EKS-ORC-00264

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00264

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	446.9	3.3E-134	234	521	288

Status

Unreviewed

Ensembl Protein

ENSOCUP00000014542

UniProt Accession

G1TCM6;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1A

Gene Synonyms/Alias

BMPR1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000016925	ENSOCUP00000014542	ENSOCUT00000016925

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

532

Protein Sequence
(FASTA)

MTQLCVHIRL LGAYLFIISR VHGQNLDSML HGTGVKSESD QKKSENGATL APEDTLPFLK 60

CYCSGHCPDD AVNNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR 120

TIECCRTHLC NQYLQPTLPP AVVGPFFDGS VRWLVVLVSM AICIVAMIIF SSCFCYKHYC 180

KSMSSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240

GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300

SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360

RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN 420

HFQPYIMADI YSFGLIIWEM ARRCVTGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 480

PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532

Nucleotide Sequence
(FASTA)

ATGACTCAGC TCTGTGTGCA CATCAGGTTA CTGGGAGCCT ATCTGTTCAT CATTTCTCGT 60

GTTCACGGAC AGAATCTAGA CAGTATGCTC CATGGCACTG GGGTGAAATC AGAGTCCGAC 120

CAGAAGAAGT CAGAAAATGG AGCCACCTTA GCGCCAGAGG ACACGCTGCC TTTTTTGAAG 180

TGCTATTGCT CAGGACACTG CCCTGATGAC GCTGTCAATA ACACATGCAT AACTAATGGA 240

CATTGCTTTG CCATCATAGA AGAAGATGAC CAGGGAGAAA CCACACTGGC GTCAGGGTGT 300

ATGAAATATG AAGGGTCTGA CTTTCAGTGC AAGGATTCAC CTAAAGCCCA GCTGCGCCGG 360

ACCATAGAGT GCTGCCGCAC CCACCTGTGT AACCAGTATT TGCAGCCGAC ACTGCCCCCT 420

GCTGTTGTAG GTCCTTTCTT CGATGGCAGC GTCCGGTGGC TGGTTGTGCT TGTGTCCATG 480

GCCATCTGCA TCGTTGCTAT GATCATCTTC TCCAGCTGCT TTTGTTACAA ACATTACTGC 540

AAGAGCATGT CCAGTCGACG TCGTTACAAT CGAGACTTGG AGCAGGATGA GGCGTTTATC 600

CCCGTGGGAG AGTCGCTGAA AGACCTCATC GACCAGTCGC AGAGCTCTGG GAGCGGATCT 660

GGCCTTCCTC TGCTGGTTCA GCGAACTATC GCCAAACAGA TTCAGATGGT GCGGCAAGTT 720

GGAAAGGGCC GGTATGGAGA AGTGTGGATG GGTAAATGGC GTGGAGAGAA AGTGGCAGTC 780

AAGGTGTTTT TCACCACTGA AGAGGCCAGC TGGTTTCGAG AAACAGAAAT CTACCAAACA 840

GTGCTGATGC GACACGAGAA CATACTCGGT TTCATAGCAG CGGACATTAA AGGCACAGGC 900

TCCTGGACTC AACTCTACCT GATCACCGAC TACCACGAGA ACGGGTCCCT CTATGACTTC 960

CTGAAATGTG CCACCCTGGA CACCAGAGCT CTGCTCAAGT TGGCTTACTC GGCTGCCTGT 1020

GGTCTGTGCC ACTTGCACAC AGAAATTTAT GGCACCCAAG GGAAGCCTGC CATTGCCCAT 1080

CGAGACCTGA AGAGCAAAAA CATCCTCATC AAGAAAAACG GGAGCTGTTG TATTGCTGAC 1140

CTGGGCCTTG CTGTTAAATT CAACAGTGAC ACGAATGAAG TGGATGTGCC CCTGAACACC 1200

AGGGTGGGCA CCAAGCGCTA CATGGCTCCC GAGGTGCTGG ACGAGAGCCT GAACAAAAAC 1260

CACTTCCAGC CCTACATCAT GGCGGACATC TACAGCTTCG GCCTCATCAT CTGGGAGATG 1320

GCCCGCCGCT GCGTCACGGG AGGGATCGTG GAAGAGTACC AGCTGCCGTA CTACAACATG 1380

GTGCCCAGCG ACCCGTCCTA CGAGGACATG CGCGAGGTCG TGTGCGTCAA GCGGCTGCGG 1440

CCGATTGTGT CCAACCGCTG GAACAGCGAC GAGTGCCTGC GGGCCGTGCT GAAGCTGATG 1500

TCAGAGTGCT GGGCCCACAA TCCAGCCTCC AGACTCACGG CGCTGCGGAT CAAGAAGACG 1560

CTGGCCAAGA TGGTGGAGTC GCAGGATGTA AAGATCTGA 1599

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 234   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk  tld++ ll+la+s+a+Gl+hLH+ei gt+

Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQ  353

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+kk+++cciaDlGLa+k++++++e+d+  n++vGtkRYmaPE

Q: 354   G--KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPE  411

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+ + +aD+Ys+gL++WE+a+Rc + +++veey+lp++++v+sdPs+e+m

Q: 412   VLDESLNKNHFQPYIMADIYSFGLIIWEMARRCVT-GGIVEEYQLPYYNMVPSDPSYEDM  470

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalr+kk+l

Q: 471   REVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL  521

         *************************************************97

Domain Sequence
(FASTA)

IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDFLKC ATLDTRALLK LAYSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKKN GSCCIADLGL AVKFNSDTNE VDVPLNTRVG TKRYMAPEVL 180

DESLNKNHFQ PYIMADIYSF GLIIWEMARR CVTGGIVEEY QLPYYNMVPS DPSYEDMREV 240

VCVKRLRPIV SNRWNSDECL RAVLKLMSEC WAHNPASRLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005524	; F:ATP binding
GO:0000981	; F:sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0051216	; P:cartilage development
GO:0048589	; P:developmental growth
GO:0009950	; P:dorsal/ventral axis specification
GO:0007398	; P:ectoderm development
GO:0042733	; P:embryonic digit morphogenesis
GO:0048568	; P:embryonic organ development
GO:0003272	; P:endocardial cushion formation
GO:0060914	; P:heart formation
GO:0035137	; P:hindlimb morphogenesis
GO:0006955	; P:immune response
GO:0001701	; P:in utero embryonic development
GO:0048368	; P:lateral mesoderm development
GO:0030324	; P:lung development
GO:0048382	; P:mesendoderm development
GO:0001707	; P:mesoderm formation
GO:0001880	; P:Mullerian duct regression
GO:0050768	; P:negative regulation of neurogenesis
GO:0014032	; P:neural crest cell development
GO:0021998	; P:neural plate mediolateral regionalization
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0060021	; P:palate development
GO:0048352	; P:paraxial mesoderm structural organization
GO:0021983	; P:pituitary gland development
GO:0030501	; P:positive regulation of bone mineralization
GO:0050679	; P:positive regulation of epithelial cell proliferation
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0001756	; P:somitogenesis
GO:0019827	; P:stem cell maintenance

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013