EKS-ORC-00373
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00373
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl549.71.2E-165539804266
StatusUnreviewed
Ensembl ProteinENSOCUP00000014325
UniProt AccessionG1TC42;
Protein Name
Protein Synonyms/Alias
Gene NameAXL
Gene Synonyms/Alias AXL;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000016651ENSOCUP00000014325ENSOCUT00000016660
OrganismOryctolagus cuniculus
Functional Description
Protein Length897
Protein Sequence
(FASTA)
QGLRCGARRM GRIPLAWCLV LCCWGCLAPR GAQAEEHPFV RSPGNVTRAR GLTGTLQCEL 60
RIQREPPEVV WLRDGQILEL ADSTQTQVPL GEDGQDDWKV VSKLRISSLR LSDAGRYQCA 120
VVLGGQTFVS QPGYLGLEGL PYFLEEPEDR AVPADTPFNL SCRAQGPPEP VDLLWLQDAA 180
PLAPAVGQGP QDSLRVPGLN RTSSFSCEAH NAKGVTTSRT ATITVIPQRP RDLHLVSRWP 240
TELEVAWTPG LSGIYPLTHC TLQAVLSDDG VGLWPGQPDP PEEPLTLQAA VPPHHLRLGS 300
LYPHTSYHIR VSCTSSQGPS PWTHWLPVRR RREVMPLGPP ENVSAVRNGS QALVRWQEPK 360
APLQGTLLGY RLAYRSQDTP EVLMDIGLKR EVTLELRGDR PVPNLTVCVA AYTAAGDGPW 420
SLPVPLEPWR PGQGQPVHQL VSEPPAPAFS WPWWYVLLGA VVAAACVLIL ALFLVHRRKK 480
ETRYGEVFEP TVERGELVVR YRVRKSYSRR TTEATLNSLG ISEDLKEKLR DVMVDRHKVA 540
LGKTLGEGEF GAVMEGQLNQ DDSILKVAVK TMKIAICTRS ELEDFLSEAV CMKEFDHPNV 600
MKLLGVCFQG SEREGFPAPV VILPFMKHGD LHSFLLYSRL GDQPMFLPTQ MLVKFMTDIA 660
SGMEYLSTKR FIHRDLAARN CMLNENMSVC VADFGLSKKI YNGDYYRQGR IAKMPVKWIA 720
IESLADRVYT SKSDVWSFGV TMWEIATRGQ TPYPGVENSE IYDYLRQGNR LKQPADCLDG 780
LYALMSRCWE LNPRDRPSFS ELREDLENTL KALPPAQEPD EILYVNMDEG GGHSEPRGAA 840
GGAEPHTQPD PKDSCSCLTA AEVHPAGRYV LCPSTAPGPA LPADRSSQAP PAQEDGV 897
Nucleotide Sequence
(FASTA)
CAAGGACTGC GCTGTGGTGC CCGGAGGATG GGCAGGATCC CACTGGCCTG GTGCTTGGTG 60
CTATGCTGCT GGGGGTGCCT GGCCCCCAGG GGTGCGCAGG CTGAGGAGCA CCCCTTTGTG 120
AGAAGCCCAG GGAACGTCAC CCGTGCCCGG GGACTCACGG GCACCCTTCA GTGCGAGCTC 180
CGGATCCAGA GGGAGCCCCC CGAGGTGGTC TGGCTGCGGG ATGGACAGAT CCTGGAGCTG 240
GCGGACAGCA CCCAGACCCA GGTGCCCCTG GGCGAAGACG GCCAGGATGA CTGGAAAGTG 300
GTCAGCAAAC TCAGAATCTC ATCCCTGCGG CTGTCGGATG CAGGGCGGTA CCAGTGTGCG 360
GTGGTCCTGG GGGGACAGAC TTTTGTGTCT CAGCCTGGCT ATCTGGGGCT GGAAGGCCTA 420
CCTTACTTCC TGGAGGAGCC TGAGGACAGG GCTGTGCCTG CCGATACTCC CTTCAACCTG 480
AGCTGCCGGG CCCAGGGGCC CCCAGAACCC GTGGACCTAC TCTGGCTCCA GGATGCAGCC 540
CCCTTGGCCC CGGCCGTGGG GCAGGGCCCC CAGGACAGCC TGCGTGTTCC CGGCCTGAAC 600
AGGACGTCGT CCTTCTCCTG CGAAGCTCAT AATGCCAAGG GGGTCACCAC ATCCCGCACG 660
GCCACCATTA CAGTGATCCC CCAGCGGCCC CGTGACCTCC ACCTGGTTTC TCGCTGGCCT 720
ACAGAGCTGG AGGTGGCTTG GACCCCAGGC CTCAGCGGAA TCTACCCCCT CACCCACTGC 780
ACCCTGCAGG CAGTGCTGTC AGATGATGGG GTGGGCCTCT GGCCAGGACA GCCCGACCCC 840
CCGGAGGAGC CCCTCACCTT GCAAGCAGCC GTGCCCCCTC ACCATCTGCG GCTGGGCAGC 900
CTCTATCCTC ACACCTCTTA CCACATCCGG GTGTCGTGCA CCAGCAGCCA GGGCCCCTCG 960
CCCTGGACCC ACTGGCTGCC CGTGCGACGC CGGAGGGAGG TAATGCCCCT GGGCCCCCCC 1020
GAGAACGTTA GCGCCGTGCG GAACGGAAGC CAGGCCCTCG TGCGTTGGCA AGAGCCAAAG 1080
GCACCCCTGC AGGGCACCCT GCTAGGATAC CGGCTGGCGT ATCGAAGCCA GGACACCCCC 1140
GAGGTGCTAA TGGACATAGG GCTCAAGCGA GAAGTGACCC TGGAGCTGCG GGGAGACAGG 1200
CCTGTGCCCA ACCTGACGGT GTGTGTGGCA GCCTACACGG CTGCTGGGGA TGGGCCCTGG 1260
AGCCTCCCCG TGCCCTTGGA GCCCTGGCGT CCAGGGCAAG GACAGCCAGT CCACCAGCTG 1320
GTGAGTGAAC CCCCAGCTCC CGCCTTCTCA TGGCCCTGGT GGTATGTACT GCTGGGAGCA 1380
GTTGTGGCCG CTGCTTGCGT CCTCATCTTG GCCCTCTTCC TTGTCCACCG GCGGAAGAAG 1440
GAGACTCGCT ATGGAGAGGT GTTTGAGCCA ACAGTGGAGC GGGGTGAGCT GGTGGTCAGA 1500
TACCGGGTCC GCAAGTCCTA CAGTCGCCGG ACTACTGAAG CTACCTTGAA CAGCCTGGGC 1560
ATCAGTGAAG ACTTGAAGGA GAAGCTGCGG GACGTGATGG TGGACCGGCA CAAGGTGGCC 1620
CTGGGGAAGA CCTTGGGAGA AGGAGAGTTT GGAGCCGTGA TGGAGGGTCA GCTCAACCAG 1680
GACGACTCCA TTCTCAAGGT GGCCGTGAAG ACGATGAAGA TCGCCATCTG CACCAGGTCG 1740
GAGCTGGAGG ACTTCCTGAG CGAAGCTGTC TGCATGAAAG AATTTGACCA CCCCAACGTC 1800
ATGAAGCTGC TTGGCGTCTG TTTCCAGGGT TCTGAACGAG AAGGCTTCCC GGCACCTGTG 1860
GTCATCTTAC CTTTCATGAA ACATGGAGAC TTACACAGCT TCCTCCTCTA CTCGCGGCTT 1920
GGGGACCAGC CGATGTTCCT CCCCACGCAG ATGCTGGTGA AGTTCATGAC AGACATCGCC 1980
AGTGGCATGG AGTACCTGAG TACCAAGAGG TTCATACACC GGGACCTGGC TGCCAGGAAT 2040
TGCATGCTGA ATGAGAACAT GTCCGTGTGT GTGGCCGACT TCGGGCTTTC CAAGAAGATC 2100
TACAACGGGG ACTACTACCG CCAGGGCCGC ATTGCCAAGA TGCCCGTCAA GTGGATCGCA 2160
ATCGAGAGCC TGGCTGACCG CGTCTACACC AGCAAGAGCG ACGTGTGGTC CTTTGGGGTG 2220
ACCATGTGGG AGATCGCCAC CCGCGGTCAG ACGCCGTACC CAGGCGTGGA GAACAGCGAG 2280
ATTTATGACT ACCTGCGCCA GGGAAACCGC CTGAAGCAGC CTGCAGACTG TCTGGATGGA 2340
CTGTATGCCC TGATGTCCCG GTGCTGGGAG CTGAACCCCC GAGACCGGCC AAGTTTTTCA 2400
GAGCTGCGGG AAGACCTGGA GAACACGCTG AAGGCCCTGC CCCCTGCCCA GGAGCCTGAC 2460
GAAATCCTCT ACGTCAACAT GGACGAGGGC GGAGGTCATT CCGAGCCCCG TGGAGCTGCC 2520
GGAGGAGCAG AGCCGCACAC CCAGCCCGAC CCGAAGGACT CCTGCAGCTG CCTTACGGCC 2580
GCGGAGGTCC ATCCTGCCGG ACGCTACGTC CTCTGCCCTT CCACGGCTCC TGGCCCTGCT 2640
CTGCCTGCCG ACAGGAGCTC CCAAGCACCC CCGGCACAGG AGGATGGAGT CTGA 2694
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lgk+lgegefg+vmegql+q+d silkvavkt+k++i++rse+e+flsea+cmkefdh
Q: 539   VALGKTLGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDH  597
         68**********************.***********************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnv++l+gv++++se++ +p+pvvilpfmk+gdlh+fllysrlg++p++lp+q+lvkfm 
Q: 598   PNVMKLLGVCFQGSEREGFPAPVVILPFMKHGDLHSFLLYSRLGDQPMFLPTQMLVKFMT  657
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         diasgmeyls+++fihrdlaarncml+e+m+vcvadfglskkiy+gdyyrqgriak+pvk
Q: 658   DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK  717
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvw+fgvtmweiatrgqtpy+gven+eiydyl+qgnrlkqp+dc
Q: 718   WIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADC  777
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlre  267
         ld+ly+lm+rcwe++p+drpsfs+lre
Q: 778   LDGLYALMSRCWELNPRDRPSFSELRE  804
         *************************96
Domain Sequence
(FASTA)
VALGKTLGEG EFGAVMEGQL NQDDSILKVA VKTMKIAICT RSELEDFLSE AVCMKEFDHP 60
NVMKLLGVCF QGSEREGFPA PVVILPFMKH GDLHSFLLYS RLGDQPMFLP TQMLVKFMTD 120
IASGMEYLST KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG NRLKQPADCL 240
DGLYALMSRC WELNPRDRPS FSELRE 266
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00371
EKS-ANC-00385
EKS-BOT-00398
EKS-CAJ-00402
EKS-CAP-00425
EKS-CII-00235
EKS-EQC-00386
EKS-GAA-00486
EKS-GOG-00386
EKS-HOS-00402
EKS-ICT-00374
EKS-LAC-00413
EKS-LOA-00405
EKS-MAM-00398
EKS-MOD-00383
EKS-MUM-00431
EKS-MUP-00391
EKS-MYL-00394
EKS-ORN-00509
EKS-ORL-00466
EKS-OTG-00401
EKS-PAT-00376
EKS-PEM-00218
EKS-POA-00389
EKS-RAN-00410
EKS-SAH-00366
EKS-TAR-00500
EKS-TEN-00498
EKS-XET-00509
EKS-XIM-00501
Gene Ontology
GO:0009986; C:cell surface
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0001786; F:phosphatidylserine binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0001974; P:blood vessel remodeling
GO:0048469; P:cell maturation
GO:0031668; P:cellular response to extracellular stimulus
GO:0035457; P:cellular response to interferon-alpha
GO:0071222; P:cellular response to lipopolysaccharide
GO:0097028; P:dendritic cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0034101; P:erythrocyte homeostasis
GO:0021885; P:forebrain cell migration
GO:0006954; P:inflammatory response
GO:0001779; P:natural killer cell differentiation
GO:2000669; P:negative regulation of dendritic cell apoptotic process
GO:0032689; P:negative regulation of interferon-gamma production
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0001764; P:neuron migration
GO:0042698; P:ovulation cycle
GO:0030168; P:platelet activation
GO:0001961; P:positive regulation of cytokine-mediated signaling pathway
GO:0032825; P:positive regulation of natural killer cell differentiation
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013106; Ig_V-set.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF07686; V-set; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013