EKS-ORC-00265

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00265

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.6	7.2E-126	192	478	287

Status

Unreviewed

Ensembl Protein

ENSOCUP00000021620

UniProt Accession

G1TBJ7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000016398	ENSOCUP00000014096	ENSOCUT00000016400
ENSOCUG00000016398	ENSOCUP00000021620	ENSOCUT00000022740

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

FGNIWSLPII IFILNCLIGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM 120

EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240

MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480

QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

TTTGGAAATA TTTGGTCACT TCCCATTATT ATTTTCATAC TTAATTGTCT TATAGGTGCT 60

ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ACGCTAATTG GGAAAGAGAC 120

AGAACTAATC AAACTGGTGT TGAACCCTGT TATGGTGACA AAGATAAACG GCGGCATTGT 180

TTTGCTACTT GGAAGAATAT TTCTGGTTCC ATCGAAATAG TGAAACAAGG TTGTTGGCTG 240

GATGATATCA ACTGCTATGA TAGGACTGAC TGTATAGAAA AAAAAGACAG CCCTGAAGTA 300

TATTTTTGTT GCTGCGAGGG CAACATGTGT AATGAAAAGT TTTCTTATTT TCCGGAGATG 360

GAAGTCACTC AGCCCACTTC AAATCCAGTT ACACCTAAAC CACCCTATTA CAATATCCTG 420

CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 480

TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAGGA CCCGGGACCA 540

CCCCCACCTT CTCCATTACT AGGTTTGAAG CCACTACAGT TATTAGAAGT AAAAGCAAGG 600

GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTCAACG AATATGTAGC TGTCAAAATA 660

TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAGTATG AAGTCTATAG TTTGCCAGGA 720

ATGAAGCACG AGAACATACT ACAGTTCATT GGTGCAGAAA AACGGGGCAC CAGTGTTGAT 780

GTGGATCTTT GGCTAATCAC AGCATTTCAT GAAAAGGGTT CATTGTCAGA CTTTCTTAAG 840

GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACAATGGC GAGAGGACTA 900

GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCTGC CATATCTCAC 960

AGGGACATCA AAAGTAAAAA TGTGCTGTTA AAAAACAATC TGACAGCTTG CATTGCTGAT 1020

TTTGGGTTGG CGTTAAAGTT TGAAGCTGGC AAGTCTGCAG GTGATACCCA TGGACAGGTT 1080

GGTACCCGGA GGTATATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 1140

GCATTTTTGA GGATAGATAT GTACGCCATG GGATTAGTCC TGTGGGAACT GGCTTCTCGC 1200

TGTACTGCTG CAGATGGACC TGTAGATGAG TATATGTTGC CATTTGAGGA GGAAATTGGC 1260

CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAGAA GAGGCCTGTT 1320

TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC GATAGAAGAA 1380

TGTTGGGATC ACGATGCAGA AGCCAGGCTA TCAGCTGGAT GTGTAGGTGA AAGAATTACT 1440

CAGATGCAAA GACTAACAAA TATCATCACC ACAGAGGACA TTGTAACAGT GGTCACGATG 1500

GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 192   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 429   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  478

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0034673	; C:inhibin-betaglycan-ActRII complex
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0015026	; F:coreceptor activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048706	; P:embryonic skeletal system development
GO:0001702	; P:gastrulation with mouth forming second
GO:0007498	; P:mesoderm development
GO:0043084	; P:penile erection
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510	; P:regulation of BMP signaling pathway
GO:0050999	; P:regulation of nitric-oxide synthase activity
GO:0060011	; P:Sertoli cell proliferation
GO:0023014	; P:signal transduction by phosphorylation
GO:0042713	; P:sperm ejaculation
GO:0007283	; P:spermatogenesis

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013