EKS-ORC-00266

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00266

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	396.6	7.3E-119	214	507	294

Status

Unreviewed

Ensembl Protein

ENSOCUP00000013719

UniProt Accession

G1TAL4;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000015963	ENSOCUP00000013719	ENSOCUT00000015962

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

SVNNDMMVTD NNGAVKFPQL CKFCDVRSST CDNQKSCMSN CSITSICEKA HEVCVAVWRK 60

NDENITLETV CHDPKLAYHG FLLEDSASPK CIMKEKKVFG ETFFMCSCST DECNDHIIFS 120

EEYTTSSPDL LLVIFQVTGV SLLPPLGIAI AVIVTFYCYR VHRQQKLSPS WETSKPRKLM 180

EFSEHCAIIL EDDRSDISST CANNINHNTE LLPIELDTLV GKGRFAEVYK AKLRQNTSEQ 240

FETVAVKIFP YEEYASWKTE KDIFSDINLK HENILQFLTA EERKTELGKQ YWLITAFHAK 300

GNLQEYLTRH VISWEDLRKL GSSLARGIAH LHSDHTPCGR PKMPIVHRDL KSSNILVKND 360

LTCCLCDFGL SLRLDPTLSV DDLANSGQVG TARYMAPEVL ESRMNLENVE SFKQTDVYSM 420

ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE HPCVESMKDN VLRDRGRPEI PSFWLNHQGI 480

QMVCETLTEC WDHDPEARLT AQCVAERFSE LEYLDRLSGR SCSEEKIPED GSLNTTK 537

Nucleotide Sequence
(FASTA)

TCAGTTAATA ACGACATGAT GGTCACGGAC AACAATGGCG CCGTCAAGTT CCCACAACTG 60

TGCAAGTTTT GCGATGTGCG ATCTTCCACC TGTGACAACC AGAAGTCCTG CATGAGCAAC 120

TGCAGCATCA CGTCCATCTG TGAGAAGGCA CACGAAGTCT GCGTGGCCGT CTGGAGGAAG 180

AACGATGAAA ACATAACCCT GGAGACTGTG TGTCACGACC CCAAGCTCGC CTACCATGGA 240

TTCCTTCTGG AAGATTCTGC CTCTCCAAAG TGTATCATGA AAGAAAAGAA GGTGTTTGGG 300

GAGACTTTCT TCATGTGTTC CTGCAGCACT GACGAGTGCA ATGACCACAT CATCTTCTCT 360

GAGGAATACA CCACCAGCAG TCCGGATCTG CTGCTAGTCA TATTTCAAGT GACCGGCGTC 420

AGCCTCCTGC CACCGCTGGG AATTGCCATC GCCGTCATCG TCACCTTCTA CTGCTACCGC 480

GTTCACCGGC AGCAGAAGCT GAGTCCCTCC TGGGAGACCA GCAAGCCGCG GAAGCTCATG 540

GAGTTCAGCG AGCACTGCGC CATCATTCTG GAAGACGACC GCTCCGACAT CAGCTCCACG 600

TGCGCCAACA ACATCAACCA CAACACGGAG CTGCTGCCCA TCGAGCTGGA CACCCTGGTG 660

GGCAAAGGTC GATTCGCCGA GGTCTACAAG GCCAAGCTGA GGCAGAACAC ATCCGAGCAG 720

TTCGAGACCG TGGCCGTCAA GATCTTCCCC TACGAGGAGT ACGCCTCTTG GAAGACGGAG 780

AAAGACATCT TCTCGGACAT CAACCTGAAG CACGAGAACA TCCTGCAGTT CCTGACGGCC 840

GAGGAGCGCA AGACTGAGCT CGGGAAGCAG TACTGGCTGA TCACCGCCTT CCATGCCAAG 900

GGCAACCTGC AGGAGTATCT CACACGCCAC GTCATCAGCT GGGAGGACCT GCGCAAGCTG 960

GGCAGCTCCC TGGCCCGGGG CATTGCCCAC CTCCACAGCG ACCACACCCC CTGTGGGAGG 1020

CCCAAGATGC CCATCGTGCA TAGAGACCTC AAGAGCTCCA ACATCCTGGT GAAGAACGAC 1080

CTGACCTGCT GCCTGTGTGA CTTTGGGCTG TCCCTGCGCC TGGACCCTAC GCTGTCTGTG 1140

GATGACCTGG CTAACAGTGG GCAGGTGGGG ACTGCAAGAT ACATGGCGCC GGAAGTCCTG 1200

GAATCCAGGA TGAATCTGGA GAACGTGGAG TCCTTCAAGC AGACTGATGT CTACTCCATG 1260

GCGCTGGTGC TCTGGGAAAT GACGTCCCGC TGCAATGCGG TGGGGGAGGT CAAAGATTAC 1320

GAGCCTCCGT TTGGTTCCAA GGTGCGGGAG CACCCCTGTG TGGAGAGCAT GAAAGACAAT 1380

GTGCTGCGAG ATCGAGGTCG ACCAGAAATC CCCAGCTTCT GGCTTAACCA CCAGGGCATA 1440

CAGATGGTGT GTGAGACACT GACCGAATGC TGGGACCATG ACCCGGAGGC CCGTCTCACG 1500

GCCCAGTGCG TGGCGGAACG CTTCAGCGAG TTGGAGTACC TGGACAGACT CTCGGGAAGG 1560

AGCTGCTCTG AGGAGAAGAT TCCAGAAGAT GGCTCGCTGA ACACTACCAA GTAG 1614

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kaklr+      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 214   IELDTLVGKGRFAEVYKAKLRQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  273

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 274   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  333

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 334   D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  392

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 393   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  451

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip+ w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 452   PCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  507

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL RQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120

DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSF WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0007420	; P:brain development
GO:0060434	; P:bronchus morphogenesis
GO:0051216	; P:cartilage development
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0035162	; P:embryonic hemopoiesis
GO:0007369	; P:gastrulation
GO:0007507	; P:heart development
GO:0001701	; P:in utero embryonic development
GO:0002088	; P:lens development in camera-type eye
GO:0060463	; P:lung lobe morphogenesis
GO:0060443	; P:mammary gland morphogenesis
GO:0043011	; P:myeloid dendritic cell differentiation
GO:0060021	; P:palate development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0060440	; P:trachea formation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013