EKS-ORC-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	515.7	3.9E-155	89	382	294

Status

Unreviewed

Ensembl Protein

ENSOCUP00000019033

UniProt Accession

G1TPU5;

Protein Name

Protein Synonyms/Alias

Gene Name

STK38

Gene Synonyms/Alias

STK38;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000016165	ENSOCUP00000019033	ENSOCUT00000028299
ENSOCUG00000016165	ENSOCUP00000013897	ENSOCUT00000016168

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

466

Protein Sequence
(FASTA)

MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE 60

EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120

RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 180

KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA 240

HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 300

KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS EKAKDLILRF 360

CCEWEHRIGA PGVEEIKCNS FFEGVDWEHI RYTHRSLVAN QKKSIDDTSN FDEFPESDIL 420

KPTVATSNHP ETDYKNKDWV FINYTYKRFE GLTARGAIPS YMKAAK 466

Nucleotide Sequence
(FASTA)

ATGGCAATGA CAGGCTCAAC ACCTTGCTCG TCTATGAGTA ATCACACAAA GGAAAGGGTG 60

ACGATGACCA AAGTGACATT GGAGAATTTT TATAGTAACC TTATCGCTCA ACATGAAGAA 120

CGAGAAATGA GACAAAAGAA GTTAGAAAAA GTGATGGAAG AAGAGGGCCT AAAAGATGAA 180

GAGAAACGGC TCAGGAGATC AGCGCATGCT CGGAAGGAGA CTGAGTTTCT GCGTTTGAAG 240

AGAACAAGAC TTGGATTGGA AGATTTTGAG TCCTTAAAAG TCATAGGCAG AGGAGCATTT 300

GGTGAGGTGC GGCTTGTTCA AAAGAAAGAT ACGGGGCACG TGTATGCCAT GAAAATACTC 360

CGTAAAGCAG ATATGCTTGA AAAAGAGCAG GTTGGCCACA TTCGTGCGGA GCGCGACATT 420

CTAGTGGAGG CAGACAGTTT GTGGGTTGTG AAAATGTTCT ATAGTTTTCA GGATAAGCTA 480

AACCTCTACC TAATCATGGA GTTCCTGCCT GGAGGAGACA TGATGACCTT GTTAATGAAA 540

AAAGACACTC TGACAGAAGA GGAGACTCAG TTTTATATAG CAGAAACAGT GCTAGCCATA 600

GACTCCATTC ACCAGCTTGG ATTCATCCAC AGAGACATAA AGCCGGACAA CCTTCTCCTG 660

GACAGCAAGG GCCATGTGAA ACTCTCTGAC TTTGGTCTTT GCACAGGACT GAAAAAAGCA 720

CATAGGACAG AATTTTACAG GAATCTGAAC CACAGCCTGC CCAGTGATTT CACATTCCAG 780

AATATGAATT CCAAGAGGAA AGCAGAAACC TGGAAAAGAA ATAGACGTCA ACTAGCCTTC 840

TCCACAGTAG GCACTCCTGA CTACATTGCT CCCGAGGTGT TCATGCAGAC CGGGTACAAC 900

AAGCTCTGTG ATTGGTGGTC GCTTGGGGTG ATCATGTATG AGATGCTCAT CGGCTACCCA 960

CCTTTCTGTT CTGAGACCCC TCAGGAGACG TACAAGAAGG TGATGAACTG GAAAGAAACT 1020

TTGACTTTTC CTCCGGAAGT TCCCATCTCT GAGAAAGCCA AGGATCTAAT TTTGAGATTC 1080

TGCTGTGAGT GGGAACACAG AATTGGAGCG CCAGGAGTTG AGGAAATCAA ATGTAATTCT 1140

TTTTTTGAAG GCGTTGACTG GGAACACATC AGGTACACCC ATCGTTCATT GGTTGCTAAC 1200

CAGAAGAAAA GCATTGATGA TACCTCAAAT TTCGACGAGT TTCCAGAATC TGATATCCTT 1260

AAACCAACAG TGGCCACCAG TAACCACCCT GAGACCGACT ACAAGAACAA AGACTGGGTC 1320

TTCATCAATT ACACCTACAA GCGCTTCGAG GGCCTGACTG CAAGGGGGGC TATCCCTTCC 1380

TACATGAAAG CAGCCAAGTA G 1401

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w

Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk nlyl+me+lPGGd+mtll+kk++l+ee+++fyiae+vla++s+h+lGf

Q: 149   VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF  208

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+d+kGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+ ++    ++++

Q: 209   IHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ----NMNS  264

         *************************************************555....5555

S: 181   rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla  236

         ++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++

Q: 265   KRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS  324

         5544556*****************************************************

S: 237   etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         etpqetykkv+nwketl+fp+ev++se+akdli r+++++e+r+g+ Gv+eik ++ff

Q: 325   ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAPGVEEIKCNSFF  382

         ********************************************************98

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60

VVKMFYSFQD KLNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYIAETVL AIDSIHQLGF 120

IHRDIKPDNL LLDSKGHVKL SDFGLCTGLK KAHRTEFYRN LNHSLPSDFT FQNMNSKRKA 180

ETWKRNRRQL AFSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYKKVMNWK ETLTFPPEVP ISEKAKDLIL RFCCEWEHRI GAPGVEEIKC NSFF 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043407	; P:negative regulation of MAP kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013