EKS-ORC-00144
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00144
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/NDR507.89.8E-1536991004306
StatusUnreviewed
Ensembl ProteinENSOCUP00000014329
UniProt AccessionG1TC45;
Protein Name
Protein Synonyms/Alias
Gene NameLATS1
Gene Synonyms/Alias LATS1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000016667ENSOCUP00000014329ENSOCUT00000016666
OrganismOryctolagus cuniculus
Functional Description
Protein Length1124
Protein Sequence
(FASTA)
MKRSEKPEGY RQMRPKTFPA SNYTGSSRQM LQEIRESLRN LSKPSDAAKA EHNMSKMLTE 60
DPRQVRNPPK FGTYHKALQE IRNSLLPFAN ETSSSSRSTS EVNPQMFQDL QAAGFDEDMV 120
IQALQKTNNR SIEAAIEFIS KMSYQDPRRE QMAAAAARPI NASLKPGSVQ QPINRKQSWK 180
GSKESLVPQR HGTALGDSVA YRSESPNSQT DVGRPLSGSG LTAFAQAHPS NGQRVNPPPP 240
PQVRSVTPPP PPRGTTPPPP SWEPNSQTKR YSGNMEYVIS RISPVPPGTW QEGYPPPPLN 300
TSSMSPPSQG QRAVSSVPVG RQPIIMQSSN KFNFPPGRPG IQNGSGQTDF MIHQNVVPAS 360
AVSRQPPPPY PLTPTNGQSS STLQTGGSAA PSSYTNGSIP QSMMVPNRNS HNMELYNINV 420
PGLQTTWPQS SSAPTQSSPS SGHEIPTWQP NIPVRSNSFN NPLGNRASHS TNSQPSATTV 480
TAITPAPIQQ PVKSMRVLKP ELQTALAPTH PSWIPQPIQT TQTSPFSEGT TSNMTVMAPV 540
AEAPNYQGPP PPYPKHLLHQ NPPVPPYESI NKSSKEDQPI LPKEDEGEKS YESVDNGDKE 600
KKQITTSPIT VRKNKKDEER RESRIQSYSP QAFKFFMEQH VENVLKSHQQ RLHRKKQLEN 660
EMMRVGLSQD AQDQMRKMLC QKESNYIRLK RAKMDKSMFV KIKTLGIGAF GEVCLARKVD 720
TKALYATKTL RKKDVLLRNQ VAHVKAERDI LAEADNEWVV RLYYSFQDKD NLYFVMDYIP 780
GGDMMSLLIR MGIFPENLAR FYIAELTCAV ESVHKMGFIH RDIKPDNILI DRDGHIKLTD 840
FGLCTGFRWT HDSKYYQSGD HPRQDSMDFS NEWGDPSNCR CGDRLKPLER RAARQHQRCL 900
AHSLVGTPNY IAPEVLLRTG YTQLCDWWSV GVILFEMLVG QPPFLAQTPL ETQMKVINWQ 960
TSLHIPPQAK LSPEASDLII KLCRGPEDRL GKNGADEIKA HPFFKTIDFS SDLRQQSASY 1020
IPKITHPTDT SNFDPVDPDK LWSDDNEEEN VNDTLNGWYK NGKHPEHAFY EFTFRRFFDD 1080
NGYPYNYPKP IEYEYINSQG SEQQSDEDDQ HTGSEIKNRD LVYV 1124
Nucleotide Sequence
(FASTA)
ATGAAGAGGA GTGAAAAGCC AGAAGGTTAC AGGCAAATGA GGCCTAAGAC CTTTCCTGCC 60
AGTAACTACA CTGGCAGCAG TCGGCAGATG TTGCAAGAAA TTCGGGAATC TCTTAGGAAT 120
TTATCCAAAC CATCTGATGC TGCAAAGGCT GAGCATAACA TGAGCAAAAT GTTGACTGAA 180
GATCCTCGAC AAGTTAGGAA TCCACCCAAA TTTGGGACAT ATCACAAGGC CTTGCAGGAA 240
ATTCGAAACT CTCTGCTGCC ATTTGCCAAT GAAACCAGTT CTTCCTCCAG GAGTACTTCA 300
GAAGTTAATC CACAGATGTT TCAAGACTTG CAAGCTGCTG GATTTGATGA GGATATGGTT 360
ATACAAGCTC TTCAAAAAAC TAATAACAGA AGCATAGAAG CAGCAATTGA ATTCATTAGT 420
AAAATGAGCT ATCAAGATCC TCGACGGGAG CAGATGGCTG CAGCAGCTGC CAGACCTATT 480
AATGCCAGCT TGAAACCCGG AAGTGTGCAA CAACCTATTA ACCGCAAGCA AAGCTGGAAA 540
GGTTCTAAGG AATCCTTAGT TCCTCAGAGA CATGGCACAG CACTAGGAGA CAGTGTGGCT 600
TATCGTTCTG AAAGTCCCAA CTCACAGACG GATGTAGGAA GACCTTTGTC TGGATCCGGT 660
TTAACAGCAT TTGCTCAAGC TCACCCTAGC AATGGACAGA GAGTGAACCC CCCACCACCT 720
CCTCAAGTAA GGAGTGTCAC TCCACCACCA CCTCCAAGAG GTACAACTCC ACCTCCCCCT 780
TCGTGGGAAC CAAACTCTCA AACTAAGCGC TATTCTGGGA ATATGGAATA CGTAATCTCT 840
CGAATCTCTC CTGTTCCCCC TGGGACCTGG CAGGAGGGCT ATCCTCCACC ACCTCTTAAC 900
ACTTCCTCCA TGAGTCCTCC TAGTCAGGGG CAGAGAGCAG TTAGTTCTGT TCCTGTGGGC 960
AGGCAGCCAA TCATCATGCA GAGTTCTAAC AAATTTAACT TTCCCCCAGG GAGGCCTGGA 1020
ATTCAGAATG GTAGTGGTCA GACTGATTTT ATGATCCACC AAAATGTTGT CCCTGCCAGT 1080
GCTGTGAGTA GGCAGCCACC TCCTCCATAT CCTCTGACCC CTACAAATGG ACAAAGCTCT 1140
TCTACTTTAC AAACAGGGGG GTCTGCTGCT CCTTCATCAT ATACAAATGG AAGTATTCCT 1200
CAGTCTATGA TGGTGCCAAA CAGAAACAGT CATAACATGG AACTCTACAA CATTAATGTA 1260
CCTGGACTAC AGACAACGTG GCCTCAGTCA TCTTCTGCTC CAACCCAGTC ATCCCCAAGC 1320
AGTGGGCATG AGATCCCTAC CTGGCAACCT AACATACCAG TGAGGTCAAA TTCTTTTAAT 1380
AATCCATTAG GAAATAGAGC AAGTCACTCT ACTAATTCTC AGCCATCAGC TACAACAGTC 1440
ACTGCGATTA CACCAGCTCC TATTCAACAG CCTGTGAAAA GCATGCGTGT ATTAAAACCA 1500
GAGTTACAGA CTGCTTTAGC ACCTACCCAC CCTTCTTGGA TACCACAACC AATTCAGACT 1560
ACTCAAACCA GTCCGTTTTC TGAGGGTACC ACTTCAAATA TGACCGTTAT GGCACCTGTT 1620
GCTGAAGCTC CAAACTATCA AGGTCCACCA CCACCTTATC CAAAACATCT GCTGCACCAG 1680
AACCCACCTG TTCCCCCATA TGAATCAATC AATAAGTCTA GCAAAGAGGA TCAGCCTATC 1740
TTGCCCAAGG AAGACGAGGG TGAAAAGAGT TATGAAAGTG TTGATAATGG AGATAAAGAA 1800
AAGAAACAGA TCACAACTTC ACCTATCACT GTTAGGAAAA ACAAGAAAGA TGAAGAGCGA 1860
AGGGAATCTC GGATTCAAAG TTATTCTCCC CAGGCATTTA AATTCTTTAT GGAGCAACAC 1920
GTAGAAAATG TGCTCAAATC CCATCAGCAA CGTCTACATC GTAAAAAACA ATTAGAGAAC 1980
GAAATGATGC GGGTTGGATT GTCTCAAGAT GCCCAGGACC AAATGAGAAA GATGCTTTGC 2040
CAAAAAGAAT CTAATTACAT CCGTCTTAAA AGGGCTAAAA TGGACAAGTC TATGTTTGTG 2100
AAGATTAAGA CACTAGGAAT AGGAGCGTTT GGTGAAGTCT GTCTAGCAAG AAAAGTAGAT 2160
ACTAAGGCTT TGTATGCAAC AAAAACTCTT CGAAAGAAAG ATGTTCTGCT TCGAAACCAA 2220
GTTGCTCATG TTAAAGCTGA GAGAGATATT CTGGCTGAAG CTGACAATGA GTGGGTCGTT 2280
CGTTTATATT ATTCATTCCA AGATAAGGAC AATTTATATT TTGTAATGGA CTACATTCCT 2340
GGGGGTGACA TGATGAGCCT ATTAATTAGA ATGGGCATCT TTCCAGAAAA TCTGGCGCGA 2400
TTCTATATAG CAGAACTTAC CTGTGCAGTT GAAAGTGTTC ATAAAATGGG CTTTATTCAT 2460
AGAGATATTA AACCTGATAA CATTTTGATT GATCGTGATG GTCACATTAA ATTGACTGAC 2520
TTTGGCCTCT GCACTGGCTT CAGATGGACA CATGATTCTA AGTACTATCA GAGCGGTGAC 2580
CATCCACGGC AAGATAGCAT GGACTTCAGT AATGAATGGG GTGATCCCTC AAACTGTCGA 2640
TGTGGAGATA GACTAAAGCC ACTAGAGCGG AGAGCTGCAC GCCAGCACCA GCGATGTCTA 2700
GCACATTCTT TGGTTGGGAC TCCCAATTAT ATTGCACCTG AAGTATTGCT ACGAACAGGA 2760
TATACACAGT TATGTGATTG GTGGAGTGTT GGTGTTATTC TCTTTGAAAT GCTAGTGGGA 2820
CAACCTCCTT TCTTGGCACA AACGCCATTA GAAACACAAA TGAAGGTTAT CAACTGGCAA 2880
ACATCTCTTC ACATCCCACC ACAAGCTAAA CTGAGTCCTG AAGCTTCAGA TCTGATTATT 2940
AAACTTTGCC GAGGACCAGA AGATCGTTTA GGCAAGAACG GTGCTGATGA AATAAAGGCT 3000
CATCCATTTT TTAAGACAAT TGATTTCTCC AGTGACCTGA GACAGCAGTC TGCTTCATAC 3060
ATTCCTAAAA TCACACACCC AACAGATACA TCAAATTTTG ACCCTGTTGA CCCTGATAAG 3120
TTATGGAGTG ATGATAATGA GGAGGAAAAT GTCAATGACA CTCTGAATGG GTGGTATAAA 3180
AATGGAAAAC ACCCTGAACA TGCCTTCTAC GAATTTACCT TTCGGAGGTT TTTTGATGAC 3240
AATGGCTACC CGTATAATTA TCCAAAGCCT ATTGAATATG AATACATTAA TTCACAAGGC 3300
TCAGAGCAAC AGTCAGATGA AGATGATCAA CACACAGGCT CAGAAATCAA AAATCGCGAT 3360
CTAGTGTATG TCTAG 3375
Domain Profile
S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60
         f k+k++g+GafGev+l+rk dtk++ya+k+lrkkd+l +nqvahvkaerdilaead+ew
Q: 699   FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW  758
         889*********************************************************
S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120
         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+++i++e+larfyiael++avesvhk+Gf
Q: 759   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF  818
         ************************************************************
S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173
         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ ++ ++d++++s+       
Q: 819   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNewgdpsn  878
         ***************************************************999******
S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228
              +lk+lerr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvil+eml
Q: 879   crcgdRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML  938
         ************************************************************
S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288
         vG+pPfla+tp et++kvinw+++l++p++++ls+ea+dli +l+  +e+rlgk+G+dei
Q: 939   VGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEI  998
         ************************************************************
S: 289   kkhpff  294
         k+hpff
Q: 999   KAHPFF  1004
         *****9
Domain Sequence
(FASTA)
FVKIKTLGIG AFGEVCLARK VDTKALYATK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60
VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMGIFPENL ARFYIAELTC AVESVHKMGF 120
IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHPRQDSMD FSNEWGDPSN 180
CRCGDRLKPL ERRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILFEML 240
VGQPPFLAQT PLETQMKVIN WQTSLHIPPQ AKLSPEASDL IIKLCRGPED RLGKNGADEI 300
KAHPFF 306
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00146
EKS-ANC-00146
EKS-BOT-00153
EKS-CAE-00122
EKS-CAJ-00158
EKS-CAF-00161
EKS-CAP-00153
EKS-CII-00092
EKS-DAR-00439
EKS-DRM-00073
EKS-EQC-00151
EKS-ERE-00024
EKS-FEC-00144
EKS-GAG-00131
EKS-GAA-00180
EKS-GOG-00152
EKS-HOS-00159
EKS-ICT-00147
EKS-LAC-00162
EKS-LOA-00153
EKS-MAM-00150
EKS-MEG-00121
EKS-MOD-00153
EKS-MUM-00158
EKS-MUP-00158
EKS-MYL-00161
EKS-NOL-00146
EKS-ORN-00188
EKS-ORA-00131
EKS-ORL-00175
EKS-OTG-00159
EKS-PAT-00144
EKS-PES-00136
EKS-POA-00150
EKS-PTV-00143
EKS-RAN-00150
EKS-SAH-00148
EKS-SUS-00134
EKS-TAG-00181
EKS-TAR-00197
EKS-TAS-00057
EKS-TEN-00188
EKS-TUT-00146
EKS-VIP-00072
EKS-XET-00142
EKS-XIM-00182
Gene Ontology
GO:0005737; C:cytoplasm
GO:0000922; C:spindle pole
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0051220; P:cytoplasmic sequestering of protein
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0035329; P:hippo signaling cascade
GO:0009755; P:hormone-mediated signaling pathway
GO:0030216; P:keratinocyte differentiation
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0030833; P:regulation of actin filament polymerization
GO:0000819; P:sister chromatid segregation
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR009060; UBA-like.
IPR000449; UBA/transl_elong_EF1B_N.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
PF00627; UBA; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50030; UBA; 1.
Prints
Created Date20-Feb-2013