EKS-ORC-00343

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00343

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	451.3	1.0E-135	271	520	250

Status

Unreviewed

Ensembl Protein

ENSOCUP00000013559

UniProt Accession

G1TA73;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN

Gene Synonyms/Alias

FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000015784	ENSOCUP00000013559	ENSOCUT00000015782

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60

LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120

EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180

TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 240

RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 300

LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR 360

ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 420

TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 480

RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL 537

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TGCAATGTAA GGACAAAGAA GCAACAAAAC TGACTGAGGA GAGGGACGGC 60

AGCCTGAACC AGAGCTCCGG CTACCGCTAT GGCACAGACC CCACCCCTCA GCACTACCCA 120

AGCTTCGGCG TGACCTCCAT CCCCAACTAC AACAACTTCC ACGCGGCTGG TGGCCAGGGG 180

CTCACCGTCT TCGGGGGTGT GAACTCTTCG TCTCACACTG GGACCTTGCG CACAAGAGGA 240

GGGACAGGAG TGACACTGTT TGTGGCCCTC TATGACTACG AAGCCCGGAC GGAAGATGAC 300

CTGAGTTTTC ACAAAGGAGA AAAATTTCAG ATCCTGAACA GCTCAGAAGG AGACTGGTGG 360

GAAGCCCGCT CGCTGACGAC GGGAGAGACG GGTTACATTC CCAGCAACTA TGTGGCTCCA 420

GTCGACTCTA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TGGGCCGGAA AGATGCAGAG 480

CGGCAGCTTT TGTCCTTTGG AAACCCAAGA GGTACCTTTC TTATCCGCGA GAGTGAAACC 540

ACCAAAGGTG CCTATTCACT TTCTATCCGT GATTGGGATG ATATGAAAGG AGACCATGTC 600

AAACATTATA AAATCCGCAA GCTTGACAAT GGTGGATACT ACATCACCAC CCGGGCCCAG 660

TTTGAAACCC TTCAGCAGCT CGTACAGCAT TACTCAGAGA GAGCCGCAGG TCTGTGCTGC 720

CGCCTAGTAG TGCCCTGTCA CAAAGGGATG CCAAGGCTTA CCGATCTGTC TGTCAAAACC 780

AAAGATGTCT GGGAAATCCC TCGAGAATCC CTGCAGTTGA TCAAGAGACT GGGAAATGGG 840

CAGTTTGGGG AAGTATGGAT GGGTACCTGG AACGGAAACA CAAAAGTAGC CATAAAGACT 900

CTCAAGCCAG GCACGATGTC CCCAGAGTCG TTCCTCGAGG AAGCGCAGAT CATGAAGAAG 960

CTGAAACATG ACAAGCTGGT GCAGCTGTAC GCCGTGGTGT CCGAGGAGCC CATCTACATC 1020

GTCACCGAGT ACATGAACAA AGGAAGTTTA CTTGATTTCT TAAAAGACGG AGAAGGAAGG 1080

GCCCTGAAGC TACCAAACCT GGTGGACATG GCGGCACAGG TCGCTGCAGG AATGGCTTAC 1140

ATTGAGCGCA TGAATTACAT CCACAGAGAC CTGCGGTCAG CAAACATTCT GGTGGGCAAT 1200

GGACTCATAT GCAAGATCGC CGACTTCGGA TTGGCCCGGT TGATTGAAGA CAACGAGTAC 1260

ACAGCACGAC AAGGCGCCAA GTTCCCCATC AAGTGGACGG CCCCCGAAGC CGCCCTGTAC 1320

GGGAGATTCA CGATCAAGTC TGACGTGTGG TCTTTTGGAA TCTTACTCAC AGAGCTGGTC 1380

ACCAAAGGGA GAGTGCCATA CCCAGGCATG AACAACCGGG AGGTGCTGGA GCAGGTGGAA 1440

CGCGGCTACA GGATGCCCTG CCCGCAGGAC TGCCCCATCT CTCTGCACGA GCTCATGATC 1500

CACTGCTGGA AAAAGGACCC CGAGGAGCGC CCCACTTTTG AGTACTTGCA GAGCTTCCTG 1560

GAAGACTACT TTACGGCCAC AGAGCCCCAG TATCAACCTG GTGAAAACCT CTAA 1614

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+ly

Q: 271   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY  330

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 331   AVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  389

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 390   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  449

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpee

Q: 450   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE  509

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 510   RPTFEYLQSFL  520

         ********986

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY 60

AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD 120

LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER 240

PTFEYLQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005768	; C:endosome
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0050798	; P:activated T cell proliferation
GO:0048813	; P:dendrite morphogenesis
GO:0050966	; P:detection of mechanical stimulus involved in sensory perception of pain
GO:0030900	; P:forebrain development
GO:0010629	; P:negative regulation of gene expression
GO:0042177	; P:negative regulation of protein catabolic process
GO:0001764	; P:neuron migration
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0008360	; P:regulation of cell shape
GO:0045471	; P:response to ethanol
GO:0050852	; P:T cell receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013