EKS-ORC-00048
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00048
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF405.31.6E-121313570258
StatusUnreviewed
Ensembl ProteinENSOCUP00000024992
UniProt AccessionG1U6F0;
Protein Name
Protein Synonyms/Alias
Gene NameARAF
Gene Synonyms/Alias ARAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000016449ENSOCUP00000014138ENSOCUT00000016448
ENSOCUG00000016449ENSOCUP00000024992ENSOCUT00000025650
OrganismOryctolagus cuniculus
Functional Description
Protein Length609
Protein Sequence
(FASTA)
MEPPRGPPAN GAEPSRAVGT VKVYLPNKQR TVITVRDGMS VYDSLDKALK VRGLNQDCCV 60
VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF 120
HGFRCQTCGY KFHQHCSSKV PTVCVDMSTS RRQPSRFYHS IQDLSGSSRQ HEAPSSRPLN 180
EPLTPQGPSS CTQHHDPERF PFPAPANAPL QRIRSTSTPN VHMVSTAAPT DSSLMQVGAQ 240
GHATAAAGGR GGGDGAPRGS PSPASMSSGR KSPHSKSPSE QRERKSTADD KKKVKNLGYR 300
DSGYYWEVPP SEVQLLKRIG TGSFGTVFRG RWHGDVAVKV LKVAQPTAEQ AQAFKNEMQV 360
LRKTRHVNIL LFMGFMTRPG FAIITQWCEG SSLYHHLHVA DTRFDMVQLI DVARQTAQGM 420
DYLHAKNIIH RDLKSNNIFL HEGLTVKIGD FGLATVKTRW SGAQPLEQPS GSVLWMAAEV 480
IRMQDPNPYS FQSDVYAYGV VLYELMTGSL PYSHIGSRDQ IIFMVGRGYL SPDLSKISSN 540
CPKAMRRLLS DCLKFQREER PLFPQILATI ELLQRSLPKI ERSASEPSLH RTQADELPAC 600
LLSAARLVP 609
Nucleotide Sequence
(FASTA)
ATGGAGCCGC CACGAGGTCC CCCTGCCAAC GGGGCCGAGC CGTCCCGGGC AGTGGGCACC 60
GTGAAAGTGT ACCTGCCCAA CAAGCAACGC ACGGTGATAA CTGTCCGGGA TGGCATGAGT 120
GTCTACGACT CTCTAGACAA GGCCCTCAAA GTGCGGGGTC TCAATCAGGA CTGCTGTGTG 180
GTGTACCGAC TCATCAAGGG GCGAAAGACA GTCACTGCCT GGGACACGGC CATCGCCCCC 240
CTGGATGGCG AGGAGCTCAT TGTTGAGGTC CTTGAAGACG TCCCGCTGAC CATGCACAAT 300
TTTGTGCGCA AGACCTTCTT CAGCCTGGCA TTCTGTGACT TCTGCCTTAA GTTTCTGTTC 360
CATGGTTTCC GCTGCCAAAC CTGTGGCTAC AAGTTCCACC AGCATTGTTC CTCCAAGGTT 420
CCCACAGTGT GTGTGGACAT GAGTACCAGC CGCCGACAGC CCTCAAGGTT CTACCACAGC 480
ATCCAGGATT TGTCCGGAAG CTCCAGGCAG CATGAGGCTC CCTCCAGCCG CCCCCTGAAT 540
GAGCCACTCA CCCCCCAGGG TCCCAGCTCC TGCACCCAGC ACCATGACCC GGAGCGGTTC 600
CCCTTCCCTG CCCCGGCCAA CGCCCCCCTT CAGCGCATCC GCTCCACGTC CACTCCCAAT 660
GTCCACATGG TCAGCACCGC AGCCCCCACG GACTCCAGCC TCATGCAGGT GGGTGCCCAG 720
GGGCATGCCA CTGCAGCTGC TGGTGGTAGA GGTGGTGGTG ATGGAGCCCC CCGGGGAAGC 780
CCCAGCCCGG CCAGCATGTC CTCGGGGAGG AAGTCCCCAC ATTCCAAGTC ACCATCAGAG 840
CAACGAGAGC GGAAGTCCAC GGCCGATGAC AAGAAGAAAG TGAAGAACCT GGGGTACCGG 900
GACTCAGGCT ATTACTGGGA GGTACCCCCC AGTGAGGTGC AGCTGCTGAA GAGGATCGGG 960
ACTGGCTCAT TTGGCACCGT GTTTCGTGGA CGGTGGCATG GCGACGTGGC CGTGAAGGTG 1020
CTCAAGGTGG CCCAGCCCAC AGCCGAGCAG GCCCAGGCCT TCAAGAATGA GATGCAGGTG 1080
CTCAGGAAGA CACGGCATGT CAACATCTTG CTATTCATGG GCTTCATGAC CCGACCGGGC 1140
TTTGCCATCA TCACACAGTG GTGCGAGGGC TCCAGCCTCT ACCACCACCT ACATGTGGCC 1200
GACACGCGCT TTGACATGGT CCAGCTCATC GACGTGGCCC GGCAGACTGC CCAGGGCATG 1260
GACTACCTCC ATGCCAAGAA CATCATCCAC CGAGACCTCA AGTCTAACAA CATCTTCCTA 1320
CATGAGGGGC TCACAGTGAA GATCGGTGAC TTTGGCCTGG CCACCGTGAA GACGCGGTGG 1380
AGCGGGGCCC AGCCCTTGGA GCAGCCTTCA GGCTCTGTGC TTTGGATGGC GGCTGAGGTG 1440
ATCCGCATGC AGGACCCGAA CCCCTACAGC TTCCAGTCGG ACGTCTATGC CTACGGGGTT 1500
GTGCTCTACG AACTCATGAC CGGCTCACTG CCTTACAGCC ACATTGGCAG CCGTGACCAG 1560
ATCATCTTTA TGGTGGGCCG TGGCTATCTG TCCCCGGACC TCAGTAAAAT CTCCAGCAAC 1620
TGCCCCAAGG CCATGCGGCG TCTGCTGTCT GACTGCCTCA AGTTCCAGCG GGAGGAGCGG 1680
CCTCTCTTCC CCCAGATCCT GGCCACGATT GAGCTGCTGC AACGGTCACT CCCCAAGATT 1740
GAGCGGAGTG CCTCCGAACC CTCCTTGCAC CGCACCCAGG CTGACGAGCT GCCTGCCTGC 1800
CTCCTCAGTG CAGCCCGCCT TGTGCCT 1827
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+l ++iG+G+fGtv+rg+whGdvavk+l+v ++++eq++aFk+e+++++ktRh+ni+LF
Q: 313   VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLF  372
         67899*******************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mG++++p +ai+t++c+gssLy++lh+++t++d+++lid+arq+aqgmdYLhak+i+h+D
Q: 373   MGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRD  432
         ************************************************************
S: 121   lksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleq  180
         lks+ni+l+egl+v+i+DFgl++vk+++sg  ++ le+p+g++l++a+evir+      q
Q: 433   LKSNNIFLHEGLTVKIGDFGLATVKTRWSG--AQPLEQPSGSVLWMAAEVIRM------Q  484
         ******************************..9********************......*
S: 181   delpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpke  238
         d +p+s++sDvya+G+vlyel++++lpy++  s+dqi+f+vgrG l+pdlsk++s++pk+
Q: 485   DPNPYSFQSDVYAYGVVLYELMTGSLPYSHiGSRDQIIFMVGRGyLSPDLSKISSNCPKA  544
         ************************************************************
S: 239   lkellleClkfekeeRPlftqilkkl  264
         +++ll++Clkf++eeRPlf+qil+++
Q: 545   MRRLLSDCLKFQREERPLFPQILATI  570
         **********************9875
Domain Sequence
(FASTA)
VQLLKRIGTG SFGTVFRGRW HGDVAVKVLK VAQPTAEQAQ AFKNEMQVLR KTRHVNILLF 60
MGFMTRPGFA IITQWCEGSS LYHHLHVADT RFDMVQLIDV ARQTAQGMDY LHAKNIIHRD 120
LKSNNIFLHE GLTVKIGDFG LATVKTRWSG AQPLEQPSGS VLWMAAEVIR MQDPNPYSFQ 180
SDVYAYGVVL YELMTGSLPY SHIGSRDQII FMVGRGYLSP DLSKISSNCP KAMRRLLSDC 240
LKFQREERPL FPQILATI 258
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00045
EKS-BOT-00052
EKS-CAJ-00052
EKS-CAF-00053
EKS-CAP-00052
EKS-CIS-00058
EKS-DAR-00067
EKS-EQC-00051
EKS-FEC-00050
EKS-GAA-00070
EKS-GOG-00051
EKS-HOS-00053
EKS-ICT-00049
EKS-LAC-00056
EKS-LOA-00052
EKS-MAM-00052
EKS-MAE-00026
EKS-MUM-00053
EKS-MUP-00054
EKS-MYL-00054
EKS-ORN-00071
EKS-ORL-00065
EKS-OTG-00055
EKS-POA-00049
EKS-SAH-00049
EKS-SUS-00043
EKS-TAR-00072
EKS-TEN-00076
EKS-TUT-00052
EKS-XIM-00069
Gene Ontology
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013