EKS-ORC-00399

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORC-00399

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	321.8	3.5E-96	107	355	249

Status

Unreviewed

Ensembl Protein

ENSOCUP00000020469

UniProt Accession

G1TD59;

Protein Name

Protein Synonyms/Alias

Gene Name

PKMYT1

Gene Synonyms/Alias

PKMYT1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOCUG00000017181	ENSOCUP00000014763	ENSOCUT00000017180
ENSOCUG00000017181	ENSOCUP00000020469	ENSOCUT00000030352

Organism

Oryctolagus cuniculus

Functional Description

Protein Length

471

Protein Sequence
(FASTA)

RLPALAMPVP TEGTPPPLSG TPVPVPAYFR HAQPGFSLKR PGGLSRSLPP RPPAKGSIPI 60

SRIFPPRTPG WHQPQPRRVS FRSETSETLQ SPGYDPSRPE SFFQQNFQRL GRLGHGSYGE 120

VFKVRSKEDG RLYAVKRSMS PFRGPKDRAR KLAEVGGHEK VGRHPRCVRL EQAWEEGGIL 180

YLQTELCGPS LQQHCEAWGA SLPEAQVWGY LRDTLLALAH LHGQGLVHLD VKPANIFLGP 240

RGRCKLGDFG LLVELGAVGA GEAQEGDPRY MAPELLQGSC GTAADVFSLG LTILEVACNM 300

ELPHGGEGWQ QLRQGYLPPE FTAGLSPELR SVLVMMLEPD PQLRATAEAL LALPMLRPPR 360

PWSVLWFLAA EALSRGWALW QALLALLCWL WHGLAHPASW LQPPGPPATP PGSPPCSLLL 420

DGSLSSSWDE DSLRATLSSE ATLARAAGST STPRSRYPPR QCTPLRLAPA A 471

Nucleotide Sequence
(FASTA)

AGGCTTCCTG CACTGGCCAT GCCTGTGCCC ACAGAAGGCA CCCCGCCGCC CCTGAGCGGC 60

ACCCCTGTCC CAGTCCCGGC CTACTTCCGC CACGCACAAC CTGGCTTCTC CCTCAAGAGG 120

CCTGGGGGGC TCAGCCGGAG CCTCCCGCCC CGACCCCCTG CCAAGGGCAG CATCCCCATC 180

AGTCGCATCT TCCCTCCTCG GACCCCGGGC TGGCACCAGC CCCAGCCCCG GAGGGTGTCA 240

TTTCGGAGCG AGACCTCAGA GACCCTGCAG AGCCCTGGGT ACGACCCGAG CCGGCCAGAA 300

TCCTTCTTCC AGCAGAACTT CCAGAGGCTC GGCCGCCTGG GCCATGGCTC CTACGGGGAG 360

GTCTTCAAGG TGCGCTCCAA GGAGGATGGC CGGCTCTATG CAGTCAAGCG CTCCATGTCG 420

CCGTTCCGGG GCCCCAAGGA CCGGGCCCGC AAGCTGGCCG AGGTGGGCGG CCACGAGAAG 480

GTGGGGCGGC ACCCACGTTG TGTGCGGCTG GAGCAGGCCT GGGAGGAGGG TGGCATCTTG 540

TACCTGCAGA CGGAGCTGTG TGGGCCCAGT CTGCAGCAGC ACTGTGAGGC CTGGGGTGCC 600

AGCCTGCCCG AAGCCCAGGT CTGGGGCTAC CTGCGGGACA CCCTGCTCGC CCTGGCGCAC 660

CTGCATGGCC AAGGCCTGGT CCACCTTGAT GTCAAGCCTG CCAACATCTT CCTGGGGCCC 720

CGGGGCCGCT GCAAGCTGGG TGACTTTGGG CTGCTGGTGG AGCTGGGTGC AGTCGGGGCT 780

GGCGAGGCCC AGGAGGGAGA CCCCCGCTAC ATGGCCCCCG AGCTGCTGCA GGGCTCCTGT 840

GGAACAGCAG CTGATGTTTT CAGTCTGGGT CTCACCATCC TGGAAGTGGC ATGCAACATG 900

GAGCTGCCCC ATGGTGGGGA GGGCTGGCAG CAGCTGCGCC AGGGCTACCT GCCCCCTGAG 960

TTCACTGCCG GTCTGTCCCC CGAGCTCCGT TCTGTCCTTG TCATGATGCT GGAGCCTGAC 1020

CCCCAGTTGC GGGCCACTGC TGAGGCCCTG CTGGCCCTGC CCATGCTGAG GCCACCACGG 1080

CCCTGGAGCG TCCTGTGGTT CCTGGCTGCC GAGGCCCTGA GCCGTGGGTG GGCCCTGTGG 1140

CAGGCTCTGC TTGCCCTGCT GTGCTGGCTC TGGCATGGGC TAGCCCACCC TGCCAGCTGG 1200

CTGCAGCCCC CAGGCCCGCC AGCCACCCCT CCCGGCTCAC CGCCCTGCAG CCTGCTCCTG 1260

GACGGCAGCC TCTCCAGCAG CTGGGACGAG GACAGTCTAC GGGCCACGCT CTCCTCAGAG 1320

GCCACCCTGG CCCGGGCTGC TGGCAGTACC TCCACTCCCC GGAGCAGATA CCCACCCAGG 1380

CAGTGCACGC CCCTGCGCTT GGCCCCGGCC GCC 1413

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F+++ ++G+G++gevfkv+++edg+lyA+k+s++p++g ++++++l+Ev +h+++g+h+

Q: 107   FQRLGRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGGHEKVGRHPR  166

         89999*******************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         +vr+ +aWee ++ly+qtElC g sL+++   cea+ ++l+ea+++ +l d ll+l +lH

Q: 167   CVRLEQAWEEGGILYLQTELC-GPSLQQH---CEAWGASLPEAQVWGYLRDTLLALAHLH  222

         *********************.*******...****************************

S: 121   ssslvHlDikpenifitkevtlklgDlGlvtelnsedkskveEGDsrylakEilqeeysk  180

          + lvHlD+kp+nif+  ++++klgD+Gl++el++  + +++EGD ry+a+E+lq++  +

Q: 223   GQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGAVGAGEAQEGDPRYMAPELLQGSCGT  282

         ************************************************************

S: 181   lkaDiFslgltilevaanvelPsnGeaWhklRkgklpdeilkelsedlrellklmlepdp  240

         + aD+Fslgltileva+n+elP+ Ge W++lR+g+lp+e+++ ls +lr++l +mlepdp

Q: 283   A-ADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSPELRSVLVMMLEPDP  341

         *.**********************************************************

S: 241   erRptaeellkhev  254

         + R+tae+ll+ ++

Q: 342   QLRATAEALLALPM  355

         **********9876

Domain Sequence
(FASTA)

FQRLGRLGHG SYGEVFKVRS KEDGRLYAVK RSMSPFRGPK DRARKLAEVG GHEKVGRHPR 60

CVRLEQAWEE GGILYLQTEL CGPSLQQHCE AWGASLPEAQ VWGYLRDTLL ALAHLHGQGL 120

VHLDVKPANI FLGPRGRCKL GDFGLLVELG AVGAGEAQEG DPRYMAPELL QGSCGTAADV 180

FSLGLTILEV ACNMELPHGG EGWQQLRQGY LPPEFTAGLS PELRSVLVMM LEPDPQLRAT 240

AEALLALPM 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0010923	; P:negative regulation of phosphatase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013