EKS-ORC-00282
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00282
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR452.25.7E-136707963257
StatusUnreviewed
Ensembl ProteinENSOCUP00000014890
UniProt AccessionG1TDH0;
Protein Name
Protein Synonyms/Alias
Gene NameERBB3
Gene Synonyms/Alias ERBB3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000017322ENSOCUP00000014890ENSOCUT00000017328
OrganismOryctolagus cuniculus
Functional Description
Protein Length1339
Protein Sequence
(FASTA)
MRGSRALQVL GVLLSLARGS EVGNSQAVCP GTLNGLSVTG DAGNQSQTLH KLYEKWEVVM 60
GTPGIVFPGP PADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 120
LNYNTNSSHA LRQLRFTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDP GAEIVVKDNG 180
RSCPPCHEVC KGRCWGPGPE DCQTLTKTIC APQCNGHCFG PDPNQCCHDE CAGGCSGPQD 240
TDCFACRHFN DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVVSC PHNFVVDQTS 300
CVRACPPDKM EVDKNGLKIC EPCGGLCPKA CEGTGAGSRF QTVDSSNIDG FVNCTKILGN 360
LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420
RSLYNRGFSL LIMKNLNVTS LGLRSLKEIS AGRIYISANR QLCYHHSLNW TRLLRGPAEE 480
RLDIKHNRPR RECVAEGKVC DPLCSPGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP 540
REFAHEDECF SCHPECQPME GTATCNGSGS DACAQCAHFR DGPHCVSSCP NGVLGAKGPI 600
YKYPDVHNEC RPCHENCTQG CKGPELQDCL GQTLVLISKT HLAMAVTVGL AVIFLILGGT 660
FLYWRGRRIQ NKRAMRRYLE RGESLEPLDP SEKANKVLAR IFKETELRKL KVLGSGVFGT 720
VHKGVWIPEG ESIKIPVCIK VIEDKSGRQS FQAVTDHMLA IGSLDHAHIV RLLGLCPGSS 780
LQLVTQYLPL GSLLDHVRQQ RESLGPQLLL NWGVQIAKGM YYLEEHGMVH RNLAARNVLL 840
KSASQVQVAD FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 900
ELMTFGAEPY AGLRLAEVPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE NIRPTFKELA 960
NEFTRMARDP PRYLVIKRES GPGVPPGAEP SALTNKELEE VELEPELDLD LDLEAEEDTL 1020
ATTLGSALSL PVGTLTRPRG SQSLLSPSSG YMPMNQSVLG EACQESAVCG GSERCPRPVS 1080
LHPVPRGRLT SESSEGHVTG SEAELPEKVS VCRSRSRSRS PRPRGDSAYH SQRHSLLTPV 1140
TPLAPPGLEE EDVNGYVMPD THLKGTPSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRR 1200
RRPSPSHPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL NPVPVISTAG TTPDEDYEYM 1260
NRRRGAGGPG GDYTAMGACP AAEQGYEEMR AFQGPGPHAP SVRYARLKTL RSLEATDSAF 1320
DNPDYWHSRL FPKANAQRT 1339
Nucleotide Sequence
(FASTA)
ATGCGGGGAA GCCGGGCTCT GCAGGTGCTG GGTGTCCTGC TCAGCCTGGC CCGGGGCTCC 60
GAGGTGGGCA ACTCGCAGGC AGTGTGTCCT GGGACTCTGA ACGGGCTGAG CGTGACTGGC 120
GATGCCGGGA ACCAATCCCA AACTCTGCAC AAGCTTTATG AGAAATGGGA GGTGGTGATG 180
GGGACCCCCG GAATTGTGTT CCCCGGCCCC CCCGCGGATC TCTCCTTCCT CCAGTGGATC 240
CGAGAAGTGA CGGGCTACGT CCTCGTGGCC ATGAACGAGT TCTCTACGCT ACCCTTGCCC 300
AACCTCCGAG TGGTGCGCGG GACTCAGGTG TACGATGGGA AGTTCGCCAT CTTTGTCATG 360
TTGAACTACA ATACCAACTC CAGCCACGCG CTGCGCCAGC TCCGCTTCAC TCAGCTCACC 420
GAGATTCTGT CCGGGGGCGT TTATATCGAG AAGAATGACA AGCTTTGTCA CATGGACACG 480
ATCGACTGGA GGGACATCGT GAGGGACCCA GGAGCTGAGA TAGTGGTGAA GGACAATGGC 540
CGGAGCTGTC CCCCGTGTCA CGAGGTCTGC AAGGGGAGAT GCTGGGGTCC TGGACCAGAA 600
GACTGCCAGA CACTGACCAA GACCATCTGT GCCCCTCAGT GTAACGGCCA CTGCTTTGGG 660
CCCGACCCCA ACCAGTGCTG CCATGATGAG TGCGCCGGGG GCTGCTCAGG CCCTCAGGAC 720
ACCGACTGCT TCGCCTGCCG ACACTTCAAT GACAGCGGAG CCTGCGTACC CCGGTGTCCA 780
CAACCTCTCG TCTACAACAA GCTGACTTTC CAGCTAGAAC CCAACCCCCA TACCAAGTAC 840
CAGTACGGAG GGGTTTGTGT GGTCAGCTGT CCTCATAACT TTGTGGTGGA TCAAACTTCC 900
TGCGTCAGGG CCTGTCCTCC TGACAAGATG GAAGTGGACA AAAATGGGCT GAAGATATGC 960
GAGCCTTGTG GGGGGCTGTG CCCCAAAGCC TGCGAGGGGA CGGGCGCTGG GAGTCGCTTC 1020
CAGACTGTGG ACTCGAGCAA CATCGATGGA TTTGTGAACT GCACCAAGAT CCTGGGCAAC 1080
CTGGACTTTC TTATCACCGG CCTCAACGGA GACCCCTGGC ACAAGATCCC TGCCCTGGAC 1140
CCTGAGAAGC TCAACGTCTT CCGCACAGTC CGGGAGATCA CAGGCTACCT GAATATACAA 1200
TCCTGGCCTC CCCACATGCA CAACTTCAGC GTTTTTTCCA ACCTCACGAC CATCGGGGGC 1260
AGAAGCCTCT ACAACCGGGG CTTCTCTTTG TTGATCATGA AGAACTTGAA CGTGACGTCT 1320
CTGGGCCTCC GATCCCTGAA AGAGATTAGT GCTGGGCGTA TCTATATAAG TGCCAACCGG 1380
CAGCTGTGCT ACCACCATTC TCTGAACTGG ACCCGGCTGC TCCGGGGGCC TGCGGAAGAG 1440
AGACTGGACA TCAAGCATAA TCGGCCGCGC AGGGAGTGTG TGGCGGAGGG CAAAGTGTGT 1500
GACCCGCTGT GCTCCCCCGG GGGATGCTGG GGCCCAGGCC CGGGTCAGTG CCTCTCCTGT 1560
CGGAACTACA GCCGCGGAGG TGTCTGTGTG ACCCACTGCA ACTTTCTGAA CGGGGAGCCT 1620
CGAGAGTTTG CTCATGAGGA CGAATGTTTC TCCTGCCACC CGGAATGCCA GCCCATGGAA 1680
GGCACTGCCA CGTGCAATGG CTCGGGCTCC GATGCTTGTG CCCAGTGTGC CCATTTTCGA 1740
GATGGGCCCC ACTGTGTGAG CAGCTGCCCC AATGGAGTTC TAGGTGCCAA GGGCCCGATC 1800
TACAAGTACC CGGATGTTCA CAATGAATGT CGGCCGTGCC ACGAGAACTG CACCCAGGGG 1860
TGTAAGGGAC CAGAACTACA AGACTGTTTA GGCCAAACAC TGGTGCTGAT CAGCAAAACC 1920
CATCTGGCAA TGGCTGTGAC AGTAGGATTG GCAGTGATCT TCCTGATTCT GGGGGGCACA 1980
TTTCTCTACT GGCGTGGGCG CCGGATTCAG AATAAAAGGG CTATGAGGCG CTACCTGGAA 2040
CGTGGTGAGA GCTTAGAGCC TCTGGATCCC AGCGAGAAGG CTAACAAAGT CTTGGCCAGA 2100
ATCTTCAAAG AGACAGAGCT GAGGAAGCTT AAAGTGCTTG GTTCCGGCGT CTTTGGAACT 2160
GTGCACAAAG GTGTGTGGAT CCCCGAGGGT GAATCCATCA AGATTCCAGT GTGCATTAAA 2220
GTCATCGAAG ACAAGAGTGG ACGGCAAAGT TTTCAGGCCG TGACGGATCA CATGCTGGCC 2280
ATCGGCAGCC TGGACCACGC CCACATCGTA CGGCTGCTGG GACTGTGCCC AGGGTCATCG 2340
CTGCAGCTCG TCACTCAATA CCTGCCTCTG GGTTCCCTGC TGGATCATGT GAGGCAGCAG 2400
CGGGAGTCGC TGGGGCCACA GCTGCTGCTC AACTGGGGCG TACAAATCGC TAAGGGCATG 2460
TACTATCTTG AGGAGCACGG TATGGTGCAC AGGAACCTGG CTGCCCGCAA CGTGCTGCTG 2520
AAGTCAGCCA GTCAGGTTCA GGTGGCAGAT TTTGGTGTGG CTGACCTGCT GCCCCCAGAT 2580
GATAAGCAGC TCCTCCACAG TGAAGCCAAG ACTCCAATTA AGTGGATGGC TCTTGAGAGT 2640
ATCCACTTTG GGAAATACAC ACACCAGAGT GACGTCTGGA GCTACGGTGT GACAGTTTGG 2700
GAGCTGATGA CCTTCGGTGC AGAGCCCTAT GCAGGGCTGC GATTAGCAGA AGTACCAGAC 2760
CTGTTGGAGA AGGGGGAACG GTTGGCACAG CCCCAGATCT GCACCATTGA TGTCTACATG 2820
GTCATGGTCA AGTGTTGGAT GATTGATGAG AACATTCGCC CAACCTTTAA AGAACTAGCC 2880
AATGAGTTCA CCAGGATGGC CCGAGATCCA CCACGGTATC TAGTCATAAA GAGGGAGAGT 2940
GGGCCTGGAG TACCTCCTGG GGCAGAGCCC TCTGCTCTGA CAAACAAGGA ACTGGAGGAA 3000
GTAGAGCTGG AGCCAGAACT TGACCTAGAC CTAGACTTGG AGGCAGAAGA GGACACCCTG 3060
GCAACCACAC TGGGCTCTGC TCTCAGCCTA CCAGTTGGAA CTCTTACTCG ACCACGGGGG 3120
AGCCAGAGCC TGTTAAGTCC ATCATCTGGA TACATGCCCA TGAACCAGAG TGTTCTTGGA 3180
GAGGCCTGCC AGGAGTCTGC AGTTTGTGGG GGCAGTGAAC GATGCCCTCG TCCGGTCTCT 3240
CTGCACCCAG TGCCACGGGG CCGCCTGACC TCCGAATCGT CAGAAGGTCA CGTGACAGGC 3300
TCTGAGGCTG AGCTCCCGGA GAAGGTGTCG GTGTGCAGGA GCCGCAGCCG CAGCCGCAGC 3360
CCACGGCCAA GGGGAGATAG TGCCTACCAT TCCCAGCGCC ATAGCCTGCT TACGCCCGTC 3420
ACCCCTCTTG CCCCGCCAGG ATTGGAAGAA GAGGATGTCA ACGGTTATGT CATGCCAGAT 3480
ACACACCTCA AAGGTACTCC TTCTTCCCGA GAAGGTACTC TTTCCTCAGT GGGTCTCAGC 3540
TCTGTCCTGG GTACTGAAGA GGAAGATGAA GATGAGGAGT ATGAATACAT GAACCGTCGG 3600
AGAAGGCCCA GCCCATCTCA TCCCCCTCGG CCCGGCTCCC TTGAGGAGCT GGGCTATGAG 3660
TACATGGACG TGGGGTCAGA CCTCAGTGCC TCCCTGGGCA GCACGCAGAG TTGTCCTCTC 3720
AACCCTGTGC CCGTCATATC CACTGCTGGC ACGACACCAG ATGAGGACTA TGAGTATATG 3780
AATCGGCGAC GCGGTGCAGG TGGCCCGGGA GGGGATTACA CAGCCATGGG GGCCTGCCCA 3840
GCAGCTGAGC AAGGGTATGA AGAGATGCGA GCTTTCCAGG GGCCTGGTCC GCATGCCCCT 3900
AGTGTCCGCT ACGCCCGCCT CAAAACCCTC CGCAGTTTAG AAGCCACCGA CTCCGCCTTT 3960
GACAACCCTG ATTACTGGCA TAGCAGGCTT TTCCCCAAGG CTAACGCCCA GAGAACATAG 4020
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+klkvlGsG+fGtv+kG+wipege++kipv+ikv+e+k+g++++++++d++l+++sldh
Q: 707   LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDH  766
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         a++vrllglc  s+lqlvtq+lplG+lld+vr+++++lG+q llnw+vqiakGm+ylee+
Q: 767   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQQRESLGPQLLLNWGVQIAKGMYYLEEH  826
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
          +vhr+laarnvl+ks ++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky
Q: 827   GMVHRNLAARNVLLKSASQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  886
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw
Q: 887   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  946
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+++rp+fkela+ef
Q: 947   MIDENIRPTFKELANEF  963
         ****************9
Domain Sequence
(FASTA)
LRKLKVLGSG VFGTVHKGVW IPEGESIKIP VCIKVIEDKS GRQSFQAVTD HMLAIGSLDH 60
AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQQRESLGP QLLLNWGVQI AKGMYYLEEH 120
GMVHRNLAAR NVLLKSASQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180
THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240
MIDENIRPTF KELANEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00281
EKS-ANC-00291
EKS-BOT-00299
EKS-CAJ-00306
EKS-CAF-00306
EKS-CAP-00335
EKS-DAR-00648
EKS-EQC-00291
EKS-FEC-00285
EKS-GAA-00372
EKS-ICT-00282
EKS-LAC-00311
EKS-LOA-00310
EKS-MAM-00303
EKS-MOD-00294
EKS-MUM-00331
EKS-MUP-00297
EKS-MYL-00301
EKS-NOL-00276
EKS-OCP-00048
EKS-ORN-00390
EKS-ORL-00361
EKS-OTG-00305
EKS-POA-00291
EKS-PTV-00063
EKS-RAN-00316
EKS-SAH-00281
EKS-SUS-00263
EKS-TAR-00393
EKS-TEN-00390
EKS-TUT-00065
EKS-XET-00373
EKS-XIM-00380
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016328; C:lateral plasma membrane
GO:0005524; F:ATP binding
GO:0030296; F:protein tyrosine kinase activator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0021545; P:cranial nerve development
GO:0003197; P:endocardial cushion development
GO:0007162; P:negative regulation of cell adhesion
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0051048; P:negative regulation of secretion
GO:0009968; P:negative regulation of signal transduction
GO:0051402; P:neuron apoptotic process
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0042127; P:regulation of cell proliferation
GO:0014037; P:Schwann cell differentiation
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013