EPS-ORC-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	210.2	5.3E-62	949	1194	246

Status

Unreviewed

Ensembl Protein

ENSOCUP00000013534

UniProt Accession

G1TA51;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1

Gene Synonyms/Alias

PHLPP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000015736	ENSOCUP00000013534	ENSOCUT00000015755

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1452

Protein Sequence
(FASTA)

KKGRRGARSG AGAPQTTAGG AAAVPGAGHG ANSLLLRRGR LKRNLSAAAA AAVSSCSASA 60

SLCTRSLDRK TLLLKHRQVM PLQPSDRDWV RQQLRRGCLH VFDRHTASAY LRPVLCTLDT 120

TAGEVAARLL QLGHKGGGVL KVLGQGPGPA GAEASPADLP LTAGGPGPDC NRPQDMTGKR 180

GLSLVQTLDR PRCTARSSAR PREAPRASDI AGGAAPEGPR PEEAAAAAAE APGGAPSKVP 240

PPPTLYVQLH GETTRRLEAD EKPLQIQNDY LFQLGFGELW RVQEEGMDSE IGCLIRFYVG 300

KPHSTSSSER IQLSGMYNVR KGKMQLPVNR WTRRQVILCG TCLIVSSVKD SLTGKMHVLP 360

LIGGKVEEVK KHQHCLAFSS SGPQSQTYYI CFDTFTEYLR WLRQVSKVAS QRISSVDLSC 420

CSLEHLPVNL FYSQDLTHLN LKQNFLRQNS SLSSTRGLNE LQRFTKLKSL NLSNNHLGDF 480

PLAVCSIPTL AELNVSCNAL QAVPAAVGAM HNLQTFLLDG NFLQSLPAEL ENMHQLSYLG 540

LSFNEFTDIP EVLEKLTAVD KLCMSGNCME TLRLQALRKM PHIKHVDLRL NVIREVIADA 600

VDFVQHVTQL DLRDNKLSEL DAMIFNNIEV LHCERNQLVT LNICGYFLKA LYASSNELVQ 660

IDVYPVPNYL SYMDVSRNRL ENVPEWVCES RKLEVLDIGH NQICELPARL FCNSSLRKLL 720

AGHNQLARLP ERLERTLVEV LDVQHNQLLE LPPNLLMKAD SLRFLNASAN KLETLPPATL 780

CEETSSILQE LYLTNNNLTD KCVPLLTGHP HLKILHMAYN RLQSFPASKM AKLEELEEID 840

ISGNKLKAIP TTIMNCRRMH TVIAHSNCIE VFPEVMQLPE IKCVDLSCNE LSEVTLPENL 900

PPKLQELDLT GNPRLSLDHK TLELLNNIRC FKIDQPSAGD ASGAPAVWSH GYTEASGVKN 960

KLCVAALSVN NFCDNREALY GVFDGDRNVE VPYLLQCTMS DILAEELQKT KNEEEYMVNT 1020

FIVMQRKLGT AGQKLGGSAV LCHIKHDPVD PGGSFTLTSA NVGKCQTVLC RNGKPLPLSR 1080

SYVMSCEEEL KRIKQHKAII TEDGKVNGVT ESTRILGYTF LHPSVVPRPH VQSVLLTPQD 1140

EFFILGSKGL WDSLSIQEAV EAVRNVPDAL AAAKKLCTLA QSYGCHDSIS AVVVQLSVTE 1200

DSFCCCELSA GGSVPPPSPG IFPPSVNMVI KDRPPDGLGV PSSSSGMASE ISSELSTSEM 1260

SSEVGSTASD EPPNGALNES SPAYPSEQRC MLHPVCLSNS FQRQLSSATF SSAFSDNGLD 1320

SDDEEPIEGV FSNGSRVEVE VDIHCSRAKE KEKQQQVLQV PAEASDEGIV ISANEDEPGL 1380

PRKADFSAVG TIGRRRANGS VAPQERSHNV IEVAAEAPLR KPGGYFAAPA QPDPDDQFII 1440

PPELEEEVKE IM 1452

Nucleotide Sequence
(FASTA)

AAGAAAGGGC GCCGGGGCGC AAGAAGCGGA GCGGGGGCGC CTCAGACCAC GGCCGGCGGG 60

GCAGCCGCGG TTCCGGGGGC CGGCCACGGC GCTAACTCGC TGCTGCTGAG GAGAGGGCGG 120

CTCAAGAGGA ATCTGTCCGC CGCTGCCGCG GCTGCCGTCT CGTCCTGCTC GGCCTCGGCG 180

TCGCTGTGCA CCCGGAGCTT GGACAGGAAG ACGCTGCTGC TGAAGCACCG GCAGGTGATG 240

CCGCTGCAGC CGTCGGACCG GGACTGGGTG AGGCAGCAGC TCCGGCGGGG CTGCCTGCAC 300

GTCTTCGACC GCCACACGGC CTCCGCCTAC CTGCGCCCGG TGCTCTGCAC GCTGGACACC 360

ACGGCCGGGG AGGTGGCCGC CCGCCTGCTG CAGCTCGGCC ACAAAGGCGG CGGCGTGCTG 420

AAGGTTCTGG GCCAGGGGCC CGGACCCGCT GGCGCCGAGG CTTCCCCCGC CGACCTGCCC 480

CTAACGGCCG GCGGCCCGGG CCCTGATTGT AATCGTCCAC AAGACATGAC GGGGAAAAGA 540

GGTCTTTCCT TGGTTCAAAC GCTAGACCGA CCGAGATGCA CTGCCAGATC GAGCGCTCGG 600

CCGAGAGAAG CACCTAGGGC CTCGGACATC GCAGGCGGCG CTGCCCCCGA GGGGCCTCGG 660

CCGGAGGAGG CGGCGGCGGC GGCGGCCGAG GCCCCAGGAG GCGCCCCGTC GAAGGTGCCC 720

CCGCCGCCCA CCCTCTACGT GCAGCTCCAC GGAGAGACCA CCCGGCGCTT GGAGGCGGAC 780

GAGAAGCCGC TGCAGATCCA GAATGACTAC CTCTTCCAGC TGGGATTCGG GGAGCTGTGG 840

CGGGTGCAGG AGGAGGGCAT GGACTCGGAG ATCGGCTGTC TCATCCGCTT CTATGTAGGG 900

AAGCCTCACA GTACCAGCAG CTCTGAACGG ATTCAGCTCT CAGGAATGTA TAATGTCCGG 960

AAAGGCAAAA TGCAGCTGCC AGTGAACCGA TGGACACGAC GTCAAGTTAT CCTGTGTGGG 1020

ACCTGCTTGA TAGTATCCTC TGTGAAAGAC AGCCTAACCG GAAAGATGCA TGTTCTGCCA 1080

CTGATAGGTG GAAAAGTAGA AGAAGTGAAA AAGCACCAGC ACTGTTTAGC ATTTAGCTCC 1140

TCTGGACCCC AAAGCCAGAC GTACTACATT TGCTTTGATA CTTTCACAGA GTATTTAAGG 1200

TGGCTGCGAC AAGTCTCCAA GGTCGCATCC CAGCGCATTA GCTCCGTGGA CCTCTCGTGC 1260

TGTAGCCTGG AACACTTGCC TGTCAACCTC TTCTACAGCC AAGACCTCAC TCATCTCAAT 1320

TTAAAACAAA ACTTCCTAAG GCAGAATTCC AGCCTCTCAT CTACCAGGGG ACTCAACGAA 1380

CTGCAAAGGT TCACCAAGTT GAAGAGTCTT AACCTTTCCA ATAATCATTT AGGAGACTTC 1440

CCACTAGCAG TCTGCAGTAT TCCAACCCTG GCAGAGCTGA ATGTGTCCTG CAATGCCCTG 1500

CAAGCCGTCC CAGCAGCTGT CGGAGCTATG CACAATTTAC AGACATTTTT GTTAGATGGA 1560

AACTTTCTCC AGTCCCTTCC TGCTGAGTTG GAAAACATGC ACCAGCTTAG TTATCTTGGT 1620

CTCTCATTCA ACGAATTTAC TGACATTCCA GAGGTATTGG AGAAACTGAC TGCTGTGGAT 1680

AAACTTTGTA TGTCTGGAAA CTGTATGGAG ACTCTTAGGC TACAGGCTTT AAGAAAAATG 1740

CCTCACATTA AGCATGTGGA TCTAAGATTG AACGTAATTC GGGAGGTAAT AGCGGATGCA 1800

GTGGACTTTG TGCAGCACGT CACTCAGCTT GACCTGAGAG ACAATAAGCT GAGCGAACTG 1860

GATGCCATGA TTTTCAACAA CATTGAAGTT TTACACTGTG AAAGGAATCA GTTGGTGACA 1920

TTAAACATCT GTGGCTATTT CCTAAAAGCA CTCTATGCCT CTTCCAATGA ACTTGTCCAA 1980

ATTGATGTTT ACCCAGTTCC GAATTATCTG TCCTACATGG ATGTTTCAAG GAATCGCTTA 2040

GAAAATGTGC CTGAATGGGT ATGTGAAAGC CGAAAGCTAG AAGTTTTGGA TATTGGCCAT 2100

AATCAAATAT GTGAGCTTCC TGCCCGCTTA TTTTGTAATA GTAGCCTCCG GAAACTGCTG 2160

GCAGGACACA ACCAATTGGC AAGGCTGCCT GAAAGACTTG AAAGAACCTT GGTGGAGGTC 2220

TTGGACGTGC AACACAACCA GCTCCTTGAG CTACCGCCAA ACCTCCTGAT GAAGGCAGAC 2280

AGCCTGAGAT TCCTGAATGC ATCTGCAAAC AAACTGGAGA CCCTTCCTCC AGCCACACTT 2340

TGTGAAGAGA CGAGCAGTAT CTTACAAGAA TTGTATTTGA CAAACAACAA CCTCACAGAC 2400

AAATGTGTGC CCTTGTTAAC AGGGCATCCC CATCTGAAGA TCCTTCACAT GGCTTATAAC 2460

CGACTTCAGA GTTTTCCAGC CAGTAAAATG GCAAAACTGG AGGAACTTGA GGAAATTGAT 2520

ATCAGTGGGA ATAAACTGAA AGCCATTCCG ACAACTATTA TGAATTGTAG GCGCATGCAC 2580

ACCGTGATTG CTCACTCCAA TTGCATTGAA GTCTTCCCTG AAGTTATGCA GCTCCCAGAA 2640

ATCAAGTGTG TGGACCTGAG CTGTAATGAG CTAAGTGAAG TCACTTTACC AGAGAACCTG 2700

CCTCCTAAAC TGCAGGAGCT GGACCTGACT GGGAACCCTC GCCTTAGCCT GGATCACAAG 2760

ACGCTGGAAC TGCTGAATAA CATCCGCTGT TTCAAGATTG ACCAGCCTTC GGCTGGAGAT 2820

GCATCTGGAG CCCCAGCTGT GTGGAGTCAT GGCTACACCG AAGCTTCGGG AGTGAAAAAC 2880

AAGTTGTGTG TGGCAGCCCT GTCAGTGAAT AACTTCTGTG ACAACCGGGA GGCCCTGTAC 2940

GGTGTGTTTG ATGGAGACCG GAACGTGGAG GTGCCCTACC TTCTCCAGTG TACCATGAGT 3000

GACATTTTGG CTGAAGAGCT ACAGAAAACA AAAAATGAAG AAGAGTACAT GGTCAATACG 3060

TTCATTGTTA TGCAAAGGAA ACTTGGAACT GCTGGGCAGA AGCTCGGAGG TTCTGCTGTC 3120

CTTTGCCATA TCAAGCATGA CCCTGTGGAC CCAGGTGGTT CCTTCACCTT GACCTCTGCC 3180

AATGTGGGCA AGTGCCAAAC AGTGCTCTGT CGCAATGGGA AGCCGCTGCC TCTGTCCAGA 3240

TCTTACGTCA TGAGCTGTGA GGAAGAACTG AAGAGGATTA AACAGCACAA GGCCATCATC 3300

ACTGAGGACG GCAAGGTGAA CGGAGTGACT GAGTCCACAC GCATCCTGGG CTACACCTTC 3360

CTCCACCCCA GTGTGGTGCC TCGCCCCCAC GTGCAGTCTG TGCTGCTGAC CCCCCAGGAT 3420

GAGTTCTTCA TCCTAGGCAG CAAGGGCTTG TGGGACAGCC TGTCCATCCA GGAGGCAGTG 3480

GAGGCCGTGC GCAATGTGCC TGACGCCCTG GCTGCTGCCA AGAAGCTGTG CACCCTGGCC 3540

CAGAGCTATG GCTGCCATGA CAGCATCAGC GCCGTGGTGG TGCAGCTCAG CGTCACCGAG 3600

GACAGCTTCT GCTGCTGCGA GCTCAGTGCC GGCGGGAGCG TGCCGCCACC CAGCCCTGGC 3660

ATCTTCCCCC CCTCCGTCAA CATGGTGATC AAGGATCGGC CCCCCGACGG GCTGGGCGTG 3720

CCGTCCTCCA GCAGCGGCAT GGCCTCGGAG ATCAGCAGTG AGCTCTCCAC TTCCGAGATG 3780

AGCAGCGAGG TGGGGTCCAC GGCCTCCGAC GAGCCCCCAA ACGGAGCCCT GAATGAGAGC 3840

AGCCCCGCCT ACCCGAGCGA GCAGCGCTGC ATGCTGCACC CCGTCTGTCT GTCCAACTCC 3900

TTCCAGCGCC AGCTGTCCAG CGCCACCTTC TCTAGCGCCT TCTCAGACAA TGGCCTTGAC 3960

AGCGACGACG AGGAGCCGAT CGAGGGTGTC TTCAGCAACG GCAGCCGGGT GGAGGTGGAA 4020

GTGGATATCC ACTGCAGCCG AGCCAAGGAG AAGGAGAAGC AGCAGCAGGT GCTTCAGGTG 4080

CCGGCCGAGG CCAGCGACGA GGGTATTGTC ATCAGTGCCA ACGAGGACGA GCCAGGGCTG 4140

CCCAGGAAGG CCGACTTCTC TGCCGTGGGG ACCATTGGGC GCCGAAGGGC CAATGGCTCT 4200

GTCGCGCCCC AGGAGAGGAG CCACAATGTG ATAGAGGTCG CTGCAGAAGC CCCCCTGCGG 4260

AAGCCTGGCG GGTATTTTGC TGCCCCCGCT CAGCCGGATC CTGACGATCA GTTTATCATT 4320

CCTCCCGAGC TGGAGGAAGA AGTCAAGGAA ATCATG 4356

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s++nf++++e+     ++gv+DG+++ ev + +++++++il

Q: 949   SHGYTEASGVKNKLCVAALSVNNFCDNREA-----LYGVFDGDRNVEVPYLLQCTMSDIL  1003

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aeel+    ++++ ++++ ++F+ ++++l       ++ +k G +av+++ik++

Q: 1004  AEELQ----KTKNEEEYMVNTFIVMQRKL------GTAGQKLGGSAVLCHIKHDpvdpgg  1053

         ***99....999*****************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG++++vLcrngk+++ls+ + +s+e+El+Ri+++++ ++++   +v+Gv++

Q: 1054  sfTLTSANVGKCQTVLCRNGKPLPLSRSYVMSCEEELKRIKQHKAIITEDG--KVNGVTE  1111

         *99*****************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R lG ++l+p v+p+P+v+s+ lt++def+iL+s+Glwd +s +eav++vr+v +

Q: 1112  STRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSIQEAVEAVRNVPD---  1168

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          + +aakkL++la+++g++d++sa+vv

Q: 1169  -ALAAAKKLCTLAQSYGCHDSISAVVV  1194

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNNFCDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ 60

KTKNEEEYMV NTFIVMQRKL GTAGQKLGGS AVLCHIKHDP VDPGGSFTLT SANVGKCQTV 120

LCRNGKPLPL SRSYVMSCEE ELKRIKQHKA IITEDGKVNG VTESTRILGY TFLHPSVVPR 180

PHVQSVLLTP QDEFFILGSK GLWDSLSIQE AVEAVRNVPD ALAAAKKLCT LAQSYGCHDS 240

ISAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>