EKS-ORC-00108
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00108
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/MLCK252.64.6E-75298550253
StatusUnreviewed
Ensembl ProteinENSOCUP00000020542
UniProt AccessionG1TU19;
Protein Name
Protein Synonyms/Alias Myosin light chain kinase 2, skeletal/cardiac muscle;
Gene NameMYLK2
Gene Synonyms/Alias MYLK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000017328ENSOCUP00000020542ENSOCUT00000022106
ENSOCUG00000017328ENSOCUP00000014888ENSOCUT00000017326
OrganismOryctolagus cuniculus
Functional Description
Protein Length606
Protein Sequence
(FASTA)
MATENGAVEL GIQSLSTDEA SKGAASEESL AAEKDPAPPD PEKGPGPSDT KQDPDPSAPK 60
KDANTPAPEK GDVVPAQPSA GGSQGPAGEG GQGEAPAEGS AGKPAALPQQ TATAEASEKK 120
PEAEKGPSGH QDPGEPTVGK KVAEGQAAAR RGSPAFLHSP SCPAIIASTE KLPAQKPLSE 180
ASELIFEGVP ATPGPTEPGP AKAEGGVDLL AESQKEAGEK APGQADQAKV QGDTSRGIEF 240
QAVPSERPRP EVGQALCLPA REEDCFQILD DCPPPPAPFP HRIVELRTGN VSSEFSMNSK 300
EALGGGKFGA VCTCTEKSTG LKLAAKVIKK QTPKDKQAPL TSLHLLGQVE RRPRADLEER 360
LPFPGDTNFF SGRIESPVKM QRPAKEHDGQ PLSLSFSSRK CFSVNWVRGQ PRPHLSPQPE 420
NILCVNTTGH LVKIIDFGLA RRYNPNEKLK VNFGTPEFLS PEVVNYDQIS DKTDMWSLGV 480
ITYMLLSGLS PFLGDDDTET LNNVLSGNWY FDEETFEAVS DEAKDFVSNL IVKEQGARMS 540
AAQCLAHPWL NNLAEKAKRC NRRLKSQILL KKYLMKRRWK KNFIAVSAAN RFKKISSSGA 600
LMALGV 606
Nucleotide Sequence
(FASTA)
ATGGCGACAG AAAACGGAGC AGTCGAGCTG GGAATCCAGA GCCTGTCAAC AGACGAGGCT 60
TCTAAAGGTG CTGCAAGCGA AGAGTCCTTG GCTGCAGAGA AAGACCCTGC CCCCCCAGAC 120
CCAGAGAAGG GTCCTGGCCC CTCAGACACA AAGCAAGATC CCGATCCATC CGCGCCGAAG 180
AAAGATGCCA ACACCCCTGC CCCAGAGAAA GGGGATGTTG TCCCAGCCCA ACCCTCAGCC 240
GGCGGCAGCC AGGGTCCTGC GGGAGAGGGC GGCCAGGGTG AGGCACCTGC GGAGGGCAGT 300
GCTGGGAAGC CAGCAGCCCT GCCCCAGCAG ACTGCGACGG CCGAGGCCAG CGAGAAGAAG 360
CCAGAGGCCG AGAAAGGTCC CTCGGGACAC CAGGACCCAG GAGAGCCCAC GGTGGGCAAG 420
AAGGTAGCAG AGGGCCAAGC AGCCGCCAGG AGAGGCTCAC CCGCGTTTCT ACACAGCCCC 480
AGCTGCCCCG CCATCATTGC AAGCACCGAG AAGCTGCCGG CCCAGAAGCC CCTCAGTGAG 540
GCATCAGAGC TCATCTTTGA AGGGGTGCCC GCGACCCCCG GCCCCACCGA GCCCGGACCA 600
GCCAAGGCAG AAGGAGGGGT GGACTTGCTG GCAGAGAGCC AGAAGGAAGC AGGAGAGAAA 660
GCCCCAGGCC AGGCTGACCA GGCTAAGGTG CAAGGGGACA CCTCAAGGGG GATCGAGTTC 720
CAGGCTGTTC CCTCAGAGAG ACCGAGACCG GAGGTGGGGC AGGCCCTCTG TCTCCCAGCC 780
AGGGAGGAGG ACTGTTTCCA GATTTTAGAT GACTGCCCGC CACCCCCAGC CCCGTTTCCC 840
CACCGCATCG TGGAGCTGAG GACTGGGAAT GTCAGCAGTG AATTCAGCAT GAACTCTAAG 900
GAGGCGCTGG GAGGGGGAAA GTTTGGAGCA GTCTGCACCT GCACAGAGAA ATCCACAGGC 960
CTCAAGCTGG CAGCCAAGGT CATCAAGAAA CAGACCCCCA AAGACAAGCA GGCCCCTCTC 1020
ACCTCCCTGC ACCTCCTGGG CCAGGTTGAG AGGAGACCAC GAGCAGACTT GGAGGAACGC 1080
CTGCCTTTCC CTGGGGACAC CAATTTCTTC AGCGGCAGAA TAGAGTCCCC AGTTAAAATG 1140
CAGCGCCCCG CGAAGGAACA CGATGGGCAG CCTCTGTCAT TAAGCTTTTC ATCAAGAAAA 1200
TGCTTCTCGG TCAACTGGGT CAGAGGCCAA CCCAGGCCAC ACCTCTCTCC GCAGCCAGAG 1260
AACATCCTGT GTGTCAACAC CACGGGCCAT TTGGTGAAGA TCATTGACTT CGGCTTGGCA 1320
CGGAGGTATA ACCCCAACGA GAAGCTCAAG GTGAATTTTG GGACCCCAGA GTTCCTGTCA 1380
CCTGAGGTGG TGAATTACGA CCAAATCTCC GATAAGACAG ACATGTGGAG CTTGGGGGTC 1440
ATCACCTACA TGCTGCTGAG CGGCCTCTCC CCTTTCCTGG GAGATGACGA CACCGAGACC 1500
CTAAACAACG TGCTCTCCGG CAACTGGTAC TTCGACGAGG AGACCTTCGA GGCCGTATCG 1560
GACGAGGCCA AAGACTTCGT CTCCAACCTC ATCGTCAAGG AGCAGGGGGC CCGGATGAGC 1620
GCTGCCCAGT GCCTCGCCCA CCCCTGGCTC AACAACCTGG CGGAGAAAGC CAAGCGCTGT 1680
AACCGACGTC TCAAATCCCA GATCTTGCTT AAGAAATACC TCATGAAGAG GCGCTGGAAG 1740
AAAAACTTCA TTGCCGTCAG CGCTGCCAAC CGCTTCAAGA AGATCAGCAG CTCCGGGGCA 1800
CTGATGGCTC TAGGGGTGTG A 1821
Domain Profile
S: 2     sikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliql  61
         + ke+lg Gkfg+v++++ekstg klaak++k +++kdk+   + ++ l q++ +  + l
Q: 298   NSKEALGGGKFGAVCTCTEKSTGLKLAAKVIKKQTPKDKQAPLTSLHLLGQVERRPRADL  357
         67899*******************************************************
S: 62    ydafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHl  121
          +      +  +++ ++e    ++r ++e+         +f    + +++++  +   Hl
Q: 358   EERLPFPGDTNFFSGRIESPVKMQRPAKEHD--GQPLSLSFSSRKCFSVNWVRGQPRPHL  415
         ******************9877778777665..556667899999***************
S: 122   dlkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDm  181
           +penil+++++++ +K+idFGlar+++++eklkv+fgtpef++PEvvn++++s +tDm
Q: 416   SPQPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDM  475
         ************************************************************
S: 182   WsvGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkek  241
         Ws+Gvity+LlsGlsPFlgd+d+etl+nv s+++ fdee+f++vs+eakdF+s+l+vke+
Q: 476   WSLGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKEQ  535
         ************************************************************
S: 242   kkRmsaeeaLkhkwl  256
          +Rmsa+++L+h+wl
Q: 536   GARMSAAQCLAHPWL  550
         **************8
Domain Sequence
(FASTA)
NSKEALGGGK FGAVCTCTEK STGLKLAAKV IKKQTPKDKQ APLTSLHLLG QVERRPRADL 60
EERLPFPGDT NFFSGRIESP VKMQRPAKEH DGQPLSLSFS SRKCFSVNWV RGQPRPHLSP 120
QPENILCVNT TGHLVKIIDF GLARRYNPNE KLKVNFGTPE FLSPEVVNYD QISDKTDMWS 180
LGVITYMLLS GLSPFLGDDD TETLNNVLSG NWYFDEETFE AVSDEAKDFV SNLIVKEQGA 240
RMSAAQCLAH PWL 253
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00105
EKS-BOT-00115
EKS-CAJ-00117
EKS-CAF-00118
EKS-CAP-00112
EKS-EQC-00111
EKS-FEC-00107
EKS-GOG-00114
EKS-HOS-00117
EKS-ICT-00109
EKS-LOA-00111
EKS-MAM-00113
EKS-MIM-00051
EKS-MOD-00113
EKS-MUM-00116
EKS-MUP-00117
EKS-NOL-00106
EKS-OTG-00118
EKS-RAN-00113
EKS-SAH-00107
EKS-SUS-00101
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0055007; P:cardiac muscle cell differentiation
GO:0055008; P:cardiac muscle tissue morphogenesis
GO:0007274; P:neuromuscular synaptic transmission
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0010628; P:positive regulation of gene expression
GO:0046777; P:protein autophosphorylation
GO:0032971; P:regulation of muscle filament sliding
GO:0014816; P:satellite cell differentiation
GO:0035914; P:skeletal muscle cell differentiation
GO:0006941; P:striated muscle contraction
KEGG
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013