EKS-ORC-00415
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORC-00415
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK461.78.5E-13945307263
StatusUnreviewed
Ensembl ProteinENSOCUP00000015019
UniProt AccessionG1TY77;
Protein Name
Protein Synonyms/Alias
Gene NameROCK2
Gene Synonyms/Alias ROCK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOCUG00000017477ENSOCUP00000000666ENSOCUT00000000768
ENSOCUG00000017477ENSOCUP00000022038ENSOCUT00000023540
ENSOCUG00000017477ENSOCUP00000015019ENSOCUT00000017482
OrganismOryctolagus cuniculus
Functional Description
Protein Length1341
Protein Sequence
(FASTA)
DGLNSLVLDL DFPALRKNKN IDNFLNRYEK IVKKIRGLQM KAEDYDVVKV IGRGAFGEVQ 60
LVRHKASQKV YAMKLLSKFE MIKRSDSAFF WEERDIMAFA NSPWVVQLFC AFQDDRYLYM 120
VMEYMPGGDL VNLMSNYDVP EKWAKFYTAE VVLALDAIHS MGLIHRDVKP DNMLLDKHGH 180
LKLADFGTCM KMDETGMVHC DTAVGTPDYI SPEVLKSQGG DGYYGRECDW WSVGVFLFEM 240
LVGDTPFYAD SLVGTYSKIM DHKNSLCFPE DAEISKHAKN LICAFLTDRE VRLGRNGVEE 300
IKQHPFFKND QWNWDNIRET AAPVVPELSS DIDSSNFDDI EDDKGDVETF PIPKAFVGNQ 360
LPFIGFTYYR ENLYLVSEVP SQTEYFVTSV VCKYIQRQIQ KKLYTLEEHL SNELQAKEEL 420
EQKCKSVNSR LEKTAKELEE EITLRKTVES ALRQLEREKA LLQHKNAEYQ RRAEHEADRK 480
RNLENDVNSL KDQLEDLKRR NQNSQISTEK VNQLQKQLDE TNALLRTESD AAARLRKTQA 540
ESSKQIQQLE SNNRDLQDKN CLLETAKLKL EKEFLNLQSA LESERRDRTH GSEMISDLQG 600
RISGLEEDLK NGKILLAKIE LEKRQLQERF TDLEKEKSNM EIDMTYQLKV IQQSLEQEEA 660
EHKTTKARLA DKNKIYESIE EAKSEAMKEM EKKLLEERTL KQKVENLLLE AEKRCSLLDC 720
DLKQSQQKLS ELLTQKDVLN EDVRNLTLKI EQETQKRCLT QNDLKMQTQQ VSSLRVSEKQ 780
LRQENSHLTE VRVSLEKQNA ELRKERQDAD GQMKELQDQL EAEQYFSTLY KTQVKELKEE 840
CEEKTKLCKE LQQKKQELQD ERDSLAAQLE ITLTKADSEQ LARSIAEEQY SDLEKEKIMK 900
ELEIKEMMAR HKQELTEKDA TIASLEETNR TLTGDVANLA SEKEELNNKL KDAQEQLSRL 960
KDEEISAAAI KAQFEKQLLT ERTLKTQAVN KLAEIMNRKE PVKRGSDTDM RRKEKENRKL 1020
HMELKSEREK LTQQMIKYQK ELNEMQAQIA EESQIRIELQ MTLDSKDSDI EQLRSQLQAL 1080
HTGLDSSSIG SGPGDAEADD GFPESRLEGW LSLPVRNNTK KFGWVKKYVI VSSKKILFYD 1140
SEQDKEQSNP YMVLDIDKLF HVRPVTQTDV YRADAKEIPR IFQILYANEG ESKKEQEFPV 1200
EPVGEKSNYI CHKGHEFIPT LYHFPTNCEA CMKPLWHMFK PPPALECRRC HIKCHKDHMD 1260
KKEEIIAPCK VYYDISTAKN LLLLANSTEE QQKWVSRLVK KIPKKPPAPD PFARSSPRTS 1320
MKIQQNQSIR RPSRQLAPNK Q 1341
Nucleotide Sequence
(FASTA)
GATGGTTTAA ATTCCTTGGT CCTTGATTTG GATTTTCCCG CTTTGAGAAA AAACAAGAAC 60
ATAGATAATT TCTTAAATAG ATATGAGAAA ATTGTGAAAA AAATCAGAGG CCTACAAATG 120
AAGGCAGAAG ACTATGATGT TGTTAAAGTT ATTGGAAGAG GTGCTTTTGG TGAAGTCCAG 180
TTGGTTCGTC ATAAGGCATC ACAGAAGGTT TATGCCATGA AGCTTCTTAG TAAGTTTGAA 240
ATGATAAAAA GATCAGATTC TGCTTTTTTT TGGGAAGAAA GAGATATTAT GGCCTTTGCC 300
AACAGTCCCT GGGTGGTTCA GCTCTTCTGT GCCTTTCAGG ATGACAGGTA TCTGTACATG 360
GTAATGGAAT ACATGCCTGG TGGAGACCTT GTAAACCTGA TGAGTAATTA TGATGTGCCT 420
GAAAAGTGGG CCAAATTCTA TACTGCGGAA GTTGTTCTTG CCCTGGATGC GATACACTCC 480
ATGGGCCTGA TCCACAGGGA CGTGAAGCCT GACAACATGC TACTGGATAA ACACGGACAT 540
CTCAAATTGG CAGATTTCGG CACGTGTATG AAGATGGATG AAACAGGCAT GGTACATTGT 600
GATACAGCAG TTGGCACACC TGATTACATA TCCCCTGAGG TCCTGAAGTC ACAAGGGGGT 660
GATGGCTACT ACGGACGGGA ATGTGACTGG TGGTCTGTGG GTGTTTTCCT TTTTGAGATG 720
CTAGTGGGAG ACACTCCATT TTATGCAGAT TCACTTGTAG GAACTTACAG TAAAATTATG 780
GATCATAAAA ATTCACTATG TTTCCCTGAA GATGCAGAAA TTTCTAAACA CGCGAAGAAT 840
CTCATCTGCG CCTTCTTAAC AGATAGGGAG GTACGACTTG GGCGAAATGG GGTAGAAGAA 900
ATCAAACAGC ATCCTTTCTT TAAGAATGAT CAATGGAATT GGGATAACAT AAGAGAGACG 960
GCAGCTCCTG TGGTCCCTGA ACTCAGCAGT GACATAGACA GCAGCAATTT TGACGACATT 1020
GAAGATGATA AAGGCGATGT GGAAACCTTC CCGATTCCTA AAGCTTTTGT GGGAAACCAG 1080
CTGCCTTTTA TAGGATTTAC CTACTATAGA GAGAATTTGT ATTTAGTCAG TGAGGTGCCA 1140
TCACAAACTG AATATTTTGT GACCTCTGTT GTTTGTAAGT ATATTCAAAG ACAGATTCAG 1200
AAAAAATTAT ATACATTAGA AGAACACCTT AGCAATGAGT TACAAGCCAA AGAGGAGCTG 1260
GAGCAGAAGT GCAAATCTGT TAATTCTCGC CTGGAGAAAA CAGCAAAGGA GCTAGAAGAA 1320
GAGATCACCT TAAGGAAAAC TGTGGAGTCC GCACTGAGAC AACTGGAAAG AGAAAAGGCG 1380
CTTCTTCAGC ACAAGAACGC AGAGTATCAG CGCAGGGCTG AGCATGAAGC GGACAGGAAA 1440
CGAAACCTGG AAAACGATGT TAACAGCTTA AAAGATCAGC TTGAGGATTT GAAAAGAAGA 1500
AATCAGAATT CCCAAATATC CACTGAGAAA GTGAATCAAC TCCAGAAACA ACTGGATGAA 1560
ACCAATGCTT TGCTGCGAAC AGAATCTGAT GCTGCAGCCC GATTAAGAAA AACACAGGCA 1620
GAAAGTTCAA AACAGATCCA GCAGCTGGAA TCCAACAACA GAGATCTACA AGATAAAAAC 1680
TGCCTGCTGG AGACTGCCAA GCTGAAGCTT GAAAAGGAGT TTCTTAACCT TCAGTCAGCT 1740
CTGGAGTCTG AGAGGAGGGA CCGCACTCAC GGATCAGAGA TGATCAGTGA TTTGCAAGGT 1800
AGAATATCTG GCCTAGAAGA AGACTTAAAG AATGGCAAAA TCTTATTAGC AAAAATAGAA 1860
CTGGAGAAGA GGCAACTACA GGAGAGATTC ACTGATTTGG AAAAGGAAAA GAGCAACATG 1920
GAAATAGACA TGACATACCA ACTAAAAGTT ATTCAGCAGA GCTTAGAACA AGAAGAAGCT 1980
GAACATAAGA CCACAAAAGC ACGGTTAGCA GATAAAAATA AGATCTATGA ATCCATTGAA 2040
GAAGCTAAAT CAGAAGCCAT GAAAGAAATG GAGAAGAAGC TCTTGGAGGA AAGGACATTA 2100
AAACAGAAAG TGGAGAACCT GTTGCTGGAA GCTGAGAAAA GATGCTCCCT GTTAGACTGT 2160
GACCTCAAAC AGTCACAGCA GAAGCTGAGT GAGCTCCTCA CACAGAAAGA TGTGCTGAAC 2220
GAAGATGTTA GAAACCTGAC ATTAAAAATA GAGCAGGAGA CCCAGAAGCG CTGCCTCACC 2280
CAGAACGACC TGAAGATGCA GACGCAGCAG GTGAGCAGCC TGAGGGTGTC GGAGAAGCAG 2340
CTGCGGCAGG AGAACAGCCA CCTCACGGAG GTGAGAGTGA GCCTGGAGAA GCAGAACGCG 2400
GAGCTCCGCA AAGAACGTCA GGACGCAGAT GGGCAAATGA AAGAGCTCCA GGATCAGCTG 2460
GAAGCAGAAC AGTATTTCTC AACCCTTTAT AAAACACAAG TCAAGGAACT TAAAGAAGAA 2520
TGTGAAGAGA AGACCAAACT TTGTAAAGAA TTACAGCAGA AGAAGCAAGA ACTGCAGGAC 2580
GAAAGGGACT CCTTGGCCGC CCAGCTGGAA ATCACCTTGA CCAAAGCAGA TTCGGAGCAG 2640
CTGGCACGCT CCATCGCTGA AGAGCAGTAC TCCGACTTAG AGAAGGAGAA GATCATGAAG 2700
GAGCTGGAGA TCAAGGAGAT GATGGCTAGA CATAAACAGG AGCTCACTGA GAAAGATGCC 2760
ACCATTGCCT CTCTTGAAGA AACCAACAGA ACACTAACTG GTGATGTTGC CAATCTCGCG 2820
AGTGAGAAGG AAGAATTAAA CAACAAGTTG AAAGATGCTC AAGAGCAGCT GTCACGGCTG 2880
AAGGACGAGG AGATCAGCGC AGCGGCGATT AAAGCGCAGT TTGAGAAGCA GCTGCTGACA 2940
GAAAGAACGC TCAAGACTCA GGCCGTGAAT AAGCTGGCTG AGATCATGAA TCGAAAAGAA 3000
CCTGTCAAAC GTGGTAGTGA CACTGATATG CGCAGAAAAG AGAAGGAGAA TAGGAAGCTA 3060
CACATGGAGC TTAAATCTGA ACGTGAAAAA CTGACCCAGC AGATGATCAA ATATCAGAAA 3120
GAACTGAATG AAATGCAGGC TCAAATAGCT GAAGAGAGCC AGATCCGGAT TGAACTGCAG 3180
ATGACCCTGG ACAGTAAAGA CAGCGACATC GAGCAGCTGC GCTCACAGCT GCAGGCCTTG 3240
CACACTGGTC TGGACAGTTC GAGCATCGGC AGCGGGCCCG GAGACGCTGA GGCGGATGAT 3300
GGCTTTCCAG AATCAAGATT AGAAGGATGG CTTTCATTAC CTGTGCGCAA TAACACTAAG 3360
AAGTTTGGAT GGGTTAAGAA GTATGTGATT GTAAGCAGTA AGAAGATTCT TTTCTATGAC 3420
AGTGAACAGG ATAAAGAACA ATCTAACCCT TACATGGTGT TAGATATAGA CAAGTTGTTT 3480
CACGTGCGGC CAGTCACACA GACGGATGTC TATAGAGCAG ATGCCAAAGA AATCCCAAGG 3540
ATATTCCAGA TTCTGTATGC CAATGAAGGA GAGAGTAAAA AGGAACAAGA ATTTCCAGTG 3600
GAGCCAGTGG GAGAAAAATC TAATTACATT TGTCACAAAG GACATGAATT TATTCCTACT 3660
CTTTATCACT TCCCAACCAA CTGTGAGGCT TGTATGAAGC CATTGTGGCA CATGTTTAAG 3720
CCCCCTCCAG CGTTAGAGTG CCGGCGCTGC CATATCAAAT GTCACAAAGA TCACATGGAC 3780
AAAAAGGAGG AGATCATAGC TCCTTGCAAA GTGTACTATG ATATTTCGAC GGCAAAGAAT 3840
CTGTTGTTAT TAGCAAATTC TACAGAAGAG CAACAGAAGT GGGTTAGTCG GTTGGTGAAA 3900
AAGATACCTA AAAAACCCCC AGCCCCAGAT CCTTTTGCAC GGTCTTCTCC TAGAACTTCA 3960
ATGAAGATTC AGCAGAACCA GTCCATCAGA AGGCCAAGTC GACAGCTTGC CCCAAACAAA 4020
CAA 4023
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         ++++kviGrGafgev++vr+ka++kvyamk+l+k+e++kr++saff+eerd++++a+s+w
Q: 45    YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  104
         799*********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         +vql++afqd++yly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g
Q: 105   VVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  162
         **********************************..9***********************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180
         ++hrd+kpdn+lldk+Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+
Q: 163   LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GD  221
         ********************************************************9.**
S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240
         g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl+fped+++s++ak+l
Q: 222   GYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNL  281
         ************************************************************
S: 241   ikklltsreerlgregiedlkkhpff  266
         i+++lt+re rlgr+g+e++k+hpff
Q: 282   ICAFLTDREVRLGRNGVEEIKQHPFF  307
         *************************9
Domain Sequence
(FASTA)
YDVVKVIGRG AFGEVQLVRH KASQKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60
VVQLFCAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120
HRDVKPDNML LDKHGHLKLA DFGTCMKMDE TGMVHCDTAV GTPDYISPEV LKSQGGDGYY 180
GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLCFPEDAEI SKHAKNLICA 240
FLTDREVRLG RNGVEEIKQH PFF 263
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00414
EKS-ANC-00429
EKS-BOT-00443
EKS-CAJ-00447
EKS-CAF-00442
EKS-CAP-00477
EKS-CII-00252
EKS-CIS-00203
EKS-DAR-00838
EKS-DRM-00209
EKS-EQC-00434
EKS-FEC-00423
EKS-GAG-00374
EKS-GAA-00538
EKS-GOG-00433
EKS-HOS-00449
EKS-LAC-00457
EKS-LOA-00452
EKS-MAM-00442
EKS-MEG-00367
EKS-MOD-00431
EKS-MUM-00475
EKS-MUP-00434
EKS-MYL-00435
EKS-NOL-00404
EKS-ORN-00562
EKS-ORA-00388
EKS-ORL-00511
EKS-OTG-00448
EKS-PAT-00418
EKS-PES-00393
EKS-PEM-00242
EKS-POA-00431
EKS-RAN-00456
EKS-SAH-00409
EKS-SUS-00392
EKS-TAG-00509
EKS-TAR-00553
EKS-TEN-00556
EKS-VIP-00080
EKS-XET-00594
EKS-XIM-00554
Gene Ontology
GO:0031616; C:spindle pole centrosome
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0051298; P:centrosome duplication
GO:0000910; P:cytokinesis
GO:0035556; P:intracellular signal transduction
GO:0016525; P:negative regulation of angiogenesis
GO:0001843; P:neural tube closure
GO:0010825; P:positive regulation of centrosome duplication
GO:0045616; P:regulation of keratinocyte differentiation
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR020684; Rho-assoc_coiled-coil_kin.
IPR015008; Rho-bd.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
PF08912; Rho_Binding; 1.
SMARTs
SM00109; C1; 1.
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
Created Date20-Feb-2013