EKS-ORC-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	348.2	4.2E-104	1269	1527	259

Status

Unreviewed

Ensembl Protein

ENSOCUP00000014749

UniProt Accession

G1TD48;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000017154	ENSOCUP00000014749	ENSOCUT00000017160

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

1534

Protein Sequence
(FASTA)

RQECTSGDSA CKSPDSDPED FPDETNTENL YGTSPPSTPR QMKRMSTKHQ RTSAGRLGSR 60

CSLKAEKMNA ANQPPHKDPG KPVESVEEYS YKQEKKMRAT LRTTERDHKK NVQCSFMLDS 120

VGGSLPKKSI PEVDLNKPYL SLGCSNAKLP VSVPMPIART ARQTSRTDCP ADRLKFFETL 180

RLLLKLTSVS KKKDREQRGQ ENTSAFWFNR SNELIWLELQ AWHAGRTIND QDLFLYTARQ 240

AIPDIINEIL TFKVNYGSFA FVRNGASFNG TPAEGQSPAA CGTKNAGYST YHEHLQRQRV 300

SFEQVKRIME LLEYIEALYP SLQALQKDYE KYAAKDFQDR VQALCLWLNI TKDLNQKLRI 360

MGTVLGIKNL SDIGWPVFEI PSPRPSRGVE LEDEGEDTEG DLKELESSTD DSEEEPETRR 420

SPESNFDVQP QDCVARKLER LESEDESLGW GAPDGSPEAG LSRHCLTSIY RPFVDKALKQ 480

MGLRKLILRL HKLMDGSLQR ARVALVKSDR PVEFSEFPDP MWGSDYVQLS STPPSAEQRS 540

SAVSWEELRA MDLPSFEPAF LVLCRVLLNV IHECLKLRLE QRPAGEPSLL SIKQLVRECK 600

EVLKGGLLMK QYYQFMLQEV LHDPERPGCD IDAFEEDLHE MLMVYGECLR DQGSQLKRIE 660

DGEQDGKSRK TRERHFFLKV AAYIPTGGIV SLCLFPDIAG MLLKSTGSFL EFGLQESCAE 720

FWTSADDGGA SDEIRRSVVE ISRALKELFH EARERASKAL GFAKMLRKDL EIAAEFVLAA 780

PVRDLLDVLK SKQYVKVQIP GLESLQVFVP DALAGEKTLI LQLLNAAAGK DCSKDSDDTL 840

VDAHLLLSKQ NARARAADDR WGAWEAQPVK VVPQVETVDT LRSMQVDNLL LVVMQSAHLT 900

MQRKAFQQSI EGLVTLRQEQ TSSQPVIAKA LQQLKNDALE LCSRISDTID RVDHMFTSEF 960

DAEVDESESV TLQQYHREAM IQGYNFGFEY HKEVVRLMSG EFRQKIGDKY ISFARKWMNY 1020

VLTKCESGRG TRPRWATQGF DFLQAIEPVF ISALPEDDFL SLQALMNECI GHVIGKPHSP 1080

VTAIHRNSPR PVKVPRCHSD PPNPHLIIPT PEGFSTRSGP SEARSHGGRR PGPSGGDCAP 1140

PKPTSSAHDT RGSSVPENDR LASIAAELQF RSLSRHSSPT EERDEPAYPR GDSSGSARRS 1200

WELRTLISQT RDAASKQGPM GAVQKSVRLF EEKRYREMRR RNIIGQVCDT PKSYDNVMHV 1260

GLRKVTFKWQ RGNKIGEGQY GKVYTCISVD TGELMAMKEI RFQPNDHKTI KETADELKIF 1320

EGIKHPNLVR YFGVELHREE MYIFMEYCDE GTLEEVSRLG LQEHVIRLYS KQITVAINVL 1380

HEHGIVHRDI KGANIFLTSS GLIKLGDFGC SVKLKNNAQT MPGEVNSTLG TAAYMAPEVI 1440

TRAKGEGHGR AADIWSLGCV VIEMVTGKRP WHEYEHNFQI MYKVGMGHKP PIPERLSREG 1500

KDFLSHCLES DPKMRWTASQ LLDHSFVKVC TDEE 1534

Nucleotide Sequence
(FASTA)

AGGCAGGAGT GCACCTCGGG AGATTCTGCG TGCAAGAGTC CTGACTCGGA TCCGGAGGAC 60

TTTCCCGATG AGACGAATAC GGAAAATCTG TATGGCACCT CTCCCCCCAG CACACCTCGG 120

CAGATGAAGC GCATGTCCAC CAAACACCAG AGGACTAGTG CAGGGAGGCT GGGCAGCCGA 180

TGTAGTTTGA AAGCAGAGAA AATGAATGCA GCAAACCAGC CTCCACATAA AGACCCTGGA 240

AAACCAGTGG AGAGTGTGGA GGAGTACAGC TATAAGCAGG AGAAAAAGAT GCGAGCAACT 300

CTTAGAACGA CTGAGCGTGA TCACAAAAAA AATGTGCAGT GCTCCTTCAT GCTGGATTCA 360

GTGGGTGGGT CTTTGCCAAA AAAGTCAATT CCGGAGGTGG ACCTGAATAA GCCTTACCTC 420

AGCCTGGGCT GTAGCAACGC TAAGCTCCCG GTCTCTGTGC CCATGCCTAT AGCCAGAACT 480

GCACGCCAGA CTTCCAGAAC CGACTGTCCC GCGGATCGGT TAAAGTTTTT TGAAACATTA 540

AGACTTTTGC TAAAGCTTAC CTCAGTCTCA AAGAAGAAGG ACCGGGAGCA GAGAGGCCAG 600

GAAAACACGT CTGCCTTCTG GTTTAACCGA TCCAACGAAC TGATCTGGTT AGAGCTGCAA 660

GCCTGGCACG CAGGACGGAC CATTAATGAC CAGGACCTGT TTCTGTATAC AGCCCGCCAA 720

GCCATCCCGG ACATCATCAA CGAGATCCTG ACGTTCAAGG TTAATTATGG GAGCTTTGCC 780

TTTGTCAGAA ATGGCGCTAG TTTCAATGGT ACTCCAGCAG AAGGGCAGAG CCCGGCCGCT 840

TGCGGCACGA AGAACGCGGG TTACTCGACG TACCACGAGC ATCTCCAACG CCAGCGGGTC 900

TCGTTCGAGC AGGTGAAACG GATAATGGAG CTGCTGGAGT ACATAGAAGC ACTTTATCCC 960

TCTTTGCAGG CCCTGCAGAA GGACTATGAA AAGTACGCCG CAAAGGACTT CCAGGACAGG 1020

GTGCAGGCGC TCTGTTTGTG GCTGAACATC ACGAAAGACT TAAACCAGAA ATTAAGGATC 1080

ATGGGCACTG TTTTGGGCAT CAAGAATTTG TCAGACATTG GCTGGCCAGT GTTTGAAATC 1140

CCTTCCCCTC GCCCGTCCAG AGGCGTTGAG CTGGAGGACG AGGGGGAAGA CACTGAAGGG 1200

GACCTGAAGG AGCTGGAGAG TAGCACGGAT GACAGCGAAG AGGAACCGGA GACCAGACGG 1260

TCCCCGGAGA GCAACTTCGA CGTGCAGCCG CAGGACTGCG TGGCCAGGAA GCTCGAGAGG 1320

CTGGAGTCTG AGGACGAGTC CCTTGGCTGG GGGGCCCCAG ACGGCAGCCC CGAGGCCGGC 1380

CTCAGTCGGC ATTGCCTGAC TTCCATTTAC AGGCCGTTTG TAGACAAAGC CCTGAAGCAG 1440

ATGGGGCTGA GAAAGTTAAT CTTGAGACTT CACAAGCTCA TGGATGGTTC CTTACAGAGG 1500

GCGCGCGTCG CCCTGGTGAA GAGTGACCGT CCAGTGGAGT TTTCTGAATT CCCGGATCCC 1560

ATGTGGGGTT CTGATTACGT GCAGCTGTCC AGCACGCCGC CGTCCGCGGA GCAGAGGAGC 1620

AGCGCCGTGT CCTGGGAAGA GCTGAGGGCC ATGGACCTGC CCTCCTTTGA GCCCGCCTTC 1680

CTGGTCCTGT GCCGAGTGCT GCTGAATGTC ATCCATGAGT GCCTCAAGCT GCGGCTGGAG 1740

CAGAGGCCCG CCGGGGAGCC GTCCCTGCTC AGCATCAAGC AGCTGGTGAG AGAGTGCAAG 1800

GAGGTGTTAA AGGGAGGCCT CCTGATGAAG CAGTACTACC AGTTCATGCT GCAGGAGGTG 1860

CTGCACGACC CGGAGAGGCC CGGCTGCGAC ATCGACGCCT TCGAGGAGGA CCTGCACGAG 1920

ATGCTGATGG TTTATGGAGA ATGCTTGAGA GATCAGGGAA GCCAGTTGAA AAGGATTGAA 1980

GATGGTGAGC AAGACGGGAA GTCGCGGAAG ACTCGTGAGA GACATTTTTT TTTAAAGGTT 2040

GCCGCTTATA TCCCAACAGG GGGCATTGTG AGCCTTTGCC TCTTCCCTGA CATTGCAGGA 2100

ATGCTGCTGA AATCCACGGG GAGCTTCCTA GAGTTCGGCC TGCAGGAGAG CTGTGCTGAG 2160

TTCTGGACCA GCGCTGACGA CGGCGGTGCT TCCGATGAAA TCAGGAGGTC CGTGGTTGAG 2220

ATCAGCCGGG CGCTGAAGGA GCTCTTTCAC GAAGCCAGAG AACGAGCTTC GAAAGCACTG 2280

GGATTCGCTA AAATGTTGAG AAAGGACCTG GAAATAGCAG CAGAATTCGT CCTTGCAGCC 2340

CCAGTTAGAG ACCTCCTGGA TGTTCTGAAA TCAAAGCAGT ATGTTAAGGT GCAGATTCCT 2400

GGGCTGGAGA GCTTGCAGGT GTTTGTTCCG GACGCGCTGG CCGGGGAGAA GACTCTGATC 2460

CTGCAGCTGC TGAACGCCGC GGCCGGGAAG GACTGCTCCA AAGACTCGGA CGACACGCTC 2520

GTCGACGCCC ACCTGCTCCT CAGCAAGCAG AACGCCCGGG CCCGCGCCGC CGATGACCGC 2580

TGGGGCGCCT GGGAGGCGCA GCCGGTCAAA GTCGTGCCCC AGGTGGAGAC GGTTGACACC 2640

CTGAGGAGCA TGCAGGTGGA CAACCTCCTG CTGGTTGTCA TGCAGTCTGC CCATCTCACC 2700

ATGCAGAGAA AGGCCTTCCA GCAGTCCATC GAGGGGCTCG TGACCCTGCG CCAGGAGCAG 2760

ACGTCCAGTC AGCCCGTCAT CGCCAAAGCT CTGCAGCAGC TGAAGAATGA TGCCTTGGAG 2820

CTGTGCAGCA GAATAAGCGA CACCATTGAC CGAGTGGACC ACATGTTCAC GTCAGAGTTC 2880

GACGCGGAAG TGGACGAGTC CGAGTCTGTC ACCCTGCAGC AGTACCACCG CGAGGCCATG 2940

ATTCAGGGCT ACAACTTCGG GTTCGAGTAT CATAAAGAAG TTGTTCGATT GATGTCTGGG 3000

GAGTTTAGAC AGAAGATAGG AGACAAATAC ATCAGCTTTG CCCGGAAGTG GATGAATTAC 3060

GTGCTGACTA AATGTGAGAG TGGCAGAGGC ACCCGACCCA GGTGGGCGAC CCAAGGATTT 3120

GATTTTCTCC AAGCCATTGA GCCCGTCTTT ATTTCAGCCT TGCCAGAAGA TGACTTCTTG 3180

AGCCTGCAAG CCCTGATGAA TGAGTGTATT GGCCACGTCA TAGGAAAGCC ACACAGTCCT 3240

GTCACAGCTA TTCACCGGAA CAGCCCCCGC CCTGTGAAGG TGCCTCGGTG CCACAGCGAC 3300

CCGCCCAACC CTCATCTGAT TATCCCGACT CCAGAGGGAT TCAGCACCCG GAGCGGGCCT 3360

TCAGAGGCGC GGAGCCACGG CGGCCGTCGC CCTGGCCCCT CTGGCGGCGA CTGCGCACCG 3420

CCCAAACCCA CCAGCAGTGC CCATGACACC AGGGGTTCCA GCGTCCCTGA AAATGACCGC 3480

TTGGCTTCCA TAGCTGCTGA GCTGCAGTTT AGGTCCCTGA GTCGGCACTC CAGCCCCACA 3540

GAGGAGCGAG ACGAACCAGC CTACCCACGC GGGGATTCCA GCGGGTCAGC GCGGAGAAGC 3600

TGGGAACTCC GGACTCTCAT CAGCCAGACC AGAGATGCCG CCTCTAAGCA AGGCCCCATG 3660

GGAGCCGTCC AGAAGTCCGT GCGATTGTTT GAAGAAAAGC GGTACCGAGA AATGAGGAGG 3720

AGGAATATCA TCGGCCAAGT GTGTGATACC CCGAAATCCT ATGACAACGT CATGCACGTT 3780

GGCTTGAGGA AGGTGACCTT CAAGTGGCAA AGAGGAAACA AGATTGGAGA AGGGCAGTAC 3840

GGGAAGGTCT ACACCTGCAT CAGCGTCGAC ACCGGAGAGC TGATGGCCAT GAAGGAGATT 3900

CGATTTCAGC CCAACGACCA TAAGACCATC AAGGAGACGG CCGACGAGCT GAAGATCTTC 3960

GAGGGGATCA AGCACCCCAA CCTGGTCCGG TACTTTGGCG TGGAGCTGCA CAGGGAAGAA 4020

ATGTACATCT TCATGGAGTA CTGTGACGAG GGCACCCTGG AGGAGGTGTC GCGCCTGGGG 4080

CTGCAGGAGC ACGTCATCAG GCTGTACTCC AAGCAGATTA CTGTCGCCAT CAACGTCCTG 4140

CACGAACACG GCATAGTGCA CCGCGACATC AAAGGTGCCA ATATCTTCCT TACGTCGTCT 4200

GGACTCATCA AACTGGGAGA CTTCGGATGC TCAGTGAAGC TTAAAAACAA TGCCCAGACC 4260

ATGCCTGGGG AAGTGAACAG CACACTGGGG ACAGCAGCAT ACATGGCCCC GGAAGTCATC 4320

ACGCGTGCTA AAGGAGAAGG CCACGGTCGC GCGGCTGACA TCTGGAGTCT GGGCTGTGTT 4380

GTCATAGAGA TGGTGACCGG CAAGAGGCCT TGGCATGAGT ATGAACACAA CTTTCAGATC 4440

ATGTATAAAG TGGGAATGGG ACATAAGCCC CCGATCCCTG AAAGATTAAG CCGTGAAGGG 4500

AAGGACTTCC TTTCTCACTG CCTTGAAAGT GACCCAAAGA TGAGGTGGAC GGCCAGCCAG 4560

CTCCTCGACC ACTCGTTCGT CAAGGTTTGC ACAGATGAAG AATGA 4605

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1269  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1325

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1326  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITVAINVLHEH  1383

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1384  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1443

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls egkd

Q: 1444  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSREGKD  1502

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle+dpk r++a++LL+h+f+

Q: 1503  FLSHCLESDPKMRWTASQLLDHSFV  1527

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITVAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERLSR EGKDFLSHCL 240

ESDPKMRWTA SQLLDHSFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0019100	; P:male germ-line sex determination
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013