EKS-ORC-00252
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00252
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK456.84.7E-137193521329
StatusUnreviewed
Ensembl ProteinENSOCUP00000013617
UniProt AccessionG1U510;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK2
Gene Synonyms/Alias HIPK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000015854ENSOCUP00000024487ENSOCUT00000026484
ENSOCUG00000015854ENSOCUP00000013617ENSOCUT00000015853
OrganismOryctolagus cuniculus
Functional Description
Protein Length1192
Protein Sequence
(FASTA)
GMASHVQVFS PHTLQSSAFC SVKKLKVEPS SSWDMTGYGS HSRVYSQSKN TAPSQPATTT 60
VSTSLPIPNP SLPYEQTIIF PGSTGHIVVT SASSTSVPGP VLGGPHNLMR RSTVSLLDTY 120
QKCGLKRKSE EIENTSSVQI IEEHPPMIQN NASGATVATA TTSTATSKNS GSNSEGDYQL 180
VQHEVLCSMT NTYEVLEFLG RGTFGQVVKC WKRGTNEIVA IKILKNHPSY ARQGQIEVSI 240
LARLSTESAD DYNFVRAYEC FQHKNHTCLV FEMLEQNLYD FLKQNKFSPL PLKYIRPVLQ 300
QVATALMKLK SLGLIHADLK PENIMLVDPS RQPYRVKVID FGSASHVSKA VCSTYLQSRY 360
YRAPEIILGL PFCEAIDMWS LGCVIAELFL GWPLYPGASE YDQIRYISQT QGLPAEYLLS 420
AGTKTTRFFN RDTDSPYPLW RLKTPDDHEA ETGIKSKEAR KYIFNCLDDM AQVNMTTDLE 480
GSDMLVEKAD RREFIDLLKK MLTIDADKRI TPIETLNHPF VTMTHLLDFP HSTHVKSCFQ 540
NMEICKRRVN MYDTVNQSKT PFITHVAPST STNLTMTFNN QLTTVHNQAP TSTSATISLA 600
NPEVSILNYQ STLYQPSAAS MAAVAQRSMP LQTGTAQICA RPDPFQQALI VCPPGFQGLQ 660
ASPSKHAGYS VRMENAVPIV TQAPGAQPLQ IQPGLLAQQA WPSGTQQILL PPAWQQLTGV 720
ATHTSVQHTA VIPETMAGTQ QLADWRNTHA HGSHYNPIMQ QPALLTGHVT LPAAQPLNVG 780
VAHVMRQQPT STTSSRKSKQ HQSSVRNVST CEVSSSQAIS SPQRSKRVKE NTPPRCAMVR 840
SSPACSTSVT CGWGDAASST TRERQRQTIV IPDTPSPTVS VITISSDTDE EEEQKHAPTS 900
TVSKQRKNVI SCVTVHDSPY SDSSSNTSPY SVQQRAGHSN ANAFDSKGTV ENHCAGNPRT 960
IIVPPLKTQA SEVLVECDSL APANTSHHAS SYKPKSSSNV TSTSGHSSGS SSGAIAYRQQ 1020
RPGPHFQQQQ PLNLSQAQQH VTTDRAGSHR RQQAYIAPTM AQAPYSFPHN SPSHSTVHPH 1080
LAAAAAAAHL PAQPHLYTYT APAALGSTGT VAHLVASQGS ARHTVQHTAY PASIVHQVPV 1140
SMGPRVLPSP TIHPSQYPAQ FTHQTYISAS PASTVYTGYP LSPAKVNQYP YI 1192
Nucleotide Sequence
(FASTA)
GGTATGGCCT CACATGTGCA AGTTTTCTCC CCTCACACCC TCCAATCAAG TGCCTTCTGT 60
AGTGTGAAGA AACTCAAAGT AGAGCCGAGT TCCAGCTGGG ACATGACTGG GTACGGCTCC 120
CACAGCAGAG TGTACAGCCA GAGCAAGAAC ACAGCACCTT CTCAGCCAGC CACCACAACC 180
GTCAGCACCT CCTTGCCAAT CCCAAACCCC AGCCTACCTT ACGAGCAGAC CATCATCTTC 240
CCAGGAAGCA CCGGGCACAT AGTGGTCACG TCCGCAAGCA GCACGTCTGT CCCTGGGCCC 300
GTCCTCGGCG GACCACATAA CCTGATGCGG CGCAGCACCG TCAGCCTCCT TGACACCTAC 360
CAGAAATGCG GACTCAAGCG TAAGAGCGAG GAGATCGAGA ACACGAGCAG CGTGCAGATC 420
ATCGAAGAGC ATCCACCCAT GATTCAGAAT AATGCCAGCG GGGCCACGGT CGCCACTGCC 480
ACCACGTCCA CTGCCACCTC CAAGAACAGC GGCTCCAACA GCGAGGGTGA CTACCAGCTG 540
GTCCAGCATG AAGTGCTGTG CTCCATGACC AACACTTACG AGGTGTTGGA GTTCCTGGGC 600
CGAGGGACGT TCGGGCAAGT GGTCAAGTGC TGGAAGCGGG GCACCAATGA AATCGTAGCC 660
ATCAAGATCC TCAAGAACCA CCCGTCCTAT GCCCGACAGG GCCAGATTGA AGTGAGCATC 720
CTGGCCCGGC TGAGCACAGA GAGTGCCGAC GACTACAACT TCGTGCGGGC CTACGAGTGC 780
TTCCAGCACA AGAATCACAC CTGCTTGGTC TTCGAGATGC TGGAGCAGAA CCTCTATGAC 840
TTTCTGAAGC AGAACAAGTT TAGCCCCTTG CCCCTGAAAT ACATCCGCCC GGTCCTCCAG 900
CAGGTAGCCA CGGCCCTGAT GAAGCTCAAG AGCCTCGGGC TCATCCACGC TGACCTCAAA 960
CCGGAGAACA TCATGCTGGT GGATCCGTCC AGGCAGCCGT ACAGGGTGAA GGTCATCGAC 1020
TTTGGGTCAG CCAGTCACGT GTCCAAGGCC GTGTGCTCCA CCTACCTGCA GTCCCGGTAT 1080
TACAGGGCGC CTGAGATCAT CCTCGGGTTA CCGTTCTGTG AAGCGATCGA CATGTGGTCG 1140
TTGGGCTGTG TCATCGCGGA ACTCTTCCTG GGCTGGCCGT TGTACCCGGG AGCTTCAGAG 1200
TATGACCAGA TTCGGTATAT TTCACAAACG CAGGGTTTGC CAGCTGAATA TTTATTAAGC 1260
GCAGGGACAA AGACAACCAG GTTCTTCAAC CGTGACACGG ATTCTCCATA TCCTTTGTGG 1320
AGGCTAAAGA CACCGGATGA CCATGAAGCA GAGACGGGGA TTAAGTCGAA AGAAGCCAGA 1380
AAGTACATTT TCAACTGTTT AGATGACATG GCCCAGGTGA ACATGACGAC AGATCTGGAA 1440
GGGAGCGACA TGTTAGTGGA AAAGGCAGAC CGGCGGGAGT TCATTGACCT GTTGAAGAAG 1500
ATGCTGACCA TAGATGCGGA TAAGAGAATC ACTCCGATCG AAACCCTGAA CCACCCCTTT 1560
GTCACCATGA CGCACCTACT CGATTTTCCC CATAGTACAC ATGTCAAATC CTGTTTCCAG 1620
AACATGGAGA TTTGCAAACG TCGGGTGAAT ATGTATGATA CAGTGAACCA GAGCAAAACC 1680
CCTTTCATCA CACATGTGGC CCCCAGCACA TCCACCAACT TGACCATGAC CTTTAACAAC 1740
CAGCTGACCA CTGTCCACAA CCAGGCTCCC ACCTCCACCA GTGCCACTAT TTCCTTAGCC 1800
AATCCCGAAG TCTCCATACT AAACTACCAA TCTACACTCT ACCAGCCCTC AGCGGCATCC 1860
ATGGCTGCCG TGGCCCAGCG GAGCATGCCC CTGCAGACGG GAACAGCCCA GATCTGCGCC 1920
CGGCCCGACC CCTTCCAGCA AGCCCTCATC GTGTGTCCCC CCGGCTTCCA AGGCTTGCAG 1980
GCCTCTCCCT CCAAGCATGC TGGCTACTCA GTGAGGATGG AGAATGCAGT GCCCATCGTC 2040
ACTCAAGCCC CAGGAGCTCA GCCACTCCAA ATCCAACCAG GTCTGCTCGC CCAGCAGGCC 2100
TGGCCAAGCG GGACCCAGCA GATCCTGCTT CCCCCAGCAT GGCAGCAGCT GACCGGAGTG 2160
GCCACCCACA CCTCCGTGCA GCACACGGCC GTGATTCCCG AGACCATGGC GGGCACCCAG 2220
CAGCTGGCTG ACTGGAGGAA CACGCACGCT CACGGCAGCC ATTACAATCC CATCATGCAG 2280
CAGCCTGCGC TCTTGACGGG TCATGTGACC CTTCCAGCAG CCCAGCCCTT AAACGTGGGT 2340
GTGGCCCATG TCATGAGGCA GCAGCCCACC AGCACCACGT CCTCCCGGAA GAGTAAGCAG 2400
CACCAGTCAT CTGTGAGAAA TGTCTCTACC TGCGAAGTGT CCTCCTCCCA GGCCATCAGC 2460
TCCCCGCAGC GATCCAAGCG CGTCAAGGAG AACACCCCTC CCCGCTGTGC CATGGTGCGC 2520
AGCAGCCCAG CCTGCAGCAC CTCAGTCACC TGTGGGTGGG GCGACGCTGC TTCCAGCACC 2580
ACCCGGGAGC GGCAGCGGCA GACAATTGTC ATTCCTGATA CCCCCAGTCC CACAGTCAGC 2640
GTCATCACCA TCAGCAGCGA CACGGACGAG GAGGAGGAGC AGAAACACGC CCCCACCAGC 2700
ACTGTCTCCA AGCAAAGGAA AAATGTCATC AGCTGCGTCA CGGTCCACGA CTCTCCCTAC 2760
TCAGATTCCT CCAGCAACAC CAGCCCCTAC TCTGTGCAGC AGCGCGCCGG GCACAGCAAC 2820
GCCAATGCCT TCGACAGCAA GGGGACCGTG GAGAACCACT GCGCTGGCAA CCCCAGGACC 2880
ATCATCGTGC CGCCCCTGAA AACCCAGGCC AGCGAGGTGC TGGTGGAGTG CGATAGCCTG 2940
GCACCAGCAA ACACCAGTCA CCACGCGTCC TCCTACAAGC CCAAGTCCTC CAGCAACGTG 3000
ACCTCCACCA GCGGTCACTC TTCAGGGAGC TCCTCTGGAG CCATCGCCTA CCGACAGCAG 3060
CGGCCAGGCC CCCACTTCCA GCAGCAGCAA CCCCTCAATC TCAGCCAGGC TCAGCAGCAC 3120
GTCACCACGG ACCGCGCCGG GAGCCACCGA CGGCAGCAGG CCTACATCGC TCCCACCATG 3180
GCTCAGGCAC CCTACTCCTT CCCGCACAAC AGCCCCAGCC ATAGCACTGT CCACCCCCAC 3240
CTGGCCGCCG CCGCAGCTGC TGCCCACCTG CCCGCCCAGC CCCACCTCTA CACCTACACA 3300
GCGCCTGCCG CCCTGGGCTC CACCGGCACC GTGGCCCACC TGGTGGCCTC CCAAGGCTCG 3360
GCGCGCCACA CCGTGCAGCA CACTGCCTAC CCGGCCAGCA TCGTGCACCA GGTCCCCGTG 3420
AGCATGGGCC CCCGGGTCCT GCCCTCTCCT ACCATCCACC CCAGCCAGTA TCCAGCCCAG 3480
TTCACCCACC AGACCTACAT CAGCGCCTCT CCAGCCTCCA CCGTCTACAC TGGATACCCA 3540
CTTAGCCCTG CCAAGGTCAA CCAGTACCCT TACATA 3576
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 193   YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ESADD  251
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr++e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 252   YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS  311
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv+++r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 312   LGLIHADLKPENIMLVDPSRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  371
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 372   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  431
         **********************************************************88
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
          t++ +p ++lkt          ks++++k+++n+ +++++++++++ e +++l ek+d+
Q: 432   dTDSPYPLWRLKTPddheaetgiKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADR  491
         87889999999999********************************************99
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + f+dllk+ml++d++kRitp e+l+hpfv
Q: 492   ReFIDLLKKMLTIDADKRITPIETLNHPFV  521
         99***************************7
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTESADDY 60
NFVRAYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPVLQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPSRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240
TDSPYPLWRL KTPDDHEAET GIKSKEARKY IFNCLDDMAQ VNMTTDLEGS DMLVEKADRR 300
EFIDLLKKML TIDADKRITP IETLNHPFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>
EKS-AIM-00249
EKS-ANC-00256
EKS-BOT-00267
EKS-CAJ-00273
EKS-CAF-00274
EKS-CAP-00302
EKS-CII-00160
EKS-DAR-00602
EKS-DRM-00137
EKS-EQC-00259
EKS-FEC-00253
EKS-GAG-00224
EKS-GAA-00331
EKS-GOG-00267
EKS-HOS-00273
EKS-ICT-00252
EKS-LAC-00284
EKS-MAM-00269
EKS-MEG-00212
EKS-MOD-00264
EKS-MUM-00298
EKS-MUP-00264
EKS-MYL-00269
EKS-NOL-00252
EKS-ORN-00344
EKS-ORL-00320
EKS-OTG-00273
EKS-PAT-00252
EKS-PES-00237
EKS-PEM-00141
EKS-POA-00263
EKS-RAN-00282
EKS-SAH-00251
EKS-SUS-00240
EKS-TAG-00282
EKS-TAR-00340
EKS-TEN-00334
EKS-TUT-00032
Gene Ontology
GO:0005813; C:centrosome
GO:0031965; C:nuclear membrane
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0001105; F:RNA polymerase II transcription coactivator activity
GO:0003714; F:transcription corepressor activity
GO:0046790; F:virion binding
GO:0007628; P:adult walking behavior
GO:0009952; P:anterior/posterior pattern specification
GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0048596; P:embryonic camera-type eye morphogenesis
GO:0060059; P:embryonic retina morphogenesis in camera-type eye
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072; P:iris morphogenesis
GO:0060235; P:lens induction in camera-type eye
GO:0030514; P:negative regulation of BMP signaling pathway
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0030182; P:neuron differentiation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0008284; P:positive regulation of cell proliferation
GO:0043388; P:positive regulation of DNA binding
GO:0046330; P:positive regulation of JNK cascade
GO:0032092; P:positive regulation of protein binding
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0010842; P:retina layer formation
GO:0060395; P:SMAD protein signal transduction
GO:0007224; P:smoothened signaling pathway
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0050882; P:voluntary musculoskeletal movement
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013