EKS-ORC-00259

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00259

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.4	2.0E-140	181	468	288

Status

Unreviewed

Ensembl Protein

ENSOCUP00000014003

UniProt Accession

G1TBB8;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000016292	ENSOCUP00000014003	ENSOCUT00000016289

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

AALLPGAAAL QCFCHLCTKD NFTCVTDGLC FVSVTETTDK VIHNSMCIAE IDLIPRDRPF 60

VCAPSSKTGS VTTTYCCNQD HCNKIELPTV VKQSPGLGPV ELAAVIAGPV CFVCISLMLM 120

VYICHNRTVI HHRVPNEEDP SLDRPFISEG TTLKDLIYDM TTSGSGSGLP LLVQRTIART 180

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 240

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 300

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 360

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 420

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTLSQ LSQQEGIKM 479

Nucleotide Sequence
(FASTA)

GCAGCACTCC TTCCAGGTGC AGCTGCATTA CAGTGTTTCT GCCACCTCTG TACAAAAGAC 60

AATTTCACAT GTGTGACAGA TGGACTCTGC TTTGTCTCTG TCACAGAGAC CACAGACAAA 120

GTTATACACA ATAGCATGTG TATAGCAGAA ATTGACTTAA TTCCTCGAGA CAGGCCATTT 180

GTATGTGCAC CCTCTTCAAA AACTGGCTCT GTTACTACAA CATACTGCTG CAATCAGGAC 240

CATTGCAATA AAATCGAACT CCCAACTGTT GTAAAGCAGT CACCTGGCCT TGGTCCTGTC 300

GAACTAGCAG CTGTCATTGC TGGACCAGTC TGCTTCGTCT GCATCTCACT CATGTTGATG 360

GTCTATATCT GCCATAACCG CACGGTCATT CACCACCGGG TGCCAAATGA GGAGGATCCT 420

TCATTAGATC GCCCTTTTAT TTCAGAGGGC ACCACGTTAA AAGATTTAAT TTATGATATG 480

ACAACATCGG GTTCGGGATC AGGTTTACCA TTGCTTGTTC AGAGAACAAT TGCAAGGACT 540

ATTGTGTTAC AAGAAAGCAT TGGCAAAGGT CGATTTGGAG AAGTTTGGCG AGGGAAGTGG 600

CGGGGAGAGG AAGTGGCTGT GAAGATTTTC TCCTCCAGGG AGGAGCGCTC CTGGTTCCGG 660

GAAGCAGAGA TTTACCAGAC CGTAATGTTA CGCCATGAGA ACATCCTGGG GTTCATTGCA 720

GCGGATAATA AAGATAATGG CACATGGACT CAGCTGTGGT TGGTGTCGGA TTACCATGAG 780

CATGGGTCCC TTTTTGATTA CTTGAACAGA TACACAGTGA CCGTGGAGGG CATGATCAAA 840

CTTGCTCTGT CTACAGCCAG TGGTCTTGCC CATCTTCACA TGGAGATTGT TGGTACCCAA 900

GGAAAACCAG CCATTGCTCA TAGAGATTTG AAATCAAAGA ACATCTTGGT AAAGAAGAAT 960

GGAACTTGCT GTATTGCAGA CTTGGGACTG GCAGTAAGAC ATGATTCAGC CACAGATACA 1020

ATTGATATTG CTCCAAACCA CAGAGTGGGA ACAAAAAGGT ACATGGCTCC TGAAGTTCTA 1080

GATGATTCCA TAAATATGAA GCATTTTGAA TCCTTCAAAC GTGCTGACAT CTATGCAATG 1140

GGCTTAGTAT TCTGGGAAAT TGCTCGACGA TGTTCCATTG GTGGAATTCA TGAGGATTAC 1200

CAGCTGCCTT ATTATGATCT TGTACCTTCT GATCCATCAG TTGAAGAAAT GAGAAAAGTT 1260

GTTTGTGAAC AGAAGTTAAG GCCAAATATT CCAAACAGAT GGCAGAGCTG TGAAGCCTTG 1320

CGAGTAATGG CTAAAATTAT GAGAGAATGT TGGTATGCCA ATGGAGCAGC TCGGCTCACA 1380

GCTTTGCGGA TTAAGAAAAC ATTGTCACAG CTCAGTCAGC AGGAAGGCAT CAAAATG 1437

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 181   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  240

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 241   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  300

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 301   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  358

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 359   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  417

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 418   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  468

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0044459	; C:plasma membrane part
GO:0043235	; C:receptor complex
GO:0005923	; C:tight junction
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000186	; P:activation of MAPKK activity
GO:0001525	; P:angiogenesis
GO:0009952	; P:anterior/posterior pattern specification
GO:0048844	; P:artery morphogenesis
GO:0001824	; P:blastocyst development
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0030199	; P:collagen fibril organization
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0043542	; P:endothelial cell migration
GO:0001837	; P:epithelial to mesenchymal transition
GO:0008354	; P:germ cell migration
GO:0007507	; P:heart development
GO:0006917	; P:induction of apoptosis
GO:0001822	; P:kidney development
GO:0002088	; P:lens development in camera-type eye
GO:0043066	; P:negative regulation of apoptotic process
GO:0032331	; P:negative regulation of chondrocyte differentiation
GO:0048663	; P:neuron fate commitment
GO:0060021	; P:palate development
GO:0060017	; P:parathyroid gland development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060037	; P:pharyngeal system development
GO:0030307	; P:positive regulation of cell growth
GO:0008284	; P:positive regulation of cell proliferation
GO:0051272	; P:positive regulation of cellular component movement
GO:0051491	; P:positive regulation of filopodium assembly
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0009791	; P:post-embryonic development
GO:0043393	; P:regulation of protein binding
GO:0031396	; P:regulation of protein ubiquitination
GO:0048538	; P:thymus development
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013