EKS-ORC-00031
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00031
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak342.62.0E-102516787272
StatusUnreviewed
Ensembl ProteinENSOCUP00000017593
UniProt AccessionG1TCI4;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK2
Gene Synonyms/Alias JAK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000016853ENSOCUP00000014491ENSOCUT00000016862
ENSOCUG00000016853ENSOCUP00000017593ENSOCUT00000023029
OrganismOryctolagus cuniculus
Functional Description
Protein Length799
Protein Sequence
(FASTA)
PDIIDVSIKQ ANQEGANESR VVTIHKQDGK NLEIELSSLK EALSFVSLID GYYRLTADAH 60
HYLCKEVAPP TVLENIQSNC HGPISMDFAI SKLKKAGNQT GLYVLRCSPK DFNKYFLTFA 120
VERENVIEYK HCLITKNENG EYNLSGTKKN FSNLKDLLNC YQMETVRSDS IIFQFTKCCP 180
PKPKDKSNLL VFRTNGVSDV PLSPTLQRHN NVNQMVFHKI RNEDLIFNES LGQGTFTKIF 240
KGIRREVGDY GQLHETEVLL KVLDKAHRNY SVSFFEAASM MSQLSHKHLV LNYGVCVCGE 300
ENILVQEFVK FGSLDRKLEV AKQLAWAMHF LEEKTLIHGN VCAKNILLIR EEDRKTRNSP 360
FIKLSDPGIS ITVLPKEVLQ ERIPWVPPEC IENPKNLNLT TDKWSFGTTL WEICSGGDKP 420
LSALDSQRKL QFYEDRHQLP APKWTELANL INNCMDYEPD FRPSFRAIIR DLNSLFTPDY 480
ELLTENDMLP NMRIGALGFS GAFEDRDPTQ FEERHLKFLQ QLGKGNFGSV EMCRYDPLQD 540
NTGEVVAVKK LQHSTEEHLR DFEREIEILK SLQHDNIVKY KGVCYSAGRR NLRLIMEYLP 600
YGSLRDYLQK HKERIDHKKL LQYTFQICKG MEYLGTKRYV HRDLATRNIL VENENRVKIG 660
DFGLTKVLPQ DKEYYKVKEP GESPIFWYAP ESLTESKFSV ASDVWSFGVV LYELFTYIEK 720
SKSPPAEFMR MIGNDKQGQM IVFHLIELLK NNGRLPRPDG CPDEIYMIMT ECWNNNVNHR 780
PSFRDLALRV DQIRDNMTE 799
Nucleotide Sequence
(FASTA)
CCTGATATTA TTGATGTCAG TATTAAGCAA GCAAACCAAG AAGGTGCAAA TGAAAGCAGA 60
GTTGTAACTA TTCATAAGCA AGATGGTAAA AATTTGGAAA TTGAACTTAG CTCATTAAAG 120
GAAGCTTTGT CTTTTGTGTC GTTAATTGAT GGATATTATA GATTAACTGC AGATGCACAT 180
CATTACCTCT GTAAAGAAGT AGCTCCTCCA ACAGTGCTTG AAAATATACA AAGCAACTGT 240
CATGGCCCGA TTTCAATGGA TTTTGCCATC AGTAAGCTGA AGAAAGCAGG TAATCAGACT 300
GGACTATATG TACTTCGATG CAGTCCTAAG GACTTTAATA AATATTTTCT GACCTTCGCT 360
GTTGAGAGAG AAAATGTCAT TGAATATAAA CACTGTTTGA TTACCAAAAA TGAGAATGGA 420
GAGTATAACC TCAGTGGGAC TAAGAAGAAC TTCAGTAATC TTAAAGATCT TCTGAATTGC 480
TACCAGATGG AAACTGTTCG CTCAGACAGT ATAATTTTCC AGTTTACTAA GTGCTGCCCC 540
CCAAAGCCAA AGGATAAGTC AAATCTTCTA GTCTTCAGAA CCAATGGTGT TTCTGATGTA 600
CCGCTCTCAC CAACTTTACA GAGGCATAAT AATGTCAACC AAATGGTGTT TCACAAAATC 660
AGAAATGAAG ATTTGATATT CAATGAAAGT CTTGGCCAAG GTACTTTTAC AAAAATTTTT 720
AAAGGTATAA GAAGAGAAGT AGGAGACTAT GGTCAACTAC ATGAAACAGA AGTTCTTTTA 780
AAAGTCCTGG ATAAAGCACA TAGAAACTAT TCAGTTTCTT TCTTTGAAGC AGCAAGCATG 840
ATGAGCCAGC TTTCTCATAA ACATTTGGTT TTAAATTATG GAGTATGTGT GTGTGGAGAG 900
GAGAATATTC TGGTTCAGGA GTTTGTAAAA TTTGGATCAC TAGATAGGAA ACTTGAAGTG 960
GCTAAACAGT TGGCATGGGC CATGCATTTT CTAGAAGAAA AAACCCTTAT TCATGGGAAT 1020
GTGTGTGCCA AAAATATTCT ACTTATCAGA GAAGAAGACA GGAAGACGAG AAACTCCCCT 1080
TTCATCAAAC TTAGTGATCC TGGCATTAGT ATTACTGTTT TGCCGAAAGA AGTTCTGCAG 1140
GAGAGAATAC CATGGGTACC ACCTGAATGC ATTGAAAATC CTAAAAATCT AAATTTAACA 1200
ACAGACAAAT GGAGTTTTGG TACCACTTTG TGGGAAATCT GCAGTGGAGG AGATAAGCCT 1260
TTGAGTGCTC TGGATTCTCA ACGAAAACTA CAATTTTATG AAGATAGACA CCAGCTTCCT 1320
GCACCAAAGT GGACAGAATT AGCAAACCTT ATAAATAATT GTATGGATTA CGAACCAGAT 1380
TTTAGGCCTT CTTTCAGAGC CATCATACGA GATCTTAACA GTTTGTTTAC TCCAGATTAT 1440
GAACTATTAA CGGAAAATGA CATGTTACCA AATATGAGGA TAGGTGCCCT AGGGTTTTCT 1500
GGTGCTTTTG AAGATAGGGA CCCTACACAG TTTGAAGAAA GACATTTGAA ATTTCTGCAA 1560
CAACTTGGCA AGGGTAATTT TGGAAGTGTG GAGATGTGCC GGTATGACCC TCTGCAGGAC 1620
AACACTGGAG AGGTGGTGGC TGTGAAAAAG CTCCAGCACA GTACTGAAGA GCACCTCAGA 1680
GACTTTGAAA GGGAAATTGA AATCCTAAAA TCCTTACAAC ATGACAACAT TGTAAAGTAC 1740
AAAGGAGTGT GCTACAGTGC TGGCCGGCGT AATCTAAGAT TGATTATGGA ATATTTACCA 1800
TATGGAAGTT TACGGGACTA TCTCCAGAAA CATAAAGAAA GGATAGATCA CAAAAAACTT 1860
CTGCAGTACA CATTTCAAAT ATGCAAGGGT ATGGAATATC TTGGTACAAA AAGGTATGTC 1920
CACAGGGATC TGGCAACAAG AAATATATTG GTAGAGAATG AGAACAGAGT TAAAATAGGA 1980
GATTTTGGGT TAACCAAAGT ATTACCACAA GACAAAGAAT ATTACAAAGT GAAAGAACCT 2040
GGTGAAAGTC CCATCTTCTG GTATGCTCCA GAATCACTGA CAGAGAGTAA GTTTTCTGTT 2100
GCTTCAGATG TTTGGAGCTT TGGAGTGGTT CTGTACGAAC TTTTCACGTA TATTGAAAAG 2160
AGTAAAAGTC CACCAGCGGA ATTTATGCGC ATGATTGGCA ATGACAAACA AGGACAGATG 2220
ATTGTGTTCC ATTTAATAGA ACTCTTGAAG AATAATGGGA GATTACCAAG ACCAGATGGA 2280
TGTCCAGATG AGATTTATAT GATTATGACA GAATGCTGGA ACAATAACGT AAATCATCGT 2340
CCATCTTTTA GGGACCTAGC TCTTCGAGTG GATCAAATAA GGGACAACAT GACTGAATGA 2400
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+
Q: 516   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  575
         6899********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke++++++ll+++ q++k+meYL+
Q: 576   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTFQICKGMEYLG  635
         **********999888********************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         +k++vhrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a
Q: 636   TKRYVHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  689
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224
         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el
Q: 690   PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIEL  748
         ********.*******************************999999999***********
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262
         l+++ rlp+p+ cp+e++++mt+c++++ ++rpsFr+++
Q: 749   LKNNGRLPRPDgCPDEIYMIMTECWNNNVNHRPSFRDLA  787
         ************************************995
Domain Sequence
(FASTA)
LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60
NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERI DHKKLLQYTF QICKGMEYLG 120
TKRYVHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180
SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240
PRPDGCPDEI YMIMTECWNN NVNHRPSFRD LA 272
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00026
EKS-ANC-00025
EKS-BOT-00031
EKS-CAJ-00030
EKS-CAF-00031
EKS-CAP-00032
EKS-CII-00224
EKS-DAR-00042
EKS-DRM-00011
EKS-EQC-00028
EKS-FEC-00028
EKS-GAG-00025
EKS-GAA-00046
EKS-GOG-00030
EKS-HOS-00032
EKS-ICT-00030
EKS-LAC-00033
EKS-LOA-00030
EKS-MAM-00031
EKS-MEG-00027
EKS-MOD-00030
EKS-MUM-00032
EKS-MUP-00032
EKS-MYL-00032
EKS-NOL-00029
EKS-ORN-00046
EKS-ORA-00025
EKS-ORL-00043
EKS-OTG-00031
EKS-PAT-00029
EKS-PES-00027
EKS-POA-00028
EKS-PTV-00030
EKS-RAN-00032
EKS-SAH-00029
EKS-SUS-00028
EKS-TAG-00028
EKS-TAR-00046
EKS-TEN-00050
EKS-XET-00030
EKS-XIM-00044
Gene Ontology
GO:0005901; C:caveola
GO:0005737; C:cytoplasm
GO:0005856; C:cytoskeleton
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0035401; F:histone kinase activity (H3-Y41 specific)
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0060396; P:growth hormone receptor signaling pathway
GO:0035722; P:interleukin-12-mediated signaling pathway
GO:0061180; P:mammary gland epithelium development
GO:0030099; P:myeloid cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0043392; P:negative regulation of DNA binding
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:0050727; P:regulation of inflammatory response
GO:0046677; P:response to antibiotic
GO:0007262; P:STAT protein import into nucleus
GO:0033209; P:tumor necrosis factor-mediated signaling pathway
GO:0007260; P:tyrosine phosphorylation of STAT protein
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693; Tyr_kinase_non-rcpt_Jak2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR01825; JANUSKINASE2.
PR00109; TYRKINASE.
Created Date20-Feb-2013