSMG HIKLTDFGLS KVGLMSMTTN LYEGHIEKDA REFLDKQVCG 540

TPEYIAPEVI LRQGYGKPVD WWAMGIILYE FLVGCVPFFG DTPEELFGQV ISDEINWPEK 600

DEAPPPDAQD LITLLLRQNP LERLGTGGAY EVKQHRFFRS LDWNSLLRQK AEFIPQLESE 660

DDTSYFDTRS EKYHHMETEE EDDTNDEDFT VEIRQFSSCS HRFSKV 706

Nucleotide Sequence
(FASTA)

ATGGATGAGT CCAGCATTCT AAGACGGAGA GGGCTGCAGA AGGAGCTGAG TTTGCCCCGA 60

AGAGGAAGTC TTTGCCGAAC AAGCAACCGG AAAAGCTTGA TAGGCAATGG ACAGTCACCA 120

GCATTGCCTC GACCGCACTC ACCTCTCTCT GCTCATGCAG CAGGAAACAG CCCTCAAGAT 180

AGTCCAAGGA ATTTCTCCCC CAGTGCCTCA GCCCACTTTT CATTTGCACG GAGGACTGAC 240

GGACGCCGCT GGTCACTGGC TTCTCTCCCC TCCTCTGGCT ATGGGACCAA CACCCCCAGC 300

TCCACCGTCT CTTCATCCTG TTCCTCCCAG GAGAAGTTAC ATCAGTTGCC ATACCAACCG 360

ACGCCAGATG AATTGCACTT CTTATCGAAA CATTTTTGTA CTACCGAAAG CATTGCCGCT 420

GAGAACAGAT GCAGGAACAC CCCGATGCGG CCCCGATCCC GAAGTCTGAG CCCCGGACGT 480

TCTCCTGCCT GCTGCGACCA TGAAATAATT ATGATGAACC ATGTCTACAA AGAAAGGTTC 540

CCAAAGGCTA CGGCTCAGAT GGAAGAGCGC CTGAAGGAGA TCATCACCAG CTACTCTCCC 600

GACAACGTCC TTCCCCTCGC AGACGGAGTG CTGAGCTTCA CTCACCACCA GATTATTGAG 660

CTGGCCCGGG ACTGCTTGGA TAAATCCCAC CAGGGTCTCA TCACCTCCCG ATACTTCCTG 720

GAATTGCAGC ACAAGTTAGA TAAGTTGCTA CAGGAGGCTC ATGATCGCTC AGAGAGTGGA 780

GAGTTGGCCT TTATTAAACA GCTCGTCCGG AAGATCCTGA TCGTCATTGC CCGCCCTGCT 840

CGGTTACTGG AGTGCCTGGA ATTTGATCCT GAAGAATTTT ATTATTTATT GGAAGCAGCA 900

GAAGGCCATG CAAAGGAAGG CCAGGGGATT AAAACTGACA TTCCCAGGTA CATCATCAGC 960

CAACTGGGGC TGAATAAGGA TCCTCTGGAA GGTGAGTGCC CTGCTTGGAC CAATGTGTCA 1020

CTCGCTCAGG CCCACTTTTT CAAGAGCTCT AATGCATCCC TGAAACTTCG AAGGAAACCT 1080

CGAGAAAGTG ATTTTGAAAC AATCAAGTTG ATTAGCAATG GGGCCTATGG GGCAGTTTAC 1140

TTTGTTCGGC ATAAGGAATC CCGGCAGAGG TTCGCCATGA AGAAGATTAA CAAACAGAAC 1200

CTCATCCTTC GAAACCAGAT CCAGCAGGCC TTTGTGGAAC GGGACATCTT GACGTTTGCG 1260

GAGAACCCCT TTGTGGTCAG CATGTATTGC TCCTTTGAGA CCCGGCGCCA CTTGTGCATG 1320

GTCATGGAAT ACGTGGAAGG TGGAGATTGT GCTACCTTGA TGAAAAACAT GGGTCCTCTT 1380

CCTGTTGATA TGGCCAGAAT GTATTTTGCT GAGACAGTCT TGGCTTTGGA ATACCTACAT 1440

AATTATGGCA TTGTACACAG AGATTTGAAA CCAGACAACT TGTTGGTCAC CTCCATGGGG 1500

CACATAAAGC TGACAGATTT TGGATTGTCT AAAGTGGGAC TAATGAGCAT GACCACCAAT 1560

CTTTATGAAG GTCATATTGA GAAGGATGCT CGAGAGTTCC TAGATAAACA GGTCTGTGGC 1620

ACACCTGAAT ACATTGCACC AGAAGTGATT CTAAGGCAGG GCTATGGGAA GCCGGTGGAC 1680

TGGTGGGCCA TGGGAATTAT CCTCTATGAA TTTCTGGTTG GATGCGTGCC ATTCTTTGGG 1740

GATACGCCAG AAGAGCTATT TGGACAAGTC ATCAGTGATG AGATCAACTG GCCTGAAAAG 1800

GATGAGGCCC CACCGCCGGA CGCCCAGGAT CTGATCACCC TGCTTCTCAG GCAGAACCCC 1860

CTGGAGAGGC TGGGAACAGG TGGCGCGTAC GAAGTCAAGC AACATCGATT CTTCCGTTCT 1920

TTGGACTGGA ACAGTTTGCT GAGACAGAAG GCAGAATTTA TTCCCCAACT GGAATCCGAG 1980

GACGACACTA GCTATTTTGA TACTCGGTCA GAGAAGTATC ATCATATGGA AACTGAAGAG 2040

GAGGATGACA CCAATGATGA AGACTTCACC GTGGAGATTA GGCAGTTTTC CTCATGTTCG 2100

CACAGGTTTT CAAAAGTG 2118

Domain Profile

S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60

         fe+iklis+GayGavy+vrhke+r+rfa+kki+kq+lil+nq+qq+f+erdil++aenpf

Q: 365   FETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF  424

         99**********************************************************

S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120

         vvs+y+s+etrr+l++vmeyveGGd+++l+kn+G+l+v+mar+y+ae+vlaleylh+yGi

Q: 425   VVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGI  484

         ************************************************************

S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180

         vhrdlkPdnll+ts+GhikltdfGlskvglms+ttnlyeg+i+kdarefldkqvcgtPey

Q: 485   VHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEY  544

         ************************************************************

S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240

         iaPevilrqgygkpvdwwa+giilyeflvg+vpffgdtpeelf+qv+sdei+wPekdea

Q: 545   IAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAP  604

         ************************************************************

S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274

         +++a++li+ ll++nP erlgtg+a+evkqh+f+

Q: 605   PPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFF  638

         ********************************97

Domain Sequence
(FASTA)

FETIKLISNG AYGAVYFVRH KESRQRFAMK KINKQNLILR NQIQQAFVER DILTFAENPF 60

VVSMYCSFET RRHLCMVMEY VEGGDCATLM KNMGPLPVDM ARMYFAETVL ALEYLHNYGI 120

VHRDLKPDNL LVTSMGHIKL TDFGLSKVGL MSMTTNLYEG HIEKDAREFL DKQVCGTPEY 180

IAPEVILRQG YGKPVDWWAM GIILYEFLVG CVPFFGDTPE ELFGQVISDE INWPEKDEAP 240

PPDAQDLITL LLRQNPLERL GTGGAYEVKQ HRFF 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR015022	; MA_Ser/Thr_Kinase_dom.
IPR023142	; MAST_pre-PK_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08926	; DUF1908; 1.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00228	; PDZ; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013