EPS-ORC-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORC-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	169.0	1.9E-49	319	505	187

Status

Unreviewed

Ensembl Protein

ENSOCUP00000015844

UniProt Accession

G1TFZ7;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1G

Gene Synonyms/Alias

PPM1G;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000017104	ENSOCUP00000015844	ENSOCUT00000030912
ENSOCUG00000017104	ENSOCUP00000014700	ENSOCUT00000017104

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

549

Protein Sequence
(FASTA)

MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 60

GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 120

PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGAGTGEE 180

PGSQGLNGEA GPEDPSRETP SQENGPTSKA HTGLSSNSEH GTEAGQVGEP GTPTGEAGPS 240

CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAR NEEDEDDTEE 300

AEEDEEEEEE EEEEMMVPGM EGKEEPGSDS GTTAVVALIR GKQLIVANAG DSRCVVSEAG 360

KALDMSYDHK PEDEVELARI KNAGGKVTMD GRVNGGLNLS RAIGDHFYKR NKNLPPEEQM 420

ISALPDIKVL TLTDDHEFMV IACDGIWNVM SSQEVVDFIQ SKISQRDENG ELRLLSSIVE 480

ELLDQCLAPD TSGDGTGCDN MTCIIICFKP RNTAALQPES GKRKLEEVLS AEGAEENGSS 540

DKKKKAKRD 549

Nucleotide Sequence
(FASTA)

ATGGGTGCCT ACCTCTCCCA GCCCAACACA GTGAAGTGCT CCGGGGACGG GGTCGGTGCC 60

CCGCGCCTGC CGCTGCCCTA TGGCTTCTCC GCCATGCAGG GCTGGCGCGT CTCTATGGAG 120

GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT 180

GGACATGGAG GAGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 240

GACCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC TTTCTTGGCT 300

ATTGATGCCA AACTGACAAC TGAGGAAGTC ATTAAGGAGC TGGCACAGAT TGCAGGGCGA 360

CCCACTGAGG ATGAGGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 420

GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC 480

GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGCTGGGAC AGGCGAGGAA 540

CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCCGAGG ACCCATCTAG GGAAACTCCT 600

TCACAGGAAA ATGGCCCCAC ATCCAAGGCC CACACAGGCC TTTCCTCCAA CTCGGAACAT 660

GGGACTGAGG CAGGCCAGGT TGGTGAGCCT GGCACTCCTA CTGGTGAGGC TGGGCCTTCC 720

TGCTCTTCAG CCTCCGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 780

GAGGATGAGT CAGATGAGGC GGAGGAGGAA GAGGAAGACA GTGAGGAATG CAGTGAGGAA 840

GAGGATGGCT ACAGCAGTGA GGAGGCAAGG AATGAGGAAG ATGAGGATGA CACTGAGGAG 900

GCTGAAGAGG ATGAAGAGGA GGAGGAAGAA GAGGAGGAAG AGATGATGGT GCCTGGGATG 960

GAAGGCAAAG AGGAGCCTGG CTCTGACAGT GGTACAACAG CGGTGGTGGC TCTGATACGA 1020

GGGAAGCAGT TGATTGTAGC CAATGCAGGA GACTCTCGCT GTGTGGTGTC TGAGGCTGGC 1080

AAAGCTTTAG ACATGTCGTA TGACCACAAA CCGGAGGATG AAGTGGAGCT AGCACGCATC 1140

AAGAATGCTG GTGGCAAGGT TACTATGGAT GGGCGAGTCA ACGGGGGCCT CAACCTTTCC 1200

AGAGCCATTG GAGACCACTT CTACAAGAGA AACAAGAACC TGCCACCTGA GGAGCAGATG 1260

ATTTCAGCCC TTCCTGACAT CAAGGTGCTG ACTCTCACGG ATGACCACGA GTTCATGGTC 1320

ATTGCCTGTG ACGGCATCTG GAATGTGATG AGCAGCCAAG AAGTTGTAGA CTTCATTCAA 1380

TCAAAGATCA GCCAACGTGA TGAAAATGGG GAACTTCGGT TATTGTCATC CATTGTGGAG 1440

GAGCTGCTGG ATCAGTGCCT GGCACCCGAC ACTTCTGGGG ATGGTACAGG GTGTGACAAC 1500

ATGACCTGCA TCATCATTTG CTTCAAGCCC CGGAACACAG CCGCGCTGCA GCCAGAGAGC 1560

GGCAAGCGGA AACTGGAGGA AGTGCTCTCC GCTGAGGGCG CTGAGGAAAA CGGCAGCAGC 1620

GACAAGAAGA AGAAGGCCAA GCGGGAC 1647

Domain Profile

S: 92    vleeksldidksGstavvalikdsklyvanvGdSravLcrngkavelssdHkpsredEle  151

          +e k++  + sG+tavvali++++l+van+GdSr+v +  gka+ +s dHkp+ e El+

Q: 319   GMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELA  378

         23344444555*************************************************

S: 152   RieeaggsvilkdgaRvlGvLavsRalGdlylk.........pyvtpePevtshrltsed  202

         Ri++agg+v+ +   Rv+G L++sRa+Gd ++k         +++++ P++ + +lt ++

Q: 379   RIKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrnknlppeeQMISALPDIKVLTLTDDH  436

         ************9..*********************************************

S: 203   efliLasDGlwdvvsneeavslvrdvle......kkeaeqeaakkLvklalargsk....  252

         ef+++a+DG+w+v+s++e+v+++++ ++      + + ++++ ++L++++la  ++

Q: 437   EFMVIACDGIWNVMSSQEVVDFIQSKISqrdengELRLLSSIVEELLDQCLAPDTSgdgt  496

         *************************99988776666677889999999999999987777

S: 253   ..dnvsaiv  259

           dn++ i+

Q: 497   gcDNMTCII  505

777777766

Domain Sequence
(FASTA)

GMEGKEEPGS DSGTTAVVAL IRGKQLIVAN AGDSRCVVSE AGKALDMSYD HKPEDEVELA 60

RIKNAGGKVT MDGRVNGGLN LSRAIGDHFY KRNKNLPPEE QMISALPDIK VLTLTDDHEF 120

MVIACDGIWN VMSSQEVVDF IQSKISQRDE NGELRLLSSI VEELLDQCLA PDTSGDGTGC 180

DNMTCII 187

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 2.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013