EKS-ORC-00213

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00213

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	388.9	1.0E-116	56	307	252

Status

Unreviewed

Ensembl Protein

ENSOCUP00000014332

UniProt Accession

G1TW80;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK3

Gene Synonyms/Alias

MARK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000016664	ENSOCUP00000014332	ENSOCUT00000016668
ENSOCUG00000016664	ENSOCUP00000021323	ENSOCUT00000027003

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

753

Protein Sequence
(FASTA)

MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTGRTGARCR NSIASCADEQ PHIGNYRLLK 60

TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKRIVHRDLK 180

AENLLLDADM NIKIADFGFS NEFTVGSKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240

VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 300

IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 360

YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 420

HAGPAVPSVV AYPKRSQTST ADSDLKEDGI PSRKTGVSAA AGKGIAPASP MLGNASNPNK 480

ADIPERKKSS AVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENST VPDQRTPVAS 540

THSISSAATP DRIRFPRGTA TRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 600

STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN KEAKPRSLRF 660

TWSMKTTSSM DPSDMMREIR KVLDANSCDY EQRERFLLFC VHGDGHAENL VQWEMEVCKL 720

PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL 753

Nucleotide Sequence
(FASTA)

ATGTCCACTC GGACTCCGCT GCCCACGGTG AATGAACGAG ACACTGAAAA CCACACGTCA 60

CATGGAGATG GGCGTCAAGA AGTTACCTCT CGCACTGGGC GCACTGGAGC TCGGTGTAGA 120

AACTCCATAG CTTCCTGTGC AGATGAACAA CCTCATATCG GAAACTACAG ACTGTTGAAA 180

ACAATCGGCA AGGGAAATTT TGCAAAAGTG AAATTGGCAA GACATATCCT TACAGGCAGA 240

GAGGTTGCCA TAAAAATAAT TGACAAAACT CAGTTGAATC CAACAAGTCT ACAAAAGCTC 300

TTCAGAGAAG TACGAATAAT GAAGATTTTA AATCATCCAA ACATAGTGAA GTTATTTGAA 360

GTCATTGAAA CTGAAAAAAC ACTCTACCTA ATCATGGAGT ATGCAAGCGG AGGTGAAGTT 420

TTTGACTATT TGGTTGCACA TGGAAGAATG AAGGAAAAAG AAGCAAGAGC TAAATTTAGA 480

CAGATCGTGT CTGCAGTACA GTACTGCCAC CAAAAACGAA TCGTGCACAG AGACCTCAAG 540

GCTGAAAATC TATTGTTAGA TGCGGATATG AACATTAAAA TAGCAGACTT TGGTTTCAGC 600

AATGAGTTTA CTGTTGGCAG TAAACTGGAT ACGTTTTGTG GCAGTCCTCC GTACGCAGCC 660

CCCGAGCTCT TCCAGGGCAA GAAGTACGAT GGGCCAGAAG TTGACGTGTG GAGTCTTGGC 720

GTCATCCTGT ACACGCTAGT CAGCGGGTCC CTTCCCTTTG ACGGGCAAAA TCTAAAGGAA 780

CTGAGAGAGA GAGTATTAAG AGGGAAATAC AGAATCCCTT TCTACATGTC CACAGACTGT 840

GAAAACCTCC TCAAACGCTT CCTGGTGCTG AATCCAATCA AACGAGGCAC TCTAGAGCAA 900

ATCATGAAGG ACAGGTGGAT CAATGCAGGG CATGAGGAAG ACGAACTAAA ACCATTTGTC 960

GAACCTGAAC TAGACATCTC CGATCAGAAG AGAATAGATA TTATGGTGGG AATGGGATAT 1020

TCACAAGAAG AAATTCAAGA ATCTCTTAGT AAAATGAAAT ATGATGAAAT CACAGCAACG 1080

TATTTGTTGT TGGGGAGAAA ATCTTCAGAG CTGGATGCTA GTGATTCCAG TTCTAGCAGC 1140

AATCTCTCAC TTGCTAAGGT CAGGCCGAGC AGTGACCTCA ACAACAGTAC TGGTCAGTCT 1200

CCTCATCACA AAGTACAGAG AAGTGTTTCT TCAAGCCAGA AACAGAGAAG GTACAGTGAC 1260

CATGCTGGAC CAGCTGTTCC TTCTGTTGTG GCCTATCCAA AACGGAGTCA GACCAGCACT 1320

GCAGATAGTG ACCTCAAAGA AGATGGAATC CCCTCCCGGA AAACGGGCGT CAGTGCTGCT 1380

GCAGGAAAGG GGATTGCTCC AGCCAGCCCA ATGCTTGGCA ATGCAAGTAA TCCCAATAAG 1440

GCAGATATTC CTGAACGCAA GAAAAGCTCT GCTGTCCCTA GTAGTAACAC AGCATCTGGT 1500

GGAATGACAC GGCGAAATAC TTACGTTTGC AGTGAGAGAA CCACAGCTGA TAGACACTCA 1560

GTGATTCAGA ATGGCAAAGA GAACAGCACC GTCCCTGACC AGAGGACCCC AGTCGCTTCA 1620

ACTCACAGTA TTAGCAGTGC AGCCACGCCG GATCGAATCC GCTTCCCAAG AGGCACTGCC 1680

ACCCGTAGCA CTTTCCACGG CCAGCCCCGG GAGCGGCGAA CGGCAACATA CAATGGCCCA 1740

CCCGCCTCAC CCAGCCTGTC CCACGAAGCC ACACCGTTGT CCCAGACTCG CAGCCGGGGC 1800

TCCACGAACC TCTTTAGTAA ATTAACTTCA AAACTCACGA GAAGAAACAT GTCATTCAGG 1860

TTTATCAAAA GGCTTCCAAC TGAATATGAG AGGAACGGGA GATATGAGGG CTCAAGTCGC 1920

AACGTATCTG CTGAGCAAAA GGACGAGAAC AAAGAAGCGA AACCTCGCTC CCTGCGCTTC 1980

ACCTGGAGCA TGAAGACCAC CAGCTCCATG GACCCCAGCG ACATGATGCG GGAGATCCGC 2040

AAAGTGCTGG ACGCCAACAG CTGCGACTAT GAGCAGAGAG AGCGCTTCTT GCTCTTCTGT 2100

GTCCACGGCG ATGGGCACGC AGAGAACCTC GTGCAGTGGG AAATGGAGGT GTGCAAGCTG 2160

CCAAGACTGT CTCTGAACGG GGTCCGGTTT AAGCGGATAT CAGGGACCTC CATAGCTTTC 2220

AAAAATATTG CTTCCAAAAT TGCCAACGAG CTAAAGCTG 2259

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 56    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  115

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lyl++eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 116   VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIV  175

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 176   HRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  235

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 236   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR  295

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 296   GTLEQIMKDRWI  307

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLIMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKRIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPIKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013